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Jinjiang Pang, Qihua Xu, Xiangbin Xu, Hongchao Yin, Rongkun Xu, Shu Guo, Wei Hao, Luya Wang, Chen Chen, Ji-Min Cao
Growth hormone-releasing peptides (GHRP) and ghrelin are synthetic and natural ligands of growth hormone secretagogue receptor (GHSR) respectively and are shown to exert protective actions on cardiac dysfunction. Because ghrelin has been reported to inhibit proinflammatory responses in human endothelium and GHSR has been identified in blood vessels, we hypothesized that GHRP could alleviate the development of atherosclerosis (As). Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0...
April 2010: Peptides
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