Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Isabelle Bolon, Lukáš Picek, Andrew M Durso, Gabriel Alcoba, François Chappuis, Rafael Ruiz de Castañeda
BACKGROUND: Snakebite envenoming is a neglected tropical disease that kills an estimated 81,000 to 138,000 people and disables another 400,000 globally every year. The World Health Organization aims to halve this burden by 2030. To achieve this ambitious goal, we need to close the data gap in snake ecology and snakebite epidemiology and give healthcare providers up-to-date knowledge and access to better diagnostic tools. An essential first step is to improve the capacity to identify biting snakes taxonomically...
August 2022: PLoS Neglected Tropical Diseases
#22
JOURNAL ARTICLE
Mitchell T Gray, Kyle P Davis, Bryan J McEntire, B Sonny Bal, Micah W Smith
Background: Degeneration of the lumbar spine is common in aging adults and reflects a significant morbidity burden in this population. In selected patients that prove unresponsive to non-surgical treatment, posterior lumbar fusion (PLF) surgery, with or without adjunctive transforaminal lumbar interbody fusion (TLIF) can relieve pain and improve function. We describe here the radiographic fusion rates for PLF versus TLIF, using an intervertebral spinal cage made of silicon nitride ceramic (chemical formula Si3 N4 )...
March 2022: Journal of Spine Surgery (Hong Kong)
#23
EDITORIAL
Joseph W Duke, Andrew T Lovering
No abstract text is available yet for this article.
April 2022: Chest
#24
JOURNAL ARTICLE
Jes Hooper
This research explores the intersection between zoonosis and the trade in wild animals by applying the Asian palm civet ( Paradoxurus hermaphroditus ) as a lens through which to analyse the ways humans and animals shape, and are shaped by, multi-species entanglements. Civets occupy a unique space within contemporary human-animal relations, as they have become an increasingly popular companion species despite being vectors of severe acute respiratory syndrome (SARS) coronavirus. The 2002 SARS outbreak not only killed 774 humans, but its confirmed species origin instigated the retribution-like public slaughter of an estimated 10,000 civets...
April 2022: Journal of Applied Animal Welfare Science: JAAWS
#25
REVIEW
Joseph W Duke, Adam J Lewandowski, Steven H Abman, Andrew T Lovering
Progressive improvements in perinatal care and respiratory management of preterm infants have resulted in increased survival of newborns of extremely low gestational age over the past few decades. However, the incidence of bronchopulmonary dysplasia, the chronic lung disease after preterm birth, has not changed. Studies of the long-term follow-up of adults born preterm have shown persistent abnormalities of respiratory, cardiovascular and cardiopulmonary function, possibly leading to a lower exercise capacity...
February 2022: Journal of Physiology
#26
JOURNAL ARTICLE
Kexin Yuan, Pei Zhao, Lili Wang
We investigated the expression levels of microRNA-1 (miRNA-1) and microRNA-21 (miRNA-21) in the atrial tissues of patients with atrial fibrillation (AF) and the molecular mechanism of action in atrial remodeling. Patients with valvular heart disease were selected as the subjects. The ultrastructure, degree of myocardial fibrosis, apoptosis index (AI), expression of microRNA-1, expression of microRNA-21, and mRNA of TIMP-1, MMP-9, BCL-2, and Bax of patients were compared and analyzed in each group. The results showed that the degree of myocardial fibrosis and AI in patients with AF of the same age were extremely higher than those of patients with sinus rhythm (SR) ( P < 0...
December 2021: Bioengineered
#27
JOURNAL ARTICLE
Timothy M Rawson, Richard C Wilson, Luke S P Moore, Alasdair P Macgowan, Andrew M Lovering, Mark Bayliss, Mathew Kyriakides, Mark Gilchrist, Jason A Roberts, William W Hope, Alison H Holmes
This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.
December 2021: Open Forum Infectious Diseases
#28
JOURNAL ARTICLE
Pokkate Wongsasuluk, Aung Zaw Tun, Srilert Chotpantarat, Wattasit Siriwong
Exposure to heavy metals in mining activities is a health issue among miners. This study was carried out at three small-scale gold mining sites situated in Banmauk Township, Myanmar and aims to assess the occupational health risks of small-scale gold miners who are exposed to arsenic (As), cadmium (Cd), mercury (Hg) and lead (Pb) in the soil through the dermal route. Soil samples were analyzed through atomic absorption spectroscopy (AAS). The concentrations of the heavy metals in soils found As, ranged 1.04 mg/kg to 22...
November 24, 2021: Scientific Reports
#29
REVIEW
Shama R Iyer, Eric S Folker, Richard M Lovering
Intermediate filaments (IFs) are a primary structural component of the cytoskeleton extending throughout the muscle cell (myofiber). Mechanotransduction, the process by which mechanical force is translated into a biochemical signal to activate downstream cellular responses, is crucial to myofiber function. Mechanical forces also act on the nuclear cytoskeleton, which is integrated with the myofiber cytoskeleton by the linker of the nucleoskeleton and cytoskeleton (LINC) complexes. Thus, the nucleus serves as the endpoint for the transmission of force through the cell...
2021: Frontiers in Physiology
#30
EDITORIAL
Andrew T Lovering, Joseph W Duke
No abstract text is available yet for this article.
January 1, 2022: American Journal of Respiratory and Critical Care Medicine
#31
JOURNAL ARTICLE
Musab M Ali Albsheer, Andrew A Lover, Sara B Eltom, Leena Omereltinai, Nouh Mohamed, Mohamed S Muneer, Abdelrahim O Mohamad, Muzamil Mahdi Abdel Hamid
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infections throughout sub-Saharan Africa, there is a pressing need for population-level data at on the prevalence of G6PDd. Such evidence-based data will guide the expansion of primaquine and potentially tafenoquine for radical cure of P. vivax infections. This study aimed to quantify G6PDd prevalence in two geographically distinct areas in Sudan, and evaluating the performance of a qualitative CareStart rapid diagnostic test as a point-of-care test...
October 2021: PLoS Neglected Tropical Diseases
#32
JOURNAL ARTICLE
Shirin C C Saverimuttu, Barbara Kramarz, Milagros Rodríguez-López, Penelope Garmiri, Helen Attrill, Katherine E Thurlow, Marios Makris, Sandra de Miranda Pinheiro, Sandra Orchard, Ruth C Lovering
The role of the blood-brain barrier (BBB) in Alzheimer's and other neurodegenerative diseases is still the subject of many studies. However, those studies using high-throughput methods have been compromised by the lack of Gene Ontology (GO) annotations describing the role of proteins in the normal function of the BBB. The GO Consortium provides a gold-standard bioinformatics resource used for analysis and interpretation of large biomedical data sets. However, the GO is also used by other research communities and, therefore, must meet a variety of demands on the breadth and depth of information that is provided...
October 26, 2021: Database: the Journal of Biological Databases and Curation
#33
JOURNAL ARTICLE
Saddiq Mohammad Qazi, Kristian Kandler, Peter Skov Olsen
Introduction: Earlier studies have shown that re-operation for bleeding after cardiac surgery is associated with increased mortality and morbidity in both acute and elective patients. The aim of the study was to assess the effect of re-operation for bleeding on short- and long-term survival and the causes of re-operation on an exclusively elective population. Methods: This was a single-center, retrospective study conducted at the Department of Cardiothoracic Surgery at Copenhagen University Hospital. Rigshospitalet, Denmark...
2021: Journal of Cardiovascular and Thoracic Research
#34
JOURNAL ARTICLE
Ruth García-Jiménez, Juan M Pérez-García, Antoni Margalida, Zebensui Morales-Reyes
Scavengers provide significant nature's contributions to people (NCP), including disease control through carcass removal, but their non-material NCP are rarely considered. For the first time, we assess the extent and value of the NCP provided by European avian scavengers through a scavenger-based tourism at Pyrenean supplementary feeding sites (SFS). Using a two-step cluster analysis, two different types of visitor were identified (specialist avian scavenger-watchers and generalist nature-lovers) at those SFS offering recreational experiences (n = 20, i...
February 1, 2022: Science of the Total Environment
#35
JOURNAL ARTICLE
Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann, Franziska Pankratz
BACKGROUND: Diet-induced obesity can result in the development of a diverse spectrum of cardiovascular and metabolic diseases, including type 2 diabetes, dyslipidemia, non-alcoholic liver steatosis and atherosclerotic disease. MicroRNAs have been described to be important regulators of metabolism and disease development. METHODS: In the current study, we investigated the effects of ubiquitous miR-100 overexpression on weight gain and the metabolic phenotype in a newly generated transgenic mouse strain under normal chow and high fat diet and used microarray expression analysis to identify new potential target genes of miR-100...
September 6, 2021: Molecular Medicine
#36
JOURNAL ARTICLE
R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G Aragam, Geraldine Asselin, Joshua D Backman, Mary L Biggs, Heather L Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R Brown, Hans-Peter Brunner-La Rocca, David J Carey, Mark D Chaffin, Daniel I Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H Chung, William Chutkow, John G F Cleland, James P Cook, Simon de Denus, Abbas Dehghan, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Åsa K Hedman, Anna Helgadottir, Hans Hillege, Craig L Hyde, Jaison Jacob, J Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B Margulies, Nicholas A Marston, Winfried März, John J V McMurray, Olle Melander, Giorgio Melloni, Ify R Mordi, Michael P Morley, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Christopher Newton-Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L O'Donoghue, Anjali T Owens, Colin N A Palmer, Guillaume Paré, Markus Perola, Louis-Philippe Lemieux Perreault, Eliana Portilla-Fernandez, Bruce M Psaty, Kenneth M Rice, Paul M Ridker, Simon P R Romaine, Carolina Roselli, Jerome I Rotter, Christian T Ruff, Marc S Sabatine, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Kari Stefansson, Steen Stender, David J Stott, Garðar Sveinbjörnsson, Mari-Liis Tammesoo, Jean-Claude Tardif, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M Visscher, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Peter E Weeke, Raul Weiss, Harvey D White, Kerri L Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Jemma B Wilk, Hilma Holm, Naveed Sattar, Steven A Lubitz, David E Lanfear, Svati Shah, Michael E Dunn, Quinn S Wells, Folkert W Asselbergs, Aroon D Hingorani, Marie-Pierre Dubé, Nilesh J Samani, Chim C Lang, Thomas P Cappola, Patrick T Ellinor, Ramachandran S Vasan, J Gustav Smith
AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months...
September 3, 2021: ESC Heart Failure
#37
JOURNAL ARTICLE
Teah Snyder, Johanna Ravenhurst, Estee Y Cramer, Nicholas G Reich, Laura Balzer, Dominique Alfandari, Andrew A Lover
OBJECTIVES: To estimate the seroprevalence of anti-SARS-CoV-2 IgG and IgM among Massachusetts residents and to better understand asymptomatic SARS-CoV-2 transmission during the summer of 2020. DESIGN: Mail-based cross-sectional survey. SETTING: Massachusetts, USA. PARTICIPANTS: Primary sampling group: sample of undergraduate students at the University of Massachusetts, Amherst (n=548) and a member of their household (n=231)...
August 17, 2021: BMJ Open
#38
REVIEW
Shama R Iyer, Sameer B Shah, Richard M Lovering
The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating in the motor neuron to action potentials in the muscle fiber. The consideration of contributing factors to skeletal muscle injury, muscular dystrophy and sarcopenia cannot be restricted only to processes intrinsic to the muscle, as data show that these conditions incur denervation-like findings, such as fragmented NMJ morphology and corresponding functional changes in neuromuscular transmission...
July 28, 2021: International Journal of Molecular Sciences
#39
JOURNAL ARTICLE
Joni V Lindbohm, Nina Mars, Keenan A Walker, Archana Singh-Manoux, Gill Livingston, Eric J Brunner, Pyry N Sipilä, Kalle Saksela, Jane E Ferrie, Ruth C Lovering, Stephen A Williams, Aroon D Hingorani, Rebecca F Gottesman, Henrik Zetterberg, Mika Kivimäki
INTRODUCTION: Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20-year follow-ups. METHODS: In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years...
April 2022: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#40
COMPARATIVE STUDY
Sara Fernández, Ana B Moreno-Castaño, Marta Palomo, Julia Martinez-Sanchez, Sergi Torramadé-Moix, Adrián Téllez, Helena Ventosa, Ferran Seguí, Ginés Escolar, Enric Carreras, Josep M Nicolás, Edward Richardson, David García-Bernal, Carmelo Carlo-Stella, José M Moraleda, Paul G Richardson, Maribel Díaz-Ricart, Pedro Castro
BACKGROUND: Endotheliopathy is a key element in COVID-19 pathophysiology, contributing to both morbidity and mortality. Biomarkers distinguishing different COVID-19 phenotypes from sepsis syndrome remain poorly understood. OBJECTIVE: To characterize circulating biomarkers of endothelial damage in different COVID-19 clinical disease stages compared with sepsis syndrome and normal volunteers. METHODS: Patients with COVID-19 pneumonia (n = 49) were classified into moderate, severe, or critical (life-threatening) disease...
January 1, 2022: Shock
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
