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Heart failure related diabetes

Marketa Marvanova, Paul Jacob Henkel
OBJECTIVES: To summarize select continuing pharmacy education (CPE) topics and hours related to geriatric care completed by community, hospital/clinic, and long-term care (LTC)/consultant pharmacists in the previous 12 months, whether pharmacy workplace influenced topic selection or completion, and to describe CPE sources used by community versus hospital/clinic pharmacists. DESIGN: Cross-sectional survey (2017). SETTING AND PARTICIPANTS: Licensed pharmacists in North Dakota, South Dakota, Minnesota, Iowa, and Nebraska with primary practice settings in community pharmacies, hospitals, or clinics or those practicing as consultant pharmacists...
February 13, 2019: Journal of the American Pharmacists Association: JAPhA
Manuel Raya-Cruz, Antonio Payeras-Cifre, Lola Ventayol-Aguiló, Paz Díaz-Antolín
BACKGROUND: Skin and soft tissue infections (SSTIs) are a common cause of consultation, and complicated cases require hospitalization. We describe factors that are related to readmission and/or mortality of hospitalized patients diagnosed with SSTIs. METHODS: Retrospective review of hospital-admitted patients with a diagnosis of cellulitis, abscess, hidradenitis, fasciitis, and Fournier's gangrene. Cases from January 2002 to October 2015 were extracted from the diagnostic codification database of the Archives and Clinical Documentation Department...
February 15, 2019: International Journal of Dermatology
M Rochoy, V Rivas, E Chazard, E Decarpentry, G Saudemont, P-A Hazard, F Puisieux, S Gautier, R Bordet
Alzheimer's disease (AD) is a frequent pathology, with a poor prognosis, for which no curative treatment is available in 2018. AD prevention is an important issue, and is an important research topic. In this manuscript, we have synthesized the literature reviews and meta-analyses relating to modifiable risk factors associated with AD. Smoking, diabetes, high blood pressure, obesity, hypercholesterolemia, physical inactivity, depression, head trauma, heart failure, bleeding and ischemic strokes, sleep apnea syndrome appeared to be associated with an increased risk of AD...
2019: Journal of Prevention of Alzheimer's Disease
Christina M Ackerman, Marissa H Platner, Erica S Spatz, Jessica L Illuzzi, Xiao Xu, Katherine H Campbell, Graeme N Smith, Michael J Paidas, Heather S Lipkind
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of pregnancy-related death in the United States. (1) Identification of short-term indicators of cardiovascular morbidity has the potential to alter the course of this devastating disease among women. It has been established that hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease 10-30 years after delivery; however, little is known about the association of hypertensive disorders of pregnancy with cardiovascular (CV) morbidity during the delivery hospitalization...
February 8, 2019: American Journal of Obstetrics and Gynecology
Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G Dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
The protein kinase C (PKC) and closely related protein kinase N (PKN) families of serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA), protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase (S6K). Involvement of PKC family members in heart disease has been well documented over the years, as their activity and levels are mis-regulated in several pathological heart conditions, such as ischemia, diabetic cardiomyopathy, as well as hypertrophic or dilated cardiomyopathy...
February 8, 2019: Journal of Molecular and Cellular Cardiology
Sjur Lehmann, Elham Baghestan, Per Engebret Børdahl, Lorentz Muller Irgens, Svein Arvid Rasmussen
INTRODUCTION: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate. MATERIAL AND METHODS: In a cohort study (n=57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Preterm, multiple, and non-cephalic deliveries were excluded...
February 8, 2019: Acta Obstetricia et Gynecologica Scandinavica
Pieter Martens, Joyce Janssens, Jobbe Ramaekers, Matthias Dupont, Wilfried Mullens
BACKGROUND: The choice of glucose lowering agent in heart failure (HF)-patients can have a strong effect on HF-related adverse events, with some classes increasing and other classes reducing the risk. Little data is available about the choice of glucose lowering agents in HF-patients with type-2-diabetes. METHODS: We performed a cross-sectional single centre point analysis of all patients with both a diagnoses of HF and type-2-diabetes followed in a tertiary HF-clinic...
February 8, 2019: Acta Cardiologica
Kelly McHugh, Adam D DeVore, Jingjing Wu, Roland A Matsouaka, Gregg C Fonarow, Paul A Heidenreich, Clyde W Yancy, Jennifer B Green, Natasha Altman, Adrian F Hernandez
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of HF, affecting over 3 million adults in the United States alone. HFpEF is a heterogenous syndrome. One important phenotype may be related to comorbid conditions, including diabetes mellitus (DM). DM has a prevalence of approximately 45% in HFpEF, but characteristics and outcomes of this population are poorly understood. In this review, the authors summarize data from several clinical trials of HFpEF therapeutics and provide original data from a large cohort using the Get With The Guidelines-HF registry, which together suggest that DM is associated with increased morbidity and long-term mortality in HFpEF...
February 12, 2019: Journal of the American College of Cardiology
Giuseppe Seghieri, Laura Policardo, Elisa Gualdani, Roberto Anichini, Paolo Francesconi
AIMS: Diabetic foot syndrome (DFS) increases the risk for atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), or mortality. The present study aims at ascertaining whether such DFS-related excess risk differs between genders, retrospectively investigating a population with diabetes from Tuscany, Italy, followed-up for 6 years (2011-2016). METHODS: People with diabetes living in Tuscany on January 1st 2011 identified by administrative databases, were divided by baseline history of prior DFS hospitalizations, stratified by presence/absence of peripheral vascular disease and evaluating, by Cox regression analysis, whether adjusted DFS-related excess risk of incident ASCVD, CKD or mortality differed between genders...
February 5, 2019: Acta Diabetologica
Naoya Yoshida, Hiroyuki Yamamoto, Hideo Baba, Hiroaki Miyata, Masayuki Watanabe, Yasushi Toh, Hisahiro Matsubara, Yoshihiro Kakeji, Yasuyuki Seto
OBJECTIVE: We aimed to elucidate whether minimally invasive esophagectomy (MIE) can be safely performed by reviewing the Japanese National Clinical Database. SUMMARY OF BACKGROUND DATA: MIE is being increasingly adopted, even for advanced esophageal cancer that requires various preoperative treatments. However, the superiority of MIE's short-term outcomes compared with those of open esophagectomy (OE) has not been definitively established in general clinical practice...
January 31, 2019: Annals of Surgery
Kelly Arps, Vincent A Pallazola, Rhanderson Cardoso, Joseph Meyer, Richard Jones, Jacqueline Latina, Ty J Gluckman, Neil J Stone, Roger S Blumenthal, John W McEvoy
Efforts to better control risk factors for cardiovascular disease and prevent the development of subsequent cardiovascular events are crucial to maintaining healthy populations. In today's busy practice environment and with the overwhelming pace of new research findings, ensuring appropriate emphasis and implementation of evidence-based preventive cardiovascular care can be challenging. The ABCDEF approach to cardiovascular disease prevention is intended to improve dissemination of contemporary best practices and ease the implementation of comprehensive preventive strategies for clinicians...
February 1, 2019: American Journal of Medicine
Husam Abdel-Qadir, Paaladinesh Thavendiranathan, Peter C Austin, Douglas S Lee, Eitan Amir, Jack V Tu, Kinwah Fung, Geoffrey M Anderson
Background: Data are limited regarding the risk of heart failure (HF) requiring hospital-based care after early stage breast cancer (EBC) and its relationship to other types of cardiovascular disease (CVD). Methods: We conducted a population-based, retrospective cohort study of EBC patients (diagnosed April 1, 2005-March 31, 2015) matched 1:3 on birth-year to cancer-free control subjects. We identified hospitalizations and emergency department visits for CVD through March 31, 2017...
January 31, 2019: Journal of the National Cancer Institute
Steven G Chrysant, George S Chrysant
OBJECTIVES: Obesity has risen in the US and worldwide, and has become a major risk factor for type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease, and heart failure (HF), mostly HF with preserved ejection fraction (HFpEF). Also, the prevalence of HF is quite high in the US accounting for 6.6 million adults at present and is projected to reach 8.5 million by the year 2030 and is equally divided between HFpEF and heart failure reduced ejection fraction (HFrEF). Patients with HFpEF are resistant to treatment with drugs usually used for the treatment of HFrEF, but the reasons for this resistance are not clearly known...
February 4, 2019: Hospital Practice (Minneapolis)
Marissa Blieden Betts, Sandra Milev, Meredith Hoog, Hyosung Jung, Dušan Milenković, Yi Qian, Ming-Hui Tai, Lucie Kutikova, Guillermo Villa, Christine Edwards
OBJECTIVES: To identify risk equations for cardiovascular diseases (CVDs) in primary and secondary prevention settings that are used or recommended by health technology assessment (HTA) organizations and in clinical guidelines (CGs). METHODS: A targeted literature review was conducted using a two-stage search strategy. First, HTA reviews of manufacturers' drug submissions, reports from established HTA organizations (Europe, Canada, and Australia), and CGs from countries with and without HTA organizations, including the United States, were identified...
February 2019: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Thomas A Zelniker, Petr Jarolim, Michael G Silverman, Erin A Bohula, Jeong-Gun Park, Marc P Bonaca, Benjamin M Scirica, David A Morrow
Background Growth differentiation factor (GDF)-15 has been shown to predict cardiovascular (CV) outcomes in acute coronary syndrome (ACS) using non-commercial assays. We evaluated the prognostic performance of GDF-15 measured with the first clinically available assay. Furthermore, we evaluated whether GDF-15 was associated with CV death or heart failure (HF) across the spectrum of risk in non-ST-segment elevation (NSTE)-ACS. Methods We measured baseline GDF-15 (Roche, Elecsys) in 4330 patients with NSTE-ACS enrolled in MERLIN-TIMI 36...
February 2, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
Qingguo Lu, Xuan Li, Jia Liu, Xiaodong Sun, Thomas Rousselle, Di Ren, Nanwei Tong, Ji Li
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of anti-diabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injury, improving heart failure (HF) and ventricular remodeling, ameliorating vascular endothelial dysfunction, anti-chronic inflammation, anti-apoptosis and regulating autophagy...
February 1, 2019: Bioscience Reports
Meredith Hay, Robin Polt, Michael L Heien, Todd W Vanderah, Tally M Largen-Milnes, Kathleen E Rodgers, Torsten Falk, Mitchell J Bartlett, Kristian Doyle, John Konhilas
A growing body of evidence indicates that decreased brain blood flow, increased reactive oxygen species production (ROS), and pro-inflammatory mechanisms accelerate the progression of neurodegenerative diseases such as vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's disease and related dementias (ADRD). There is an urgent clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment known to occur in patients with VCID and chronic inflammatory diseases such as heart failure (HF), hypertension and diabetes...
February 1, 2019: Journal of Pharmacology and Experimental Therapeutics
S C Yang, Y C Chiu, P H Liu, T J Hsieh, Y H Kao, Y K Tu
Benign prostatic hyperplasia is one of the most common diseases in the elderly male population. The urinary tract symptoms may increase the risk of falls and fractures. The results indicated that patients with benign prostatic hyperplasia could increase the risk of vertebral compression fractures in both the thoracic and lumbar spine and also hip fractures, but did not increase the risk of wrist fracture. INTRODUCTION: The relationship between benign prostatic hyperplasia and the development of fall-related fractures, especially vertebral compression fractures, has been seldom mentioned in the literature...
January 31, 2019: Osteoporosis International
Emily Hanson, Mark Sheldon, Brenda Pacheco, Mohammed Alkubeysi, Veena Raizada
Friedreich's ataxia (FRDA), which occurs in 1/50000 live births, is the most prevalent inherited neuromuscular disorder. Nearly all FRDA patients develop cardiomyopathy at some point in their lives. The clinical manifestations of FRDA include ataxia of the limbs and trunk, dysarthria, diabetes mellitus, and cardiac diseases. However, the broad clinical spectrum makes FRDA difficult to identify. The diagnosis of FRDA is based on the presence of suspicious clinical factors, the use of the Harding criteria and, more recently, the use of genetic testing for identifying the expansion of a triplet nucleotide sequence...
January 26, 2019: World Journal of Cardiology
Elric Zweck, Julia Szendrödi, Malte Kelm, Michael Roden
Type 2 Diabetes mellitus (T2 D) is an independent risk factor for cardiovascular diseases and non-ischemic heart failure, an underestimated complication of T2 D. Diastolic dysfunction is an early sign of diabetes-related heart failure preceding its progression to systolic damage. The etiology of heart failure in these patients has recently been partially unveiled. Along with other mechanisms, hyperinsulinemia and hyperlipidemia cause increased myocardial lipid accumulation and oxidation, which leads to lipotoxicity, oxidative stress, inflammatory response and eventually impaired mitochondrial efficiency, fibrosis, apoptosis and contractile dysfunction...
February 2019: Deutsche Medizinische Wochenschrift
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