Hongbao Fang, Lianting Hu, Qixin Chen, Shanshan Geng, Kangqiang Qiu, Chengjun Wang, Mingang Hao, Zhiqi Tian, Huimin Chen, Lei Liu, Jun-Lin Guan, Yuncong Chen, Lei Dong, Zijian Guo, Weijiang He, Jiajie Diao
The endoplasmic reticulum's (ER) dynamic nature, essential for maintaining cellular homeostasis, can be influenced by stress-induced damage, which can be assessed by examining the morphology of ER dynamics and, more locally, ER properties such as hydrophobicity, viscosity, and polarity. Although numerous ER-specific chemical probes have been developed to monitor the ER's physical and chemical parameters, the quantitative detection and super-resolution imaging of its local hydrophobicity have yet to be explored...
January 2023: Biomaterials