Hyoung-Yun Han, Bo-Kyung Kim, Jinhyung Rho, Se-Myo Park, Mi-Sun Choi, Soojin Kim, Min Beom Heo, Young-Su Yang, Jung-Hwa Oh, Tae Geol Lee, Seokjoo Yoon
Cerium oxide nanoparticles (CeO2 NPs, NM-212) are well-known for their catalytic properties and antioxidant potential, and have many applications in various industries, drug delivery, and cosmetic formulations. CeO2 NPs exhibit strong antimicrobial activity and can be used to efficiently remove pathogens from different environments. However, knowledge of the toxicological evaluation of CeO2 NPs is too limited to support their safe use. In this study, CeO2 NPs were orally administered to Sprague Dawley rats for 13 weeks at the doses of 0, 10, 100, and 1000 mg/kg bw/day, followed by a four week recovery period...
March 7, 2024: Scientific Reports