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Melanoma dermoscopy pathological correlation

G Brancaccio, B Brunetti, E Fulgione, E Moscarella, R Alfano, G Argenziano
No abstract text is available yet for this article.
June 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Teresa Russo, Vincenzo Piccolo, Gerardo Ferrara, Marina Agozzino, Roberto Alfano, Caterina Longo, Giuseppe Argenziano
Dermoscopy is a widely used technique whose role in the clinical (and preoperative) diagnosis of melanocytic and non-melanocytic skin lesions has been well established in recent years. The aim of this paper is to clarify the correlations between the "local" dermoscopic findings in melanoma and the underlying histology, in order to help clinicians in routine practice.
May 2017: Journal of Dermatology
Joana Cabete, André Lencastre, Alexandre João
Dermoscopy can be applied to fixed tissues, and dermoscopic patterns correlate with microscopic findings. Data on the influence of ex vivo dermoscopy on pathologic diagnosis of melanocytic lesions are limited. Therefore, we aimed to determine whether this technique could aid on the histopathological evaluation of melanocytic neoplasms. Sequential cutaneous excisional biopsies of melanocytic lesions and their corresponding ex vivo dermoscopic images were prospectively analyzed. Additional sectioning was executed in areas of dermoscopic concern, having, by reference, a dermoscopic mapping of the sectioned specimens...
March 2016: American Journal of Dermatopathology
Alexia Vanden Daelen, Ingrid Ferreira, Liliane Marot, Isabelle Tromme
IMPORTANCE: The diagnosis of extrafacial lentigo maligna can be a challenge because the dermoscopic features are not well described. These features can share some of the criteria of superficial spreading melanoma and some of facial lentigo maligna; however, these features are often absent. A new dermoscopic pattern has recently been described as forming angulated lines. OBSERVATIONS: We report 4 cases of extrafacial lentiginous lesions in 3 patients in whom straight angulated lines have been observed as the only key for diagnosis...
February 2016: JAMA Dermatology
Maria Scotto di Santolo, Marco Sagnelli, Marcello Mancini, Massimiliano Scalvenzi, Mario Delfino, Fabrizio Schonauer, Guido Molea, Fabio Ayala, Marco Salvatore
UNLABELLED: High-resolution (17 MHz) color-Doppler ultrasound (US) is used in the evaluation of normal and pathological skin. To analyze retrospectively the sonographic pattern of healthy skin and of some skin lesions using Doppler US and to compare the results with dermoscopy examination and histology to identify specific patterns of ultrasound for differentiating benign from malignant lesions. To select among them the Melanomas to describe their US pattern, the presence and morphology of vascular signal and to compare their thickness at US with the Breslow index...
September 2015: Archives of Dermatological Research
Ioannis Valavanis, Ilias Maglogiannis, Aristotelis A Chatziioannou
Multimodal data combined in an integrated dataset can be used to aim the identification of instrumental biological actions that trigger the development of a disease. In this paper, we use an integrated dataset related to cutaneous melanoma that fuses two separate sets providing complementary information (gene expression profiling and imaging). Our first goal is to select a subset of genes that comprise candidate genetic biomarkers. The derived gene signature is then utilized in order to select imaging features, which characterize disease at a macroscopic level, presenting the highest, mutual information content to the selected genes...
January 2015: IEEE Journal of Biomedical and Health Informatics
Maria A Pizzichetta, Vincenzo Canzonieri, Peter H Soyer, Pietro Rubegni, Renato Talamini, Cesare Massone
It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil...
May 2014: American Journal of Dermatopathology
Tamar Hajar-Serviansky, Daniela Gutierrez-Mendoza, Iris Lavinia Galvan, Lorena Lammoglia-Ordiales, Adalberto Mosqueda-Taylor, Maria de Lourdes Hernandez-Cázares, Sonia Toussaint-Caire
BACKGROUND: Most patients with oral mucosal melanoma have had a mucosal hyper pigmented area for months or even years before the diagnosis, it is important to consider the differential diagnosis of mucosal melanoma, which in many cases is a difficult diagnosis and because of the aggressive biological behavior of mucosal melanoma it is important to do a quick diagnosis. MAIN OBSERVATION: A 40-year-old Mexican male patient, presented with a lesion on the lower right half of the lip covering almost the entire vermillion border, 1 mm below the white roll...
March 27, 2012: Journal of Dermatological Case Reports
Khalid Amin, Garth R Fraga
Clinical dermoscopy has provided new insights into the diagnosis and classification of melanocytic neoplasms. There are only limited data on its applications in dermatopathology. In our laboratory, we routinely photograph all skin biopsies with ex vivo dermoscopy (EVD). We retrospectively reviewed 517 cutaneous biopsies with corresponding EVD images to determine whether EVD provides useful ancillary information in the histopathologic diagnosis of melanocytic neoplasms. Four hundred eighty-three cases (93.4%) yielded usable images...
October 2012: American Journal of Dermatopathology
Louise Lovato, Gabriel Salerni, Susana Puig, Cristina Carrera, Josep Palou, Josep Malvehy
Juvenile xanthogranuloma in adulthood is an infrequent non-Langerhans cell histiocytosis, which may simulate malignant tumors such as basal cell carcinoma (BCC) or amelanotic melanoma. Dermoscopy has been described as a useful tool in the preoperative diagnosis of xanthogranuloma. We report a xanthogranuloma on the suprapubic area of a 48-year-old female, which clinically and dermoscopically mimicked a BCC with a yellowish hue and arborizing vessels. Reflectance confocal microscopy exhibited large highly refractive atypical cells in the dermis, some of them with pleomorphic nuclei, corresponding to Touton cells in the histopathological study...
2010: Dermatology: International Journal for Clinical and Investigative Dermatology
Gerardo Ferrara, Giuseppe Argenziano, Caterina M Giorgio, Iris Zalaudek, Harald Kittler
The increasing use of dermoscopy in preoperative diagnosis of melanocytic skin neoplasms is impacting on routine histopathology to a relevant extent. We herein present the dermoscopic-pathologic features of 6 cases of histopathologically controversial melanocytic skin neoplasms. By illustrating these cases, we emphasize at least 3 different fields of interest for a combined (clinico-)dermoscopic-pathologic diagnostic approach, namely, information about the evolution of lesions; detection of gross sampling errors; definition of peculiar clinicopathologic entities...
September 2009: Seminars in Cutaneous Medicine and Surgery
N Bories, S Dalle, S Debarbieux, B Balme, S Ronger-Savlé, L Thomas
BACKGROUND: Metastatic melanoma of unknown origin is a difficult challenge diagnostically and therapeutically. Diagnosis of the putative primary lesion is difficult. This difficulty increases when the primary lesion has undergone complete regression. OBJECTIVE: To define the dermoscopic features of fully regressed melanoma. PATIENTS AND METHODS: A single-institution, register-based study of an unselected consecutive series of seven cases of metastatic melanoma in the lymph nodes with no known or visible primary lesion was carried out...
June 2008: British Journal of Dermatology
Alon Scope, Klaus J Busam, Josep Malvehy, Susana Puig, Steve A McClain, Ralph P Braun, Ashfaq A Marghoob
BACKGROUND: We have identified cases of skin cancer with discordances between clinical, dermoscopic, and histopathologic findings that were likely due to sampling errors in the pathology laboratory. This has prompted us to explore the use of ex vivo dermoscopy as an ancillary method of gross pathology, which may serve to guide tissue sectioning. Noncontact polarized dermoscopy was applied to pigmented lesions before excision and at least 6 hours after specimen fixation in formalin. OBSERVATIONS: The orientation of the lesion, overall dermoscopic pattern, and dermoscopic pigmented structures (network, globules, and peripheral streaks) were readily correlated between the in vivo and ex vivo images for 2 melanomas and 4 dysplastic nevi...
December 2007: Archives of Dermatology
Vincenzo de Giorgi, Serena Sestini, Daniela Massi, Vincenza Maio, Benvenuto Giannotti
Completely amelanotic melanomas are rare and therefore often misclassified, with tragic consequences for patients. The use of dermoscopy for these lesions has not been validated yet because of the lack of studies that are based on large series. The analysis of the vascular pattern, which is often the only dermoscopic parameter to be seen, is therefore essential for a correct diagnosis. We present a case of "true" amelanotic melanoma on the forehead of an 89-year-old man, which clinically mimicked squamous cell carcinoma...
February 2006: Journal of the American Academy of Dermatology
V de Giorgi, D Massi, S Sestini, B Alfaioli, G Carelli, P Carli
The association of contiguous or 'collision' tumours in the same biopsy specimen is not uncommon and is often reported in the literature. The most common association, basal cell carcinoma (BCC) and naevus, is very difficult to diagnose clinically. We describe a 38-year-old woman with a previous history of melanoma, who presented with a modified pigmented lesion of the hip that had begun to change 6 months earlier. Histologically, the lesion was a melanocytic compound naevus and a BCC with a seborrhoeic keratosis...
April 2005: British Journal of Dermatology
V de Giorgi, D Massi, C Salvini, F Mannone, P Carli
The diagnosis of seborrheic keratosis is, in general, a clinical one, but in some cases, the differential diagnosis between pigmented seborrheic keratosis and malignant melanoma is difficult. Dermoscopy may improve the early diagnosis of vulvar melanoma and thus play a role in the preoperative classification of pigmented lesions at this particular site. We report the first case of a pigmented seborrheic keratosis of the vulva clinically mimicking a malignant melanoma, whose dermoscopic features have been investigated together with their pathologic correlates...
January 2005: Clinical and Experimental Dermatology
Gerardo Ferrara, Giuseppe Argenziano, Lorenzo Cerroni, Francesco Cusano, Arturo Di Blasi, Carmelo Urso, H Peter Soyer
We examined a combined (dermoscopic-pathological) approach to the telediagnosis of melanocytic skin lesions. A store-and-forward teleconsultation was simulated. Dermoscopic and histopathology images from 12 melanocytic lesions were stored in a telepathology workstation. A dermoscopy consultant, a histopathology consultant and an expert in dermoscopic-pathological correlation gave their diagnoses and comments on the images. The consensus diagnosis between two teleconsultants on the original histological slides was regarded as the gold standard...
2004: Journal of Telemedicine and Telecare
I Zalaudek, G Argenziano, G Ferrara, H P Soyer, R Corona, F Sera, L Cerroni, A Carbone, A Chiominto, L Cicale, G De Rosa, A Ferrari, R Hofmann-Wellenhof, J Malvehy, K Peris, M A Pizzichetta, S Puig, M Scalvenzi, S Staibano, V Ruocco
BACKGROUND: Benign melanocytic skin lesions may be difficult to differentiate from melanoma both clinically and dermoscopically. One of the most confounding dermoscopic features, commonly seen in melanoma but in our experience also in melanocytic naevi, is represented by the so-called blue-white structures (BWS). OBJECTIVES: To evaluate diagnostic significance and histopathological correlates of BWS seen by dermoscopy in a series of clinically equivocal melanocytic skin lesions that were excised...
January 2004: British Journal of Dermatology
Carlos A Charles, Ashfaq A Marghoob, Klaus J Busam, Lesley Clark-Loeser, Allan C Halpern
BACKGROUND/PURPOSE: New techniques are being explored for improving diagnostic accuracy of pigmented skin lesions. Confocal scanning laser microscopy (CSLM) may represent such a novel technique. The purpose of this report was to demonstrate the potential application of CSLM as an aid in the diagnosis of a pigmented skin lesion that is clinically suspicious for melanoma. METHODS: An irregular pigmented lesion was examined clinically and dermoscopically. The lesion was imaged by CSLM and subsequently excised for histologic examination...
November 2002: Skin Research and Technology
D Massi, V De Giorgi, P Carli, M Santucci
In epiluminescence microscopy, the perception of a blue hue is generally considered a clue to malignancy, especially in clinically equivocal melanocytic skin lesions. However, melanocytic nevi can seldom show a blue hue under dermoscopy. The aim of the current study was to evaluate the histopathologic correlates of the blue hue seen in dermoscopy, to clarify its significance and diagnostic value. From a series of 224 consecutive pigmented skin lesions submitted to surgical excision, we selected all the melanocytic skin lesions (n...
October 2001: American Journal of Dermatopathology
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