keyword
https://read.qxmd.com/read/38374407/mettl3-mediated-m-6-a-modification-of-lncrna-tspan12-promotes-metastasis-of-hepatocellular-carcinoma-through-senp1-depentent-desumoylation-of-eif3i
#21
JOURNAL ARTICLE
Bei Li, Xianze Xiong, Jianrong Xu, Dingzhong Peng, Guilin Nie, Ningyuan Wen, Yaoqun Wang, Jiong Lu
In a previous study, we discovered that the level of lnc-TSPAN12 was significantly elevated in hepatocellular carcinoma (HCC) and correlated with a low survival rate. However, the function and mechanism of lnc-TSPAN12 in modulating epithelial-mesenchymal transition (EMT) and metastasis in HCC remains poorly understood. This study demonstrates that lnc-TSPAN12 positively influences migration, invasion, and EMT of HCC cells in vitro and promotes hepatic metastasis in vivo. The modification of N6-methyladenosine, driven by METTL3, is essential for the stability of lnc-TSPAN12, which may partially contribute to the upregulation of lnc-TSPAN12...
February 19, 2024: Oncogene
https://read.qxmd.com/read/38372948/targeting-lef1-mediated-epithelial-mesenchymal-transition-reverses-lenvatinib-resistance-in-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
Xinxiu Li, Hongmeng Su, Wenqing Tang, Shihui Shu, Luyu Zhao, Jinghan Sun, Hong Fan
Acquired resistance is a significant hindrance to clinical application of lenvatinib in unresectable hepatocellular carcinoma (HCC). Further in-depth investigation of resistance mechanisms can help to develop additional therapeutic strategies to overcome or delay resistance. In our study, two lenvatinib-resistant (LR) HCC cell lines were established by treatment with gradient increasing concentration of lenvatinib, named Hep3B-LR and HepG2-LR. Interestingly, continuous lenvatinib treatment reinforced epithelial-mesenchymal transition (EMT), cell migration, and cell invasion...
February 19, 2024: Investigational New Drugs
https://read.qxmd.com/read/38369410/gcnt3-regulated-muc13-to-promote-the-development-of-hepatocellular-carcinoma-through-the-gsk3%C3%AE-%C3%AE-catenin-pathway
#23
JOURNAL ARTICLE
Qiu Kang, Wu Tingting, Dong Bingzi, Zou Hao, Xie Yuwei, Sun Chuandong, Zhu Chengzhan
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Extensive research is currently directed at identifying novel targets for its diagnosis and treatment. AIMS: We investigated the biological functions and clinical significance of mucin-type N-acetylglucosaminyltransferase 3 (GCNT3) in HCC. METHODS: Variations in the mRNA expression of GCNT3 were examined in normal and HCC tissues. Cell function assays and animal models characterized the effects of GCNT3 on the proliferation, invasion, and migration abilities of HCC cells...
February 17, 2024: Digestive and Liver Disease
https://read.qxmd.com/read/38364252/mir-557-inhibits-hepatocellular-carcinoma-progression-through-wnt-%C3%AE-catenin-signaling-pathway-by-targeting-rab10
#24
JOURNAL ARTICLE
Xiaoye Cheng, Can Wu, Haocheng Xu, Ruixiang Zou, Taiyuan Li, Shanping Ye
Accumulating evidence suggests that aberrant miRNAs participate in carcinogenesis and progression of hepatocellular carcinoma (HCC). Abnormal miR-557 expression is reported to interfere with the progression of several human cancers. However, the potential roles of miR-557 in HCC remain largely unknown. In the current study, we found that miR-557 was down-regulated in HCC tissues and cell lines, and was closely related to recurrence and metastasis of HCC. Notably, overexpression of miR-557 inhibited proliferation, migration, invasion, epithelial-to-mesenchymal transition (EMT) progression, blocked cells in G0/G1 phase of MHCC-97H cells in vitro , and suppressed tumor growth in vivo ...
February 15, 2024: Aging
https://read.qxmd.com/read/38355603/biomarkers-and-prognostic-factors-of-pd-1-pd-l1-inhibitor-based-therapy-in-patients-with-advanced-hepatocellular-carcinoma
#25
REVIEW
Nan Zhang, Xu Yang, Mingjian Piao, Ziyu Xun, Yunchao Wang, Cong Ning, Xinmu Zhang, Longhao Zhang, Yanyu Wang, Shanshan Wang, Jiashuo Chao, Zhenhui Lu, Xiaobo Yang, Hanping Wang, Haitao Zhao
Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however, other individuals do not respond favorably. Hence, identifying the biomarkers, the prognostic factors, and their underlying mechanisms is crucial. In this review, we summarized the latest advancements in this field. Within the tumor microenvironment, PD-L1 expression is commonly utilized to predict response...
February 14, 2024: Biomarker Research
https://read.qxmd.com/read/38347489/high-expression-of-tbrg4-in-relation-to-unfavorable-outcome-and-cell-ferroptosis-in-hepatocellular-carcinoma
#26
JOURNAL ARTICLE
Shanchun Tao, Di Cui, Huimin Cheng, Xiaofei Liu, Zhaobin Jiang, Hongwei Chen, Yong Gao
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated the expression of transforming growth factor beta regulator 4 (TBRG4) in HCC and its effects on the proliferation, invasion, and metastasis of HCC cells, and analyzed the possible molecular mechanisms. METHOD: Downloading the expression and clinical information of HCC samples in the TCGA database, analyzing the expression differences of TBRG4 by bioinformatics methods, analyzing the clinical relevance and prognostic significance...
February 12, 2024: BMC Cancer
https://read.qxmd.com/read/38340578/bufalin-suppresses-hepatocellular-carcinogenesis-by-targeting-m2-macrophage-governed-wnt1-%C3%AE-catenin-signaling
#27
JOURNAL ARTICLE
Xuemei Zhang, Xiaona Lu, Jia Shi, Yuyao Li, Yue Li, Ru Tao, Lingying Huang, Yifei Tang, Xiaojun Zhu, Man Li, Yueqiu Gao, Hai Feng, Zhuo Yu
BACKGROUND: The interplay of tumor-associated macrophages (TAMs) and tumor cells plays a key role in the development of hepatocellular carcinoma (HCC) and provides an important target for HCC therapy. The communication between them is still on the investigation. Bufalin, the active component derived from the traditional Chinese medicine (TCM) Chansu, has been evidenced to possess anti-HCC activity by directly suppressing tumor cells, while its immunomodulatory effect on the tumor microenvironment (TME) is unclear...
January 30, 2024: Phytomedicine
https://read.qxmd.com/read/38311851/dlk1-dio3-locus-upregulation-by-a-%C3%AE-catenin-dependent-enhancer-drives-cell-proliferation-and-liver-tumorigenesis
#28
JOURNAL ARTICLE
Julie Sanceau, Lucie Poupel, Camille Joubel, Isabelle Lagoutte, Stefano Caruso, Sandra Pinto, Christèle Desbois-Mouthon, Cécile Godard, Akila Hamimi, Enzo Montmory, Cécile Dulary, Sophie Chantalat, Amélie Roehrig, Kevin Muret, Benjamin Saint-Pierre, Jean-François Deleuze, Sophie Mouillet-Richard, Thierry Forné, Christophe F Grosset, Jessica Zucman-Rossi, Sabine Colnot, Angélique Gougelet
The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we aim to decipher how sustained β-catenin activation regulates DLK1/DIO3 locus expression and the role this locus plays in HB and HCC development in mouse models deleted for Apc (ApcΔhep ) or Ctnnb1-exon 3 (β-cateninΔExon3 ) and in human CTNNB1-mutated hepatic cancer cells...
February 3, 2024: Molecular Therapy
https://read.qxmd.com/read/38308164/bcg-as-an-innovative-option-for-hcc-treatment-repurposing-and-mechanistic-insights
#29
JOURNAL ARTICLE
Farzam Vaziri, Tahereh Setayesh, Ying Hu, Resmi Ravindran, Dongguang Wei, Yu-Jui Yvonne Wan
This study investigates Bacillus Calmette-Guérin (BCG) as a potential treatment for hepatocellular carcinoma (HCC), a condition often associated with unfavorable treatment outcomes. Exploiting BCG's recognized immune-boosting properties, preclinical trials are conducted using HCC mice, with a single subcutaneous dose of BCG administered post-tumor formation. Results indicate that BCG treatment effectively diminishes tumor burden and extends survival in both male and female HCC mice. Positive influences on hepatic fibrosis and metabolism are observed, leading to a reduction in lipid levels...
February 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38307410/hyperactivation-of-%C3%AE-catenin-signal-in-hepatocellular-carcinoma-recruits-myeloid-derived-suppressor-cells-through-pf4-cxcr3-axis
#30
JOURNAL ARTICLE
Kaiting Wang, Jianmin Wu, Zhao Yang, Bo Zheng, Siyun Shen, Rui-Ru Wang, Yani Zhang, Hong-Yang Wang, Lei Chen, Xinyao Qiu
The high mutation rate of CTNNB1 (37 %) and Wnt-β-catenin signal-associated genes (54 %) has been notified in hepatocellular carcinoma (HCC). The activation of Wnt-β-catenin signal pathway was reported to be associated with an immune "desert" phenotype, but the underlying mechanism remains unclear. Here we mainly employed orthotopic HCC models to explore on it. Mass cytometry depicted the immune contexture of orthotopic HCC syngeneic grafts, unveiling that the exogenous expression of β-catenin significantly increased the percentage of myeloid-derived suppressor cells (MDSCs) and decreased the percentage of CD8+ T-cells...
January 31, 2024: Cancer Letters
https://read.qxmd.com/read/38303608/pan-cancer-analyses-of-bromodomain-containing-9-as-a-novel-therapeutic-target-reveals-its-diagnostic-prognostic-potential-and-biological-mechanism-in-human-tumours
#31
JOURNAL ARTICLE
Yu Chen, Zitong Gao, Isam Mohd-Ibrahim, Hua Yang, Lang Wu, Yuanyuan Fu, Youping Deng
BACKGROUND: Mutations in one or more genes responsible for encoding subunits within the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodelling complexes are found in approximately 25% of cancer patients. Bromodomain containing 9 (BRD9) is a more recently identified protein coding gene, which can encode SWI/SNF chromatin-remodelling complexes subunits. Although initial evaluations of the potential of BRD9-based targeted therapy have been explored in the clinical application of a small number of cancer types, more detailed study of the diagnostic and prognostic potential, as well as the detailed biological mechanism of BRD9 remains unreported...
February 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38302697/natural-products-targeting-macroautophagy-signaling-in-hepatocellular-carcinoma-therapy-recent-evidence-and-perspectives
#32
REVIEW
Yuan Chen, Xiyue Tan, Wenwen Zhang, Yubing Li, Xinyu Deng, Jinhao Zeng, Lihua Huang, Xiao Ma
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer-related mortality, continues to pose significant challenges in the realm of medical oncology, impacting both clinical drug selection and mechanistic research. Recent investigations have unveiled autophagy-related signaling as a promising avenue for HCC treatment. A growing body of research has highlighted the pivotal role of autophagy-modulating natural products in inhibiting HCC progression. In this context, we provide a concise overview of the fundamental autophagy mechanism and delineate the involvement of autophagic signaling pathways in HCC development...
February 1, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38299537/the-assessment-of-circulating-tumor-dna-associated-with-wnt-%C3%AE-catenin-signaling-pathway-as-a-diagnostic-tool-for-liver-cancer-a-systematic-review-and-meta-analysis
#33
REVIEW
Xingyuan Ma, Zhe Wang, Shuaiyang Wang, Ye Tian, Bei Xie, Jing Li, Bin Ma, Linjing Li
BACKGROUND: Circulating tumor DNA (ctDNA) in peripheral blood has become a promising noninvasive biomarker. However, the diagnostic potential of Wnt/β-catenin signaling pathway-related ctDNA for liver cancer is controversial. Here, we aimed to access the diagnostic potential and clinicopathological features of Wnt/β-catenin signaling pathway-related ctDNA in liver cancer and provide data support for its clinical diagnosis and treatment. METHODS: A comprehensive literature search was conducted to identify the relevant studies...
February 1, 2024: Expert Review of Anticancer Therapy
https://read.qxmd.com/read/38297127/matrix-viscoelasticity-promotes-liver-cancer-progression-in-the-pre-cirrhotic-liver
#34
JOURNAL ARTICLE
Weiguo Fan, Kolade Adebowale, Lóránd Váncza, Yuan Li, Md Foysal Rabbi, Koshi Kunimoto, Dongning Chen, Gergely Mozes, David Kung-Chun Chiu, Yisi Li, Junyan Tao, Yi Wei, Nia Adeniji, Ryan L Brunsing, Renumathy Dhanasekaran, Aatur Singhi, David Geller, Su Hao Lo, Louis Hodgson, Edgar G Engleman, Gregory W Charville, Vivek Charu, Satdarshan P Monga, Taeyoon Kim, Rebecca G Wells, Ovijit Chaudhuri, Natalie J Török
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development1,2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions3,4 . Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness...
January 31, 2024: Nature
https://read.qxmd.com/read/38269515/molecular-insights-on-intracellular-wnt-%C3%AE-catenin-signaling-in-alcoholic-liver-disease
#35
REVIEW
Karthik Shree Harini, Devaraj Ezhilarasan, Uthirappan Mani
Alcoholic liver disease (ALD) is one of the most common health problems worldwide, especially in developing countries caused by chronic consumption of alcohol on a daily basis. The ALD spectrum is initiated with the early stages of alcoholic fatty liver (steatosis), progressing to alcoholic steatohepatitis, followed by the later stages of fibrosis and in some cases, cirrhosis and hepatocellular carcinoma (HCC). The Wnt/β-catenin signaling required for healthy liver development, function, and regeneration is found to be aberrated in ALD, attributed to its progression...
January 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38254216/zmiz2-facilitates-hepatocellular-carcinoma-progression-via-lef1-mediated-activation-of-wnt-%C3%AE-catenin-pathway
#36
JOURNAL ARTICLE
Yang Ding, Yumei Ning, Hui Kang, Yuan Yuan, Kun Lin, Chun Wang, Yun Yi, Jianghua He, Lurao Li, Xingxing He, Ying Chang
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high lethality rate. ZMIZ2 is a transcriptional co-activator implicated in various human diseases. However, the role and molecular mechanism of ZMIZ2 in HCC remains to be elucidated. METHODS: The expression and prognostic value of ZMIZ2 in HCC was excavated from public databases and explored by bioinformatic analysis. Then the expression of ZMIZ2 and related genes was further validated by quantitative RT-PCR, western blotting, and immunohistochemistry...
January 22, 2024: Experimental Hematology & Oncology
https://read.qxmd.com/read/38234409/expert-management-of-congenital-portosystemic-shunts-and-their-complications
#37
REVIEW
Valérie Anne McLin, Stéphanie Franchi-Abella, Timothée Brütsch, Atessa Bahadori, Valeria Casotti, Jean de Ville de Goyet, Grégoire Dumery, Emmanuel Gonzales, Florent Guérin, Sebastien Hascoet, Nigel Heaton, Béatrice Kuhlmann, Frédéric Lador, Virginie Lambert, Paolo Marra, Aurélie Plessier, Alberto Quaglia, Anne-Laure Rougemont, Laurent Savale, Moinak Sen Sarma, Olivier Sitbon, Riccardo Antonio Superina, Hajime Uchida, Mirjam van Albada, Hubert Petrus Johannes van der Doef, Valérie Vilgrain, Julie Wacker, Nitash Zwaveling, Dominique Debray, Barbara Elisabeth Wildhaber
Congenital portosystemic shunts are often associated with systemic complications, the most challenging of which are liver nodules, pulmonary hypertension, endocrine abnormalities, and neurocognitive dysfunction. In the present paper, we offer expert clinical guidance on the management of liver nodules, pulmonary hypertension, and endocrine abnormalities, and we make recommendations regarding shunt closure and follow-up.
January 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38230869/wnt-signaling-in-cell-adhesion-development-and-colon-cancer
#38
REVIEW
Nydia Tejeda-Muñoz, Kuo-Ching Mei
Wnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms. The loss of normal cell polarity and adhesion caused by Wnt signaling activation is a fundamental step for tumor progression and metastasis. Activating the canonical Wnt pathway is a driving force in many human cancers, especially colorectal, hepatocellular, and mammary carcinomas...
January 17, 2024: IUBMB Life
https://read.qxmd.com/read/38218109/gcf2-mediates-nicotine-induced-cancer-stemness-and-progression-in-hepatocellular-carcinoma
#39
JOURNAL ARTICLE
Jinping Li, Dayun Tuo, Tan Cheng, Zhenyan Deng, Jinfeng Gan
Cigarette smoking is one of the most impactful behavior-related risk factors for multiple cancers including hepatocellular carcinoma (HCC). Nicotine, as the principal component of tobacco, is not only responsible for smoking addiction but also a carcinogen; nevertheless, the underlying mechanisms remain unclear. Here we report that nicotine enhances HCC cancer stemness and malignant progression by upregulating the expression of GC-rich binding factor 2 (GCF2), a gene that was revealed to be upregulated in HCC and whose upregulation predicts poor prognosis, and subsequently activating the Wnt/ꞵ-catenin/SOX2 signaling pathway...
January 11, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38216836/blvra-exerts-its-biological-effects-to-induce-malignant-properties-of-hepatocellular-carcinoma-cells-via-wnt-%C3%AE-catenin-pathway
#40
JOURNAL ARTICLE
Xinju Chen, Fangming Yang, Chuanlei Zhang, Xinting Wang, Changwei Yuan, Dandan Shi, Shuaishuai Zhu, Xiaotong Zhang, Xiaoqi Chen, Wenxia Zhao
The function of Biliverdin Reductase A (BLVRA) in hepatocellular carcinoma (HCC) cells proliferation, invasion and migration remains unclear. Therefore, this research intends to explore the effect of BLVRA on HCC cells growth and metastasis. BLVRA expression was analyzed in public dataset and examined by using western blot. The malignant function of BLVRA in HCC cell lines and its effect on Wnt/β-catenin pathway were measured. Analysis from GEPIA website showed that BLVRA expression was significantly increased in HCC tissues, and high expression of BLVRA resulted in worse prognosis of HCC patients...
January 13, 2024: Journal of Molecular Histology
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