keyword
https://read.qxmd.com/read/38529883/long-term-follow-up-of-total-hip-arthroplasty-using-polyethylene-ceramic-composite-sandwich-liner
#21
JOURNAL ARTICLE
Daniel Rodríguez-Pérez, Thiago Carnaval, Marcos-Del-Carmen Rodríguez, Antonio Coscujuela-Maña, José-Luis Agulló, Sebastián Videla
INTRODUCTION: Ceramic-on-ceramic bearings have been widely used since their introduction in the 1970s. First-generation ceramics have very high fracture (breakage) rates. To overcome this, in the 1990s, modular cotyloid insert designs were developed, consisting of a ceramic and polyethylene composite (sandwich-type) liner; however, high implant fracture rates were observed in the medium term. We aimed to estimate the cumulative incidences of revision surgery (implant failure) and implant failure due to fractures, survival rates (time-to-revision surgery and time-to-fracture), and the long-term clinical and radiological outcomes in our series...
March 26, 2024: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://read.qxmd.com/read/38528893/extending-social-accountability-mandates-to-biomedical-research-in-canadian-faculties-of-medicine
#22
JOURNAL ARTICLE
Nadine Wiper-Bergeron, Holly L Adam, Kaylee Eady, Katherine A Moreau, Christopher Rj Kennedy, Claire E Kendall
BACKGROUND: Social accountability (SA), as defined by Boelen and Heck, is the obligation of medical schools to address the needs of communities through education, research and service activities. While SA is embedded within health profession education frameworks in medicine, they are rarely taught within graduate-level (MSc/PhD) education. METHODS: As these programs train future medical researchers, we invited first-year graduate students enrolled in a mandatory professionalism class at our institution ( n = 111) to complete a survey on their perceptions of the importance of SA in their research, training, and future careers...
February 2024: Canadian Medical Education Journal
https://read.qxmd.com/read/38528477/frequency-and-predictors-of-headache-in-the-first-12-months-after-traumatic-brain-injury-results-from-center-tbi
#23
JOURNAL ARTICLE
Emilie Isager Howe, Nada Andelic, Cathrine Brunborg, Marina Zeldovich, Eirik Helseth, Toril Skandsen, Alexander Olsen, Silje C R Fure, Alice Theadom, Katrin Rauen, Benedikte Å Madsen, Bram Jacobs, Joukje van der Naalt, Maria Carmela Tartaglia, Cathrine Elisabeth Einarsen, Gøril Storvig, Erling Tronvik, Cathrine Tverdal, Nicole von Steinbüchel, Cecilie Røe, Torgeir Hellstrøm
BACKGROUND: Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury...
March 25, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38527192/subcallosal-cingulate-deep-brain-stimulation-evokes-two-distinct-cortical-responses-via-differential-white-matter-activation
#24
JOURNAL ARTICLE
Andreas Seas, M Sohail Noor, Ki Sueng Choi, Ashan Veerakumar, Mosadoluwa Obatusin, Jacob Dahill-Fuchel, Vineet Tiruvadi, Elisa Xu, Patricio Riva-Posse, Christopher J Rozell, Helen S Mayberg, Cameron C McIntyre, Allison C Waters, Bryan Howell
Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature cortical evoked potential (EP), but it is unclear which of the many pathways in the vicinity of SCC is responsible for driving this response. Individualized biophysical models were built to achieve selective engagement of two target bundles: either the forceps minor (FM) or cingulum bundle (CB)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38526711/advancing-emergency-medical-services-ems-response-capability-for-behavioral-health-emergencies-los-angeles-county-s-performance-improvement-initiative
#25
JOURNAL ARTICLE
Erick H Cheung, Denise A Whitfield, Adam Kipust, Richard Tadeo, Marianne Gausche-Hill
Introduction: Behavioral health emergencies (BHEs) are a common patient encounter for emergency medical services (EMS) clinicians and other first responders, in particular law enforcement (LE) officers. It is critical for EMS clinicians to have management strategies for BHEs, yet relatively little information exists on best practices. In 2016, the Los Angeles County EMS Agency's Commission initiated a comprehensive evaluation of the 9-1-1 response for BHEs and developed a plan for improving the quality of care and safety for patients and first responders...
March 25, 2024: Prehospital Emergency Care
https://read.qxmd.com/read/38526473/a-low-cost-diy-tourniquet-simulator-with-built-in-self-assessment-for-prehospital-providers-in-guatemala-city
#26
JOURNAL ARTICLE
Rashi Jhunjhunwala, Jose Monzon, Isabella Faria, Gabriel Escalona, Analia Zinco, Pablo Ottolino, Favio Reyna, Nakul Raykar, Sabrina Asturias
BACKGROUND: Hemorrhage is the leading cause of preventable death after trauma. In high-income countries first responders are trained in hemorrhage control techniques but this is not the case for developing countries like Guatemala. We present a low-cost training model for tourniquet application using a combination of virtual and physical components. METHODS: The training program includes a mobile application with didactic materials, videos and a gamified virtual reality environment for learning...
March 25, 2024: World Journal of Surgery
https://read.qxmd.com/read/38526401/how-the-food-and-drug-administration-drug-approval-process-relates-to-the-potential-approval-of-intravenous-racemic-ketamine-for-treatment-resistant-major-depression
#27
JOURNAL ARTICLE
Sheldon H Preskorn
This column focuses on the status of intravenous racemic ketamine for the treatment of patients suffering from a form of major depressive disorder that does not respond to trials of currently available biogenic amine antidepressants. To provide context, the column reviews the 3 pivotal elements of the usual Food and Drug Administration (FDA) drug approval process: (1) the unmet medical need (ie, the indication) for which the drug is being developed, (2) the efficacy of the drug for that condition, and (3) the safety/tolerability of the drug...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38526000/well-being-of-undergraduate-dental-students-questionnaire-design-findings-and-future-directions
#28
JOURNAL ARTICLE
Charlotte Cheuk Kwan Chan, Elise Hoi Wan Fok, Yan Ting Rosealeen Lo, Wing Yan Ng, Michael George Botelho
INTRODUCTION: The recent pandemic has highlighted the importance of addressing well-being in the overall health of students. There is a need for support systems within dental schools to help students demonstrate resilience, adapt to learning environments and thrive in their professional careers. OBJECTIVES: The main aim of the study was to evaluate Bachelor of Dental Surgery (BDS) students' understanding and experience of well-being. The objectives were to create a suitable survey to assess students' well-being, investigate the factors affecting dental students' well-being and develop a student well-being action plan based on the analysis of the survey...
March 25, 2024: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://read.qxmd.com/read/38525368/identifying-the-prevalence-and-characteristics-of-diversity-equity-and-inclusion-leaders-in-academic-emergency-medicine
#29
JOURNAL ARTICLE
Ryan E Tsuchida, Neema Mbele, Zoey Chopra, Joel Moll, John C Burkhardt, Daniel J Hekman, Marcia A Perry
OBJECTIVES: Our study aims to better understand and describe the current state of diversity, equity, and inclusion (DEI) leadership in emergency medicine (EM) by identifying the prevalence of department DEI leadership positions, their demographics, and their job duty characteristics. METHODS: We disseminated an electronic survey from April to July 2022 to Society for Academic Emergency Medicine (SAEM) Association of Academic Chairs of Emergency Medicine, Academy for Diversity and Inclusion in Emergency Medicine, and the Equity and Inclusion Committee to identify department DEI leads...
April 2024: AEM Education and Training
https://read.qxmd.com/read/38524998/impact-of-work-environment-on-job-satisfaction-among-interventional-radiologists-in-japan-a-cross-sectional-study
#30
JOURNAL ARTICLE
Miyuki Sone, Hideo Yasunaga, Marie Osawa, Yuko Takeguchi, Alisa Han, Naoko Akiyama, Mika Kamiya, Reiko Woodhams, Rika Yoshimatsu, Atsuhiro Nakatsuka, Shingo Kakeda, Kei Takase, Hidefumi Mimura, Koichiro Yamakado
PURPOSE: This study aims to measure job satisfaction among interventional radiology physicians in Japan and analyze the factors affecting job satisfaction. MATERIAL AND METHODS: A web-based survey was conducted among the members of the Japanese Society of Interventional Radiology between October and December 2021. Participants were questioned regarding their job satisfaction, workplace, work status, and demographic information. Principal component analysis was applied to 15 reasons related to job satisfaction, and the factors affecting job satisfaction were analyzed...
March 1, 2024: Interventional radiology
https://read.qxmd.com/read/38524854/impacts-of-the-sars-cov-2-pandemic-on-the-dietary-practices-of-university-students-in-germany
#31
JOURNAL ARTICLE
Jana O Dreyer, Alexander C Brandt, Silke Lichtenstein, Christian Sina, Martin Smollich
PURPOSE: The dietary practices (DPs) of university students are influenced by many external factors. Therefore, we investigate how the DPs of students in Germany changed during the SARS-CoV-2 pandemic, what the main motivations were for those changes, and what effect the closure of university catering had on the DPs of students. METHODS: A total of 560 students from two universities in Lübeck (Germany) were surveyed online during a pilot phase. The final online questionnaire was subsequently administered at 10 other German universities (399 respondents)...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38524646/response-to-capmatinib-in-a-patient-with-neuroendocrine-carcinoma-of-the-gallbladder-origin-harboring-met-amplification
#32
JOURNAL ARTICLE
Shogo Yamamura, Masashi Kanai, Yasuhide Takeuchi, Natsuko Okita, Tomohiro Kondo, Masahiro Yoshioka, Junichi Matsubara, Shigemi Matsumoto, Manabu Muto
Neuroendocrine carcinoma (NEC) of the gallbladder origin is particularly rare, accounting for only 0.38% of primary malignancies of the gallbladder, and standard therapies are limited. The MET gene encodes the tyrosine kinase receptor, c-Met. Pathogenic variants of MET , such as MET exon 14 skipping and MET amplification, result in excessive downstream signaling that promotes tumor progression. A MET inhibitor, capmatinib, blocks signaling of c-Met and has been approved by the Food and Drug Administration for non-small cell lung cancer with MET exon 14 skipping...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524263/paradoxical-reaction-and-parastomal-pyoderma-gangrenosum-emergence-with-secukinumab-therapy
#33
Anas Zaher, Michael Castillo
Paradoxical reactions are characterized by the emergence or worsening of a pathological condition that typically responds to the administered drug while treating the patient for another condition. Certain drugs, such as tumor necrosis factor inhibitors, can induce pyoderma gangrenosum. Recently, the drug secukinumab has been implicated in a few case reports as a potential cause of pyoderma gangrenosum after initiation. We report the first case of biologic-refractory ulcerative colitis presenting with parastomal pyoderma gangrenosum after the initiation of secukinumab...
March 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38524107/knowledge-attitudes-and-practices-of-adolescent-girls-regarding-cervical-cancer-a-cross-sectional-study-in-enugu-state-nigeria
#34
JOURNAL ARTICLE
Kosisochi Chinwendu Amorha, Gerald Obinna Ozota, Maria-Gorreti Ogechukwu Ndunwere, Ugomma Loveth Anyaji, Ogochukwu Francisca Egbo, Obianuju Anastasia Ogugofor
INTRODUCTION: cervical cancer is the second leading cause of cancer death, among women, globally. The majority of the countries with the highest cervical cancer burden are in sub-Saharan Africa, including Nigeria. This study assessed the knowledge, attitudes, and practices regarding cervical cancer among secondary school students in an all-girls school. METHODS: this cross-sectional study was conducted in Nsukka, Enugu State, Nigeria (April 2021). A 30-item self-administered structured questionnaire was filled by conveniently sampled students in Senior Secondary School (SS 2 and SS 3)...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38523805/prevalence-and-pattern-of-contraceptive-uptake-among-adolescents-in-an-internally-displaced-camp-north-central-nigeria
#35
JOURNAL ARTICLE
O R Ilori, Olugbenga-Bello A I, O O Goodman, A A Babakundi, R A Oladejo
Internally displaced Persons are marginally sidelined in many areas of life, reproductive health issues inclusive. There is a need to know the prevalence and pattern of contraceptive use among this vulnerable group of people. This study determined the prevalence and pattern of contraceptive uptake among internally displaced adolescents in North-Central Camp, Abuja, Nigeria. A descriptive cross-sectional study, among 403 adolescents using semi-structured questionnaires. The mean age of the respondents was 19...
December 27, 2023: Journal of Public Health in Africa
https://read.qxmd.com/read/38523714/isoflurane-treatment-for-refractory-and-super-refractory-status-epilepticus-in-dogs
#36
JOURNAL ARTICLE
Eirini Sarpekidou, Georgios Polyzois, Virginia Papageorgiou, Ioannis Savvas, Zoe Polizopoulou, George Kazakos
INTRODUCTION: Resistant epileptic episodes, such as refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE), are neurological emergencies that require immediate medical treatment. Although inhalational anesthetics, such as isoflurane (ISO), have been proposed as a means of seizure control in dogs, there is currently a lack of both experimental and clinical studies on this subject. STUDY DESIGN: This is a retrospective clinical study. METHODS: Records of dogs that received ISO for the management of RSE and SRSE during their intensive care unit (ICU) hospitalization at the Companion Animal Clinic of the Aristotle University of Thessaloniki were included in the present study...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38523607/eptinezumab-for-the-preventive-treatment-of-episodic-and-chronic-migraine-a-narrative-review
#37
REVIEW
Pablo Irimia, Sonia Santos-Lasaosa, Patricia Pozo-Rosich, Rogelio Leira, Julio Pascual, José Miguel Láinez
Eptinezumab, a monoclonal antibody that targets calcitonin gene-related peptide (CGRP), was recently approved in Europe for the prophylactic treatment of migraine in adults who have at least four migraine days a month. Eptinezumab is administered by intravenous infusion every 12 weeks. During recent months, a considerable amount of evidence from eptinezumab trials has been published. The aim of this review is to describe the existing evidence on the tolerability, safety and efficacy of eptinezumab in patients with migraine...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523497/association-between-brain-fog-cardiac-injury-and-quality-of-life-at-work-after-hospitalization-due-to-covid-19
#38
JOURNAL ARTICLE
Żaneta Chatys-Bogacka, Iwona Mazurkiewicz, Joanna Słowik, Agnieszka Słowik, Leszek Drabik, Marcin Wnuk
BACKGROUND: To evaluate incidence and search for possible predictors of brain fog and quality of life at work (QoL-W) among low-to-moderate risk subjects previously hospitalized due to COVID-19. MATERIAL AND METHODS: Participants aged ≥18 retrospectively reported 8 brain fog symptoms pre-COVID-19, at 0-4, 4-12 and >12 weeks post-infection via validated clinical questionnaire. The QoL-W was assessed with a 4-point Likert scale where 0, 1, 2, and 3 meant no, mild, moderate, and severe impairment in performing activities at work, respectively...
March 22, 2024: Medycyna Pracy
https://read.qxmd.com/read/38521947/hiv-and-hepatitis-b-c-co-infection-and-correlates-of-hiv-infection-among-men-who-have-sex-with-men-in-rwanda-2021-a-respondent-driven-sampling-cross-sectional-study
#39
JOURNAL ARTICLE
Eric Remera, Elysee Tuyishime, Catherine Kayitesi, Samuel S Malamba, Beata Sangwayire, Justine Umutesi, Horacio Ruisenor-Escudero, Tom Oluoch
BACKGROUND: Men who have sex with men (MSM) are a key population group disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. In Rwanda, the HIV epidemic remains a significant public health concern, and understanding the burden of HIV and hepatitis B and C coinfections among MSM is crucial for designing effective prevention and control strategies. This study aims to determine the prevalence of HIV, hepatitis B, and hepatitis C infections among MSM in Rwanda and identify correlates associated with HIV infection within this population...
March 23, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38521924/an-in-vitro-study-elucidating-the-synergistic-effects-of-aqueous-cinnamon-extract-and-an-anti-tnf-%C3%AE-biotherapeutic-implications-for-a-complementary-and-alternative-therapy-for-non-responders
#40
JOURNAL ARTICLE
Shubrata Khedkar, Minhaj Ahmad Khan
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is a critical pro-inflammatory cytokine, and its abnormal production is associated with several immune mediated inflammatory diseases (IMID). Biological anti-TNF-α therapy includes treatment with monoclonal antibodies such as infliximab which have proven successful and are well-tolerated in most patients. Unfortunately, some patients may not respond to therapy (primary non-responders) or may lose sensitivity to the biological agent over time (early and late secondary non-responders)...
March 23, 2024: BMC complementary medicine and therapies
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