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JOURNAL ARTICLE
Safiya A Zaloum, Callum H Wood, Pooja Tank, Matthew Upcott, Nicola Vickaryous, Valerie Anderson, David Baker, Randy Chance, Nikos Evangelou, Katila George, Gavin Giovannoni, Katharine E Harding, Aimee Hibbert, Gillian Ingram, Stephen Jolles, Angray S Kang, Samantha Loveless, Stuart J Moat, Aidan Richards, Neil P Robertson, Francesca Rios, Klaus Schmierer, Mark Willis, Ruth Dobson, Emma C Tallantyre
BACKGROUND: People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear. OBJECTIVE: To report COVID-19 rates in pwMS according to vaccine serology. METHODS: PwMS with available (1) serology 2-12 weeks following COVID-19 vaccine 2 and/or vaccine 3 and (2) clinical data on COVID-19 infection/hospitalisation were included...
July 2023: Multiple Sclerosis: Clinical and Laboratory Research
#2
RANDOMIZED CONTROLLED TRIAL
Patrick M McCarthy, Brian Whisenant, Anita W Asgar, Gorav Ailawadi, James Hermiller, Mathew Williams, Andrew Morse, Michael Rinaldi, Paul Grayburn, James D Thomas, Randolph Martin, Federico M Asch, Yu Shu, Kartik Sundareswaran, Neil Moat, Saibal Kar
Background The current standard of care for the treatment of patients with primary mitral regurgitation (MR) is surgical mitral valve repair. Transcatheter edge-to-edge repair with the MitraClip device provides a less invasive treatment option for patients with both primary and secondary MR. Worldwide, >150 000 patients have been treated with the MitraClip device. However, in the United States, MitraClip is approved for use only in primary patients with MR who are at high or prohibitive risk for mitral valve surgery...
February 21, 2023: Journal of the American Heart Association
#3
JOURNAL ARTICLE
David A Keith, José R Ferrer-Paris, Emily Nicholson, Melanie J Bishop, Beth A Polidoro, Eva Ramirez-Llodra, Mark G Tozer, Jeanne L Nel, Ralph Mac Nally, Edward J Gregr, Kate E Watermeyer, Franz Essl, Don Faber-Langendoen, Janet Franklin, Caroline E R Lehmann, Andrés Etter, Dirk J Roux, Jonathan S Stark, Jessica A Rowland, Neil A Brummitt, Ulla C Fernandez-Arcaya, Iain M Suthers, Susan K Wiser, Ian Donohue, Leland J Jackson, R Toby Pennington, Thomas M Iliffe, Vasilis Gerovasileiou, Paul Giller, Belinda J Robson, Nathalie Pettorelli, Angela Andrade, Arild Lindgaard, Teemu Tahvanainen, Aleks Terauds, Michael A Chadwick, Nicholas J Murray, Justin Moat, Patricio Pliscoff, Irene Zager, Richard T Kingsford
As the United Nations develops a post-2020 global biodiversity framework for the Convention on Biological Diversity, attention is focusing on how new goals and targets for ecosystem conservation might serve its vision of 'living in harmony with nature'1,2 . Advancing dual imperatives to conserve biodiversity and sustain ecosystem services requires reliable and resilient generalizations and predictions about ecosystem responses to environmental change and management3 . Ecosystems vary in their biota4 , service provision5 and relative exposure to risks6 , yet there is no globally consistent classification of ecosystems that reflects functional responses to change and management...
October 2022: Nature
#4
REVIEW
Howard C Herrmann, Philippe Pibarot, Changfu Wu, Rebecca T Hahn, Gilbert H L Tang, Amr E Abbas, David Playford, Marc Ruel, Hasan Jilaihawi, Janarthanan Sathananthan, David A Wood, Ruggero De Paulis, Jeroen J Bax, Josep Rodes-Cabau, Duke E Cameron, Tiffany Chen, Pedro J Del Nido, Marc R Dweck, Tsuyoshi Kaneko, Azeem Latib, Neil Moat, Thomas Modine, Jeffrey J Popma, Jamie Raben, Robert L Smith, Didier Tchetche, Martyn R Thomas, Flavien Vincent, Ajit Yoganathan, Bram Zuckerman, Michael J Mack, Martin B Leon
A virtual workshop was organized by the Heart Valve Collaboratory to identify areas of expert consensus, areas of disagreement, and evidence gaps related to bioprosthetic aortic valve hemodynamics. Impaired functional performance of bioprosthetic aortic valve replacement is associated with adverse patient outcomes; however, this assessment is complicated by the lack of standardization for labelling, definitions, and measurement techniques, both after surgical and transcatheter valve replacement. Echocardiography remains the standard assessment methodology because of its ease of performance, widespread availability, ability to do serial measurements over time, and correlation with outcomes...
August 2, 2022: Journal of the American College of Cardiology
#5
JOURNAL ARTICLE
Emma C Tallantyre, Martin J Scurr, Nicola Vickaryous, Aidan Richards, Valerie Anderson, David Baker, Randy Chance, Nikos Evangelou, Katila George, Gavin Giovannoni, Katharine E Harding, Aimee Hibbert, Gillian Ingram, Stephen Jolles, Meleri Jones, Angray S Kang, Samantha Loveless, Stuart J Moat, Neil P Robertson, Francesca Rios, Klaus Schmierer, Mark Willis, Andrew Godkin, Ruth Dobson
BACKGROUND: People with MS treated with anti-CD20 therapies and fingolimod often have attenuated responses to initial COVID-19 vaccination. However, uncertainties remain about the benefit of a 3rd (booster) COVID-19 vaccine in this group. METHODS: PwMS without a detectable IgG response following COVID-19 vaccines 1&2 were invited to participate. Participants provided a dried blood spot +/- venous blood sample 2-12 weeks following COVID-19 vaccine 3. Humoral and T cell responses to SARS-CoV-2 spike protein and nucleocapsid antigen were measured...
June 4, 2022: Multiple Sclerosis and related Disorders
#6
JOURNAL ARTICLE
Pam Oliver, Neil Lindsay, Robin Kearns
The COVID pandemic has offered opportunities for islands and other relatively isolated communities to establish pandemic-protection boundaries. A July 2020 survey of Waiheke Island residents sought views on how the island had remained COVID-19 free, despite proximity to a city of 1.6 million (Auckland, NZ). Many attributed that status to 'pure luck' or a 'moat' effect. However, many also attributed freedom from COVID-19 to reinforcing high-level community cohesiveness and shared values. The Waiheke community's response can be seen as a microcosm of New Zealand as an island nation and an exemplar of a response to pandemic threats uniquely possible for small islands...
December 2021: New Zealand Geographer
#7
JOURNAL ARTICLE
Emma C Tallantyre, Nicola Vickaryous, Valerie Anderson, Aliye Nazli Asardag, David Baker, Jonathan Bestwick, Kath Bramhall, Randy Chance, Nikos Evangelou, Katila George, Gavin Giovannoni, Andrew Godkin, Leanne Grant, Katharine E Harding, Aimee Hibbert, Gillian Ingram, Meleri Jones, Angray S Kang, Samantha Loveless, Stuart J Moat, Neil P Robertson, Klaus Schmierer, Martin J Scurr, Sita Navin Shah, Jessica Simmons, Matthew Upcott, Mark Willis, Stephen Jolles, Ruth Dobson
OBJECTIVE: The purpose of this study was to investigate the effect of disease modifying therapies on immune response to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines in people with multiple sclerosis (MS). METHODS: Four hundred seventy-three people with MS provided one or more dried blood spot samples. Information about coronavirus disease 2019 (COVID-19) and vaccine history, medical, and drug history were extracted from questionnaires and medical records...
January 2022: Annals of Neurology
#8
JOURNAL ARTICLE
Srihari S Naidu, Suzanne J Baron, Marvin H Eng, Shyam K Sathanandam, David A Zidar, Dmitriy N Feldman, Frank F Ing, Faisal Latif, Michael J Lim, Timothy D Henry, Sunil V Rao, George D Dangas, James B Hermiller, Ramesh Daggubati, Binita Shah, Lawrence Ang, Herbert D Aronow, Subhash Banerjee, Lyndon C Box, Ronald P Caputo, Mauricio G Cohen, Megan Coylewright, Peter L Duffy, Andrew M Goldsweig, Donald J Hagler, Beau M Hawkins, Ziyad M Hijazi, Sasanka Jayasuriya, Henri Justino, Andrew J Klein, Chad Kliger, Jun Li, Ehtisham Mahmud, John C Messenger, Brian H Morray, Sahil A Parikh, John Reilly, Eric Secemsky, Mehdi H Shishehbor, Molly Szerlip, Steven J Yakubov, Cindy L Grines, Jennifer Alvarez-Breckenridge, Colleen Baird, David Baker, Charles Berry, Manisha Bhattacharya, Seth Bilazarian, Rosanne Bowen, Kevin Brounstein, Cole Cameron, Rafael Cavalcante, Casey Culbertson, Pedro Diaz, Susan Emanuele, Erin Evans, Rob Fletcher, Tina Fortune, Priya Gaiha, Devi Govender, Dan Gutfinger, Kurt Haggstrom, Andrea Herzog, Denise Hite, Bethany Kalich, Ann Kirkland, Toni Kohler, Holly Laurisden, Kevin Livolsi, Lois Lombardi, Sarah Lowe, Kevin Marhenke, Joie Meikle, Neil Moat, Megan Mueller, Roberto Patarca, Jeff Popma, Novena Rangwala, Chuck Simonton, Jerry Stokes, Margaret Taber, Christopher Tieche, John Venditto, Nick E J West, Laurie Zinn
The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community annually for high-level field-wide discussions. The 2021 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b) endovascular medicine, (c) structural heart disease, and (d) congenital heart disease...
November 1, 2021: Catheterization and Cardiovascular Interventions
#9
JOURNAL ARTICLE
Nick E J West, Wai-Fung Cheong, Els Boone, Neil E Moat
The global COVID-19 pandemic has led to unprecedented change throughout society.1 As the articles in this supplement outline, all segments of the broader cardiovascular community have been forced to adapt, to change models of care delivery, and to evolve and innovate in order to deliver optimal management for cardiovascular patients. The medtech/device industry has not been exempt from such change and has been forced to navigate direct and indirect COVID-associated disruption, with effects felt from supply chain logistics to the entire product lifecycle, from the running of clinical trials to new device approvals and managing training, proctoring and congresses in an increasingly-online world...
December 2020: European Heart Journal Supplements: Journal of the European Society of Cardiology
#10
JOURNAL ARTICLE
Mario Gaudino, Umberto Benedetto, Stephen Fremes, Karla Ballman, Giuseppe Biondi-Zoccai, Art Sedrakyan, Giuseppe Nasso, Jai Raman, Brian Buxton, Philip A Hayward, Neil Moat, Peter Collins, Carolyn Webb, Miodrag Peric, Ivana Petrovic, Kyung J Yoo, Irbaz Hameed, Antonino Di Franco, Marco Moscarelli, Giuseppe Speziale, John D Puskas, Leonard N Girardi, David L Hare, David P Taggart
IMPORTANCE: Observational studies have suggested that the use of radial artery grafts for coronary artery bypass grafting may improve clinical outcomes compared with the use of saphenous vein grafts, but this has not been confirmed in randomized trials. OBJECTIVE: To compare clinical outcomes between patients receiving radial artery vs saphenous vein grafts for coronary artery bypass grafting after long-term follow-up. DESIGN, SETTING, AND PARTICIPANTS: Patient-level pooled analysis comparing radial artery vs saphenous vein graft in adult patients undergoing isolated coronary artery bypass grafting from 5 countries (Australia, Italy, Serbia, South Korea, and the United Kingdom), with enrollment from 1997 to 2009 and follow-up completed in 2019...
July 14, 2020: JAMA
#11
JOURNAL ARTICLE
Reza Akbari Moghaddam Kakhki, David W L Ma, Kayla R Price, Janna R Moats, Neil A Karrow, Elijah G Kiarie
There is limited information on feeding egg-type chick breeders n-3 polyunsaturated fatty acids (PUFA) and its impact on hatching egg quality and embryonic fatty acid (FA) utilization. We investigated the effects of feeding brown and white egg-type chick breeders diets containing sources of n-3 PUFA on egg composition, apparent embryonic FA utilization, and intestinal FA transporter in hatchlings. Twenty-six-week-old ISA brown and Shaver white breeders were fed either 1) control (CON); 2) CON + 1% of microalgae (DMA, Aurantiochytrium limacinum) fermentation product, as a source of docosahexaenoic acid (DHA); or 3) CON + 2...
February 2020: Poultry Science
#12
JOURNAL ARTICLE
Mario Gaudino, Umberto Benedetto, Stephen Fremes, Karla Ballman, Giuseppe Biondi-Zoccai, Art Sedrakyan, Giuseppe Nasso, Jai Raman, Brian Buxton, Philip A Hayward, Neil Moat, Peter Collins, Carolyn Webb, Miodrag Peric, Ivana Petrovic, Kyung J Yoo, Irbaz Hameed, Antonino Di Franco, Marco Moscarelli, Giuseppe Speziale, Leonard N Girardi, David L Hare, David P Taggart
It is generally accepted that radial artery (RA) grafts have better mid-term patency rate compared to saphenous vein grafts. However, the clinical correlates of the improved patency rate are still debated. Observational studies have suggested increased survival and event-free survival for patients who receive an RA rather than a saphenous vein, but they are open to bias and confounders. The only evidence based on randomized data is a pooled meta-analysis of 6 randomized controlled trial comparing the RA and the saphenous vein published by the RADial artery International Alliance (RADIAL)...
December 1, 2019: European Journal of Cardio-thoracic Surgery
#13
JOURNAL ARTICLE
Mario Gaudino, Umberto Benedetto, Stephen E Fremes, David L Hare, Philip Hayward, Neil Moat, Marco Moscarelli, Antonino Di Franco, Giuseppe Nasso, Miodrag Peric, Ivana Petrovic, Peter Collins, Carolyn M Webb, John D Puskas, Giuseppe Speziale, Kyung Jong Yoo, Leonard N Girardi, David P Taggart
BACKGROUND: We used a large patient-level data set including 6 angiographic randomized controlled trials (RCTs) on coronary artery bypass conduits to explore incidence and determinants of coronary graft failure. METHODS: Patient-level angiographic data of 6 RCTs comparing long-term outcomes of the radial artery and other conduits were joined. Primary outcome was graft occlusion at maximum follow-up. The analysis was divided as (1) left anterior descending coronary (LAD) distribution and (2) non-LAD distribution (circumflex and right coronary artery)...
March 2020: Annals of Thoracic Surgery
#14
JOURNAL ARTICLE
Alison Duncan, Neil Moat, Matheus Simonato, Arend de Weger, Jorg Kempfert, Holger Eggebrecht, Antony Walton, Farrel Hellig, Ran Kornowski, Konstantinos Spargias, Oscar Mendiz, Raj Makkar, Mayra Guerrero, Charanjit Rihal, Isaac George, Creighton Don, Alessandro Iadanza, Vinayak Bapat, Robert Welsh, Harindra C Wijeysundera, David Wood, Janarthanan Sathananthan, Haim Danenberg, Francesco Maisano, Santiago Garcia, Sameer Gafoor, Luis Nombela-Franco, Javier Cobiella, Danny Dvir
OBJECTIVES: A large comprehensive analysis of transcatheter aortic valve replacement (TAVR) was performed for failed stentless bioprostheses. BACKGROUND: Valve-in-valve (ViV) transcatheter aortic replacement (TAVR) is an alternative to redo surgery for patients with a failing aortic bioprosthesis. METHODS: Unadjusted outcome data were collected from the VIVID (Valve-in-Valve International Data) registry between 2007 and 2016 from a total of 1,598 aortic ViV procedures (291 stentless, 1,307 stented bioprostheses)...
July 8, 2019: JACC. Cardiovascular Interventions
#15
JOURNAL ARTICLE
Mario Gaudino, Umberto Benedetto, Stephen E Fremes, David L Hare, Philip Hayward, Neil Moat, Marco Moscarelli, Antonino Di Franco, Giuseppe Nasso, Miodrag Peric, Ivana Petrovic, John D Puskas, Giuseppe Speziale, Kyung Jong Yoo, Leonard N Girardi, David P Taggart
BACKGROUND: Few studies have evaluated the effect of chronic calcium-channel blocker therapy (CCB) on the angiographic and clinical outcome of radial artery (RA) grafts used for coronary bypass surgery. OBJECTIVES: The purpose of this study was to evaluate if CCB influences midterm clinical and angiographic outcomes of RA grafts. METHODS: Patient-level data of 6 angiographic randomized trials evaluating RA graft status at midterm follow-up were joined in this observational analysis...
May 14, 2019: Journal of the American College of Cardiology
#16
JOURNAL ARTICLE
Paul Sorajja, Neil Moat, Vinay Badhwar, Darren Walters, Gaetano Paone, Brian Bethea, Richard Bae, Gry Dahle, Mubashir Mumtaz, Paul Grayburn, Samir Kapadia, Vasilis Babaliaros, Mayra Guerrero, Lowell Satler, Vinod Thourani, Francesco Bedogni, David Rizik, Paolo Denti, Nicolas Dumonteil, Thomas Modine, Ajay Sinhal, Michael L Chuang, Jeffrey J Popma, Philipp Blanke, Jonathon Leipsic, David Muller
BACKGROUND: Transcatheter mitral valve replacement (TMVR) is a rapidly evolving therapy. Follow-up of TMVR patients remains limited in duration and number treated. OBJECTIVES: The purpose of this study was to examine outcomes with expanded follow-up for the first 100 patients who underwent TMVR with the prosthesis. METHODS: The Global Feasibility Study enrolled symptomatic patients with either primary or secondary mitral regurgitation (MR) who were at high or prohibitive surgical risk...
March 26, 2019: Journal of the American College of Cardiology
#17
JOURNAL ARTICLE
Paula Rogers, Sayed Al-Aidrous, Winston Banya, Shelley Rahman Haley, Tarun Mittal, Tito Kabir, Vasileois Panoulas, Shahzad Raja, Sunil Bhudia, Heather Probert, Claire Prendergast, Mark S Spence, Simon Davies, Neil Moat, Rod S Taylor, Miles Dalby
Objectives: Transcatheter aortic valve implantation (TAVI) is often undertaken in the oldest frailest cohort of patients undergoing cardiac interventions. We plan to investigate the potential benefit of cardiac rehabilitation (CR) in this vulnerable population. Design: We undertook a pilot randomised trial of CR following TAVI to inform the feasibility and design of a future randomised clinical trial (RCT). Participants: We screened patients undergoing TAVI at a single institution between June 2016 and February 2017...
2018: Pilot and Feasibility Studies
#18
JOURNAL ARTICLE
Ciara Mahon, Anan Daqa, Alison Duncan, Neil Moat
•Critical aortic stenosis can cause severe biventricular disease.•Painless jaundice can present secondary to severe biventricular failure.•TAVR treats high-risk critical aortic stenosis.•TAVR can reverse clinical and biochemical congestive hepatopathy.•High-risk TAVR can be performed using circulatory support.
October 2018: CASE: Cardiovascular Imaging Case Reports
#19
COMPARATIVE STUDY
Mario Gaudino, Umberto Benedetto, Stephen Fremes, Giuseppe Biondi-Zoccai, Art Sedrakyan, John D Puskas, Gianni D Angelini, Brian Buxton, Giacomo Frati, David L Hare, Philip Hayward, Giuseppe Nasso, Neil Moat, Miodrag Peric, Kyung J Yoo, Giuseppe Speziale, Leonard N Girardi, David P Taggart
BACKGROUND: The use of radial-artery grafts for coronary-artery bypass grafting (CABG) may result in better postoperative outcomes than the use of saphenous-vein grafts. However, randomized, controlled trials comparing radial-artery grafts and saphenous-vein grafts have been individually underpowered to detect differences in clinical outcomes. We performed a patient-level combined analysis of randomized, controlled trials to compare radial-artery grafts and saphenous-vein grafts for CABG...
May 31, 2018: New England Journal of Medicine
#20
JOURNAL ARTICLE
Félix Forest, Justin Moat, Elisabeth Baloch, Neil A Brummitt, Steve P Bachman, Steffi Ickert-Bond, Peter M Hollingsworth, Aaron Liston, Damon P Little, Sarah Mathews, Hardeep Rai, Catarina Rydin, Dennis W Stevenson, Philip Thomas, Sven Buerki
Driven by limited resources and a sense of urgency, the prioritization of species for conservation has been a persistent concern in conservation science. Gymnosperms (comprising ginkgo, conifers, cycads, and gnetophytes) are one of the most threatened groups of living organisms, with 40% of the species at high risk of extinction, about twice as many as the most recent estimates for all plants (i.e. 21.4%). This high proportion of species facing extinction highlights the urgent action required to secure their future through an objective prioritization approach...
April 16, 2018: Scientific Reports
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