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Peptic ulcer bleeding

Kari Syrjänen, Matti Eskelinen, Ants Peetsalu, Toomas Sillakivi, Pentti Sipponen, Matti Härkönen, Lea Paloheimo, Minna Mäki, Tapani Tiusanen, Osmo Suovaniemi, Francesco DiMARIO, Zhu Ping Fan
BACKGROUND/AIM: Several clinical conditions seriously hamper the diagnostic accuracy of the commonly used tests for Helicobacter pylori (Hp), 13 C-urea breath test (UBT) and stool antigen test (SAT). The present communication is a critical review of the potential limitations of UBT and SAT, and describes the approach on how these can be avoided. Drawbacks of the Hp tests: False-negative results are most often due to low bacterial load in the stomach due to: i) use of proton pump inhibitor medication; ii) use of antibiotics; iii) presence of atrophic gastritis and hypoacid stomach; iv); bleeding peptic ulcer; v) gastric cancer (GC) and vi) mucosal-associated lymphatic tissue lymphoma...
March 2019: Anticancer Research
Jing-Jing Wei, Xue-Ping Xie, Ting-Ting Lian, Zhi-Yong Yang, Yu-Feng Pan, Zhen-Lv Lin, Guang-Wei Zheng, Ze-Hao Zhuang
AIM: To investigate the effectiveness of over-the-scope-clip (OTSC)-based endoscopic closure in patients with perforated peptic ulcer (PPU). METHODS: One hundred six patients diagnosed with PPU were treated with either OTSC (n = 26) or conservative treatments (n = 80), respectively. The outcome assessments included technical success rate, clinical success rate, post-treatment complications after 1 month, mortality rate, time to resume oral feeding, length of hospital stay, and the administration of antibiotics...
February 25, 2019: Surgical Endoscopy
Vanessa Selak, Rod Jackson, Katrina Poppe, Billy Wu, Matire Harwood, Corina Grey, Romana Pylypchuk, Suneela Mehta, Andrew Kerr, Sue Wells
Background: Many prognostic models for cardiovascular risk can be used to estimate aspirin's absolute benefits, but few bleeding risk models are available to estimate its likely harms. Objective: To develop prognostic bleeding risk models among persons in whom aspirin might be considered for the primary prevention of cardiovascular disease (CVD). Design: Prospective cohort study. Setting: New Zealand primary care. Participants: The study cohort comprised 385 191 persons aged 30 to 79 years whose CVD risk was assessed between 2007 and 2016...
February 26, 2019: Annals of Internal Medicine
Rafiye Çiftçiler, Ahmet Koluman, İbrahim C Haznedaroğlu, Nejat Akar
Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure. Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability...
February 11, 2019: Turkish Journal of Medical Sciences
Grace Lai-Hung Wong, Andy Jinhua Ma, Huiqi Deng, Jessica Yuet-Ling Ching, Vincent Wai-Sun Wong, Yee-Kit Tse, Terry Cheuk-Fung Yip, Louis Ho-Shing Lau, Henry Hin-Wai Liu, Chi-Man Leung, Steven Woon-Choy Tsang, Chun-Wing Chan, James Yun-Wong Lau, Pong-Chi Yuen, Francis Ka-Leung Chan
BACKGROUND: Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications. AIM: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding. METHODS: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding...
February 13, 2019: Alimentary Pharmacology & Therapeutics
Hak Su Kim, Hee Kyoung Kim, Won Hee Kim, Sung Pyo Hong, Joo Young Cho
Intramural hematoma of the duodenum is a relatively unusual complication associated with the endoscopic treatment of bleeding peptic ulcers. Intramural hematomas are typically resolved spontaneously with conservative treatment alone. We report a case of an intramural duodenal hematoma following endoscopic hemostasis with epinephrine injection therapy, which was associated with transient obstructive jaundice in a patient undergoing hemodialysis. The patient developed biliary sepsis due to obstruction of the common bile duct secondary to the huge hematoma...
January 25, 2019: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Eun Joo Lee, Yeoun Joo Lee, Jae Hong Park
Purpose: This study was performed to assess the clinical usefulness of transabdominal ultrasonography (TUS) in detecting peptic ulcer disease (PUD) in children. Methods: Twenty-four patients (19 boys, 5 girls; mean age, 10.6±4.5 years [range, 3.0-17.9 years]) who were admitted to the hospital for acute abdomen or gastrointestinal bleeding and diagnosed with PUD by endoscopy and who underwent TUS were included. Clinical data were retrospectively collected by reviewing patient medical records...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
Emily He, Rupert Alison, Roger Blanks, Kirstin Pirie, Gillian Reeves, Robyn L Ward, Robert Steele, Julietta Patnick, Karen Canfell, Valerie Beral, Jane Green
Background: In 2006, the Bowel Cancer Screening Programme (BCSP) in England began offering biennial faecal occult blood testing (FOBt) at ages 60-69 years. Although FOBt is aimed at detecting colorectal neoplasms, other conditions can affect the result. In a large UK prospective study, we examined associations, both before and after screening, between FOBt positivity and 10 conditions that are often associated with gastrointestinal bleeding. Methods: By electronically linking BCSP and Million Women Study records, we identified 604 495 women without previous colorectal cancer who participated in their first routine FOBt screening between 2006 and 2012...
January 21, 2019: International Journal of Epidemiology
Faraz Siddiqui, Moiz Ahmed, Saqib Abbasi, Akshay Avula, Abdul Hasan Siddiqui, Jobin Philipose, Hafiz M Khan, Tahir M A Khan, Liliane Deeb, Michel Chalhoub
Background: The goal of our study was to determine the impact of gastrointestinal bleeding (GIB) on in-hospital outcomes among acute respiratory distress syndrome (ARDS) patients, and subsequently determine the potential risk factors for the development of GIB. Methods: ARDS patients with and without GIB were identified using the National Inpatient Sample (2002 - 2012). Linear regression analysis was used to assess impact of GIB on in-hospital mortality, length of stay and total charges...
January 2019: Journal of Clinical Medicine Research
Mhamad Faour, Nicolas S Piuzzi, David P Brigati, Alison K Klika, Michael A Mont, Wael K Barsoum, Carlos A Higuera
BACKGROUND: Aspirin is established as an effective prophylaxis for venous thromboembolism (VTE) after THA; however, there is no consensus as to whether low- or regular-dose aspirin is more effective at preventing VTE. QUESTIONS/PURPOSES: (1) Is there a difference in the incidence of symptomatic VTE within 90 days of elective THA using low-dose aspirin compared with regular-dose aspirin? (2) Is there a difference in the risk of significant bleeding (gastrointestinal and wound bleeding) and mortality between low- and standard-dose aspirin within 90 days after surgery? METHODS: We retrospectively evaluated 7488 patients in our database who underwent THA between September 2012 and December 2016...
February 2019: Clinical Orthopaedics and related Research
Kazunori Nagashima, Keiichi Tominaga, Koh Fukushi, Akira Kanamori, Takako Sasai, Hideyuki Hiraishi
Background: Gastrointestinal hemorrhage occurs frequently. We reviewed the tendency of occurrence of bleeding gastric and duodenal ulcers and their association with antithrombotic therapy before and after the widespread use of Evidence-Based Clinical Practice Guidelines for Peptic Ulcer 2009 (1st edition), which was published to improve treatment outcomes and prevent peptic ulcers. Methods: The study enrolled 1105 patients with bleeding gastric and duodenal ulcers treated at our hospital between January 2000 and March 2016...
December 2018: JGH open: an open access journal of gastroenterology and hepatology
Robert T Kavitt, Anna M Lipowska, Adjoa Anyane-Yeboa, Ian M Gralnek
Peptic ulcer disease continues to be a source of significant morbidity and mortality worldwide. Approximately two-thirds of patients found to have peptic ulcer disease are asymptomatic. In symptomatic patients, the most common presenting symptom of peptic ulcer disease is epigastric pain, which may be associated with dyspepsia, bloating, abdominal fullness, nausea, or early satiety. Most cases of peptic ulcer disease are associated with Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs), or both...
January 3, 2019: American Journal of Medicine
Amol Agarwal, Petros Benias, Olaya I Brewer Gutierrez, Vivien Wong, Yuri Hanada, Juliana Yang, Vipin Villgran, Vivek Kumbhari, Anthony Kalloo, Mouen A Khashab, Philip Chiu, Saowanee Ngamruengphong
Background and study aims  Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown. Patients and methods  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Primary outcome was rate of immediate hemostasis and rate of early rebleeding (within 72 hours). Secondary outcomes included technical success, delayed rebleeding (> 72 hours), and rate of adverse events (AEs)...
December 2018: Endoscopy International Open
Sung Hee Youn, Hyun Lim, Yeonmi Ju, Jae Seung Soh, Ji Won Park, Ho Suk Kang, Sung Eun Kim, Sung Hoon Moon, Jong Hyeok Kim, Choong Kee Park, Seung In Seo, Woon Geon Shin
OBJECTIVES: Direct oral anticoagulants (DOACs) are effective in the prevention and treatment of thromboembolism; however, they are associated with upper gastrointestinal bleeding (UGIB). In this study, we evaluated the efficacy of gastroprotective agents (GPAs) in reducing the risk of UGIB in patients receiving DOACs. METHODS: We retrospectively reviewed the medical records of 2076 patients who received DOACs for the prevention or treatment of thromboembolic events between January 2008 and July 2016...
December 2018: Scandinavian Journal of Gastroenterology
Lan Wang, Dajun Pei, Yan-Qiong Ouyang, Xiaofei Nie
AIM: To quantitatively analyse factors related to gastrointestinal bleeding after percutaneous coronary intervention and provide evidence for the prevention of gastrointestinal bleeding. DATA SOURCES AND REVIEW METHODS: Cochrane Library, Pubmed, Embase, and Ovid databases were searched from inception to 31 May 2018; case-control and cohort studies published in English were included. The methodological quality of each study was assessed by two independent reviewers using the Newcastle-Ottawa Scale...
November 19, 2018: International Journal of Nursing Practice
Adriel Chan, Libby Liang, Anthony C H Tung, Angus Kinkade, Aaron M Tejani
Background: The use of proton pump inhibitors (PPIs) may cause significant harm to patients in the residential care setting, as these patients are often frail with multiple morbidities. The extent of non-evidence-based use of PPIs in residential care sites of the Fraser Health Authority in British Columbia is unknown. Objective: To determine the proportion of non-evidence-based use of PPI therapy for residential care patients of the Fraser Health Authority. Methods: This retrospective cross-sectional study was conducted in 6 Fraser Health residential care facilities in British Columbia between April 1, 2015, and March 31, 2016...
September 2018: Canadian Journal of Hospital Pharmacy
Pei-Jui Luo, Xi-Hsuan Lin, Chung-Chi Lin, Jiing-Chyuan Luo, Hsiao-Yun Hu, Po-Hsiang Ting, Ming-Chih Hou
BACKGROUND/PURPOSE: We aimed to identify the risk factors of first-time occurrence of non-variceal upper gastrointestinal bleeding (UGIB) among aspirin users after adjusting for confounding factors like age, gender, underlying co-morbidities, and medications. METHODS: Using the National Health Insurance Research Database of Taiwan and matching age, gender, underlying co-morbidities and enrollment time by propensity score, 11105 aspirin users and 11105 controls were identified for comparison from a cohort dataset of 1,000,000 randomly sampled subjects...
October 23, 2018: Journal of the Formosan Medical Association
Bilal Toka, Ahmet Tarik Eminler, Cengiz Karacaer, Mustafa Ihsan Uslan, Aydin Seref Koksal, Erkan Parlak
BACKGROUND AND AIMS: Although various methods are used in the treatment of peptic ulcer bleeding, there is not a standard recommended approach. The choice depends on multiple factors such as location of the ulcer, clinical experience of the endoscopist, and local facilities of the clinic. We aimed to compare the efficacy of monopolar hemostatic forceps soft coagulation (MHFSC) and hemoclips (HCs) in the treatment of peptic ulcer-related upper GI bleeding. METHODS: The study group included patients who had GI bleeding due to Forrest 1a, 1b, and 2a gastric or duodenal ulcers within 1 year...
October 17, 2018: Gastrointestinal Endoscopy
Vincenzo Savarino, Elisa Marabotto, Patrizia Zentilin, Manuele Furnari, Giorgia Bodini, Costanza De Maria, Gaia Pellegatta, Claudia Coppo, Edoardo Savarino
The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. Areas Covered: The following evidence-based indications for PPI use are acknowledged by many scientific societies: treatment of the various forms and complications of gastroesophageal reflux disease, eradication of H. pylori infection in combination with two or more antibiotics, short- and long-term therapy of H. pylori-negative peptic ulcers, healing, and prevention of NSAID/COXIB-associated gastric ulcers, co-therapy with endoscopic procedures to control upper digestive bleeding and medical treatment of Zollinger Ellison syndrome...
October 8, 2018: Expert Review of Clinical Pharmacology
Mingliang Lu, Gang Sun, Xiao-Mei Zhang, You-Qing Xv, Shi-Yao Chen, Ying Song, Xue-Liang Li, Bin Lv, Jian-Lin Ren, Xue-Qing Chen, Hui Zhang, Chen Mo, Yan-Zhi Wang, Yun-Sheng Yang
BACKGROUND This study aimed to discover the common cause of non-variceal upper-gastrointestinal bleeding (NVUGIB) by conducting a multi-center retrospective study from 2008 to 2012. MATERIAL AND METHODS Hospitalized patients ages ≥18 years old, from 8 hospitals in China, diagnosed with NVUGIB by endoscopy from 1 January 2008 to 31 December 2012 were enrolled. Questionnaires were developed and a data-entry graphical user interface was designed by using EpiData software. RESULTS Total of 2977 hospitalized patients from 8 medical centers were included...
October 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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