keyword
https://read.qxmd.com/read/38487972/salmonella-driven-intestinal-edema-in-mice-is-characterized-by-tensed-fibronectin-fibers
#21
JOURNAL ARTICLE
Ronja Rappold, Konstantinos Kalogeropoulos, Ulrich Auf dem Keller, Viola Vogel, Emma Slack
Intestinal edema is a common manifestation of numerous gastrointestinal diseases and is characterized by the accumulation of fluid in the interstitial space of the intestinal wall. Technical advances in laser capture microdissection and low-biomass proteomics now allow us to specifically characterize the intestinal edema proteome. Using advanced proteomics, we identify peptides derived from antimicrobial factors with high signal intensity, but also highlight major contributions from the blood clotting system, extracellular matrix (ECM) and protease-protease inhibitor networks...
March 15, 2024: FEBS Journal
https://read.qxmd.com/read/38485877/phenotypes-of-patients-with-systemic-sclerosis-in-the-chinese-han-population-a-cluster-analysis
#22
JOURNAL ARTICLE
Yaqi Zhao, Wei Xu, Wenfeng Gao, Xinya Li, Baocheng Liu, Suyan Yan, Zhenzhen Ma, Qingrui Yang
OBJECTIVE: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is commonly subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) based on the extent of skin involvement. This subclassification may not reflect the full range of clinical phenotypic variation. This study aimed to investigate clinical features and aggregation of patients with SSc in Chinese based on SSc manifestations and organ involvements, in order to achieve precise treatment of SSc early prevention of complications...
March 15, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38482230/management-and-mechanism-of-calciphylaxis-in-a-patient-treated-with-the-fgfr-inhibitor-pemigatinib-a-case-report
#23
Sreenivasa R Chandana, Austin Frisch, Sergio Mendoza, Ranu S Sinniah, Oxana Crysler, Ramandeep Banga, Diane E Perkins
BACKGROUND: Small molecule fibroblast growth factor receptor (FGFR) inhibitors, such as pemigatinib, have been developed for the treatment of cholangiocarcinoma (CCA) with rearrangements or fusions in the FGFR2. FGFR inhibitors (FGFRis) have dermatologic side effects such as dry skin or nail bed damage. However, in very rare instances, a life-threatening vascular calcification disease known as calciphylaxis has been linked to these therapies. CASE DESCRIPTION: We report a patient with metastatic CCA, who developed calciphylaxis following the start of their pemigatinib treatment...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38478667/letterer-siwe-disease-presenting-with-gastrointestinal-and-cutaneous-manifestations
#24
JOURNAL ARTICLE
Antonina Sergeevna Stadnikova, Walaa Fadhil Abbas, Olga Borisovna Tamrazova, Ekaterina Andreevna Pristanskova, Irina Nikolaevna Zakharova, Irina Vladimirovna Berezhnaya, Dmitry Alexandrovich Skobeev, Lyudmila Viktorovna Goncharova
Histiocytosis is a set of distinct proliferative illnesses defined by the proliferation and infiltration of varied numbers of dendritic cells, macrophages, and monocytes in the afflicted tissues. The skin and other organs may be impacted by the inflammatory infiltration. It can occur at any age. The severity of the symptoms can range from mild to severe, depending on the degree and type of organ involvement. Although certain forms of histiocytosis can be fatal, others can be treated successfully without sequelae...
December 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38476311/medicinal-plants-used-by-oromo-community-in-kofale-district-west-arsi-zone-oromia-regional-state-ethiopia
#25
JOURNAL ARTICLE
Geritu Bedasso Nuro, Ketema Tolossa, Mirutse Giday
PURPOSE: The purpose of this study was to record the utilization of medicinal plants by the Oromo people in the Kofale District, Oromia Regional State, Ethiopia, to control human and animal health problems. METHODS: Data regarding the use of medicinal plants were collected using ethnobotanical methods from 84 traditional medicine practitioners and 304 general informants sampled employing purposive and systematic random sampling methods, respectively, in the Kofale District...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38472904/plant-and-arthropod-ige-binding-papain-like-cysteine-proteases-multiple-contributions-to-allergenicity
#26
REVIEW
Ivana Giangrieco, Maria Antonietta Ciardiello, Maurizio Tamburrini, Lisa Tuppo, Adriano Mari, Claudia Alessandri
Papain-like cysteine proteases are widespread and can be detected in all domains of life. They share structural and enzymatic properties with the group's namesake member, papain. They show a broad range of protein substrates and are involved in several biological processes. These proteases are widely exploited for food, pharmaceutical, chemical and cosmetic biotechnological applications. However, some of them are known to cause allergic reactions. In this context, the objective of this review is to report an overview of some general properties of papain-like cysteine proteases and to highlight their contributions to allergy reactions observed in humans...
March 4, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38468236/characterization-of-the-broad-spectrum-antibacterial-activity-of-bacteriocin-like-inhibitory-substance-producing-probiotics-isolated-from-fermented-foods
#27
JOURNAL ARTICLE
Tran Thi Dieu Thuy, Hsu-Feng Lu, Carl Jay Ballena Bregente, Fong-Chi Annabelle Huang, Pei-Chun Tu, Cheng-Yen Kao
Antimicrobial peptides, such as bacteriocin, produced by probiotics have become a promising novel class of therapeutic agents for treating infectious diseases. Selected lactic acid bacteria (LAB) isolated from fermented foods with probiotic potential were evaluated for various tests, including exopolysaccharide production, antibiotic susceptibility, acid and bile tolerance, antibacterial activity, and cell adhesion and cytotoxicity to gastric cell lines. Six selected LAB strains maintained their high viability under gastrointestinal conditions, produced high exopolysaccharides, showed no or less cytotoxicity, and adhered successfully to gastric cells...
March 11, 2024: BMC Microbiology
https://read.qxmd.com/read/38465561/panniculitis-during-avapritinib-therapy-for-gastrointestinal-stromal-tumour
#28
JOURNAL ARTICLE
Changhua Zhu, Ping Wang, Qinqin Long, Sheng Lin, Lihang Lin, Xuemin Xiao
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38464780/cronkhite-canada-syndrome-an-atypical-presentation-with-subungual-hyperkeratosis
#29
Peerada Sermswan, Pravit Asawanonda, Nopadon Noppakun, Chanat Kumtornrut
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38464518/streptococcal-infection-and-autoimmune-diseases
#30
REVIEW
Ayaka Ohashi, Masanori A Murayama, Yoshishige Miyabe, Kazuo Yudoh, Chie Miyabe
Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. Streptococcus species are gram-positive bacteria that colonize the nasopharynx, respiratory tract, gastrointestinal tract, genitourinary tract, and skin. Group A Streptococcus (GAS) species cause various symptoms, ranging from mild infections, such as tonsillitis and pharyngitis, to serious infections, such as necrotizing fasciitis and streptococcal toxic shock syndrome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38463494/a-rare-case-of-cutaneous-gastric-adenocarcinoma-with-signet-ring-cell-features
#31
Alexander Garcia, Arman Maqsudlu, Ishita Dhawa, Adib Chaaya
Cutaneous metastatic disease from primary gastric cancer is quite scarce, often going unrecognized. In this case, the patient presented with an expanding rash that was biopsied, with findings concerning for metastatic adenocarcinoma from a suspected luminal upper gastrointestinal origin. Subsequent biopsies during an esophagogastroduodenoscopy confirmed poorly differentiated adenocarcinoma with signet ring cell features, most likely from an upper gastrointestinal primary (gastric vs gastroesophageal junction)...
March 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38456025/an-unusual-case-of-brucella-melitensis-related-wound-infection
#32
Ozge Alkan Bilik, Fatma Meral Ince, Nida Ozcan, Zeynep Ayaydin
BACKGROUND: Brucellosis is an anthropo-zoonotic infectious disease caused by various Brucella species. It is usually transmitted through contact with infected animals or consumption of contaminated animal products. Brucellosis most commonly affects the musculoskeletal and reticuloendothelial system with additional involvement observed in gastrointestinal system, urinary tract, reproductive system, central nervous system, and cardiovascular system. Skin involvement is extremely rare in brucellosis...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38455490/randomized-controlled-trial-of-olanexidine-gluconate-and-povidone-iodine-for-surgical-site-infection-after-gastrointestinal-surgery
#33
JOURNAL ARTICLE
Hiroya Iida, Hiromitsu Maehira, Sachiko Kaida, Katsushi Takebayashi, Toru Miyake, Masaji Tani
AIM: Antiseptics used at surgical sites are vital to preventing surgical site infections (SSI). In this study, a comparative investigation of the novel antiseptics olanexidine gluconate (OG) and povidone-iodine (PI) was conducted to determine whether OG is more effective than PI against SSI after gastrointestinal surgery. METHODS: This prospective, randomized, single-blind, interventional, single-center study was conducted between August 2018 and February 2021. Patients scheduled for large-scale gastrointestinal surgeries were randomized into two groups and administered OG (OG group) or PI (PI group) as preoperative antiseptics...
March 2024: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/38454433/adherence-to-medical-treatment-for-wilson-s-disease-in-children-and-adolescents-a-cohort-study-from-turkey
#34
JOURNAL ARTICLE
Mehmet Akif Göktaş, Nadir Yalcin
BACKGROUND: This study aimed to assess medication adherence and demographic, clinical, and psychopathological parameters such as quality of life, depression, and anxiety levels that can affect pediatrics with Wilson's Disease (WD). METHODS: A prospective cohort study was conducted at an outpatient clinic in Turkey among pediatric patients (2 to 18 years) with WD between November 2022 and April 2023. The Medication Adherence Report Scale (MARS-5) as a subjective and Medication Possession Ratio (MPR) as an objective assessment were scored...
March 7, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38453643/advanced-technologies-in-radiation-research
#35
JOURNAL ARTICLE
Carmen I Rios, Andrea L DiCarlo, Lynn Harrison, Pataje G S Prasanna, Jeffery C Buchsbaum, Michael W Rudokas, Lauren Gomes, Thomas A Winters
The U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, Advanced Technologies in Radiation Research (ATRR), which focused on the use of advanced technologies under development or in current use to accelerate radiation research...
March 8, 2024: Radiation Research
https://read.qxmd.com/read/38450897/long-term-outcomes-of-definitive-radiation-with-volumetric-modulated-arc-therapy-and-concurrent-chemotherapy-for-squamous-cell-carcinoma-of-the-anus-in-a-regional-australian-cancer-centre
#36
JOURNAL ARTICLE
Michael Ti Hsieh, Thomas Philip Shakespeare, Lauren Winkley, Daniel Goonetilleke, Shaun Zheng Liang Yap, Abdul Rahim Mohd Tahir
INTRODUCTION: Concurrent chemoradiotherapy is the standard of care in the curative intent treatment of squamous cell carcinoma (SCC) of the anus. Volumetric arc therapy (VMAT) is a highly conformal radiation therapy technique that has been implemented to reduce toxicity for these patients. However, there are few reports evaluating the long-term outcomes of VMAT. Thus, we evaluated the survival and toxicity outcomes of anal cancer patients treated in our regional cancer centre undergoing curative intent chemoradiotherapy using VMAT and following the Australian EviQ guidelines...
March 7, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38449507/exploring-the-prevalence-predictors-and-impact-of-bacterial-infections-to-guide-empiric-antimicrobial-decisions-in-cirrhosis-epic-ad
#37
JOURNAL ARTICLE
Pratibha Garg, Nipun Verma, Archana Angrup, Neelam Taneja, Arun Valsan, Venkata D Reddy, Jayant Agarwal, Roma Chaudhary, Parminder Kaur, Sahaj Rathi, Arka De, Madhumita Premkumar, Sunil Taneja, Ajay Duseja
BACKGROUND/AIMS: This study delved into cirrhosis-related infections to unveil their epidemiology, risk factors, and implications for antimicrobial decisions. METHODS: We analyzed acutely decompensated cirrhosis patients (n = 971) from North India between 2013-2023 at a tertiary center. Microbiological and clinical features based on infection sites (EASL criteria) and patient outcomes were assessed. RESULTS: Median age was 45 years; 87% were males with 47% having alcoholic hepatitis...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38442248/guide-to-utilization-of-the-microbiology-laboratory-for-diagnosis-of-infectious-diseases-2024-update-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-for-microbiology-asm
#38
JOURNAL ARTICLE
J Michael Miller, Matthew J Binnicker, Sheldon Campbell, Karen C Carroll, Kimberle C Chapin, Mark D Gonzalez, Amanda Harrington, Robert C Jerris, Sue C Kehl, Sixto M Leal, Robin Patel, Bobbi S Pritt, Sandra S Richter, Barbara Robinson-Dunn, James W Snyder, Sam Telford, Elitza S Theel, Richard B Thomson, Melvin P Weinstein, Joseph D Yao
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the health care team. This document, developed by experts in both adult and pediatric laboratory and clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. Sections are divided into anatomic systems, including Bloodstream Infections and Infections of the Cardiovascular System, Central Nervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respiratory Infections, Lower Respiratory Tract infections, Infections of the Gastrointestinal Tract, Intraabdominal Infections, Bone and Joint Infections, Urinary Tract Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups, including arboviral Infections, Viral Syndromes, and Blood and Tissue Parasite Infections...
March 5, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38439724/muir-torre-syndrome-with-novel-mutation-in-the-msh2-gene
#39
Eda Ustaoglu, Senay Agirgol, Huri Sema Aymelek, Ezgi Isil Turhan
Muir-Torre syndrome (MST) is a rare autosomal dominant subtype of hereditary non-polyposis colorectal carcinoma. The diagnosis is established based on the coexistence of sebaceous gland tumors and visceral organ malignancies. Mutations in the mismatch repair genes are responsible for Muir-Torre syndrome. Internal malignancies seen in MTS are most commonly colorectal, gastrointestinal system, endometrial, genitourinary system, breast, lung, brain, and hepatobiliary system malignancies. Detection of sebaceous neoplasia is essential in investigating Muir-Torre syndrome, allowing early detection of internal malignancies...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38433123/oral-fusidic-acid-for-the-treatment-of-mild-to-moderate-hidradenitis-suppurativa
#40
JOURNAL ARTICLE
Antonia Wiala, Sophie M Daschl, Theresa Stockinger, Klemens Rappersberger, Christian Posch
BACKGROUND: Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease. Tetracyclines are one of the few therapeutic options recommended for mild-to-moderate disease. This study aimed to investigate the efficacy of systemic fusidic acid's (FA) effectiveness in treating HS. METHODS: This retrospective study analyzed 55 FA therapy cycles (TC, average weekly dose: 6409 mg; range: 5250-9800 mg; 2-12 weeks) in 49 patients. The outcome was evaluated using the Physician's Global Assessment (PGA) scale...
March 3, 2024: International Journal of Dermatology
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