keyword
https://read.qxmd.com/read/38522847/comparison-of-platelet-transfusion-effectiveness-between-helicobacter-pylori-positive-and-negative-immune-thrombocytopenia
#21
JOURNAL ARTICLE
Shotaro Tabata, Hiroki Hosoi, Ke Wan, Ayaka Sakaki, Toshiki Mushino, Shogo Murata, Yoshiaki Tomiyama, Takashi Sonoki
Immune thrombocytopenia (ITP) is characterized by early platelet destruction and impaired platelet production. Helicobacter pylori (H. pylori) infection seems to contribute to the pathogenesis in certain ITP patients in Japan. We compared the effectiveness of platelet transfusion in severe ITP in the presence or absence of H. pylori. The median corrected count increment (CCI) at 24 h after platelet transfusion (CCI-24) of the H. pylori-positive ITP patients was higher than that of the H. pylori-negative ITP patients (6463 vs...
March 24, 2024: British Journal of Haematology
https://read.qxmd.com/read/38522794/time-dependent-changes-in-cell-population-data-obtained-using-sysmex-xn-series-hematology-analyzer-in-bacterial-infections
#22
JOURNAL ARTICLE
Makito Kaneda, Kentaro Nagaoka, Rinako Yoshida, Yosuke Iwasaki, Hideki Niimi, Yoshihiro Yamamoto
BACKGROUND: Time-dependent changes in cell populations during acute bacterial infections remain unclear. We assessed time-dependent changes in fluorescent light intensity of the neutrophil area (NE-SFL) and fluorescent light distribution width index of the neutrophil area (NE-WY) and their association with sepsis and bacteremia. METHODS: Patients with acute bacterial infections were enrolled in this prospective, observational cohort study. Blood samples were collected from all patients at the onset of bacterial infections (day 0) and on days 1 and 3...
March 22, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38522093/fanconi-anemia-neuroinflammatory-syndrome-fans-brain-lesions-and-neurologic-injury-in-fanconi-anemia
#23
JOURNAL ARTICLE
Allison L Bartlett, John E Wagner, Blaise V Jones, Susanne Wells, Anthony Sabulski, Christine Fuller, Stella M Davies
Fanconi anemia (FA) is a complex inherited bone marrow failure syndrome characterized by chromosomal instability and defective DNA repair causing sensitivity to DNA interstrand cross-linking agents. Our understanding of the full adult phenotype of the disease continues to evolve, as most patients with Fanconi Anemia died of marrow failure in the first decade of life prior to more recent advances in allogeneic hematopoietic cell transplantation. Herein, we report a previously undescribed, clinically concerning, progressive neurologic syndrome in patients with FA...
March 24, 2024: Blood Advances
https://read.qxmd.com/read/38522092/sars-cov-2-infection-modifies-the-transcriptome-of-the-megakaryocytes-in-the-bone-marrow
#24
JOURNAL ARTICLE
Isabelle Allaeys, Guillaume Lemaire, Mickael Leclercq, Emile Lacasse, Maude Fleury, Isabelle Dubuc, Leslie Gudimard, Florian Puhm, Julia Tilburg, Andrew P Stone, Kellie R Machlus, Arnaud Droit, Louis Flamand, Eric Boilard
Megakaryocytes, integral to platelet production, predominantly reside in the bone marrow and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence megakaryocyte transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated with altered platelet transcriptomes. In this study, we investigated the hypothesis that SARS-CoV-2 infection could impact the transcriptome of bone marrow megakaryocytes...
March 24, 2024: Blood Advances
https://read.qxmd.com/read/38520006/targeting-inflammation-as-cancer-therapy
#25
REVIEW
Manni Wang, Siyuan Chen, Xuemei He, Yong Yuan, Xiawei Wei
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflammation-targeted agents not only demonstrate the potential to suppress cancer development, but also to improve the efficacy of other therapeutic modalities. In this review, we describe the highly dynamic and complex inflammatory tumor microenvironment, with discussion on key inflammation mediators in cancer including inflammatory cells, inflammatory cytokines, and their downstream intracellular pathways...
March 22, 2024: Journal of Hematology & Oncology
https://read.qxmd.com/read/38518675/evaluation-of-d-dimer-and-prothrombin-time-in-alcohol-related-liver-cirrhosis-with-comparison-of-machine-learning-analyses
#26
JOURNAL ARTICLE
Hyeongyu Lee, Gilsung Yoo, Daewoo Pak, Jong-Han Lee
OBJECTIVES: Liver cirrhosis (LC) can be caused by obesity, alcohol consumption, viral infection, and autoimmune disease. Early diagnosis and management of LC is important for patient quality of life. Non-invasive diagnostic methods are useful for predicting the current status and mortality risk of LC. The purpose of this study is to identify relevant diagnostic factors measured in routine laboratory test of alcohol-related liver cirrhosis (ALC) patients. METHODS: This study analyzed data from 127 patients with ALC, including their laboratory test results and clinical information, including coagulation parameters, hematologic parameters, and biochemical parameters...
March 8, 2024: International Journal of Medical Informatics
https://read.qxmd.com/read/38518039/the-effect-of-hyperbaric-oxygen-therapy-on-hematological-indices-and-biochemical-parameters-in-patients-with-diabetic-foot
#27
JOURNAL ARTICLE
Erdinç Ercan, Gamze Aydin, Bülent Erdoğan, Fatih Özçelik
BACKGROUND: Diabetes Mellitus (DM) is a metabolic disease with a high morbidity and mortality and increasing in prevalence all over the world. Due to the hypoxic, ischemic, inflammatory, and infective environment in DM, diabetic foot ulcers have been treated with medico-surgical interventions and adjuvant hyperbaric oxygen Therapy (HBOT). The purpose of this study was to evaluate the effects of HBOT on hematological indices and biochemical parameters in patients with diabetic foot. METHODS: The study group was formed from the file records of 103 male patients who applied to Yunus Emre State Hospital HBOT Center between September 1, 2016 and December 31, 2020, and were treated HBOT with a multidisciplinary approach...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517571/molecular-monitoring-of-viral-infections-in-immunocompromised-patients-in-a-large-university-hospital-in-italy-reflections-after-thirteen-years-of-real-life-activity
#28
JOURNAL ARTICLE
Lilia Cinti, Piergiorgio Roberto, Matteo Rossi, Anna Napoli, Gianluca Russo, Anna Paola Iori, Giuseppe Gentile, Maria Augurusa, Corrado Girmenia, Guido Antonelli, Aurelia Gaeta
PURPOSE: This study aimed to investigate the prevalence and viral reactivations of clinical interest in the immunocompromised patient with particular focus on hematologic and solid organ transplant recipients. METHODS: Molecular screening data of CMV, EBV, JCV and BKV from 2011 to 2023 were analyzed. This extensive time span allowed the access to more than 100,000 samples from over 20,000 patients treated at Policlinico Umberto I. It was possible to temporally investigate patient attendance patterns, average age distribution, seasonality of infections, and positivity rates of the analyzed viruses...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38516722/-lactococcus-garvieae-associated-septicemia-in-a-central-bearded-dragon
#29
JOURNAL ARTICLE
Christian M Capobianco, Sarah N Bosch, Nicole I Stacy, James F X Wellehan
Lactococcus garvieae is the causative agent of lactococcosis in fish and an emerging zoonotic pathogen with high levels of antimicrobial resistance. We report a case of L. garvieae- associated septicemia in a central bearded dragon ( Pogona vitticeps ) confirmed via whole-blood PCR and direct sequencing. Following a 30-d course of ceftazidime (20 mg/kg IM q72h), the animal's clinical condition had not resolved; leukopenia persisted, with heterophil toxic change. Coelomic ultrasound findings were consistent with preovulatory follicular stasis, folliculitis, and coelomitis...
March 22, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38516379/efficacy-and-safety-of-different-chemotherapy-regimens-combined-with-thalidomide-in-the-treatment-of-diagnosed-hiv-associated-diffuse-large-b-cell-lymphoma
#30
REVIEW
Peng Fei Tao, Chuan Qian, Qi Wen Zhou, Sen Lin, Dan Qing Wang, Xi Wang, Shi Fen Chen, Hai Yan Min
OBJECTIVE: To investigate the short-term efficacy and safety of different chemotherapy regimens combined with thalidomide, in the treatment of low-income patients with newly diagnosed HIV-associated diffuse large B-cell lymphoma. METHODS: A retrospective analysis was performed on 42 patients with HIV-DLBCL who were admitted to the Infectious Diseases Department of Yunnan Provincial Infectious Diseases Hospital from January 2018 to December 2020. 14 cases (including 1 case in stage II and 13 cases in stage III/IV) were treated with R-CHOP, 24 cases (including 1 case in stage II and 23 cases in stage III/IV) were treated with R-DAEPOCH, and 4 cases (including 1 case in stage II and 3 cases in stage III/IV) were treated with EPOCH...
2024: Leukemia Research Reports
https://read.qxmd.com/read/38513079/targeting-neutrophil-extracellular-trap-under-flow-in-patients-with-immune-mediated-thrombotic-thrombocytopenic-purpura
#31
JOURNAL ARTICLE
Noritaka Yada, Quan Zhang, Antionia Bignotti, Sarah H Gralnek, Dennis Sosnovske, Keenan O Hogan, Zhan Ye, Liang Zheng, X Long Zheng
Neutrophil NETosis is a unique form of cell death, characterized by release of decondensed chromatin and anti-microbial contents to the extracellular space, involved in infection, inflammation, and thrombosis. However, the role of NETosis in pathogenesis of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and how a targeted therapy affects the accumulation of neutrophil extracellular traps (NETs) under flow remain to be determined. Flow cytometry demonstrated that the percentage of neutrophils undergoing NETosis in whole blood from iTTP patients on admission is significantly increased with a concurrent decrease in the capacity of inducible NETosis by shigatoxin...
March 21, 2024: Blood Advances
https://read.qxmd.com/read/38512893/screening-for-viral-hepatitis-b-infection-in-cancer-patients-before-receiving-chemotherapy-a-systematic-review-and-meta-analysis
#32
REVIEW
Soe Thiha Maung, Natee Deepan, Pakanat Decharatanachart, Roongruedee Chaiteerakij
AIM: We conducted a systematic review and meta-analysis to assess the hepatitis B virus (HBV) screening rate in cancer patients before systemic chemotherapy, aiming to identify those needing antiviral prophylaxis for HBV reactivation. METHODS: We searched PubMed, Embase, Scopus, and Google Scholar for relevant studies. The pooled screening rate was estimated using a random effects model. Subgroup analyses were conducted based on malignancy types, chemotherapy regimens, study period, and HBV endemic regions...
March 21, 2024: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/38512368/the-predictive-value-of-systemic-inflammatory-markers-in-902-patients-with-tunneled-hemodialysis-catheter
#33
JOURNAL ARTICLE
Melis Baykara Ulusan, Emine Meltem, Ilhan Nahit Mutlu, Kivilcim Ulusan
AIM: This study aimed to assess the predictive role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and mean platelet volume, on catheter survival in chronic hemodialysis patients, analyzing both infectious and non-infectious complications. METHODS: A retrospective analysis encompassed 1279 tunneled catheter insertion procedures involving 902 patients between March 2014 and October 2018. Patients were categorized into two main groups: (i) initial placement and (ii) exchange...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38508880/long-term-follow-up-of-the-combination-of-ofatumumab-high-dose-methylprednisolone-and-lenalidomide-for-untreated-chronic-lymphocytic-leukemia-with-biomarker-analysis
#34
JOURNAL ARTICLE
Julio C Chavez, Ariel Grajales, Jose Sandoval-Sus, Elyce Turba, Lisa Nodzon, Angimar Uriepero-Palma, Mohammad Ammad-Ud-Din, Eva Sahakian, Rami Komrokji, Lubomir Sokol, Frederick L Locke, Bijal Shah, Jeffrey Lancet, Eduardo M Sotomayor, Mohamed A Kharfan-Dabaja, Celeste Bello, Javier Pinilla-Ibarz
BACKGROUND: Advancements in frontline therapy and chemotherapy-sparing treatments in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have altered the treatment algorithms of this disease. We present a frontline alternative for treatment- naïve (TN) CLL/SLL patients. METHODS: This was a single-center, phase 2 study of high-dose methylprednisolone (HDMP) and ofatumumab with lenalidomide and ofatumumab consolidative therapy for all comers with TN CLL/SLL...
February 13, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38508688/investigating-the-impact-of-external-application-of-formalin-and-potassium-permanganate-on-hematological-immunological-and-biochemical-profiles-in-labeo%C3%A2-rohita-fingerlings
#35
JOURNAL ARTICLE
Lukesh Kumar Banjare, Himadri Saha, Arpit Acharya, Md Idrish Raja Khan
The present study aimed to elucidate the suitability of formalin and KMnO4 as therapeutics for fish diseases in Indian major carp, Labeo rohita , while considering their impact on fish stress levels. Acute toxicity tests revealed that the 96-hour LC50 values for formalin and KMnO4 were 66.58 ppm and 2.89 ppm, respectively. Sub-lethal concentrations of formalin (6.65 ppm, 3.32 ppm, and 2.21 ppm) and KMnO4 (0.289 ppm, 0.145 ppm, and 0.096 ppm), along with control groups, were administered to the fish for different exposure periods (24, 48, 72, and 96 hours) and different hematological, biochemical, and immunological parameters were analyzed...
March 20, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38508452/neurological-complications-of-the-central-nervous-system-after-allogeneic-stem-cell-transplantation-the-role-of-ta-tma-as-a-potential-underreported-cause
#36
JOURNAL ARTICLE
Elisa Sala, Adela M Neagoie, Jan Lewerenz, Maral Saadati, Axel Benner, Andrea Gantner, Verena Wais, Hartmut Döhner, Donald Bunjes
BACKGROUND: neurological complications (NC), especially those of the central nervous system (CNS), represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and are associated with relevant morbidity and mortality. OBJECTIVE: we aim to characterize the potential risk factors for the development of CNS-NC with a special focus on the role of calcineurin inhibitors (CNI) as a predisposing factor. For this purpose, we compared Cyclosporin A (CsA) versus Tacrolimus (TAC) with respect to their influence on the incidence and type of CNS-NC after allo-HSCT...
March 18, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38507683/amyloid-fibrinogen-aggregates-microclots-predict-risks-of-disseminated-intravascular-coagulation-and-mortality
#37
JOURNAL ARTICLE
Jeremy Schofield, Simon Timothy Abrams, Rosalind Jenkins, Steven Lane, Guozheng Wang, Cheng-Hock Toh
Microclots have been associated with various conditions, including post-acute sequelae of SARS-CoV-2 infection. They have been postulated to be amyloid-fibrin(ogen) aggregates, but their role as a prognostic biomarker remains unclear. To examine for their possible clinical utility, blood samples were collected for the first 96 hours from critically ill patients (n=104) admitted to the intensive care unit (ICU). Detection was by staining platelet-poor plasma samples with Thioflavin T and visualized by fluorescent microscopy...
March 20, 2024: Blood Advances
https://read.qxmd.com/read/38507344/accurate-and-reproducible-enumeration-of-cd4-t-cell-counts-and-hemoglobin-levels-using-a-point-of-care-system-comparison-with-conventional-laboratory-based-testing-systems-in-a-clinical-reference-laboratory-in-cameroon
#38
JOURNAL ARTICLE
Bertrand Sagnia, Fabrice Mbakop Ghomsi, Sylvie Moudourou, Ana Gutierez, Jules Tchadji, Samuel Martin Sosso, Alexis Ndjolo, Vittorio Colizzi
BACKGROUND: Measurements of CD4 T cells and hemoglobin (Hb) are conventionally used to determine the immunological state and disease progression for HIV-infected patients. We obtained a small lightweight point-of-care device, the BD FACSPrestoTM in order to demonstrate its ability to deliver CD4 and Hb analysis in comparison with two larger clinical machines the BDFACSCantoTM analyzer and Sysmex XN 1000 haematology analyzer. The advantages of using the POC device include access to HIV patient data in remote and in resource limited settings...
2024: PloS One
https://read.qxmd.com/read/38506979/severe-acute-respiratory-syndrome-coronavirus-2-related-and-imputable-deaths-in-children-results-from-the-french-pediatric-national-registry
#39
JOURNAL ARTICLE
Marguerite Lockhart-Bouron, Noémie Vanel, Michael Levy, Anaïs R Briant, Etienne Javouhey, Sophie Breinig, Julia Dina, Marion Caseris, François Angoulvant, Stéphane Leteurtre, Morgan Recher, David W Brossier
BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for an important mortality rate worldwide. We aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit (PICU). Secondary objectives were to identify risk factors for death. METHODS: This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions (PCRs) [acute corona virus disease 2019 (COVID-19) or incidental SARS-CoV-2 infection] and/or pediatric inflammatory multisystem syndrome (PIMS) recorded in the French PICU registry (PICURe) between September 1, 2021, and August 31, 2022...
March 20, 2024: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/38505695/blood-features-associated-with-viral-infection-severity-an-experience-from-covid-19-pandemic-patients-hospitalized-in-the-center-of-iran-yazd
#40
JOURNAL ARTICLE
Fatemeh Sadeghi-Nodoushan, Mohamad Reza Zare-Khormizi, Seyedhossein Hekmatimoghaddam, Fatemeh Pourrajab
Pandemics such as coronavirus disease 2019 (COVID-19) can manifest as systemic infections that affect multiple organs and show laboratory manifestations. We aimed to analyze laboratory findings to understand possible mechanisms of organ dysfunction and risk stratification of hospitalized patients in these epidemics. Methods . This retrospective study was conducted among patients admitted to COVID-19 referral treatment center, Shahid Sadoughi Hospital, Yazd, Iran, from April 21 to November 21, 2021. It was the fifth peak of COVID-19 in Iran, and Delta (VOC-21APR-02; B...
2024: International Journal of Clinical Practice
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