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caveolin stroke

Cherrie H T Kong, Simon M Bryant, Judy J Watson, David M Roth, Hemal H Patel, Mark B Cannell, Andrew F James, Clive H Orchard
NEW FINDINGS: What is the central question of this study? Overexpression of caveolin-3 (Cav-3 OE) appears to protect the heart against many of the features of heart failure (HF) normally observed in vivo. The present study investigates the cellular basis of this protection. What is the main finding and its importance? Cav-3 OE has little effect in normal ventricular myocytes but reduces cellular hypertrophy and preserves t-tubular ICa, but not local t-tubular Ca release, in HF induced by pressure-overload in mice...
February 20, 2019: Experimental Physiology
Zhenzhen Chen, Quan Hu, Qingfeng Xie, Shamin Wu, Qiongyi Pang, Meixia Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen
Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the improvement of synaptic plasticity following moderate exercise are conducive to functional recovery after ischemic damage. Our previous studies have confirmed the angiogenesis and neurogenesis through the caveolin-1/VEGF pathway in MCAO rats...
January 19, 2019: Neurochemical Research
Panneerselvam Chinnakkannu, Charles Reese, John Antony Gaspar, Saraswathi Panneerselvam, Dorea Pleasant-Jenkins, Rupak Mukherjee, Catalin Baicu, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy
Dysregulation of the renin-angiotensin system leads to systemic hypertension and maladaptive fibrosis in various organs. We showed recently that myocardial fibrosis and the loss of cardiac function in mice with transverse aortic constriction (TAC) could be averted by treatment with the caveolin-1 scaffolding domain (CSD) peptide. Here, we used angiotensin II (AngII) infusion (2.1 mg/kg/day for 2 wk) in mice as a second model to confirm and extend our observations on the beneficial effects of CSD on heart and kidney disease...
2018: PloS One
Qianyi Huang, Wei Zhong, Zhiping Hu, Xiangqi Tang
Ischemic stroke starts a series of pathophysiological processes that cause brain injury. Caveolin-1 (cav-1) is an integrated protein and locates at the caveolar membrane. It has been demonstrated that cav-1 can protect blood-brain barrier (BBB) integrity by inhibiting matrix metalloproteases (MMPs) which degrade tight junction proteins. This article reviews recent developments in understanding the mechanisms underlying BBB dysfunction, neuroinflammation, and oxidative stress after ischemic stroke, and focuses on how cav-1 modulates a series of activities after ischemic stroke...
December 20, 2018: Journal of Neuroinflammation
Qingfeng Xie, Jingyan Cheng, Guoyuan Pan, Shamin Wu, Quan Hu, Haoming Jiang, Yangyang Wang, Jianrong Xiong, Qiongyi Pang, Xiang Chen
Dendritic and synaptic plasticity in the penumbra are important processes and are considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a beneficial treatment following stroke. However, its effects and potential mechanism in promoting dendritic and synaptic plasticity remain unknown. We have previously demonstrated that the caveolin-1/VEGF signaling pathway plays a positive role in angiogenesis and neurogenesis. Here, we further investigated the effects of treadmill exercise on promoting dendritic and synaptic plasticity in the penumbra and whether they involve the caveolin-1/VEGF signaling pathway...
December 12, 2018: Experimental Neurology
Erika Reus-Chavarría, Ivette Martínez-Vieyra, Cristina Salinas-Nolasco, Araceli Evangelina Chávez-Piña, Juan Vicente Méndez-Méndez, Edgar Oliver López-Villegas, Alejandro Sosa-Peinado, Doris Cerecedo
Hypertension (HTN), i.e. abnormally high blood pressure, is a major risk factor for heart attack, stroke, and kidney failure. The Epithelial Sodium Channel (ENaC), one of the main transporters regulates blood pressure by tightly controlling the sodium reabsorption along the nephron. Recently, we have shown an α-ENaC overexpression in platelets from hypertensive patients compared to platelets from normotensive subjects, suggesting it makes a contribution to the activation state of platelets and the physiopathology of hypertension...
November 10, 2018: Biochimica et Biophysica Acta. Biomembranes
Jong-Won Chung, Dong Hee Kim, Mi Jeong Oh, Yeon Hee Cho, Eun Hee Kim, Gyeong Joon Moon, Chang-Seok Ki, Jihoon Cha, Keon Ha Kim, Pyoung Jeon, Je Young Yeon, Gyeong-Moon Kim, Jong-Soo Kim, Seung Chyul Hong, Oh Young Bang
Background and Purpose- Moyamoya disease (MMD) is a unique cerebrovascular occlusive disease characterized by progressive stenosis and negative remodeling of the distal internal carotid artery (ICA). We hypothesized that cav-1 (caveolin-1)-a protein that controls the regulation of endothelial vesicular trafficking and signal transduction-is associated with negative remodeling in MMD. Methods- We prospectively recruited 77 consecutive patients with MMD diagnosed via conventional angiography. Seventeen patients with intracranial atherosclerotic stroke and no RNF213 mutation served as controls...
November 2018: Stroke; a Journal of Cerebral Circulation
Camille Blochet, Lara Buscemi, Tifenn Clément, Sabrina Gehri, Jérôme Badaut, Lorenz Hirt
Complex cellular and molecular events occur in the neurovascular unit after stroke, such as blood-brain barrier (BBB) dysfunction and inflammation that contribute to neuronal death, neurological deterioration and mortality. Caveolin-1 (Cav-1) has distinct physiological functions such as caveolae formation associated with endocytosis and transcytosis as well as in signaling pathways. Cav-1 has been proposed to be involved in BBB dysfunction after brain injury; however, its precise role is poorly understood. The goal of this study was to characterize the expression and effect of Cav-1 deletion on outcome in the first week in a transient Middle Cerebral Artery Occlusion stroke model...
October 24, 2018: Journal of Cerebral Blood Flow and Metabolism
Mar Castellanos, Cecile van Eendenburg, Carme Gubern, Elisabet Kádár, Gemma Huguet, Josep Puig, Tomás Sobrino, Gerard Blasco, Joaquín Serena, Juan Manuel Sánchez
BACKGROUND AND PURPOSE: Experimental models of cerebral ischemia demonstrate that the decrease in the caveolin-1 membrane protein results in an increase in endothelial permeability. Because this phenomenon is responsible for hemorrhagic transformation (HT) after cerebral ischemia, we aimed to determine whether caveolin-1 levels may predict bleeding after recombinant tissue-type plasminogen activator (r-tPA) administration in patients with acute stroke. METHODS: We studied 133 patients with a first hemispheric stroke treated with r-tPA within 4...
June 2018: Stroke; a Journal of Cerebral Circulation
Han-Sen Chen, Xi Chen, Wen-Ting Li, Jian-Gang Shen
Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-reperfusion injury. RNS activate multiple signaling pathways and participate in different cellular events in cerebral ischemia-reperfusion injury. Recent studies have indicated that caveolin-1 and matrix metalloproteinase (MMP) are important signaling molecules in the pathological process of ischemic brain injury. During cerebral ischemia-reperfusion, the production of nitric oxide (NO) and peroxynitrite (ONOO- ), two representative RNS, down-regulates the expression of caveolin-1 (Cav-1) and, in turn, further activates nitric oxide synthase (NOS) to promote RNS generation...
May 2018: Acta Pharmacologica Sinica
Shuai Zhang, Qier An, Tianfu Wang, Shuping Gao, Guangqian Zhou
Post-stroke hyperglycemia during early reperfusion increases blood-brain barrier (BBB) permeability and subsequently aggravates brain injury and clinical prognosis. The decreased level of tight junction proteins (TJPs) has been reported but the underlying mechanism remains largely elusive. Herein we designed to investigate the detailed molecular events in brain microvascular endothelial cells (BMECs) ex and in vivo. After oxygen-glucose deprivation (OGD) for 90 min and reperfusion with 8 or 16 mM glucose for 30 min, glucose at 16 mM caused significant decrease in the TJP expression and particularly ZO-1 redistribution from membrane to cytoplasm of BMECs...
May 1, 2018: Neuroscience
Shanshan Wang, Brian P Head
Cardiovascular disease and associated cerebral stroke are a global epidemic attributed to genetic and epigenetic factors, such as diet, life style and an increasingly sedentary existence due to technological advances in both the developing and developed world. There are approximately 5.9 million stroke-related deaths worldwide annually. Current epidemiological data indicate that nearly 16.9 million people worldwide suffer a new or recurrent stroke yearly. In 2014 alone, 2.4% of adults in the United States (U...
February 5, 2018: Current Vascular Pharmacology
Hann-Yeh Shyu, Ming-Hua Chen, Yi-Hsien Hsieh, Jia-Ching Shieh, Ling-Rong Yen, Hsiao-Wei Wang, Chun-Wen Cheng
Endothelial nitric oxide synthase (eNOS) is localized in caveole and has important effects on caveolar coordination through its interaction with caveolin-1 (Cav-1), which supports normal functioning of vascular endothelial cells. However, the relationship between genotypic polymorphisms of e-NOS and Cav-1 genes and ischemic stroke (IS) remains lesser reported. This hospital-based case-control study aimed to determine the genetic polymorphisms of the eNOS (Glu298Asp) and Cav-1 (G14713A and T29107A) genes in association with susceptibility risk in patients who had suffered from a large artery atherosclerotic (LAA) stroke...
2017: PloS One
Qiongyi Pang, Huimei Zhang, Zhenzhen Chen, Yudan Wu, Min Bai, Yidian Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen
Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats...
May 15, 2017: Brain Research
Dorea Pleasant-Jenkins, Charles Reese, Panneerselvem Chinnakkannu, Harinath Kasiganesan, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy
Chronic ventricular pressure overload (PO) results in congestive heart failure (CHF) in which myocardial fibrosis develops in concert with ventricular dysfunction. Caveolin-1 is important in fibrosis in various tissues due to its decreased expression in fibroblasts and monocytes. The profibrotic effects of low caveolin-1 can be blocked with the caveolin-1 scaffolding domain peptide (CSD, a caveolin-1 surrogate) using both mouse models and human cells. We have studied the beneficial effects of CSD on mice in which PO was induced by trans-aortic constriction (TAC)...
April 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
Hui-Qin Li, Yan Li, Zi-Xian Chen, Xiao-Guang Zhang, Xia-Wei Zheng, Wen-Ting Yang, Shuang Chen, Guo-Qing Zheng
Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating types of stroke. Here, we aim to demonstrate that electroacupuncture on Baihui (GV20) exerts neuroprotection for acute ICH possibly via the caveolin-1/matrix metalloproteinase/blood-brain barrier permeability pathway. The model of ICH was established by using collagenase VII. Rats were randomly divided into three groups: Sham-operation group, Sham electroacupuncture group, and electroacupuncture group. Each group was further divided into 4 subgroups according to the time points of 6 h, 1 d, 3 d, and 7 d after ICH...
2016: Neural Plasticity
Kang-Ho Choi, Hyung-Seok Kim, Man-Seok Park, Eun-Bin Lee, Jung-Kil Lee, Joon-Tae Kim, Ja-Hae Kim, Min-Cheol Lee, Hong-Joon Lee, Ki-Hyun Cho
Cerebral edema from the disruption of the blood-brain barrier (BBB) after cerebral ischemia is a major cause of morbidity and mortality as well as a common event in patients with stroke. Caveolins (Cavs) are thought to regulate BBB functions. Here, we report for the first time that Cav-1 overexpression (OE) decreased brain edema from BBB disruption following ischemic insult. Edema volumes and Cav-1 expression levels were measured following photothrombosis and middle cerebral artery occlusion (MCAO). Endothelial cells that were transduced with a Cav-1 lentiviral expression vector were transplanted into rats...
October 18, 2016: Oncotarget
Oh Young Bang, Jong-Won Chung, Suk Jae Kim, Mi Jeong Oh, Soo Yoon Kim, Yeon Hee Cho, Jihoon Cha, Je Young Yeon, Keon Ha Kim, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee, Chang-Seok Ki, Pyoung Jeon, Jong-Soo Kim, Seung Chyul Hong, Gyeong Joon Moon
BACKGROUND: Moyamoya disease is a unique cerebrovascular occlusive disease of unknown etiology. Ring finger protein 213 (RNF213) was identified as a susceptibility gene for Moyamoya disease in East Asian countries. However, the pathogenesis of Moyamoya disease remains unclear. METHODS: We prospectively analyzed clinical data for 139 patients with Moyamoya disease (108 bilateral Moyamoya disease, 31 unilateral Moyamoya disease), 61 patients with intracranial atherosclerotic stroke, and 68 healthy subjects...
December 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Jun Zhang, Wusheng Zhu, Lulu Xiao, Qinqin Cao, Hao Zhang, Huaiming Wang, Zusen Ye, Yonggang Hao, Qiliang Dai, Wen Sun, Yunyun Xiong, Xinfeng Liu, Ruidong Ye, Gelin Xu
Caveolin-1 (Cav-1) plays pivotal roles in the endothelial damage following stroke. The present study aimed to investigate whether serum Cav-1 level is associated with the presence of cerebral small vessel disease (cSVD) in patients with acute ischemic stroke. To this end, 156 patients were consecutively enrolled. Cranial magnetic resonance imaging was analyzed to determine the surrogates of cSVD, including cerebral microbleeds (CMBs), silent lacunar infarcts (SLIs), and white matter hyperintensities (WMHs)...
2016: Oxidative Medicine and Cellular Longevity
M A Hassan Talukder, Marilena Preda, Larisa Ryzhova, Igor Prudovsky, Ilka M Pinz
Insulin resistance and diabetes are comorbidities of obesity and affect one in 10 adults in the United States. Despite the high prevalence, the mechanisms of cardiac insulin resistance in obesity are still unclear. We test the hypothesis that the insulin receptor localizes to caveolae and is regulated through binding to caveolin-3 (CAV3). We further test whether haploinsufficiency forCAV3 increases the susceptibility to high-fat-induced insulin resistance. We used in vivo and in vitro studies to determine the effect of palmitate exposure on global insulin resistance, contractile performance of the heart in vivo, glucose uptake in the heart, and on cellular signaling downstream of theIR We show that haploinsufficiency forCAV3 increases susceptibility to palmitate-induced global insulin resistance and causes cardiomyopathy...
March 2016: Physiological Reports
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