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Poly dopamine

Lanqing Li, Huijun Zheng, Lili Guo, Lingbo Qu, Lanlan Yu
A special electrochemical sensor was developed based on molecularly imprinted polymer (MIP), which was formed by the dopamine (DA) self-polymerization on the surface of Pd-Cu bimetallic alloy functionalized poly (diallyldimethylammonium chloride) -dispersed graphene (PDDA-Gr). This sensor takes advantages of molecularly imprinted technique and nanocomposite to realize the application of amaranth determination with high selectivity and sensitivity. In this study, the nanocomposite PDDA-Gr-(Pd-Cu) characterized by various techniques provides large surface area and accelerates the electron transfer process...
May 15, 2019: Talanta
Ming-Hua Jing, Xi-Ming Song, Da-Wei Fang, Ling Zhang, Qian Zhang
In this article, a novel electroactivity-adjustable poly (ionic liquids)/reduced graphene oxide (PIL-GP) was developed and utilized for the fabrication of multifunctional, high stable electrochemical sensors. The structure, morphology and surface charge properties of PIL-GP have been systematically studied. And the selective detection performance of dopamine (DA) on PIL-GP modified glassy carbon electrode (GCE) were further explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). More importantly, by virtue of the anion exchange property of PIL, electroactive Fe(CN)6 3- /PIL-GP/GCE and Polyoxometalates (PWA)/PIL-GP/GCE were easily fabricated and their electrochemical detection performance of ascorbic acid (AA) and bromate were investigated respectively...
May 15, 2019: Talanta
Qun Cao, Pumidech Puthongkham, B Jill Venton
The carbon-fiber microelectrode has been used for decades as a neurotransmitter sensor. Recently, new strategies have been developed for making carbon electrodes, including using carbon nanomaterials or pyrolyzing photoresist etched by nanolithography or 3D printing. This review summarizes how chemical and 3D surface structures of new carbon electrodes are optimized for neurotransmitter detection. There are effects of the chemical structure that are advantageous and nanomaterials are used ranging from carbon nanotube (CNT) to graphene to nanodiamond...
January 21, 2019: Analytical Methods: Advancing Methods and Applications
Xingzhi Liu, Hongbo Zhang, Ruoyu Cheng, Yanzheng Gu, Yin Yin, Zhiyong Sun, Guoqing Pan, Zhongbin Deng, Huilin Yang, Lianfu Deng, Wenguo Cui, Hélder A Santos, Qin Shi
Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(l-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb)...
November 1, 2018: Materials Horizons
Wen Tang, Chao Chen, Wen Sun, Ping Wang, Dongzhi Wei
Owing to dopamine's excellent adhesion ability and easy modification, it has been widely applied for enzyme immobilization, while the high cost of dopamine and low activity recovery of immobilized enzyme highly impede large-scale application of immobilized enzyme. We herein developed a low-cost and ideal activity recovery enzyme immobilization strategy based on magnetic nanoparticles by replacing dopamine with cheap Catechol/tetraethylene pentamine (CPA) binary system and introducing spacer-arms. In brief, CPA was first polymerized and deposited on the surface of magnetic nanoparticles with a modified mussel-inspired method, and the generated poly(CPA) layer was further functionalized with ethylene glycol diglycidyl ether (EGDE) molecules as spacer-arms for enzyme immobilization...
January 29, 2019: International Journal of Biological Macromolecules
Xiyuan Mao, Lili Liu, Liying Cheng, Ruoyu Cheng, Lu Zhang, Lianfu Deng, Xiaoming Sun, Yuguang Zhang, Bruno Sarmento, Wenguo Cui
Local drug delivery systems have become an important field of research as locally administration of medications may overcome most of the drawbacks associated with systemic drugs. Still, to assure continuous drug release and therapeutic drug levels, keeping the delivered drug in target area remains a physiological challenge. The aim of this study was to develop novel multipotent flap-protective adhesive mangiferin (MF)-loaded liposomes (A-MF-Lip), bioinspired in mussel architecture, for the promotion of random skin flap regeneration...
January 25, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Hao-Yang Mi, Xin Jing, Zhu-Tong Li, Yu-Jyun Lin, James A Thomson, Lih-Sheng Turng
A mismatch of mechanical properties and a high rate of thromboses are two critical challenges of creating viable artificial small-diameter vascular grafts (SDVGs). Herein, we propose a method to fabricate wavy multicomponent vascular grafts (WMVGs) via electrospinning using an assembled rotating collector. The WMVGs consisted of a wavy silk/poly(lactic acid) (PLA) inner layer and a thermoplastic polyurethane (TPU) outer layer, which mimic the structures and properties of collagen and elastin in native blood vessels, respectively...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ahmad Mobed, Mohammad Hasanzadeh, Parinaz Babaie, Mohammad Agazadeh, Ahad Mokhtarzadeh, Mohammad Ahangarzadeh Rezaee
The specific diagnosis of hard-growing bacteria is one of the most important concerns of medical bacteriology. Legionella pneumophila is one of the most important bacteria in hard growth. In spite remarkable trends in bacteriology, now day, culture is the gold standard for detection of L. pneumophila. This work is an attempt to quantification of L. pneumophila bacteria using a bioassay. The fabrication of a new electrochemical DNA-based bioassay using gold nano architecture combined with as a transducer substrate combined with toluidine blue (TB) as a redox marker was performed successful...
January 24, 2019: International Journal of Biological Macromolecules
Junqiang Zhao, Dongyang Li, Hongrui Han, Jingjing Lin, Jing Yang, Qiqi Wang, Xia Feng, Ning Yang, Yiping Zhao, Li Chen
Inspired by mussel adhesion chemistry, a kind of hydrophilic poly(vinylidene fluoride) (PVDF) microfiltration membranes with underwater superoleophobicity was prepared using thiolated hyperbranched zwitterionic poly(sulfobetaine methacrylate) (HPS) as a nanoscale surface modifier. The HPS was first synthesized via RAFT copolymerization and followed by sulfonation reaction, and then coated onto dopamine (PD) adhesive PVDF membranes via thiol-mediated Michael addition reaction. The successful and uniform coating of HPS onto the membrane surface was demonstrated by X-ray photoelectron spectroscopy and energy dispersive X-ray detector...
January 24, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Jieun Lee, Jin Yoo, Joonwon Kim, Yeongseon Jang, Kwangsoo Shin, Eunsu Ha, Sangryeol Ryu, Byung-Gee Kim, Sanghyuk Wooh, Kookheon Char
Anti-biofouling has been improved by passive or active ways. Passive antifouling strategies aim to prevent the initial adsorption of foulants, while active strategies aim to eliminate proliferative fouling by destruction of the chemical structure and inactivation of the cells. However, neither passive antifouling strategies nor active antifouling strategies can solely resist biofouling due to their inherent limitations. Herein, we successfully developed multimodal antibacterial surfaces for waterborne and airborne bacteria with the benefit of combination of anti-adhesion (passive) and bactericidal (active) properties of the surfaces...
January 14, 2019: ACS Applied Materials & Interfaces
Wanjun Hu, Shenglin Lu, Zhihang Zhang, Long Zhu, Yazhou Wen, Tianzhu Zhang, Zhenling Ji
Polypropylene (PP) meshes are one of the most commonly used prosthesis materials in repairing abdominal wall defects. However, their application is usually limited due to possible serious abdominal adhesions between the mesh and the viscera. Instilling PP meshes with excellent anti-adhesion characteristics is still a formidable challenge. In this work, in order to prevent intestinal adhesion to the PP mesh, an effective method was developed to prepare anti-adhesive PP meshes, which was inspired by mussel adhesive proteins...
January 14, 2019: Biomaterials Science
Chenghao Gao, Hao Cheng, Na Xu, Yong Li, Yangmengfan Chen, Yong Wei, Biao Gao, Jijiang Fu, Kaifu Huo, Wei Xiong
AIM: To create polydopamine (PDA) and Ag nanoparticle-loaded TiO2 nanotubes coating on titanium (Ti) alloy. MATERIALS & METHODS: TiO2 -PDA-Ag coating was fabricated on Ti implants by electrochemical anodization. The in vitro and in vivo bactericidal and antibiofilm activities were tested. Intracellular reactive oxygen species (ROS) and antioxidative capability were measured, and cell proliferation, adhesion and cell morphology were characterized. RESULTS: TiO2 -PDA-Ag coating showed satisfactory bactericidal and antibiofilm activities in vitro and in vivo, improved Ag release pattern, evident ROS scavenging properties and enhanced cell adhesion and proliferation...
January 14, 2019: Nanomedicine
Ningjing Jiang, Yongjun Hu, Wei Wei, Tingfeng Zhu, Kang Yang, Guichi Zhu, Meng Yu
A surface-enhanced Raman scattering (SERS) method is described for the determination of microRNA that is associated with various forms of cancer. The substrate consists of functionalized gold-silver bimetallic structure, and the sensitivity is strongly enhanced by making use of a re-circulated enzymatic amplification system (REAS). Poly-dopamine acts as both a reductant and a protective of the substrates. It was employed to link the gold core and silver satellite. The unique "hot spots" consisting of a Au@PDA@Ag nanocomposite improve the Raman signal and sensitivity...
January 9, 2019: Mikrochimica Acta
Hu Zhu, Félix Lussier, Charles Ducrot, Marie-Josee Bourque, Joachim P Spatz, Wenli Cui, Li Yu, Wei Peng, Louis-Eric Trudeau, C Geraldine Bazuin, Jean-François Masson
A nanothin block copolymer (BCP) brush-layer film adsorbed on glass nanofibers is shown to address the long-standing challenge of forming a template for the deposition of dense and well dispersed nanoparticles on highly curved surfaces, allowing the development of an improved nanosensor for neurotransmitters. We employed a polystyrene-block-poly(4-vinylpyridine) BCP and plasmonic gold nanoparticles (AuNPs) of 52 nm in diameter for the fabrication of the nanosensor on pulled fibers with diameters down to 200 nm...
January 7, 2019: ACS Applied Materials & Interfaces
Sumit Kumar, Al-Monsur Jiaul Haque, Jonathan Sabaté Del Río, Shreedhar Gautam, Yoon-Kyoung Cho
We report HRP-catalyzed polymerization of Tannic acid (TA) and application of the poly (Tannic acid) (p(TA)) as a versatile platform for covalent immobilization of biomolecules on various electrode surfaces based on electrochemical oxidation of the p(TA) and subsequent oxidative coupling reactions with the biomolecules. We also used this method for capturing cancer cells through a linker molecule, folic acid (FA). Furthermore, we have demonstrated that enhanced electrocatalytic activity of the p(TA)-modified surface could be used for simultaneous electrochemical determination of biologically important electroactive molecules such as ascorbic acid (AA), dopamine (DA), and uric acid (UA)...
December 13, 2018: Biosensors & Bioelectronics
Xinlei Shi, Huike Wang, Xueting Xie, Qingwen Xue, Jingyu Zhang, Siqi Kang, Conghui Wang, Jiajie Liang, Yongsheng Chen
The development of wearable strain sensors with simultaneous large stretchability (strain >55%) and high sensitivity (gauge factor >100) remains a grand challenge to this day. Drawing on inspiration from nature, nacre has demonstrated outstanding mechanical properties, especially combining high strength and toughness, which is due in part to its delicate hierarchical layered architecture with rich interfacial interactions. Herein, we demonstrate that strain sensors based on this nacre-mimetic microscale "brick-and-mortar" architecture can simultaneously achieve ultrahigh sensitivity and large stretchability, while performing well in linearity, reliability, long-term durability, and monotonicity...
December 19, 2018: ACS Nano
Hairan Zhang, Qiuyue Zhang, Ling Zhang, Tingting Pei, Erni Li, Huiting Wang, Qian Zhang, Lixin Xia
Poly(N-isopropylacrylamide) modified graphene oxide (PNIPAm-GO), which is a type of thermal responsive GO, was designed and synthesized via a covalent strategy of 'grafting-from'. The as prepared modified nanosheets well integrated the individual advantages of two components, such as the thermal sensitivity of PNIPAm-terminal and the conductivity, the open 2D structure of GO substrate. PNIPAm-GO could well perform the reversible regulation of hydrophilicity/hydrophobicity in aqueous solution upon the variation of temperature signal...
November 22, 2018: Chemistry: a European Journal
Kristopher W Kolewe, Kerianne M Dobosz, Todd Emrick, Stephen S Nonnenmann, Jessica D Schiffman
Biofilm-associated infections stemming from medical devices are increasingly challenging to treat due to the spread of antibiotic resistance. In this study, we present a simple strategy that significantly enhances the antifouling performance of covalently crosslinked poly(ethylene glycol) (PEG) and physically crosslinked agar hydrogels by incorporation of the fouling-resistant polymer zwitterion, poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC). Dopamine polymerization was initiated during swelling of the hydrogels, which provided dopamine and pMPC an osmotic driving force into the hydrogel interior...
July 16, 2018: ACS applied bio materials
Hong-Hua Qiao, Lin-Nan Zhu, Yue Wang, Jia-Liang Hui, Wei-Bing Xie, Chao Liu, Ling Chen, Ping-Ming Qiu
Methamphetamine is an amphetamine-type psychostimulant that can damage dopaminergic neurons and cause characteristic pathological changes similar to neurodegenerative diseases such as Parkinson's disease. However, its specific mechanism of action is still unclear. In the present study, we established a Parkinson's disease pathology model by exposing SH-SY5Y cells and C57BL/6J mice to methamphetamine. In vitro experiments were performed with 0, 0.5, 1.0, 1.5, 2.0 or 2.5 mM methamphetamine for 24 hours or 2.0 mM methamphetamine for 0-, 2-, 4-, 8-, 16-, and 24-hour culture of SH-SY5Y cells...
February 2019: Neural Regeneration Research
Fatemeh Elmi, Elahe Valipour, Shahram Ghasemi
Nanohybrid films containing multiwalled carbon nanotubes (MWCNTs) were successfully coated on 304-stainless steel (304ss) for anti-corrosion use. The nanocompositewas made by a self-assembly of poly (dopamine), wrapped with MWCNTs (CNT@PDA) through a mussel inspired method. In order to enhance the corrosion protection, an inner layer of L-cysteine, an adhesive amino acid to 304ss surface through thiol (-SH) functional group were constructed through a dip-coating process. Potentiodynamic polarization measurements and electrochemical impedance spectroscopy revealed that the double nano-layer could act as a noble anticorrosive coating in 3...
November 30, 2018: Bioelectrochemistry
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