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JOURNAL ARTICLE
Penina Dienstag, Rana Halsa, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people suffering from end stage renal disease. Traditionally, LDKT can be either: "directed" or "non-directed," based on whether the recipient is specified by the donor. Recently there has been an increase in conditional and semidirected live kidney donation among strangers; where the donor specifies characteristics of the recipient whom they wish to donate to. This practice has both gained popularity and sparked controversy in the State of Israel through the non-profit organization Matnat Chaim...
April 17, 2024: American Journal of Transplantation
#2
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#3
JOURNAL ARTICLE
Muthukumarassamy Rajakannu, Ashwin Rammohan, Gomathy Narasimhan, Sivakumar Murugesan, Rajesh Rajalingam, Kumar Palaniappan, Sandeep Jasper Rajasekar, Dinesh Jothimani, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela
BACKGROUND: Paucity of deceased donor livers has resulted in a 10-fold rise in living donor liver transplantations (LDLTs) performed in India over the past decade. Nonetheless, number of deceased donor liver transplantation (DDLT) performed has improved with the establishment of simplified legal framework for certification of brain death and organ donation. In this study, we present our outcomes of DDLT performed at various centers, comparing their outcomes and provide a snapshot of the increasing number of DDLT across the state over the years...
April 19, 2024: Transplantation
#4
JOURNAL ARTICLE
Francesc Vigués, Begoña Etcheverry, José I Perez Reggeti, Josep Maria Gaya, Angelo Territo, Andrea Gallioli, Camille Berquin, Giuseppe Basile, José F Suárez, Maria Fiol, Oscar Buisan, Lluís Riera, Thomas Prudhomme, Nicolas Doumerc, Alessio Pecoraro, Alberto Breda
BACKGROUND AND OBJECTIVE: Orthotopic kidney transplantation (KT) has been proposed as an option for patients ineligible for heterotopic KT. In this scenario, orthotopic robot-assisted KT (oRAKT) represents a novel, minimally invasive alternative to the open approach. Here we describe the largest oRAKT series of patients, with a focus on the surgical technique, perioperative surgical outcomes, and functional results. METHODS: We queried prospectively maintained databases from three referral centers to identify patients who underwent oRAKT and evaluated surgical and functional outcomes...
April 15, 2024: European Urology
#5
Clara Schott, Samantha Colaiacovo, Cadence Baker, Matthew A Weir, Dervla M Connaughton
RATIONALE: Alport Syndrome (AS) is a progressive genetic condition characterized by chronic kidney disease (CKD), hearing loss, and eye abnormalities. It is caused by mutations in the genes COL4A3, COL4A4 , and COL4A5 . Heterozygous mutations in COL4A4 and COL4A3 cause autosomal dominant Alport Syndrome (ADAS), and a spectrum of phenotypes ranging from asymptomatic hematuria to CKD, with variable extra-renal features. In the past, heterozygous mutations in these genes were thought to be benign, however recent studies show that about 30% of patients can progress to CKD, and 15% can progress to end stage kidney disease (ESKD)...
2024: Canadian Journal of Kidney Health and Disease
#6
JOURNAL ARTICLE
Rikako Oki, Kohei Unagami, Taro Banno, Toshihito Hirai, Kazuya Omoto, Tomokazu Shimizu, Sekiko Taneda, Junichi Hoshino, Toshio Takagi, Hideki Ishida
BACKGROUND: The number of marginal living kidney donors has increased. Medically complex donors who have hypertension, older age, or low estimated glomerular filtration rate (eGFR) have been more likely to be used. METHODS: We conducted a retrospective cohort study of living kidney donors at a single center. We analyzed 309 living donors and divided them into three groups: group with older donors (aged ≥70 years) (n = 41), middle-aged (aged 46-69 years) (n = 239), and young donors (aged <46 years) (N = 29)...
April 14, 2024: Clinical and Experimental Nephrology
#7
EDITORIAL
Amy D Waterman, LaShara A Davis, Solaf Al Awadhi
No abstract text is available yet for this article.
April 11, 2024: American Journal of Kidney Diseases
#8
JOURNAL ARTICLE
Michiel G H Betjes, Marcia M L Kho, Joke Roodnat, Annelies E de Weerd
Background : The number of kidney transplant recipients over 70 years of age is increasing but detailed data on patient and graft survival in the modern era of immune suppression are few. Methods : A single-center cohort of patients of 70 years and older (n = 349) at time of kidney transplantation from 2010-2020 were followed until January 2023. Results : The median age was 73 years with a median follow-up of 4.3 years. Fifty percent of recipients of a living donor kidney (LDK, n = 143) received their graft pre-emptively...
March 23, 2024: Journal of Clinical Medicine
#9
MULTICENTER STUDY
Karl Marius Brobak, Lene V Halvorsen, Hans Christian D Aass, Camilla L Søraas, Arleen Aune, Eirik Olsen, Ola Undrum Bergland, Stine Rognstad, Kjersti B Blom, Jon Arne K Birkeland, Aud Høieggen, Anne Cecilie K Larstorp, Marit D Solbu
INTRODUCTION: Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential biomarkers for early HMOD in healthy persons and patients with hypertension. We hypothesised that plasma levels of biomarkers: (1) are different between healthy controls and patients with hypertension, (2): can classify patients with hypertension according to the degree of hypertension severity...
December 2024: Blood Pressure
#10
JOURNAL ARTICLE
Aleksandar Senev, Anat R Tambur, Vasilis Kosmoliaptsis, Hannah Charlotte Copley, Cynthia García-Sánchez, Crystal Usenko, Suzanne T Ildstad, Joseph R Leventhal
INTRODUCTION: We investigated the potential role of HLA molecular mismatches (MM) in achieving stable chimerism, allowing for donor-specific tolerance in patients undergoing combined living donor kidney and hematopoietic stem cell transplantation (HSCT). METHODS: All patients with available DNA samples (N=32) who participated in a phase 2 clinical trial (NCT00498160) where they received an HLA mismatched co-transplantation of living donor kidney and facilitating cell-enriched HSCT were included in this study...
2024: Frontiers in Immunology
#11
JOURNAL ARTICLE
Kevin Fowler
No abstract text is available yet for this article.
April 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#12
JOURNAL ARTICLE
Yuri Wada, Takayoshi Ueno, Koji Umeshita, Kuniko Hagiwara
BACKGROUND: Previous studies on decision-making of living kidney donors have indicated issues regarding donors' autonomy is inherent in decision-making to donate their kidney. Establishing effective decision-making support that guarantees autonomy of living kidney donor candidates is important. OBJECTIVES: The aim of this study was to identify the difficulties in the decision-making support when clinical transplant coordinators advocating for the autonomy of donor candidates of living donor kidney transplantation and to identify the methods to deal with these difficulties...
April 10, 2024: Journal of Renal Care
#13
JOURNAL ARTICLE
Robert A Keenan, Aisling U Nic An Riogh, David Brennan, Martina Morrin, Michael J Lee, Niall F Davis, Atakelet A Ferede, Dilly M Little
PURPOSE: A living donor kidney transplant is the optimal treatment for chronic renal impairment. Our objective is to assess if lean skeletal muscle mass and donor factors such as body mass index, hypertension, and age impact on renal function following donor nephrectomy. METHODS: Potential donors undergo CT angiography as part of their work-up in our institution. Using dedicated software (Horos®), standardized skeletal muscle area measured at the L3 vertebrae was calculated...
April 6, 2024: World Journal of Urology
#14
REVIEW
Mohammad H Al-Thnaibat, Mohammad K Balaw, Mohammed K Al-Aquily, Reem A Ghannam, Omar B Mohd, Firas Alabidi, Suzan Alabidi, Fadi Hussein, Badi Rawashdeh
Jordan performed the Middle East's first living-donor kidney transplant in 1972. In 1977, the country became one of the first Arab countries to regulate organ donation and transplantation. Despite these early advances in living donor transplantation, Jordan's organ donation after brain death program remains inactive, making it challenging to meet organ demand and placing many patients on long transplant waiting lists. As of 2020, only 14.2% of the patients with end-stage kidney disease have access to a living donor...
2024: Journal of Transplantation
#15
REVIEW
Muhammad Abdul Mabood Khalil, Nihal Mohammed Sadagah, Jackson Tan, Furrukh Omair Syed, Vui Heng Chong, Salem H Al-Qurashi
There is shortage of organs, including kidneys, worldwide. Along with deceased kidney transplantation, there is a significant rise in live kidney donation. The prevalence of prediabetes (PD), including impaired fasting glucose and impaired glucose tolerance, is on the rise across the globe. Transplant teams frequently come across prediabetic kidney donors for evaluation. Prediabetics are at risk of diabetes, chronic kidney disease, cardiovascular events, stroke, neuropathy, retinopathy, dementia, depression and nonalcoholic liver disease along with increased risk of all-cause mortality...
March 18, 2024: World Journal of Transplantation
#16
JOURNAL ARTICLE
Jun Shoji, William C Goggins, Jason R Wellen, Patrick N Cunningham, Olwyn Johnston, Shirley S Chang, Kim Solez, Vicki Santos, Tami J Larson, Masahiro Takeuchi, Xuegong Wang
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease and frequently recurs after kidney transplantation. Recurrent FSGS (rFSGS) is associated with poor allograft and patient outcomes. Bleselumab, a fully human immunoglobulin G4 anti-CD40 antagonistic monoclonal antibody, disrupts CD40-related processes in FSGS, potentially preventing rFSGS. METHODS: A phase 2a, randomized, multicenter, open-label study of adult recipients (aged ≥18 y) of a living or deceased donor kidney transplant with a history of biopsy-proven primary FSGS...
April 1, 2024: Transplantation
#17
JOURNAL ARTICLE
Ziad Arabi, Mazin Ibrahim Musab El Sarrag, Tarek Arabi, Muhannad Alqudsi, Areez Shafqat
BACKGROUND Secondary hyperparathyroidism and coronary calcifications are common complications in chronic kidney disease. However, the relation between coronary calcium score (CCS) and persistent hyperparathyroidism (pHPT) after kidney transplantation (KT) remains unknown. MATERIAL AND METHODS This was a single-center retrospective study of KT candidates from January 2017 to May 2020. We collected patients' demographics, cardiovascular (CV) risk factors, and the findings of pre-KT CV imaging. We also collected parathyroid hormone (PTH) values before KT, at 1-6 months, 6-12 months, and 12-24 months after KT...
April 2, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
#18
BioMed Research International
[This retracts the article DOI: 10.1155/2020/5703963.].
2024: BioMed Research International
#19
JOURNAL ARTICLE
Elizabeth A Wilson, Anna Woodbury, Kirsten M Williams, Craig M Coopersmith
Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reperfusion injury (IRI), a phenomenon characterized by oxygen scarcity followed by paradoxical oxidative stress and inflammation. With the expanded use of marginal allografts more susceptible to IRI, the incidence of EAD may be increasing. This necessitates an in-depth understanding of the innate molecular mechanisms underlying EAD and interventions to mitigate its impact...
2024: PloS One
#20
JOURNAL ARTICLE
Abir Boussetta, Manel Jellouli, Tahar Gargah, Meriem Hajji, Hafedh Hedri, Ezzeddine Abderrahim
INTRODUCTION: Pediatric end-stage renal disease is a rare but severe condition that causes numerous complications and impairs the quality of life of children. Kidney transplantation is the therapy of choice in pediatric end-stage renal disease. AIM: Our study aimed to identify the predictive factors of renal graft failure after kidney transplantation in Tunisian children and young adults. METHODS: We conducted a retrospective bicentric study of children and young adults (age≤20 years) who had undergone renal transplantation between 1989 and 2019 in Tunisia...
January 5, 2024: La Tunisie Médicale
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