Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Furio Colivicchi, Marcello Arca, Stefania Angela Di Fusco, Angela Pirillo, Alberico L Catapano
Over the last decade, several innovative therapeutic options have been developed and marketed for the management of hypercholesterolemia. However, the impossibility of a contextual update of international guidelines and the limits imposed by national regulatory authorities do not allow the use of these treatments in many patients, in particular in those at higher cardiovascular risk. Real-world studies show that the use of lipid-lowering therapies is inadequate even among patients at higher cardiovascular risk, with only 20% achieving recommended low-density lipoprotein cholesterol (LDL-C) levels and the use of combination therapies implemented in only 24% of patients...
May 2024: Giornale Italiano di Cardiologia
#2
JOURNAL ARTICLE
Daniela Pavan, Adele Lillo, Maria Lorenza Muiesan, Rossella Elena Nappi, Nicoletta Orthmann
The relevance of gender medicine in cardiovascular prevention is still underestimated, and there is a lack of viable women-specific preventive, diagnostic, and therapeutic strategies. To ensure women have equal access to cardiovascular prevention, cardiovascular disease risk stratification needs to consider gender-specific factors related to women reproductive cycle phases together with the different impact that traditional risk factors have on men and women. The aim of this document is to improve the patient journey for cardiovascular risk prevention in women, enhancing the importance of a multidisciplinary approach and the role of the various professional figures involved, starting with the general practitioner, as the main actor of the first risk stratification...
March 2024: Giornale Italiano di Cardiologia
#3
JOURNAL ARTICLE
Marco Ambrosetti, Nuccia Morici, Carmine Riccio, Fabrizio Oliva
No abstract text is available yet for this article.
March 2024: Giornale Italiano di Cardiologia
#4
JOURNAL ARTICLE
Fabiana Lucà, Daniela Pavan, Michele Massimo Gulizia, Maria Teresa Manes, Maurizio Giuseppe Abrignani, Francesco Antonio Benedetto, Irma Bisceglia, Silvana Brigido, Pasquale Caldarola, Raimondo Calvanese, Maria Laura Canale, Giorgio Caretta, Roberto Ceravolo, Alaide Chieffo, Cristina Chimenti, Stefano Cornara, Ada Cutolo, Stefania Angela Di Fusco, Irene Di Matteo, Concetta Di Nora, Francesco Fattirolli, Silvia Favilli, Giuseppina Maura Francese, Sandro Gelsomino, Giovanna Geraci, Simona Giubilato, Nadia Ingianni, Annamaria Iorio, Francesca Lanni, Andrea Montalto, Federico Nardi, Alessandro Navazio, Martina Nesti, Iris Parrini, Annarita Pilleri, Andrea Pozzi, Carmelo Massimiliano Rao, Carmine Riccio, Roberta Rossini, Pietro Scicchitano, Serafina Valente, Giuseppe Zuccalà, Domenico Gabrielli, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva
It is well established that gender strongly influences cardiovascular risk factors, playing a crucial role in cardiovascular prevention, clinical pathways, diagnostic approach and treatment. Beyond the sex, which is a biological factor, gender entails a socio-cultural condition that impacts access and quality of care due to structural and institutional barriers. However, despite its great importance, this issue has not been adequately covered. Indeed sex and gender differences scarcely impact the clinical approach, creating a lot of disparities in care and outcomes of patients...
February 2024: Giornale Italiano di Cardiologia
#5
JOURNAL ARTICLE
Sergio Di Matteo, Sabrin Moumene, Giorgio Lorenzo Colombo, Leonardo De Luca
BACKGROUND: Cardiovascular diseases pose a significant challenge to the society and healthcare systems, with serious implications in terms of mortality and healthcare expenditure. The treatment of cardiovascular diseases, based on acetylsalicylic acid combined with statins in multi-pill regimens, is characterized by a lower adherence rate among patients compared to the single-pill combination. A potential solution lies in single-pill formulations, drugs that combine two or more active ingredients at a fixed dosage within the same dosage unit...
January 2024: Giornale Italiano di Cardiologia
#6
JOURNAL ARTICLE
Marcello Arca, Maurizio Averna, Claudio Borghi, Maddalena Lettino, Pasquale Perrone Filardi, Antonia Alberti, Claudio Bilato, Paolo Calabrò, Francesca Carubbi, Marco Matteo Ciccone, Francesco Cipollone, Nadia Citroni, Leonardo De Luca, Andrea Giaccari, Gabriella Iannuzzo, Alessandro Maloberti, Rossella Marcucci, Pasquale Pignatelli Spinazzola, Matteo Pirro, Livia Pisciotta, Filippo Sarullo, Angela Sciacqua, Patrizia Suppressa, Ferdinando Varbella, José Pablo Werba, Alberto Zambon
Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target of prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization...
October 2023: Giornale Italiano di Cardiologia
#7
JOURNAL ARTICLE
Carlo Ratti, Benedetta Veronesi, Gerardo De Mitri, Paolo Raggi
Patients with end-stage renal disease have a high risk of cardiovascular events, and are often referred for non-invasive screening prior to kidney transplantation. Several European and North American professional organizations have issued guidelines on what tests to perform and which patients may benefit most from them. There is some discrepancy between the various guidelines and their application varies broadly across medical centers and countries. In this review, we briefly discuss the advantages and disadvantages of the non-invasive imaging methodologies that can be used to risk stratify patients prior to transplant...
August 2023: Giornale Italiano di Cardiologia
#8
JOURNAL ARTICLE
Danilo Baccino, Antonio Francesco Amico, Stefania Angela Di Fusco, Federico Nardi, Furio Colivicchi
Erectile dysfunction (ED) is defined as the persistent or recurrent inability to achieve or sustain a penile erection, whose prevalence and severity increase in the older age. It is correlated with the use of several cardiovascular drugs or it can be associated with coronary heart disease. ED prevalence is estimated to be about 50% in patients with coronary heart disease whereas it can be an independent risk factor for future events in patients without cardiovascular disease. Diagnostic work-up in ED includes a cardiovascular screening, although the real benefit of that recommendation is at present unclear...
August 2023: Giornale Italiano di Cardiologia
#9
JOURNAL ARTICLE
Marco Micillo, Alberto Cossu, Graziella Pompei, Marta Cocco, Alberto Boccadoro, Martina De Raffele, Rita Pavasini, Giulia Passarini, Valeria Fortunato, Gabriele Guardigli, Elisabetta Tonet
Epicardial adipose tissue (EAT) has various metabolic functions aiming at heart protection. When abnormal, it is related to atherosclerotic plaque development and adverse cardiovascular outcome. Additionally, in recent years, several studies have demonstrated its role in other settings such as atrial fibrillation and heart failure with preserved ejection fraction. Future studies should aim to assess diagnostic role of EAT and the effect of medical therapy on EAT volume and attenuation.
July 2023: Giornale Italiano di Cardiologia
#10
JOURNAL ARTICLE
Roberto Spoladore, Francesca Daus, Sara Pezzini, Francesca Napoli, Luigi Cante, Stefano Savonitto
Electronic cigarettes (e-cigarettes) are battery-powered devices containing a liquid based on propylene glycol or vegetable glycerin. These compounds, when vaporized, act as a vehicle for nicotine, flavors, and other chemical components. These devices have been marketed without clear evidence of risks, long-term safety, and efficacy. Toxicological data show lower plasma concentrations of carbon monoxide and other cancer-inducing substances as compared to traditional smoking. However, several studies have highlighted an increase in sympathetic tone, vascular stiffness, and endothelial dysfunction, all factors associated with cardiovascular risk that, however, is largely inferior to the cardiovascular risk related to traditional smoking...
June 2023: Giornale Italiano di Cardiologia
#11
JOURNAL ARTICLE
Maurizio G Abrignani, Francesco Ciccirillo, Pier Luigi Temporelli, Arturo Cesaro, Giulio Binaghi, Alessandro Maloberti, Chiara Cappelletto, Fabrizio Oliva, Carmine Riccio, Pasquale Caldarola, Domenico Gabrielli, Furio Colivicchi
Progressive legalization for medical conditions or recreational use has led to an increased use of cannabis and synthetic cannabinoids over the past years. Most consumers are young and healthy, without cardiovascular risk factors; however, this population is expected to include older individuals. Thus, concerns have arisen about safety and short- and long-term potential adverse effects, with special emphasis on vulnerable groups. Studies show that cannabis might be linked with thrombosis, inflammation, and atherosclerosis, and many reports have associated cannabis and synthetic cannabinoids use with serious adverse cardiovascular complications, including myocardial infarction, cardiomyopathy, arrhythmias, stroke, and cardiac arrest...
June 2023: Giornale Italiano di Cardiologia
#12
JOURNAL ARTICLE
Gian Francesco Mureddu, Paola D'Errigo, Stefano Rosato, Roberto Ceravolo, Vito Altamura, Mirko Di Martino, Luca Fileti, Pompilio Faggiano, Leonardo De Luca, Fulvia Seccareccia
Over the last 20 years the epidemiology of acute coronary syndromes (ACS) has significantly changed, affecting both the acute and post-acute phases. In particular, although the progressive reduction in in-hospital mortality, the trend in post-hospital mortality was found to be stable or increasing. This trend was at least in part attributed to the improved short-term prognosis due to coronary interventions in the acute phase, which ultimately have increased the population of survivors at high risk of relapse...
May 2023: Giornale Italiano di Cardiologia
#13
JOURNAL ARTICLE
Angelo Avogaro, Alberto Corsini, Gianfranco Sinagra, Claudio Borghi, Edoardo Sciatti, Roberto Trevisan, Paola Fioretto, Paolo Calabrò, Giuseppe Di Pasquale, Michele Senni
The clinical guidelines, while representing an objective reference to perform correct therapeutic choices, contain grey zones, where the recommendations are not supported by solid evidence. In the fifth National Congress Grey Zones held in Bergamo in June 2022, an attempt was made to highlight some of the main grey zones in Cardiology and, through a comparison between experts, to draw shared conclusions that can illuminate our clinical practice. This manuscript contains the statements of the symposium concerning the controversies regarding cardiovascular risk factors...
May 2023: Giornale Italiano di Cardiologia
#14
JOURNAL ARTICLE
Stefania Angela Di Fusco, Furio Colivicchi
No abstract text is available yet for this article.
May 2023: Giornale Italiano di Cardiologia
#15
JOURNAL ARTICLE
Federico Nardi, Stefania Angela Di Fusco, Antonella Spinelli, Stefano Aquilani, Carmine Riccio, Pasquale Caldarola, Leonardo De Luca, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
Patients with type 2 diabetes mellitus are at an increased risk of cardiovascular disease and microvascular and macrovascular complications. Although multiple classes of antidiabetic drugs are currently available, cardiovascular complications of diabetes still cause considerable morbidity and premature cardiovascular mortality in diabetic patients. The development of new drugs represented a conceptual breakthrough in the treatment of patients with type 2 diabetes mellitus. In addition to improving glycemic homeostasis, these new treatments have consistently demonstrated relevant cardiovascular and renal benefits due to their multiple pleiotropic effects...
April 2023: Giornale Italiano di Cardiologia
#16
REVIEW
Manuela Benvenuto, Gaetano Panzarella, Ermal Shehaj, Chiara Valenti, Pasquale Caldarola, Furio Colivicchi, Domenico Gabrielli, Massimo Iacoviello
The kidney plays an important role in maintaining glucose homeostasis which is used as a metabolic substrate, generated through the mechanism of gluconeogenesis and reabsorbed in the glomerular filtrate through the action of sodium-glucose cotransporters 1 and 2 (SGLT1/2) located in the proximal tubule. Recent studies have shown that inhibition of renal glucose reabsorption, achieved through the administration of sodium-glucose cotransporter inhibitors, significantly reduces renal adverse events and exacerbations of heart failure, not only in diabetic patients, with and without confirmed cardiovascular damage, but also in patients with advanced chronic renal failure and in patients with heart failure with reduced ejection fraction regardless of the presence of diabetes...
March 2023: Giornale Italiano di Cardiologia
#17
JOURNAL ARTICLE
Sigrun Halvorsen, Julinda Mehilli, Salvatore Cassese, Trygve S Hall, Magdy Abdelhamid, Emanuele Barbato, Stefan De Hert, Ingrid de Laval, Tobias Geisler, Lynne Hinterbuchner, Borja Ibanez, Radosław Lenarczyk, Ulrich R Mansmann, Paul McGreavy, Christian Mueller, Claudio Muneretto, Alexander Niessner, Tatjana S Potpara, Arsen Ristić, L Elif Sade, Henrik Schirmer, Stefanie Schüpke, Henrik Sillesen, Helge Skulstad, Lucia Torracca, Oktay Tutarel, Peter Van Der Meer, Wojtek Wojakowski, Kai Zacharowski
No abstract text is available yet for this article.
January 2023: Giornale Italiano di Cardiologia
#18
JOURNAL ARTICLE
Felice Gragnano, Natale Guarnaccia, Paolo Calabrò
No abstract text is available yet for this article.
January 2023: Giornale Italiano di Cardiologia
#19
JOURNAL ARTICLE
Rodolfo Citro, Mario Cristiano, Ilaria Radano, Michele Bellino, Martina Caiazza, Gennaro Galasso, Giuseppe Limongelli
Fabry disease is a rare X-linked genetic disorder, caused by partial or total loss of function of the lysosomal enzyme α-galactosidase A that induces glycosphingolipid accumulation in various organs and tissues, modifying their structure and function. Cardiovascular involvement in classic and late onset forms has emerged to be a major determinant of prognosis. In recent years, a constant evolution in imaging techniques and their mindful application has led to interesting results in the diagnostic workup, progressively reducing time required to recognize early signs of this disease...
January 2023: Giornale Italiano di Cardiologia
#20
JOURNAL ARTICLE
Erica Michelotti, Francesco Negro, Riccardo Morganti, Raffaele De Caterina
In the context of secondary prevention, the efficacy of aspirin in reducing cardiovascular events is widely acknowledged. However, its use for primary prevention is still debated because of uncertain data regarding the risk-benefit ratio. Despite the reduction in atherothrombotic events, almost all randomized clinical trials and meta-analyses have failed to demonstrate a net clinical benefit, as cardiovascular outcome improvement was counterbalanced by increased bleeding. We have, however, to acknowledge that, within the population eligible for primary prevention, cardiovascular risk distribution is extremely heterogeneous...
October 2022: Giornale Italiano di Cardiologia
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
