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Cristina Cappelletti, Barbara Galbardi, Mirella Bruttini, Franco Salerno, Eleonora Canioni, Maria Barbara Pasanisi, Carmelo Rodolico, Teresa Brizzi, Marina Mora, Alessandra Renieri, Lorenzo Maggi, Pia Bernasconi, Renato Mantegazza
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disease caused by an abnormal (GCN) triplet expansion within the polyadenylate-binding protein nuclear 1 gene and consequent mRNA processing impairment and myogenic defects. Because a reduced cell proliferation potential and the consequent regeneration failure of aging muscle have been shown to be governed by lethal-7 ( let-7) microRNA-mediated mechanisms, in the present study, we evaluated the role of let-7 in the pathogenesis of OPMD. By a multidisciplinary approach, including confocal microscopy, Western blot, and quantitative PCR analyses on muscle biopsies from patients and unaffected individuals, we found a significant increase in let-7 expression in OPMD muscles associated with an unusual high percentage of paired box 7-positive satellite cells...
March 12, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Ankita Kar, V Shwetha, Vanitha Sukesh, S Reddy Sujatha, Nagaraju Rakesh, K Tupakula Pavan
BACKGROUND: Oral cancer is one of the highly prevalent cancers worldwide being. According to data of GLOBOCAN 2018, the estimated incidence, mortality and 5-year survival rates due to lip, oral cavity and salivary gland cancer in world is (2.0%), (0.5%) and (0.3%) respectively. (Bray, Ferlay and Soerjomataram, 2018). Endothelin-1 (ET-1) is a 21-amino acid peptide; its receptors have been implicated in the growth and progression of both primary and metastatic neoplasms throughout the human body...
March 8, 2019: Journal of Stomatology, Oral and Maxillofacial Surgery
Wan Maria Nabillah Ghani, Ishak Abdul Razak, Jennifer Geraldine Doss, Anand Ramanathan, Zaiton Tahir, Nurul Anis Ridzuan, Suzanna Edgar, Rosnah Binti Zain
OBJECTIVES: To evaluate the efficacy of mouth self-examination (MSE) as a self-screening tool for detection of oral mucosal lesions among an Indigenous population in Malaysia at high risk for oral premalignant and malignant disorders. METHODS: Two villages were selected as the sampling frame based on prevalence of tobacco and betel quid chewing habit. Respondents were asked to check their mouth for presence of lesion or abnormalities. Education on oral cancer, including MSE, was provided...
March 8, 2019: Journal of Public Health Dentistry
Ayan Banerjee, Brittany L Phillips, Quidong Deng, Nicholas T Seyfried, Grace K Pavlath, Katherine E Vest, Anita H Corbett
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, primarily autosomal dominant disease caused by a short GCN expansion in the polyadenylate-binding protein nuclear 1 (PABPN1) gene that results in an alanine expansion at the N-terminus of the PABPN1 protein. Expression of alanine-expanded PABPN1 is linked to the formation of nuclear aggregates in tissues from individuals with OPMD. However, as with other nuclear aggregate-associated diseases, controversy exists over whether these aggregates are the direct cause of pathology...
March 5, 2019: Journal of Biological Chemistry
Hsi-Feng Tu, Michael Yuanchien Chen, Joseph Chieh-Yui Lai, Yi-Ling Chen, Yih-Wen Wong, Cheng-Chieh Yang, Hsin-Yuan Chen, Shih-Min Hsia, Yin-Hwa Shih, Tzong-Ming Shieh
BACKGROUND: Ataxia telangiectasia mutated (ATM) regulates DNA repair and cell cycle. The present study analyzed arecoline-induced ATM expression during oral cancer progression. METHODS: In vitro studies were performed using oral squamous cell carcinoma (OSCC) cell lines treated with arecoline to analyze cell response and ATM regulation. in vivo studies were performed using immunohistochemistry to detect ATM expression in normal, oral potentially malignant disorder (OPMD), and OSCC tissues...
February 28, 2019: Head & Neck
Jyotsna Rimal, Ashish Shrestha, Iccha Kumar Maharjan, Sushmita Shrestha, Priyanka Shah
Background: Oral potentially malignant disorders (OPMDs) and oral cancer (OC) are preventable oral mucosal diseases prevalent in Asian region. This epidemiological study aims to identify oral potentially malignant disorders (OPMDs) and oral cancer (OC), confirm histopathologically, and treat or refer these cases among the population of Eastern Development Region (EDR) of Nepal. It also attempts to assess the risk factors associated in order to compare dose–response measurements of oral habits in these patients...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Y Liu, Y Gao, X J Chen, H Hua
OBJECTIVE: To evaluate the diagnostic efficiency of oral mucosa disease, especially oral squamous cell carcinoma (OSCC) and oral potential malignant disorders (OPMDs) by DNA cytometry compared with histopathological diagnosis, so as to find a convenient, simple and low-invasive method for screening and follow-up. METHODS: 203 subjects with OSCC, OPMDs and other oral mucosa disease without dysplasia according to the inclusion criteria and exclusion criteria were recruited from Peking University School and Hospital of Stomatology...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Pei-Shan Ho, Wen-Chen Wang, Yu-Ting Huang, Yi-Hsin Yang
OBJECTIVES: Our study evaluates the effectiveness of the Taiwan Oral Mucosal Screening (TOMS) program in stage-shift among oral cavity cancer patients, and identifies the related factors with early cancer diagnosis. MATERIALS AND METHODS: This retrospective cohort study used the Taiwan Cancer Registry (TCR), TOMS and Taiwan Death Registry (TDR) databases. We identified oral cavity cancer patients (ICD-C-O: C00-C06) from the TCR during 2012-2015. Patients' screening history, first screening status and subsequent screenings were analyzed with cancer stages and survival outcomes...
February 2019: Oral Oncology
Mariam El-Abiary, Charles Diaper
Oculopharyngeal Muscular Dystrophy (OPMD) is a systemic progressive autosomal dominant myopathy which results in ptosis due to levator weakness. Surgical correction can be complicated by corneal exposure and a non-surgical alternative, such as ptosis props, can be uncomfortable in patients with preserved orbicularis function. We describe a case of a 57-year-old gentleman with OPMD, who declined surgical intervention, and self-manages his ptosis with cosmetic glue.
January 27, 2019: Orbit
Meghashyam Bhat, Sreevidya Bhat, Kaye Roberts-Thomson, Loc Giang Do
Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Face-to-face interviews were conducted to collect data on sociodemographic factors, tobacco and alcohol use. Oral examinations were done to record OPMD, periodontal findings and missing teeth...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Huiluo Cao, Tingying Xia, Yanran Li, Zeling Xu, Salim Bougouffa, Yat Kei Lo, Vladimir B Bajic, Haiwei Luo, Patrick C Y Woo, Aixin Yan
Pseudomonas aeruginosa is a prevalent and pernicious pathogen equipped with both extraordinary capabilities to infect the host and to develop antimicrobials resistance (AMR). Monitoring the emergence of AMR high risk clones and understanding the interplay of their pathogenicity and antibiotic resistance is of paramount importance to avoid resistance dissemination and to control P. aeruginosa infections. In this study, we report the identification of a multidrug resistant (MDR) P. aeruginosa strain PA154197 isolated from a blood stream infection in Hong Kong...
January 22, 2019: Antimicrobial Agents and Chemotherapy
Chia-Min Chung, Chung-Chieh Hung, Chien-Hung Lee, Chi-Pin Lee, Ka-Wo Lee, Mu-Kuan Chen, Kun-Tu Yeh, Ying-Chin Ko
A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including leukoplakia or oral submucous fibrosis were recruited. Fifteen tagSNPs which were derived from somatic mutations were genotyped and examined in associations with the occurrence of oral malignancy...
2019: PloS One
Hsin-I Huang, Chung-Ho Chen, Sheng-Hung Wang, Li-Hsuan Wang, Ying-Chu Lin
BACKGROUND: The associations between malignant transformation of oral potentially malignant disorders (OPMDs), oral cancer development and prognosis, and apurinic/apyrimidinic endonuclease 1 (APE1) functional polymorphisms are unclear. METHODS: Patients with OPMDs, patients with oral cancer, and healthy controls from the community were recruited to determine the effects of APE1 polymorphisms on malignant transformation, overall survival, and genetic susceptibility, respectively...
January 16, 2019: Head & Neck
T T Sivakumar, Nisha Sam, Anna P Joseph
Oral cancer burden poses a major challenge in India. Oral cancer in the majority of instances arises from preexisting oral potentially malignant disorders (OPMDs). Early detection of OPMD and elimination of primary risk factors such as smokeless and smoking tobacco help in reduction of oral cancer. A study was conducted to find the prevalence and associated risk factors of OPMDs and oral malignant lesions (OMLs) in Punalur township of South Kerala. A total of 2368 patients were screened, out of which 156 were identified with OPMD and 5 with OML...
September 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Alberto Malerba, Fanny Roth, Pradeep Harish, Jamila Dhiab, Ngoc Lu-Nguyen, Ornella Cappellari, Susan Jarmin, Alexandrine Mahoudeau, Victor Ythier, Jeanne Lainé, Elisa Negroni, Emmanuelle Abgueguen, Martine Simonelig, Philippe Guedat, Vincent Mouly, Gillian Butler-Browne, Cécile Voisset, George Dickson, Capucine Trollet
Oculopharyngeal muscular dystrophy (OPMD) is a rare late onset genetic disease leading to ptosis, dysphagia, and proximal limb muscles at later stages. A short abnormal (GCN) triplet expansion in the polyA-binding protein nuclear 1 (PABPN1) gene leads to PABPN1-containing aggregates in the muscles of OPMD patients. Here we demonstrate that treating mice with guanabenz acetate (GA), an FDA-approved antihypertensive drug, reduces the size and number of nuclear aggregates, improves muscle force, protects myofibers from the pathology-derived turnover and decreases fibrosis...
January 14, 2019: Human Molecular Genetics
Xing Wang, Ying Han, Jianqiu Jin, Zhe Cheng, Qian Wang, Xiang Guo, Wenwen Li, Hongwei Liu
Oral leukoplakia (OLK) is one of the most common oral potentially-malignant disorders (OPMD) with complex causes, a long disease course and a high tendency for recrudescence. Although a variety of methods exist for treating this disease, canceration rates remain high. Herein, we described a case of 72-year-old male patient with OLK of the palatine mucous membrane who had achieved complete remission after being treated with five sessions of plum-blossom needle (PBN) assisted 5-aminolevulinic acid-photodynamic therapy (ALA-PDT)...
January 8, 2019: Photodiagnosis and Photodynamic Therapy
Tzer-Min Kuo, Srinivasan Nithiyanantham, Chi-Pin Lee, Hui-Ting Hsu, Shun-Yuan Luo, You-Zhe Lin, Kun-Tu Yeh, Ying-Chin Ko
Areca nut has been evaluated as a group I carcinogen to humans. However, the exact compounds of areca nut causing oral cancer remain unproven. Previous findings from our lab revealed that arecoline N-oxide (ANO), a metabolite of arecoline, exhibits an oral fibrotic effect in immune-deficient NOD/SCID mice. The aim of this study is to investigate the oral potentially malignant disorders (OPMD) inductive activity between areca-alkaloid arecoline and its metabolite ANO in C57BL/6 mice. Our findings show that ANO showed higher activity in inducing hyperplasia with leukoplakia and collagen deposition in C57BL/6 mice compared with the arecoline treated groups...
January 9, 2019: Journal of Cellular Physiology
Reema Raina, Ankita Tandon, Akanksha Banga, Nikita Gulati, Saurabh Juneja, Devicharan Shetty
BACKGROUND: Free radicals (FRs) are active chemical substances having unpaired electron(s) which participate in the causation of precancerous lesions or cancer in tobacco habituates. Alterations in the antioxidant levels are reflected throughout the antioxidant enzyme activities in blood, wherein erythrocytes are considered highly sensitive to those enzymes. Our study was therefore aimed to assess the effects of tobacco consumption on erythrocyte antioxidant enzyme- Superoxide dismutase (E-SOD) and evaluate its defensive action...
January 7, 2019: Minerva Stomatologica
S Suwasini, Kabita Chatterjee, Swapan Kumar Purkait, Dipankar Samaddar, Ananjan Chatterjee, Madhuresh Kumar
Aims and Objective: The aim of this study is to investigate the expression of p53 protein and Ki-67 antigen in normal oral mucosa and oral leukoplakia with different grades of dysplasia using immunohistochemistry and to clarify the correlation of the expression of these cell cycle regulatory proteins. Materials and Methods: A total of 20 archival tissue blocks obtained from our department which were diagnosed as mild ( n = 5), moderate ( n = 5), and severe dysplasia ( n = 5) with normal mucosa ( n = 5) as a control...
November 2018: Journal of International Society of Preventive & Community Dentistry
Amy Ming-Fang Yen, Sen-Te Wang, Bou-Yue Peng, Ya-Chung Cheng, Pallop Siewchaisakul, Chen-Yang Hsu, Sam Li-Sheng Chen
OBJECTIVES: To quantify the effect of oral potentially malignant disorder (OPMD) subtypes on mortality from oral cancer and type 2 diabetes among areca nut chewers and/or cigarette smokers. MATERIALS AND METHODS: A retrospective cohort design was devised to follow 14,749 men attending community-based screening program for oral cancer between 1998 and 2000 and followed until 2010. The Cox proportional hazards regression model was applied to assess the effect of OPMD on death...
December 27, 2018: Oral Diseases
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