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JOURNAL ARTICLE
Josefina Martínez-Ramírez, Cristina Saldivia-Siracusa, Leonor-Victoria González-Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber-Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna-Molina, Gerardo Gilligan, Wilson Delgado-Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González-Arriagada, Mariana Villarroel-Dorrego, Bernardo Venegas Rojas, Karen Patricia Domínguez Gallagher, Elena María José Román Tager, Saray Aranda-Romo, Gilda Lucía García-Heredia, Efrain Cima Garcia, Ileana Hurtado, Claudette Arambú Turcios, Leira Patricia Solis Espinal, Rúben Alexander Martínez González, Ana Carolina Prado Ribeiro, Rejane Faria Ribeiro-Rotta, Luiz Paulo Kowalski, Maria Paula Curado, Tatiana Natasha Toporcov, Thomas Peter Sollecito, Andre Lopes Carvalho, Marcio Ajudarte Lopes, Saman Warnakulasuriya, Alan Roger Santos-Silva
OBJECTIVE: This study aimed to explore perceived barriers to early diagnosis and management of oral cancer, as well as potential pathways for improvement in Latin America and the Caribbean (LAC). METHODS: This cross-sectional study used a self-administered online questionnaire created via the Research Electronic Data Capture platform. The survey was distributed to health professionals trained in Oral Medicine, Oral Pathology, Oral and Maxillofacial Surgery, and Dentists with clinical and academic expertise in oral potentially malignant disorder (OPMD) and oral cancer...
February 21, 2024: Oral Diseases
#22
REVIEW
Khalid Zabin Alotaibi, Shaul Hameed Kolarkodi
BACKGROUND AND OBJECTIVES: To enhance the abilities of healthcare professionals to make informed treatment decisions and establish accurate diagnoses, it is essential to assess the diagnostic reliability of different adjunctive aids. This systematic review aimed to compare the accuracy of various adjunctive methods for diagnosing suspected oral cancer (OC) or potentially malignant oral disorders (OPMD) in adults against histopathological investigative results. MATERIALS AND METHODS: The review protocol registered in the PROSPERO database (CRD42023463525) was developed in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Diagnostic Test Accuracy checklist...
January 2024: Saudi Dental Journal
#23
JOURNAL ARTICLE
Jun Zheng, Kaixiong Chen, Lanyu Cai, Yangyang Pan, Yan Zeng
Background: Oral squamous cell carcinoma (OSCC) is frequently diagnosed at an advanced stage, and the high mortality of patients is mainly due to the delay of diagnosis. Cellular prion protein (PrPC ) contributes to the occurrence and development of many malignant tumors. However, little has been known about the clinical and diagnostic value of PrPC in OSCC. This study investigated the levels of PrPC in the saliva and serum of patients with OSCC, OPMD and control group and their diagnostic value. Methods: The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Clinical Proteome Tumor Analysis Consortium (CPTAC) databases were analyzed to evaluate the expression of human prion protein gene ( PRNP ) mRNA and PrPC in OSCC...
2024: Journal of Cancer
#24
JOURNAL ARTICLE
Jaikrishna Balakittnen, Chameera Ekanayake Weeramange, Daniel F Wallace, Pascal H G Duijf, Alexandre S Cristino, Gunter Hartel, Roberto A Barrero, Touraj Taheri, Liz Kenny, Sarju Vasani, Martin Batstone, Omar Breik, Chamindie Punyadeera
Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD). The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs...
February 18, 2024: International Journal of Oral Science
#25
JOURNAL ARTICLE
Vasileios Zisis, Pinelopi A Anastasiadou, Athanasios Poulopoulos, Konstantinos Vahtsevanos, Konstantinos Paraskevopoulos, Dimitrios Andreadis
INTRODUCTION: The aim of this study was to detect the possible endothelial expression of embryonic-type cancer stem cells (CSC) marker SOX2 and the stemness-type CSC marker CD147 in oral potential malignant disorders (OPMDs), oral leukoplakia (OL) in particular, and oral squamous cell carcinoma (OSCC). METHODS: This study focuses on the immunohistochemical pattern of expression of CSC protein-biomarkers SOX2 and CD147 in paraffin-embedded samples of 21 OSCCs of different grades of differentiation and 30 cases of OLs with different grades of dysplasia, compared to normal oral mucosa...
January 2024: Curēus
#26
REVIEW
Miguel Ángel González-Moles, Pablo Ramos-García
A systematic review and a meta-analysis is presented on published articles on the malignant transformation of oral lichen planus (OLP) and related conditions, which, based on current evidence, updates an earlier systematic review published by our research group that included publications until November 2018. In this updated study (Nov-2023) we searched MEDLINE, Embase, Web of Science, and Scopus. We evaluated the methodological quality of studies (QUIPS tool) and carried out meta-analyses. The inclusion criteria were met by 101 studies (38,083 patients), of which, 20 new primary-level studies (11,512 patients) were published in the last 5 years and were added to our updated study...
January 31, 2024: Cancers
#27
REVIEW
Isaac Lim, Jade Tan, Anneka Alam, Majdy Idrees, Peter A Brenan, Ricardo Della Coletta, Omar Kujan
BACKGROUND: Aberrant epigenetic modifications significantly develop and progress human malignancies including head and neck squamous cell carcinoma (HNSCC). Taking into account issues of late diagnosis and poor prognosis associated with HNSCC, this systematic review is designed to provide an up-to-date insight of epigenetic changes in the management of HNSCC. METHODS: All studies that assessed the diagnostic and prognostic utilities of epigenetic changes (DNA methylation and histone modifications) among patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) were considered for inclusion till June 2023...
February 5, 2024: Journal of Oral Pathology & Medicine
#28
JOURNAL ARTICLE
Nayara Conceição Marcos Santana, Ana Carolina Velasco Pondé de Sena, Paula Alves da Silva Rocha, José Alcides Almeida de Arruda, Cassius Carvalho Torres-Pereira, Lucas Guimarães Abreu, Benjamin P J Fournier, Saman Warnakulasuriya, Tarcília Aparecida Silva
The purpose of the present study was to perform a systematic review focusing on oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) in Fanconi anemia (FA) individuals. Electronic searches were undertaken in five databases supplemented by manual scrutiny and gray literature. Case reports and/or cases series were included. The searches yielded 55 studies describing 112 cases of OSCC (n = 107) and/or OPMD (n = 5) in FA individuals. The mean age at diagnosis of OSCC/OPMD was 27...
March 2024: Oral Oncology
#29
JOURNAL ARTICLE
Yuanyuan Long, Chenxi Li, Xiaochen Zhang, Zhenhu Ren, Wei Liu
In 2020, Fanconi anemia (FA) was classified as a syndrome with insufficient epidemiological evidence in the oral potentially malignant disorder (OPMD) group by the WHO Collaborating Centre. The paucity of case reports on FA-associated OPMD limits evidence-based management, and such cases have not been analyzed collectively in detail. Hence, the objective of this short communication is to summarize the evidence on the onset and progression of OPMD in FA patients, so as to better understand the natural history of oral cancer development in patients affected by FA...
January 2024: Journal of Dental Sciences
#30
JOURNAL ARTICLE
Sung-Jae Lee, Hyun Jun Oh, Young-Don Son, Jong-Hoon Kim, Ik-Jae Kwon, Bongju Kim, Jong-Ho Lee, Hang-Keun Kim
BACKGROUND: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of cancer of the oral cavity including the tongue. The early detection of oral cavity cancers and OPMDs is critical for reducing cancer-specific morbidity and mortality. Recently, there have been studies to apply the rapidly advancing technology of deep learning for diagnosing oral cavity cancer and OPMDs. However, several challenging issues such as class imbalance must be resolved to effectively train a deep learning model for medical imaging classification tasks...
February 1, 2024: BMC Oral Health
#31
REVIEW
Pamela Pignatelli, Maria Cristina Curia, Gianluca Tenore, Danilo Bondi, Adriano Piattelli, Umberto Romeo
INTRODUCTION: Periodontal bacteria can infiltrate the epithelium, activate signaling pathways, induce inflammation, and block natural killer and cytotoxic cells, all of which contribute to the vicious circle of carcinogenesis. It is unknown whether oral dysbiosis has an impact on the etiology or prognosis of OPMD. AIMS: Within this paradigm, this work systemically investigated and reported on the composition of oral microbiota in patients with oral potentially malignant disorders (OPMD) versus healthy controls...
January 8, 2024: Archives of Oral Biology
#32
JOURNAL ARTICLE
Distribution of Epstein-Barr virus in the oral cavity of Thais with various oral mucosal conditions.
Pasinee Vorakulpipat, Nakarin Kitkumthorn, Puangwan Lapthanasupkul, Dulyapong Rungraungrayabkul, Boworn Klongnoi, Siribang-On Piboonniyom Khovidhunkit
OBJECTIVES: We aimed to examine the presence of EBV, EBV strains, and variants among 3 oral conditions including normal oral mucosa (NOM), oral potentially malignant disorders/oral cancer (OPMDs/OC) and non-OPMDs/OC in a group of Thais. MATERIAL AND METHODS: Oral exfoliated cells were obtained from 315 participants living in the northeastern and central regions of Thailand. The participants were divided into 3 groups encompassing the NOM, the OPMDs/OC and the non-OPMDs/OC groups...
January 30, 2024: Heliyon
#33
REVIEW
Jeremy Lau, Guru O, Saman Warnakulasuriya, Ramesh Balasubramaniam, Agnieszka Frydrych, Omar Kujan
This study presents the results of systematic reviews on adjunctive tools in screening and diagnosis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) and to determine if the current literature supports their use as either an adjunctive tool or replacement of gold standard techniques. Systemic reviews and meta-analysis that evaluated adjunctive tools including chemiluminescence, tissue autofluorescence, tissue fluorescence spectroscopy, vital staining and cytology techniques were systematically examined using AMSTAR II...
December 2024: Japanese Dental Science Review
#34
REVIEW
Yashpal Manchanda, Sanjay K Rathi, Arun Joshi, Sudip Das
Lichen planus (LP) is a chronic idiopathic immune-mediated inflammatory condition. LP is a heterogeneous disease with varied clinical presentations having different natural history, prognosis, sequelae, and outcomes. It can affect skin, hair, nails, and mucosae. Mucosal LP (including oral LP) tends to be persistent and resistant to treatment, compared to cutaneous LP. Oral LP (OLP) is broadly divided into two main categories: hyperkeratotic (usually asymptomatic) and erosive (commonly symptomatic). It can present with symptoms including odynophagia, dysphagia, dysgeusia, and sensitivity to hot spicy foods...
2024: Indian Dermatology Online Journal
#35
JOURNAL ARTICLE
Razia Aamir, Fozia Rauf, Fatima Iqbal, Sarah Yousuf, Asif Rehman, Ahmareen K Sheikh, Sardar Muhammad
BACKGROUND: Increased epidermal growth factor receptor (EGFR) expression has been implicated in several tumors and is associated with increased tumor advancement as well as a potential drug target. The objective of the study was to compare the immunohistochemical expression of EGFR in oral squamous cell carcinoma (OSCC) with oral potentially malignant disorders (OPMDs) and their demographic and pathologic parameters. METHODS: This study was a comparative cross-sectional analytical study...
January 25, 2024: Applied Immunohistochemistry & Molecular Morphology: AIMM
#36
REVIEW
Monalisha Mahapatra, Abikshyeet Panda, Harish Kumar, Diplina Barman, Rounik Talukdar, Prachurya Dakshinakabat
This systematic review and meta-analysis was planned with the objective of evaluating the level of Lactate Dehydrogenase (LDH) in oral submucous fibrosis patients and in controls and comparing them. For this meta-analysis, we searched Google Scholar, PubMed, Scopus, and Directory of Open Access Journals (DOAJ) databases using a search methodology that included combinations of MeSH terms and keywords and included cross-sectional studies to evaluate the levels of LDH in patients with Oral Submucous Fibrosis (OSMF), Oral Squamous Cell Carcinoma (OSCC) and compared it with the controls...
December 2023: Curēus
#37
REVIEW
Gaia Viglianisi, Alessandro Polizzi, Cristina Grippaudo, Salvatore Cocuzza, Rosalia Leonardi, Gaetano Isola
Oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) represent a significant global health burden due to their potential for malignant transformation and the challenges associated with their diagnosis and treatment. Chemoprevention, an innovative approach aimed at halting or reversing the neoplastic process before full malignancy, has emerged as a promising avenue for mitigating the impact of OPMD and OSCC. The pivotal role of chemopreventive strategies is underscored by the need for effective interventions that go beyond traditional therapies...
January 9, 2024: Bioengineering
#38
REVIEW
Nur Syahirah Binti Mohd Nazar, Anand Ramanathan, Wan Maria Nabillah Ghani, Faezah Binti Rokhani, Pulikkotil Shaju Jacob, Nurul Elma Binti Sabri, Mohd Sukri Hassan, Kathreena Kadir, Lalli Dharmarajan
OBJECTIVES: The aim of this systematic review and meta-analysis is to assess the diagnostic potential of salivary metabolomics in the detection of oral potentially malignant disorders (OPMDs) and oral cancer (OC). MATERIALS AND METHODS: A systematic review was performed in accordance with the 3rd edition of the Centre for Reviews and Dissemination (CRD) and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Electronic searches for articles were carried out in the PubMed, Web of Science, and Scopus databases...
January 16, 2024: Clinical Oral Investigations
#39
JOURNAL ARTICLE
Milad Shademan, Hailiang Mei, Baziel van Engelen, Yavuz Ariyurek, Susan Kloet, Vered Raz
BACKGROUND: Alternative polyadenylation (APA) at the 3-UTR of transcripts contributes to the cell transcriptome. APA is suppressed by the nuclear RNA binding protein, PABPN1. Aging-associated reduced PABPN1 levels in skeletal muscles lead to muscle wasting. Muscle weakness in oculopharyngeal muscular dystrophy (OPMD) is caused by short alanine expansion in PABPN1 exon1. The expanded PABPN1 forms nuclear aggregates, an OPMD hallmark. Whether the expanded PABPN1 affect APA and how contributes to muscle pathology is unresolved...
January 11, 2024: HGG advances
#40
JOURNAL ARTICLE
T Walpola, K L T D Jayawardene, I Weerasekara
BACKGROUND: Human ABO blood group type and the antigenic secretor status are hypothesized to associate with oral diseases including oral cancer. Secretor status is the ability of individuals to secrete blood group antigens into body fluids. This study aimed to evaluate the secretor status of ABO antigens of saliva in patients with oral cancers or oral potentially malignant disorders (OPMDs) relative to healthy adults. METHODS: A systematic and comprehensive online search from inception to April 28, 2022, was carried out in MEDLINE, Embase, PsycInfo, and Emcare...
January 2, 2024: Systematic Reviews
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