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Reactive oxygen nano

Wei Tong, Yanhua Xiong, Shun Duan, Xiaokang Ding, Fu-Jian Xu
The design of novel antibacterial materials has attracted increasing attention for combating bacterial infections. Herein, we conjugated zinc(ii) monoamino phthalocyanine (ZnMAPc) to poly(glycidyl methacrylate) (PGMA) via a ring-opening reaction, and the excess epoxy groups were scavenged by ethylenediamine (ED). The resultant macro-photosensitizer (PGED-Pc) can be easily dispersed in aqueous solution to form self-assembled nanoparticles and generate reactive oxygen species for inactivation of bacteria when exposed to light illumination...
February 14, 2019: Biomaterials Science
Alexandre Martiniere, Jean Bernard Fiche, Marija Smokvarska, Stéphane Mari, Carine Alcon, Xavier Dumont, Kian Hematy, Yvon Jaillais, Marcelo Nollmann, Christophe Maurel
Physiological acclimation of plants to an ever-changing environment is governed by complex combinatorial signaling networks that perceive and transduce various abiotic and biotic stimuli. Reactive oxygen species (ROS) serve as one of the second messengers in plant responses to hyperosmotic stress. The molecular bases of ROS production and the primary cellular processes that they target were investigated in the Arabidopsis (Arabidopsis thaliana) root. Combined pharmacological and genetic approaches showed that RESPIRATORY BURST OXIDASE HOMOLOG (RBOH) pathway and an additional pathway involving apoplastic ascorbate and iron can account for ROS production upon hyperosmotic stimulation...
February 4, 2019: Plant Physiology
Pengfei Tang, Lu Han, Pengfei Li, Zhanrong Jia, Kefeng Wang, Hongping Zhang, Hui Tan, Tailin Guo, Xiong Lu
Wound repair and tissue regeneration are complex processes that involves many physiological signals. Thus, it is a possible solution by employing novel wound dressings with potent biological activity and physiological signal response ability to accelerate wound healing. Herein, inspired by mussel chemistry, we developed a polydopamine-reduced GO (pGO)-incorporated chitosan (CS) and silk fibroin (SF) (pGO-CS/SF) scaffold with good mechanical, electroactive, and anti-oxidative properties as an efficient wound dressing...
February 4, 2019: ACS Applied Materials & Interfaces
Xianlei Li, Xuan Wang, Caiyan Zhao, Leihou Shao, Jianqing Lu, Yujia Tong, Long Chen, Xinyue Cui, Huiling Sun, Junxing Liu, Mingjun Li, Xiongwei Deng, Yan Wu
BACKGROUND: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. RESULTS: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT)...
February 2, 2019: Journal of Nanobiotechnology
Jian Ju, Sagar Regmi, Afu Fu, Sierin Lim, Quan Liu
Graphene quantum dots (GQD), the new zero-dimensional carbon nanomaterial, has been demonstrated as a promising material for biomedical applications due to its good biocompatibility and low toxicity. However, the integration of multiple therapeutic approaches into a nano-sized platform based on the GQD has not been explored yet to our best knowledge. In this report, we regulate the generation of reactive oxygen species (ROS) when using the GQD as a photosensitizer by varying the doping amount of nitrogen atoms to achieve efficiency controllable photodynamic therapy (PDT)...
January 30, 2019: Journal of Biophotonics
Tarun K Upadhyay, Nida Fatima, Akanksha Sharma, Deepak Sharma, Rolee Sharma
Recently, yeast-derived glucan particles (GP) have emerged as novel drug delivery agents that provide for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. In our previous study, we prepared GP loaded with high payload (40.5 + 1.9%) of rifabutin (RB) nano-particles [(RB-NPs)-GP]. We investigated the anti-mycobacterial efficacy and cellular activation responses within Mycobacterium tuberculosis (M. tuberculosis) infected J774 macrophage cells following exposure to the (RB-NPs)-GP formulation...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Mohammad M Farag, Zainab M Al-Rashidy, Manar M Ahmed
Ce-containing bioactive glasses are known to decrease reactive oxygen activities inside the body. That is because of their excellent catalytic activities which come from the fast interchange of Ce3+ /Ce4+ oxidation states. This research was mainly aimed at preparing new Ce-doped nano-bioactive glasses based on 60SiO2 -(10-x)B2 O3 -25CaO-5P2 O5 -xCeO2 , in mole% (x = 0 and 5 mol%) as multifunctional bone fillings. Moreover, the glasses were used as a delivery system for ciprofloxacin to intensely solve the bone infection complications...
January 22, 2019: Journal of Materials Science. Materials in Medicine
Marta Bottagisio, Arianna B Lovati, Fabio Galbusera, Lorenzo Drago, Giuseppe Banfi
The increase of multidrug-resistant bacteria remains a global concern. Among the proposed strategies, the use of nanoparticles (NPs) alone or associated with orthopedic implants represents a promising solution. NPs are well-known for their antimicrobial effects, induced by their size, shape, charge, concentration and reactive oxygen species (ROS) generation. However, this non-specific cytotoxic potential is a powerful weapon effective against almost all microorganisms, but also against eukaryotic cells, raising concerns related to their safe use...
January 20, 2019: Materials
Guangli Zhang, Yaobin Ding, Wenshan Nie, Heqing Tang
Ibuprofen (IBU), a nonsteroidal anti-inflammatory drug, is becoming an important member of pharmaceuticals and personal care products (PPCPs) as emerging pollutants. To degrade IBU, magnetic Fe3 C nanoparticles embedded on N-doped carbon (Fe3 C/NC) were prepared as a catalyst by a sol-gel combustion method. As characterized, the Fe3 C/NC nanoparticles were composed of a NC nano-sheet and capsulated Fe3 C particles on the sheet. The Fe3 C/NC nanoparticles were confirmed an efficient catalyst for peroxymonosulfate (PMS) activation to generate sulfate radicals (SO4 •- ), single oxygen (1 O2 ) and hydroxyl radicals (•OH) toward the degradation of IBU...
April 2019: Journal of Environmental Sciences (China)
Yating Jia, Fan Hu, Yuancai Lv, Yuancai Chen, Yongyou Hu
Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and challenges for water treatment due to their persistence and toxicity. In this study, the reduction of 2'2'4'4'-tetrabromodiphenyl ether (BDE-47) was investigated in a nano-bio-integrated system. Results showed that the introducing of P. putida could markedly accelerate the demineralization of BDE-47 in nZVI/Pd-P.p system; the continuous generation of acidic metaboliates by P. putida could decrease pH, which could alleviate the surface passivation to some extent, resulting in the releasing of Fe2+ and high generation of H2 O2 , the shift in reactive oxygen species from Fe(IV) to •OH...
January 7, 2019: Chemosphere
Qian Zhang, Zhimin Liu, Junting Du, Wei Qin, Manman Lu, Haiyan Cui, Xiaoxiao Li, Shumao Ding, Rui Li, Junlin Yuan
Due to its excellent properties such as ultraviolet obscuration, chemical stability and small particle size, nano-titanium dioxide (nano-TiO2 ) is widely used, particularly in sunblock products. The skin is therefore a chief route for exposure. Studies have found that oral or respiratory exposure to nano-TiO2 has an adverse impact on the cardiovascular system. The relationship between dermal exposure to nano-TiO2 and cardiovascular system toxicity, particularly the causative mechanisms, remain unclear. In this study, we used Balb/c mice to evaluate cardiovascular toxicity from nano-TiO2 dermal exposure, and the underlying mechanisms associated with the human umbilical vein endothelial cells (HUVECs) were explored...
2019: Journal of Toxicological Sciences
Xiutong Fang, Hongxing Song
Biomedical applications like spinal cord injury repair; anticancer requires functional platforms and specific properties like antioxidant, autocatalytic and biocompatibility. This work demonstrated the synthesis of CeO2 nanoparticles which is shown to have promising applications in various fields exclusively biomedical field like scavenging of reactive oxygen species which is mainly responsible for carcinogenic effects. CeO2 nanoparticles were synthesized using the biocompatible ionic liquid followed by their loading with biopolymeric chitosan which was obtained by the deacetylation processing of chitin arrived from the shells of crab...
November 22, 2018: Journal of Photochemistry and Photobiology. B, Biology
Jia-Ming Zhu, Mojgan Hosseini, Ali Fakhri, Saboura Salari Rad, Tayebeh Hadadi, Nastaran Nobakht
In the present work we report the enhanced UV light photocatalytic performance of cadmium titanate photocatalyst by MoO3 for Drug pollutant degradation. The nano photocatalyst sample was synthesized employing the Pechini-ultrasonic-hydrothermal route. Therefore, the nano photocatalyst were characterized by various analytical devices. The wide scan X-ray photoelectron spectral study confirmed the MoO3 in the CdTiO3 matrix. The crystallite size calculated with the Debye-Scherrer equation (55.4, 57.0, 61.2 and 63...
December 21, 2018: Journal of Photochemistry and Photobiology. B, Biology
Po-Ting Wu, Chih-Ling Lin, Che-Wei Lin, Ning-Chu Chang, Wei-Bor Tsai, Jiashing Yu
Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it is hard for the dye to penetrate through the cell membrane, leading to poor cellular uptake; thus, drug carriers, which could enhance the cellular uptake, are a suitable solution. In addition, the defective vessels resulting from fast vessel outgrowth leads to an enhanced permeability and retention (EPR) effect, which gives nanoscale drug carriers a promising potential...
December 23, 2018: Nanomaterials
Talat Tariq Khalil, Rana Bazzi, Stéphane Roux, Michel Fromm
Plasmid DNA in aerated aqueous solution is used as a probe to determine whose of the reactive oxygen species (ROS) generated after absorption of ultra-soft X-rays (USX) take part in biomolecule damage in the presence and in absence of Gold Nano-Particles (GNP) and specific scavengers. Citrate-coated GNPs with core sizes of 6, 10 and 25 nm are synthetized and characterized, especially in terms of plasmon band shift, ζ-potential and hydrodynamic radii (respectively 9, 21 and 30 nm). We confirm the radiosensitizing effect of GNP and show that the SSB number per plasmid increases when, for a same mass of gold element, the core size of the gold nanoparticles decreases...
December 17, 2018: Colloids and Surfaces. B, Biointerfaces
Dalong Ni, Dawei Jiang, Christopher J Kutyreff, Jianhao Lai, Yongjun Yan, Todd E Barnhart, Bo Yu, Hyung-Jun Im, Lei Kang, Steve Y Cho, Zhaofei Liu, Peng Huang, Jonathan W Engle, Weibo Cai
Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS...
December 21, 2018: Nature Communications
Natarajan Duraipandy, Govindarajan Dharunya, Rachita Lakra, Purna Sai Korapatti, Manikantan Syamala Kiran
The redox state of the endothelial cells plays a key role in the regulation of the angiogenic process. The modulation of the redox state of endothelial cells (ECs) could be a viable target to alter angiogenic response. In the present work, we synthesized a redox modulator by caging 5-hydroxy 2-methyl 1, 4-napthoquinone (Plumbagin) on silver nano framework (PCSN) for tunable reactive oxygen species (ROS) inductive property and tested its role in ECs during angiogenic response in physiological and stimulated conditions...
December 17, 2018: Journal of Cellular Physiology
Saurabh Srivastava, Shadab Mohammad, Shalini Gupta, Abbas Ali Mahdi, Rakesh Kumar Dixit, Vibha Singh, Fahad Mansoor Samadi
Introduction: Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mouth cavity. 5-fluorouracil (5-FU) chemotherapy was focused to kill the cancer cell, but it would affect the surrounding normal cells during oral cancer treatment. This study included the evaluation of chemoprotective effects of curcumin (CU), as an herbal remedy, on 5-FU-induced-cytotoxicity toward oral cancer treatment, loaded within a nanocarrier system. CU was combined with 5-FU chemotherapy as a combinational drug-delivery system to evaluate synergistic effects...
July 2018: National Journal of Maxillofacial Surgery
Ya Wang, Xiaoyu Huang, Yunyun Tang, Jianhua Zou, Peng Wang, Yewei Zhang, Weili Si, Wei Huang, Xiaochen Dong
Emerging treatment approaches, such as gas therapy (GT), photodynamic therapy (PDT) and photothermal therapy (PTT), have received widespread attention. The development of an intelligent multifunctional nano-platform responding to tumor microenvironments for multimodal therapy is highly desirable. Herein, a near-infrared (NIR) light-responsive nitric oxide (NO) photodonor (4-nitro-3-trifluoromethylaniline, NF) and a pH-sensitive group (dimethylaminophenyl) have been introduced into a diketopyrrolopyrrole core (denoted as DPP-NF)...
November 14, 2018: Chemical Science
Wang Sik Lee, Hyun-Ju Cho, Eungwang Kim, Yang Hoon Huh, Hyo-Jeong Kim, Bongsoo Kim, Taejoon Kang, Jeong-Soo Lee, Jinyoung Jeong
As nano- and micro-sized plastics accumulate in the environment and the food chain of animals, including humans, it is imperative to assess the effects of nanoplastics in living organisms in a systematic manner, especially because of their ability to adsorb potential toxicants such as pollutants, heavy metals, and organic macromolecules that coexist in the environment. Using the zebrafish embryo as an animal model, we investigated the bioaccumulation and in vivo toxicity of polystyrene (PS) nanoplastics individually or in combination with the Au ion...
December 10, 2018: Nanoscale
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