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JOURNAL ARTICLE
Dilip B Magdum, Noopur A Kulkarni, Pratibha G Kavle, Swati Paraye, Pritam S Pohankar, Amol V Giram
INTRODUCTION: Inflammation is a definitive characteristic of carcinogenesis. The neutrophil-to-lymphocyte ratio (NLR) is an easy and efficient indicator of inflammation and a valuable marker in individuals with malignancies. The present study was performed to ascertain NLR values in salivary samples collected from individuals with oral premalignant disorders (OPMDs) and to assess the prognostic significance of NLR in distinguishing OPMDs from oral malignancies. MATERIALS AND METHODS: This study was conducted on 50 patients histopathologically diagnosed with OPMDs with mild dysplasia...
March 2024: Curēus
#2
REVIEW
J H Shazia Fathima, Selvaraj Jayaraman, Ramya Sekar, Nazmul Huda Syed
Oral premalignant disorders (OPMDs) are a group of potentially malignant conditions that pose a significant health burden globally. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as crucial regulators of gene expression and have been implicated in various biological processes, including carcinogenesis. This review synthesizes existing knowledge to provide a comprehensive understanding of the molecular mechanisms underlying OPMDs and to highlight the potential of miRNAs as promising biomarkers and therapeutic targets...
April 15, 2024: Odontology
#3
REVIEW
Stephen S Prime, Piotr Darski, Keith D Hunter, Nicola Cirillo, E Kenneth Parkinson
We explore the possibility that defects in genes associated with the response and repair of DNA double strand breaks predispose oral potentially malignant disorders (OPMD) to undergo malignant transformation to oral squamous cell carcinoma (OSCC). Defects in the homologous recombination/Fanconi anemia (HR/FA), but not in the non-homologous end joining, causes the DNA repair pathway to appear to be consistent with features of familial conditions that are predisposed to OSCC (FA, Bloom's syndrome, Ataxia Telangiectasia); this is true for OSCC that occurs in young patients, sometimes with little/no exposure to classical risk factors...
April 7, 2024: International Journal of Molecular Sciences
#4
REVIEW
Khalid Aljohani, Ali Alqarni, Molly Harte, Rawia Alghamdi, Saja Alzahrani, Rui Albuquerque
Background: Oral potentially malignant disorders (OPMDs) are a group of chronic oral mucosal diseases associated with an increased risk of malignant transformation. Multiple studies have investigated the prevalence of these conditions in multiple regions; however, there are limited data about the prevalence of OPMDs in the Kingdom of Saudi Arabia (KSA). This paper aims to review the prevalence of OPMDs in the KSA, to ensure better understanding of the population risk and propose a more standardised approach to the diagnosis and management of this group across the KSA...
February 28, 2024: Journal of Clinical Medicine
#5
JOURNAL ARTICLE
Narges Ghazi, Nasrollah Saghravanian, Majid Mirhashemi, Hamidreza Shahabi
AIM: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disease classified as an oral potentially malignant disorder (OPMD) and increased transformation risk to oral cancer. Oral lichenoid reactions (OLRs) share the clinical manifestations of OLP. This study aimed to determine histomorphometric changes in OLPs and OLRs in comparison to the healthy control, which helps to plan for the establishment of diagnostic criteria. MATERIALS AND METHODS: This cross-sectional prospective study was conducted on a total of 75 tissue-embedded paraffin-block samples, including OLPs (n = 25), OLR cases (n = 25), and healthy control individuals (n = 25)...
April 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#6
REVIEW
Simran Uppal, Priyanshu Kumar Shrivastav, Atiya Khan, Aditi Sharma, Ayush Kumar Shrivastava
BACKGROUND: Oral Potentially Malignant Disorders (OPMDs) refer to a heterogenous group of clinical presentations with heightened rate of malignant transformation. Identification of risk levels in OPMDs is crucial to determine the need for active intervention in high-risk patients and routine follow-up in low-risk ones. Machine learning models has shown tremendous potential in several areas of dentistry that strongly suggest its application to estimate rate of malignant transformation of precancerous lesions...
March 22, 2024: International Journal of Medical Informatics
#7
JOURNAL ARTICLE
Matthew P Confer, Kianoush Falahkheirkhah, Subin Surendran, Sumsum P Sunny, Kevin Yeh, Yen-Ting Liu, Ishaan Sharma, Andres C Orr, Isabella Lebovic, William J Magner, Sandra Lynn Sigurdson, Alfredo Aguirre, Michael R Markiewicz, Amritha Suresh, Wesley L Hicks, Praveen Birur, Moni Abraham Kuriakose, Rohit Bhargava
Oral potentially malignant disorders (OPMDs) are precursors to over 80% of oral cancers. Hematoxylin and eosin (H&E) staining, followed by pathologist interpretation of tissue and cellular morphology, is the current gold standard for diagnosis. However, this method is qualitative, can result in errors during the multi-step diagnostic process, and results may have significant inter-observer variability. Chemical imaging (CI) offers a promising alternative, wherein label-free imaging is used to record both the morphology and the composition of tissue and artificial intelligence (AI) is used to objectively assign histologic information...
March 13, 2024: Journal of Personalized Medicine
#8
REVIEW
Jakub Zdrojewski, Monika Nowak, Kacper Nijakowski, Jakub Jankowski, Andrea Scribante, Simone Gallo, Maurizio Pascadopoli, Anna Surdacka
Oral cancer is a prevalent global health issue, with significant morbidity and mortality rates. Despite available preventive measures, it remains one of the most common cancers, emphasising the need for improved diagnostic and prognostic tools. This review focuses on oral potentially malignant disorders (OPMDs), precursors to oral cancer, specifically emphasising oral epithelial dysplasia (OED). The World Health Organisation (WHO) provides a three-tier grading system for OED, and recent updates have expanded the criteria to enhance diagnostic precision...
March 5, 2024: Biomedicines
#9
REVIEW
Dardo Menditti, Mario Santagata, David Guida, Roberta Magliulo, Giovanni Maria D'Antonio, Samuel Staglianò, Ciro Emiliano Boschetti
Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer with a low survival rate, causing over 200,000 new cases globally each year. Despite advancements in diagnosis and treatment, the five-year survival rate for OSCC patients remains under 50%. Early diagnosis can greatly improve the chances of survival. Therefore, understanding the development and transformation of OSCC and developing new diagnostic methods is crucial...
February 28, 2024: Bioengineering
#10
JOURNAL ARTICLE
Carlota Suárez-Fernández, María García-Pola
OBJECTIVE: The goal was to identify the lifestyle risk factors associated with benign and potentially malignant oral disorders. METHOD AND MATERIALS: The study enrolled first-time patients from the Oral Pathology Section, volunteers from Oviedo, and first-time patients from University of Oviedo dental clinic. Patients underwent a survey that included sociodemographic information, lifestyle habits, and medical history. Then, a comprehensive examination of the oral mucosa was conducted...
March 25, 2024: Quintessence International
#11
EDITORIAL
Abhimanyu Kumar Jha
No abstract text is available yet for this article.
2024: Front Oral Health
#12
JOURNAL ARTICLE
Irena Duś-Ilnicka, Agnieszka Hałoń, Andrea Perra, Małgorzata Radwan-Oczko
BACKGROUND: The association of Human Papilloma Virus (HPV) and Human Syncytial Virus (HSV) infection with inflammatory and potentially malignant disorders of the oral cavity (OPMD) is unknown. The aim of this cross-sectional study was to stablish the expression of the p16INK4A and HSV proteins, to test potential correlation between those parameters in biopsies from clinically diagnosed oral lesions. METHODS: Immunochemical analysis of 211 formalin-fixed, paraffin-embedded (FFPE) blocks from 211 individuals was provided...
March 18, 2024: BMC Oral Health
#13
REVIEW
Daniel Bastías, Alejandro Maturana, Constanza Marín, René Martínez, Sven Eric Niklander
Different efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included...
February 23, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Elizabeth Fitriana Sari, Newell W Johnson, Michael John McCullough, Nicola Cirillo
Detection of subjects with oral potentially malignant disorders in a population is key to early detection of oral cancer (OC) with consequent reduction of cancer-related morbidity and mortality. Our aim was to investigate the prevalence and associated risk factors for OPMD in representative provinces of Indonesia. This cross-sectional study was undertaken in five Indonesian provinces: West Java (WJ), Jakarta (JKT), West Papua (WP), West Kalimantan (WK) and Banda Aceh (BA). Respondents answered a previously validated questionnaire including information on ethnicity, occupation, socioeconomic status (SES), oral health practices, and behaviours associated with oral cancer...
March 4, 2024: Scientific Reports
#15
JOURNAL ARTICLE
Samreen Khan, Muhammad Mohiuddin Alamgir
Oral squamous cell carcinoma (OSCC) is the most prevalent cancer in Pakistani population because of consumption of different tobacco-containing products whether smoked or chewed. These patients commonly report at a late stage of the disease. The patient's survival only depends upon early-stage diagnosis. Literature has reported that there is an increased tendency of transformation of oral potentially malignant disorder (OPMD) into OSCC. Biopsy is the gold standard measure for diagnosis but for OPMD cases biopsy was not recommended and most of the times the patients were also not willing to have a biopsy done...
February 2024: JPMA. the Journal of the Pakistan Medical Association
#16
JOURNAL ARTICLE
Yin Jing, Rong Shu, Tingting Wu, Dongqi Liu, Xiao Luo, Jun Sun, Fangchun Chen
OBJECTIVE: To investigate the clinical efficacy of aminovalerate hydrochloride photodynamic therapy (PDT) for oral potentially malignant disorder (OPMD),oral leukoplakia (OLK), along with identifying the influencing factors.Additionally, the study aims to detect the rates of recurrence and malignancy after PDT. METHOD: 60 patients with OPMD who received PDT at our hospital from 2006 to 2021 were included in this study. Relevant patient medical data were collected and analyzed using SAS 9...
February 23, 2024: Photodiagnosis and Photodynamic Therapy
#17
JOURNAL ARTICLE
Jiaxin Zhang, Qiao Ma, Caihong Wang, Nan Meng
Pseudomonas aeruginosa, which can produce several toxins and form biofilm, is listed among the priority pathogens. Indole is a ubiquitous aromatic pollutant and signaling molecule produced by tryptophanase in bacteria. Herein, the impacts of indole on a newly isolated P. aeruginosa strain Jade-X were systematically investigated. Indole (0.5-2.0 mM) enhanced the biofilm production by 1.33-2.31-fold after 24 h incubation at 30 °C. However, the effects indole on biofilm formation were intricate and closely intertwined with factors such as incubation temperature, bacterial growth stage, and indole concentration...
February 20, 2024: Chemosphere
#18
JOURNAL ARTICLE
Anirudha R Bartake, Sachin Sarode, Sangeeta Palaskar, Amit Girme, Gargi Sarode, Samruddhi Kamble, Bindiya Narang, Pradnya Bhale
BACKGROUND: Tobacco is one of the main etiological factors for oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). CYP1B1 is an enzyme which plays a major role in the phase I detoxification of tobacco, the byproducts of which are subsequently detoxified by phase II enzymes Glutathione S Transferase (GST). We attempted to evaluate the L432V polymorphism and tissue expression of CYP1B1, along with the oxidant-antioxidant status in OSCC progression model...
2024: Journal of Oral Biology and Craniofacial Research
#19
JOURNAL ARTICLE
Josefina Martínez-Ramírez, Cristina Saldivia-Siracusa, Leonor-Victoria González-Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber-Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna-Molina, Gerardo Gilligan, Wilson Delgado-Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González-Arriagada, Mariana Villarroel-Dorrego, Bernardo Venegas Rojas, Karen Patricia Domínguez Gallagher, Elena María José Román Tager, Saray Aranda-Romo, Gilda Lucía García-Heredia, Efrain Cima Garcia, Ileana Hurtado, Claudette Arambú Turcios, Leira Patricia Solis Espinal, Rúben Alexander Martínez González, Ana Carolina Prado Ribeiro, Rejane Faria Ribeiro-Rotta, Luiz Paulo Kowalski, Maria Paula Curado, Tatiana Natasha Toporcov, Thomas Peter Sollecito, Andre Lopes Carvalho, Marcio Ajudarte Lopes, Saman Warnakulasuriya, Alan Roger Santos-Silva
OBJECTIVE: This study aimed to explore perceived barriers to early diagnosis and management of oral cancer, as well as potential pathways for improvement in Latin America and the Caribbean (LAC). METHODS: This cross-sectional study used a self-administered online questionnaire created via the Research Electronic Data Capture platform. The survey was distributed to health professionals trained in Oral Medicine, Oral Pathology, Oral and Maxillofacial Surgery, and Dentists with clinical and academic expertise in oral potentially malignant disorder (OPMD) and oral cancer...
February 21, 2024: Oral Diseases
#20
REVIEW
Khalid Zabin Alotaibi, Shaul Hameed Kolarkodi
BACKGROUND AND OBJECTIVES: To enhance the abilities of healthcare professionals to make informed treatment decisions and establish accurate diagnoses, it is essential to assess the diagnostic reliability of different adjunctive aids. This systematic review aimed to compare the accuracy of various adjunctive methods for diagnosing suspected oral cancer (OC) or potentially malignant oral disorders (OPMD) in adults against histopathological investigative results. MATERIALS AND METHODS: The review protocol registered in the PROSPERO database (CRD42023463525) was developed in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Diagnostic Test Accuracy checklist...
January 2024: Saudi Dental Journal
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