keyword
https://read.qxmd.com/read/38461808/the-first-case-of-hyperosmolar-diabetic-ketoacidosis-in-a-patient-diagnosed-with-mody-5-maturity-onset-diabetes-of-the-young-type-5-and-17q12-microdeletion-syndrome
#1
JOURNAL ARTICLE
Jun Lee, Minji Kim, Sukdong Yoo, Ju Young Yoon, Chong Kun Cheon
No abstract text is available yet for this article.
February 2024: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/38421235/race-ethnicity-and-intensive-care-utilization-for-common-pediatric-diagnoses-u-s-pediatric-health-information-system-2019-database-study
#2
JOURNAL ARTICLE
Katherine N Slain, Matt Hall, Manzilat Akande, J Daryl Thornton, Peter J Pronovost, Jay G Berry
OBJECTIVES: Racial and ethnic disparities in healthcare delivery for acutely ill children are pervasive in the United States; it is unknown whether differential critical care utilization exists. DESIGN: Retrospective study of the Pediatric Health Information System (PHIS) database. SETTING: Multicenter database of academic children's hospitals in the United States. PATIENTS: Children discharged from a PHIS hospital in 2019 with one of the top ten medical conditions where PICU utilization was present in greater than or equal to 5% of hospitalizations...
February 29, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38381182/use-of-teplizumab-in-children-and-adolescents-at-risk-of-type-1-diabetes-perspectives-of-parents-and-caregivers-from-an-italian-pediatric-diabetes-center
#3
JOURNAL ARTICLE
Bruno Bombaci, Stefano Passanisi, Maria Pecoraro, Lacrima Sorrenti, Mattia Papa, Giuseppina Salzano, Fortunato Lombardo
AIMS: In view of the imminent introduction of a novel category of disease-modifying treatments for type 1 diabetes (T1D) in European countries, it becomes imperative to understand the existing awareness and viewpoints of parents and caregivers of children and adolescents predisposed to T1D. This study aims to evaluate the perspectives of a cohort of parents and caregivers regarding using teplizumab to delay the onset of T1D in predisposed children and adolescents. METHODS: This single-center study used a survey-based approach...
February 21, 2024: Acta Diabetologica
https://read.qxmd.com/read/38339873/revised-one-bag-iv-fluid-protocol-for-pediatric-dka-a-feasible-approach-and-retrospective-comparative-study
#4
JOURNAL ARTICLE
Durmuş Doğan, Hatice D C Gökalp, Erdal Eren, Halil Sağlam, Ömer Tarım
BACKGROUND: This study compared the effectiveness of the traditional and revised one-bag protocols for pediatric diabetic ketoacidosis (DKA) management. METHODS: This single-center retrospective cohort study included children diagnosed with DKA upon admission between 2012 and 2019. Our institution reevaluated and streamlined the traditional one-bag protocol (revised one-bag protocol). The revised one-bag protocol rehydrated all pediatric DKA patients with dextrose (5 g/100 ml) containing 0...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38303767/not-all-diabetic-ketoacidosis-in-infant-is-type-1-a-case-report-permanent-neonatal-diabetes
#5
Doua Khalid Al Homyani, Lina Al Homaiani
BACKGROUND/OBJECTIVE: Neonatal diabetes is a monogenic type of diabetes mellitus. It arises at the first 6 months of age and can be classified as permanent or transient. There are limited cases of neonates with DKA who have heterozygous mutations in INS and PKHD1 genes, especially in Saudi Arabia. We present a case of neonatal diabetes with diabetic ketoacidosis (DKA) born to consanguineous parents in Saudi Arabia. This study aims to highlight the importance of the genetic mutations associated with neonatal diabetes and identify the clinical manifestation features of neonatal diabetes...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38299727/drug-utilisation-in-children-and-adolescents-before-and-after-the-start-of-the-covid-19-pandemic-interrupted-time-series-analyses-in-three-european-countries
#6
JOURNAL ARTICLE
Elisabeth Pedersen, Elena Tripodi, Mia Aakjaer, Huiqi Li, Anna Cantarutti, Fredrik Nyberg, Morten Andersen, Angela Lupattelli, Hedvig Nordeng
BACKGROUND: The COVID-19 pandemic has affected children and adolescents in several ways, including worsened mental health, improvement of asthma, and increases in diabetes ketoacidosis. Less is known about how medication use in children and adolescents has been affected by the pandemic. OBJECTIVES: To explore how the COVID-19 pandemic affected drug utilisation in children and adolescents in Norway, Sweden, and Italy, by child age. METHODS: We conducted a longitudinal drug utilisation study among all children and adolescents (<18 years old) in Norway and Sweden and a nationwide paediatric database covering 3% of the paediatric population in Italy...
February 1, 2024: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/38287388/covid-19-and-diabetes-in-children-advances-and-strategies
#7
REVIEW
Zhaoyuan Wu, Jinling Wang, Rahim Ullah, Minghao Chen, Ke Huang, Guanping Dong, Junfen Fu
BACKGROUND: Throughout the COVID-19 pandemic, there has been a notable increase in the incidence of new-onset diabetes and diabetic ketoacidosis (DKA). Simultaneously, children diagnosed with type 1 diabetes (T1D) have encountered difficulties in maintaining optimal blood glucose levels. The mechanisms underpinning these correlations still remain a puzzle. We reviewed the studies that examined changes in incidence during the pandemic. These studies utilized various metrics for comparison, which encompassed the timing of data collection, diagnostic criteria, as well as the numbers and incidence rates of diabetes and DKA...
January 29, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38281148/a-new-onset-drug-induced-diabetes-mellitus-presenting-with-diabetic-ketoacidosis-in-a-child-undergoing-treatment-for-b%C3%A2-cell-acute-lymphoblastic-leukemia-a-case-report-and-review-of-literature
#8
Preeti Sharma, Varuna Vyas, Siyaram Didel, Kuldeep Singh
OBJECTIVES: Hyperglycemia is a known side effect of anticancer chemotherapeutic drugs. This entity known as drug-induced diabetes mellitus usually does not present with the development of diabetic ketoacidosis (DKA). We hereby report a case of drug induced diabetes mellitus in a child with acute leukemia presenting with DKA. CASE PRESENTATION: We report a case of a teenage boy diagnosed with B cell acute lymphoblastic leukemia and was started on induction phase chemotherapy as per the Indian Collaborative Childhood Leukemia group (ICICLe) acute lymphoblastic leukemia-14 protocol...
January 29, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38269461/-risk-factors-for-ketoacidosis-in-children-adolescents-with-type-1-diabetes-mellitus-and-establishment-of-a-predictive-model
#9
JOURNAL ARTICLE
Xiao-Jia Wang, Ai-Hong Gong, Sheng-Hong Qi, Lan Liu
OBJECTIVES: To investigate the risk factors for diabetic ketoacidosis (DKA) in children/adolescents with type 1 diabetes mellitus (T1DM) and to establish a model for predicting the risk of DKA. METHODS: A retrospective analysis was performed on 217 children/adolescents with T1DM who were admitted to General Hospital of Ningxia Medical University from January 2018 to December 2021. Among the 217 children/adolescents,169 cases with DKA were included as the DKA group and 48 cases without DKA were included as the non-DKA group...
January 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/38266824/challenges-in-achieving-adequate-glycemic-control-among-children-with-type-1-diabetes-mellitus-in-a-resource-limited-setting-a-cross-sectional-study-from-sudan
#10
JOURNAL ARTICLE
Lena Ali, Mohammed Alhassan
OBJECTIVE: To assess glycemic control and associated factors in children with type 1 diabetes mellitus (T1DM) attending the pediatric diabetes clinic in Wad-Madani City, Sudan. METHODS: This cross-sectional observational study was conducted at a referral center in Sudan. The study population consisted of children aged 1-18 years who had been diagnosed with T1DM for more than 1 year and were under regular follow-up in the clinic. Data on their glycemic control and sociodemographic and clinical characteristics were captured...
January 22, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38255417/the-role-of-systemic-family-psychotherapy-in-glycemic-control-for-children-with-type-1-diabetes
#11
JOURNAL ARTICLE
Andreea Salcudean, Maria Melania Lica
(1) Background: Family factors play an important role in the management of diabetes, establishing a relationship between conflicts and non-adherence to therapy. High values of HbA1c are involved in specific complications of the disease (retinopathy, nephropathy, neuropathy, ketoacidosis). This study aimed to determine the role of systemic family psychotherapeutic interventions in increasing the quality of parent-child/adolescent relationships and in optimizing the child's glycemic control. (2) Methods: In this prospective observational study, 64 parents of children and adolescents with type 1 diabetes were evaluated regarding their relationship with their children, using the Child-Parent Relationship Scale-Short Form (CPRS-short form)...
January 15, 2024: Children
https://read.qxmd.com/read/38178064/characterization-of-newly-diagnosed-type-1-diabetes-in-children-and-adolescents-from-2017-to-2022-in-china-a-single-center-analysis
#12
JOURNAL ARTICLE
Shimin Wu, Yuan Gao, Shusen Guo, Lina Fu, Yanqin Ying, Wei Wu, Ling Hou, Yan Liang, Xiaoping Luo
OBJECTIVE: This study investigated the characteristics of newly diagnosed type 1 diabetes mellitus (T1DM) related to autoimmunity and the frequency of diabetic ketoacidosis (DKA) in children and adolescents from 2017-2022 in China. RESEARCH DESIGN AND METHODS: Single-center regional data from the Department of Pediatric Endocrinology, Tongji Hospital, were used to compare 88 children and adolescents newly diagnosed with T1DM from 2020 to 2022 (i.e. during the COVID-19 pandemic in China) and 76 children and adolescents diagnosed with T1DM from 2017 to 2019...
January 4, 2024: BMC Pediatrics
https://read.qxmd.com/read/38171347/mixed-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolarity-in-a-girl-with-nephronophthisis-4-presenting-with-rhabdomyolysis-and-pancreatitis
#13
JOURNAL ARTICLE
Eu-Seon Noh, Chiwoo Kim, Sung Yoon Cho
No abstract text is available yet for this article.
December 2023: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/38167416/from-neglect-to-peril-diabetic-ketoacidosis-unleashing-colonic-necrosis-and-perforation-in-an-adolescent-girl-with-type-1-diabetes-mellitus
#14
JOURNAL ARTICLE
Mritunjay Kumar, Rini Dixit, Rohit Kapoor, Sunita Singh
OBJECTIVES: Abdominal pain is a common presentation in patients of diabetic ketoacidosis (DKA). However, this pain generally resolves with resolution of dehydration and acidosis. Persistence of abdominal pain even after resolution of ketosis and acidosis should warrant careful reassessment to find evidence of sepsis and concomitant abdominal pathology. CASE PRESENTATION: We report a rare case of type 1 diabetes mellitus in a 15 year old girl diagnosed 6 months ago who presented with mild DKA (pH 7...
January 4, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38163851/safety-and-tolerability-of-sodium-glucose-cotransporter-2-inhibitors-in-children-and-young-adults-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Lakshmi Nagendra, Deep Dutta, Harish Bg, Deepak Khandelwal, Tejal Lathia, Meha Sharma
PURPOSE: Sodium glucose co-transporter-2 inhibitors (SGLT2i) have been evaluated in children with type-2 diabetes (T2DM), Type-1 diabetes (T1DM) and several other non-diabetic conditions. Potential tolerability issues have been preventing us from routinely using SGLT2i in children with diabetes. No meta-analysis till date has evaluated the safety and tolerability of SGLT2i in children. This systematic review and meta-analysis aimed to address this knowledge-gap. METHODS: Databases were searched for randomized controlled trials (RCTs), case-control and cohort studies involving children receiving SGLT2i in intervention-arm...
January 2, 2024: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/38128074/association-of-diabetic-ketoacidosis-in-childhood-new-onset-type-1-diabetes-with-day-of-presentation-in-germany
#16
JOURNAL ARTICLE
Clemens Kamrath, Marina Sindichakis, Marie Auzanneau, Silke Schmid, Hugo Segerer, Valentina Lahn, Sven Golembowsky, Dorothee Roessner-Cold, Kristina Rauh, Ulf Manuwald, Reinhard W Holl
OBJECTIVE: Whether the day of the week on which the child presents affects timely diagnosis and risk of diabetic ketoacidosis (DKA) in children with new-onset type 1 diabetes (T1D) is not known. RESEARCH DESIGN AND METHODS: We used data of 30,717 children with new-onset T1D during the last 10 years from the German Prospective Diabetes Registry. We determined the odds ratios of T1D diagnosis and DKA on a weekday, public holiday, and school vacation. RESULTS: Compared with workdays, the odds ratios of being diagnosed with T1D were lower on weekends (0...
December 21, 2023: Diabetes Care
https://read.qxmd.com/read/38108684/challenges-in-pediatric-diabetes-classification-a-case-report
#17
JOURNAL ARTICLE
Stephanie Fossum, Traci R Snedden
Type 2 diabetes (T2DM) incidence and prevalence are increasing in pediatrics. All children aged > 10 years or postpubertal should be screened in primary care for T2DM if they are overweight with one risk factor or have signs of insulin resistance or associated conditions. Classifying pediatric diabetes is challenging. An accurate, timely diagnosis is critical to optimize care, as children with T2DM are at risk for more severe disease as adults. We describe a 10-year-old female referred to endocrine following abnormal laboratory results in primary care...
December 18, 2023: Journal of Pediatric Health Care
https://read.qxmd.com/read/38072157/self-reported-food-security-in-adolescents-with-type-1-diabetes-association-with-hemoglobin-a1c-and-mental-health-symptoms-independent-of-household-food-security
#18
JOURNAL ARTICLE
Emmanuel F Julceus, Edward A Frongillo, Jason A Mendoza, Katherine A Sauder, Faisal S Malik, Elizabeth T Jensen, Lawrence M Dolan, Anna Bellatorre, Dana Dabelea, Beth A Reboussin, Kristi Reynolds, Catherine Pihoker, Angela D Liese
BACKGROUND: Typically, child exposure to food insecurity is assessed by caregiver report of household food security. Child report has a potential for greater accuracy because it pertains only to the child whose experiences may differ from caregiver reports. OBJECTIVE: We assessed if adolescent-reported food insecurity was associated with levels of hemoglobin A1c (HbA1c ), acute diabetes-related complications, depressive symptoms, and disordered eating behaviors in adolescents with type 1 diabetes, independently from household food security...
December 8, 2023: Journal of Nutrition
https://read.qxmd.com/read/38050487/increased-use-of-hyperosmolar-therapy-for-suspected-clinically-apparent-brain-injury-in-pediatric-patients-with-diabetic-ketoacidosis-during-the-peak-of-the-covid-19-pandemic
#19
JOURNAL ARTICLE
Svetlana Azova, Enju Liu, Joseph Wolfsdorf
The incidence of pediatric diabetic ketoacidosis (DKA) increased during the peak of the COVID-19 pandemic. The objective of this study was to investigate whether rates of hyperosmolar therapy administration for suspected clinically apparent brain injury (CABI) complicating DKA also increased during this period as compared to the three years immediately preceding the pandemic and to compare the characteristics of patients with suspected CABI before the pandemic, patients with suspected CABI during the peak of the pandemic, and those with DKA but without suspected CABI during the pandemic...
2023: Pediatric Diabetes
https://read.qxmd.com/read/38019672/sirolimus-induced-hypertriglyceridemia-leads-to-acute-pancreatitis-and-diabetic-ketoacidosis-post-stem-cell-transplant-for-sickle-cell-disease
#20
JOURNAL ARTICLE
Subhasish Paul, Garima Nirmal, Vaibhav Chadha, Rahul Sharma, Ips Kochar, Namith Jerath, Rohit Vohra, Gaurav Kharya
Sirolimus (mammalian target of rapamycin inhibitor) is a potent immunosuppressive agent, used in patients receiving hematopoietic stem cell transplant (HSCT) for Graft vs Host disease prophylaxis. Compared to calcineurin inhibitors, sirolimus has no neurotoxicity or nephrotoxicity, but sirolimus causes dose-dependent thrombocytopenia, leukopenia, delayed wound healing, hyperlipidemia, and hypertriglyceridemia. Here we report a case of acute pancreatitis and diabetic ketoacidosis in a patient with sickle cell disease post haploidentical family donor HSCT which was managed conservatively without plasmapheresis...
November 30, 2023: Journal of Pediatric Hematology/oncology
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