keyword
https://read.qxmd.com/read/38531539/patient-satisfaction-with-ultrasound-whole-body-ct-and-whole-body-diffusion-weighted-mri-for-pre-operative-ovarian-cancer-staging-a-multicenter-prospective-cross-sectional-survey
#21
JOURNAL ARTICLE
Patrícia Pinto, Lil Valentin, Martina Borčinová, Markéta Wiesnerová, Fruhauf Filip, Andrea Burgetova, Martin Masek, Lukas Lambert, Valentina Chiappa, Dorella Franchi, Antonia Carla Testa, Francesca Moro, Giacomo Avesani, Camilla Panico, Sarah Alessi, Paola Pricolo, Raffaella Vigorito, Giuseppina Calareso, Roman Kocian, Jiri Slama, Anna Fagotti, Ailyn Mariela Vidal Urbinati, Mauro Signorelli, Francesca Bertolina, David Cibula, Daniela Fischerova
BACKGROUND: In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. OBJECTIVE: To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients' experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) for pre-operative ovarian cancer work-up...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38531444/feasibility-of-sulfated-bpa-and-bps-as-wastewater-based-epidemiology-biomarkers-insights-from-wastewater-and-reported-human-urine-analysis
#22
JOURNAL ARTICLE
Hao Wang, Rui Gao, Weiqian Liang, Yingyue Zhou, Zhuo Wang, Longxia Lan, Jinfeng Chen, Feng Zeng
In wastewater-based epidemiology (WBE), the selection of appropriate biomarkers presents a significant challenge. Recently, sulfated bisphenols have garnered attention as potential WBE biomarkers due to their increased stability in wastewater compared to glucuronide conjugates. This study aims to comprehensively assess the feasibility of employing sulfated BPA and BPS as WBE biomarkers by analyzing both WBE and human biomonitoring data. To conduct this research, wastewater samples were collected from six domestic wastewater treatment plants in Guangzhou, China, and urinary concentration of BPA and BPS were obtained from peer-reviewed literature...
March 24, 2024: Science of the Total Environment
https://read.qxmd.com/read/38531278/hydrogen-bonded-cytosine-endowed-supramolecular-polymeric-nanogels-highly-efficient-cancer-cell-targeting-and-enhanced-therapeutic-efficacy
#23
JOURNAL ARTICLE
Wen-Lu Fan, Shan-You Huang, Xiu-Jing Yang, Fasih Bintang Ilhami, Jem-Kun Chen, Chih-Chia Cheng
We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy-and thus hold significant potential as a new perspective for development of drug delivery systems. Herein, we successfully developed physically cross-linked supramolecular polymers (PECH-PEG-Cy) comprised of hydrogen-bonding cytosine pendant groups, hydrophilic poly(ethylene glycol) side chains, and a hydrophobic poly(epichlorohydrin) main chain...
March 23, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38531213/quantifying-emergency-department-nursing-workload-at-the-task-level-using-nasa-tlx-an-exploratory-descriptive-study
#24
JOURNAL ARTICLE
Sookyung Park, Junsang Yoo, Yerim Lee, Pamela Baker DeGuzman, Min-Jeoung Kang, Patricia C Dykes, So Yeon Shin, Won Chul Cha
BACKGROUND: Emergency departments (ED) nurses experience high mental workloads because of unpredictable work environments; however, research evaluating ED nursing workload using a tool incorporating nurses' perception is lacking. Quantify ED nursing subjective workload and explore the impact of work experience on perceived workload. METHODS: Thirty-two ED nurses at a tertiary academic hospital in the Republic of Korea were surveyed to assess their subjective workload for ED procedures using the National Aeronautics and Space Administration Task Load Index (NASA-TLX)...
March 25, 2024: International Emergency Nursing
https://read.qxmd.com/read/38530941/confined-synthesis-of-noble-metal-clusters-assisted-by-liquid-film-for-photocatalytic-co-2-reduction
#25
JOURNAL ARTICLE
Dongkun Gong, Yingjie Wu, Hao Jiang, Chunzhong Li, Yanjie Hu
The important concept of confined synthesis is considered a promising strategy for the design and synthesis of definable nanostructured materials with controllable compositions and specific morphology, such as highly loaded single-atom catalysts capable of providing abundant active sites for photocatalytic reactions. In recent years, researchers have been working on developing new confined reaction systems and searching for new confined spaces. Here, we present for the first time the concept of a bubble liquid film as a novel confined space...
March 26, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38530888/normalizing-granuloma-vasculature-and-matrix-improves-drug-delivery-and-reduces-bacterial-burden-in-tuberculosis-infected-rabbits
#26
JOURNAL ARTICLE
Meenal Datta, Laura E Via, Véronique Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin S Kumar, Sonu Subudhi, Lei Xu, Clifton E Barry, Rakesh K Jain
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno-modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing and normalizing the aberrant granuloma-associated vasculature, here we demonstrate that FDA-approved therapies (bevacizumab and losartan, respectively) can be repurposed as HDTs to normalize blood vessels and extracellular matrix (ECM), improve drug delivery, and reduce bacterial loads in TB granulomas...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530871/working-memory-components-modulation-of-attentional-disengagement-from-evaluative-distractor
#27
JOURNAL ARTICLE
Minmin Yan, Yanying Tian, Min Hai, Bohua Zhang, Antao Chen
It is important for people to disengage attention from a distraction, which can help them complete the task at hand as quickly as possible. Recent studies have shown that people's attention stays longer on reward-distractors than on loss-distractors, and a delay in attentional disengagement is noted when reward-distractors are present. However, few studies have examined whether attentional disengagement from an evaluative distractor relies upon working memory (WM) components. In the present study, we used an attentional disengagement paradigm in which reward- or loss-distractors were presented at a central location and the target was presented at a peripheral location, in combination with different WM tasks...
March 26, 2024: PsyCh Journal
https://read.qxmd.com/read/38530621/semantic-stroop-interference-is-modulated-by-the-availability-of-executive-resources-insights-from-delta-plot-analyses-and-cognitive-load-manipulation
#28
JOURNAL ARTICLE
Simone Sulpizio, Giacomo Spinelli, Michele Scaltritti
We investigated whether, during visual word recognition, semantic processing is modulated by attentional control mechanisms directed at matching semantic information with task-relevant goals. In previous research, we analyzed the semantic Stroop interference as a function of response latency (delta-plot analyses) and found that this phenomenon mainly occurs in the slowest responses. Here, we investigated whether this pattern is due to reduced ability to proactively maintain the task goal in these slowest trials...
March 26, 2024: Memory & Cognition
https://read.qxmd.com/read/38530323/zeolitic-pickering-emulsifier-with-intrinsic-amphiphilicity
#29
JOURNAL ARTICLE
Zhifeng Zeng, Fei Ma, Shuangjia Wang, Jiali Wen, Xiangqiong Jiang, Gaoyu Li, Yan Tong, Xiaolong Liu, Jiuxing Jiang
The formation of oil-in-water Pickering emulsions stabilized by lamellar zeolite MWW (International Zeolite Association, three-letters code) emulsifier without surface grafting is investigated. The crucial emulsification factors are the oligolayer morphology and amphiphilicity developed upon acidic treatment (NH4 + exchange/calcination, HNO3 treatment). In contrast with the readily available/abundant hydrophilic ≡Si-OH group in layer MWW , the lipophilicity generated by strong acid sites is another key to the success of emulsification...
March 26, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38530281/enhancing-oncolytic-virus-efficiency-with-methionine-and-n-3-aminoprolil-methacrylamide-modified-acrylamide-cationic-block-polymer
#30
JOURNAL ARTICLE
Gong Chen, Yuan Yuan, Ying Li, Qianyuan He, Zizhen Qin, Han Hu, Congcong Gao, Zushun Xu, Qi Xu, Qinglei Gao, Fei Li
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity, and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system are the main factors limiting their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses. Still, it is limited in its uptake efficiency by tumor cells. Herein, we constructed an N -hydroxymethyl acrylamide- b -( N -3-aminopropyl methacrylamide)- b -DMC block copolymer (NMA- b -APMA- b -DMA, NAD) as an oncolytic virus carrier, which not only improves the long-term circulation of oncolytic viruses in the body but also shows excellent stability for loading an oncolytic virus...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38530082/extracellular-vesicles-loaded-with-long-antisense-rnas-repress-severe-acute-respiratory-syndrome-coronavirus-2-infection
#31
JOURNAL ARTICLE
Adi Idris, Surya Shrivastava, Aroon Supramaniam, Roslyn M Ray, Galina Shevchenko, Dhruba Acharya, Nigel A J McMillan, Kevin V Morris
Long antisense RNAs (asRNAs) have been observed to repress HIV and other virus expression in a manner that is refractory to viral evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) disease, has a distinct ability to evolve resistance around antibody targeting, as was evident from the emergence of various SARS-CoV-2 spike antibody variants. Importantly, the effectiveness of current antivirals is waning due to the rapid emergence of new variants of concern, more recently the omicron variant...
March 26, 2024: Nucleic Acid Therapeutics
https://read.qxmd.com/read/38530067/bayesian-optimization-of-environmentally-sustainable-graphene-inks-produced-by-wet-jet-milling
#32
JOURNAL ARTICLE
Lindsay E Chaney, Anton van Beek, Julia R Downing, Jinrui Zhang, Hengrui Zhang, Janan Hui, E Alexander Sorensen, Maryam Khalaj, Jennifer B Dunn, Wei Chen, Mark C Hersam
Liquid phase exfoliation (LPE) of graphene is a potentially scalable method to produce conductive graphene inks for printed electronic applications. Among LPE methods, wet jet milling (WJM) is an emerging approach that uses high-speed, turbulent flow to exfoliate graphene nanoplatelets from graphite in a continuous flow manner. Unlike prior WJM work based on toxic, high-boiling-point solvents such as n-methyl-2-pyrollidone (NMP), this study uses the environmentally friendly solvent ethanol and the polymer stabilizer ethyl cellulose (EC)...
March 26, 2024: Small
https://read.qxmd.com/read/38529482/high-intensity-interval-training-improves-respiratory-and-cardiovascular-adjustments-before-and-after-initiation-of-exercise
#33
JOURNAL ARTICLE
Go Ito, Marina Feeley, Toru Sawai, Hideomi Nakata, Shingo Otsuki, Hidehiro Nakahara, Tadayoshi Miyamoto
Purpose: High-intensity interval training (HIIT) may induce training-specific physiological adaptations such as improved respiratory and cardiovascular adjustments before and after the onset of high-intensity exercise, leading to improved exercise performance during high-intensity exercise. The present study investigated the effects of HIIT on time-dependent cardiorespiratory adjustment during maximal exercise and before and after initiation of high-intensity exercise, as well as on maximal exercise performance...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38528936/shape-programming-in-hyperelasticity-through-differential-growth
#34
JOURNAL ARTICLE
Rogelio Ortigosa-Martínez, Jesús Martínez-Frutos, Carlos Mora-Corral, Pablo Pedregal, Francisco Periago
This paper is concerned with the growth-driven shape-programming problem, which involves determining a growth tensor that can produce a deformation on a hyperelastic body reaching a given target shape. We consider the two cases of globally compatible growth, where the growth tensor is a deformation gradient over the undeformed domain, and the incompatible one, which discards such hypothesis. We formulate the problem within the framework of optimal control theory in hyperelasticity. The Hausdorff distance is used to quantify dissimilarities between shapes; the complexity of the actuation is incorporated in the cost functional as well...
2024: Applied Mathematics and Optimization
https://read.qxmd.com/read/38528925/controllable-fabrication-of-coni-bimetallic-alloy-for-high-performance-electromagnetic-wave-absorption
#35
JOURNAL ARTICLE
Hai Xie, Jinmei Li, Rui Yang, Juan Yang, Tingmei Wang, Qihua Wang
With the coming era of artificial intelligence (AI) dominated by high-tech electronics, developing high-performance microwave absorption materials (MAMs) is imperative to solve the problem of increasing electromagnetic inference and pollution. Herein, a metal-organic framework (MOF)-derived CoNi bimetallic alloy (CoNi/C) with an irregular rod-like structure is prepared by a thermal reduction method. Introducing the CoNi alloy facilitates the balance between conduction loss and polarization loss and forms good impedance matching, leading to excellent microwave absorption performance...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38528298/activated-long-term-memory-and-visual-working-memory-during-hybrid-visual-search-effects-on-target-memory-search-and-distractor-memory
#36
JOURNAL ARTICLE
Stephanie M Saltzmann, Brandon Eich, Katherine C Moen, Melissa R Beck
In hybrid visual search, observers must maintain multiple target templates and subsequently search for any one of those targets. If the number of potential target templates exceeds visual working memory (VWM) capacity, then the target templates are assumed to be maintained in activated long-term memory (aLTM). Observers must search the array for potential targets (visual search), as well as search through memory (target memory search). Increasing the target memory set size reduces accuracy, increases search response times (RT), and increases dwell time on distractors...
March 25, 2024: Memory & Cognition
https://read.qxmd.com/read/38528220/asphaltene-derived-nanocomposites-for-the-removal-of-emerging-pollutants-and-its-antimicrobial-effects-batch-and-continuous-column-studies
#37
JOURNAL ARTICLE
Abhishek Nayak, Vaishnavi P Karkare, Kapil Sadani, Harshini Dasari, Arumugam Sivasamy, Nethaji Sundarabal
Emerging contaminants are diverse ecotoxic materials requiring unique treatment for removal. Asphaltenes are environmentally hazardous carbon-rich solid waste product of the petroleum industry. In the current work, asphaltene-derived activated carbon (AC) was loaded with silver (Ag/AC) and used to remove amoxicillin (AMX) and tetracycline (TC) from aqueous phase. The prepared Ag/AC was characterised using FESEM, FTIR, XRD and surface area analysis. The FESEM micrographs confirmed the spherical silver nanoparticle-laden porous AC, and the BET surface area was found to be 213 m2 /g...
March 26, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38527668/an-improved-mouse-model-of-sepsis-based-on-intraperitoneal-injections-of-the-enriched-culture-of-cecum-slurry
#38
JOURNAL ARTICLE
Rajat Atre, Rahul Sharma, Alexander G Obukhov, Uzma Saqib, Sadiq Umar, Gajanan N Darwhekar, Mirza S Baig
AIM: Sepsis is a life-threatening clinical syndrome comprising multiorgan dysfunctions caused by a disproportionate body immune response. There are several animal sepsis models which are based on cecum ligation, cecal puncture, and cecum slurry injection. The major limitation of all current sepsis models is the high variability owing to the variable degree of ligation, puncture and inconsistent microbial composition used for sepsis initiation. The primary objective of this work is to demonstrate the feasibility of a standardized method for sepsis development...
March 23, 2024: Life Sciences
https://read.qxmd.com/read/38527626/infrared-microspectroscopy-to-elucidate-the-underlying-biomolecular-mechanisms-of-flash-radiotherapy
#39
JOURNAL ARTICLE
Immaculada Martínez-Rovira, Pierre Montay-Gruel, Benoît Petit, Ron Leavitt, Roberto González-Vegas, Pascal Froidevaux, Marjorie Juchaux, Yolanda Prezado, Ibraheem Yousef, Marie-Catherine Vozenin
BACKGROUND: FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue. The biological studies showed the potential of FLASH-RT to revolutionize radiotherapy cancer treatments. However, the complex biological basis of FLASH-RT is not fully known yet. AIM: Within this context, our aim is to get deeper insights into the biomolecular mechanisms underlying FLASH-RT through Fourier Transform Infrared Microspectroscopy (FTIRM)...
March 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38527198/dynamic-imaging-of-force-chains-in-3d-granular-media
#40
JOURNAL ARTICLE
Wei Li, Ruben Juanes
Granular media constitute the most abundant form of solid matter on Earth and beyond. When external forces are applied to a granular medium, the forces are transmitted through it via chains of contacts among grains-force chains. Understanding the spatial structure and temporal evolution of force chains constitutes a fundamental goal of granular mechanics. Here, we introduce an experimental technique, interference optical projection tomography, to study force chains in three-dimensional (3D) granular packs under triaxial shear loads and illustrate the technique with random assemblies of spheres and icosahedra...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
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