Isabelle Allaeys, Guillaume Lemaire, Mickael Leclercq, Emile Lacasse, Maude Fleury, Isabelle Dubuc, Leslie Gudimard, Florian Puhm, Julia Tilburg, Andrew P Stone, Kellie R Machlus, Arnaud Droit, Louis Flamand, Eric Boilard
Megakaryocytes, integral to platelet production, predominantly reside in the bone marrow and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence megakaryocyte transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated with altered platelet transcriptomes. In this study, we investigated the hypothesis that SARS-CoV-2 infection could impact the transcriptome of bone marrow megakaryocytes...
March 24, 2024: Blood Advances