Periventricular Leucomalacia

THE AIM: Case study reports for the first time about development of massive iris neovascular complication in course of retinopathy of prematurity related to systemic and ocular ischemic syndrome due to tracheostomy-requiring extremely severe premature respiratory failure. MATERIAL AND METHOD: Premature female, 950 grams birth weight, born from 17-year-old gravida 1, at 28 weeks' gestation by cesarean section due to premature placental abruption with threatening hemorrhages, with 1 to 5 Apgar score...

BACKGROUND AND AIM: Children with periventricular leucomalacia (PVL) are known to have visual impairment of various forms starting from reduced vision, field defects, congnitive problems, and problems with hand eye coordination. There is very scant data/literature on the visual evoked potentials (VEPs) at an early age in children with PVL. We did a study to evaluate the flash visual evoked potentials (fVEPs) in children with PVL less than 1 year of age. MATERIALS AND METHODS: A total of nine children diagnosed as having PVL on magnetic resonance imaging were included in the study...

OBJECTIVE: To study associations between placental histopathology and neonatal outcome in preeclampsia (PE). STUDY DESIGN: The cohort consisted of 544 singleton pregnancies complicated by PE and managed at Karolinska University Hospital, Stockholm, Sweden during 2000-2009. Evaluation of placental histopathology was made by one senior perinatal pathologist, blinded to outcome. Clinical outcome was obtained from prospectively collected medical registry data and medical records...

AIM: To investigate the ophthalmological outcome of very preterm children at 2.5 years corrected age (CA) and perform a test of visuospatial and cognitive abilities. METHODS: A population-based, prospective study (LOVIS study) in Uppsala County, Sweden, comprised 111 very preterm children (<32 w gestational age [GA]) born between 1 January 2004 and 31 December 2007. Ophthalmic evaluations were undertaken in 98/109 children (89.9%) alive at 2.5 years. Spatial cognition was investigated with a test of five alternative blocks in 48 preterm and 25 term-born children...

BACKGROUND: Zinc plays a pivotal role in the pathogenesis of many diseases and in body growth. Preterm neonates have high zinc requirements. OBJECTIVE: The objective of the study was to investigate the efficacy of zinc supplementation in reducing morbidity and mortality in preterm neonates and to promote growth. DESIGN: This was a prospective, double-blind, randomized controlled study of very-low-birth-weight preterm neonates randomly allocated on the seventh day of life to receive (zinc group) or not receive (control group) oral zinc supplementation...

BACKGROUND: In women with a multiple pregnancy, spontaneous preterm delivery is the leading cause of perinatal morbidity and mortality. Interventions to reduce preterm birth in these women have not been successful. We assessed whether a cervical pessary could effectively prevent poor perinatal outcomes. METHODS: We undertook a multicentre, open-label randomised controlled trial in 40 hospitals in the Netherlands. We randomly assigned women with a multiple pregnancy between 12 and 20 weeks' gestation (1:1) to pessary or control groups, using a web-based application with a computer-generated list with random block sizes of two to four, stratified by hospital...

UNLABELLED: The use of assisted reproduction technologies is undoubtedly successful in the treatment of sterility. However it sets up numerous of issues for the obstetricians and neonatologists. AIMS: To evaluate the incidence, the specific problems and the neonatal outcome of newborns with very low birth weight (VLBW) <1500 g born from pregnancies after in vitro fertilization (IVF). METHODS: The study enrolled all 563 VLBW infants admitted in the NICU of the "Maichin Dom" hospital from 01...

BACKGROUND: Clinical spectrum of cerebral palsy (CP) is different in developing and developed countries. We evaluated the clinical profile, etiological factors and co-morbidities of children with CP in North India, and compared with our previous study. METHODS: 1212 children with CP registered in last 10 years in our rehabilitation center were compared with our previous study of 1000 children from same center. RESULTS: Spastic quadriplegia is the commonest type of CP (51...

OBJECTIVE: To present a series of children with enlarged optic disc excavation (EODE) and to define clinicaL parameters for additional investigational workup. MATERIALS AND METHODS: Retrospective review of medical records. RESULTS: Twelve children were included in this study. The average cup to disc ratio was 0.75 in both eyes. Indications for neuroimaging included: premature birth, a congenital syndrome, and visual field defects. Neuroimaging was also performed in 3 cases of incidental EODE...

BACKGROUND: The propensity for sustained inflammation after bacterial infection in neonates, resulting in inflammatory sequelae such as bronchopulmonary dysplasia and periventricular leucomalacia, is well known, but its molecular mechanisms remain elusive. Termination of inflammatory reactions physiologically occurs early after removal of bacteria by phagocytosis-induced cell death (PICD) of immune effector cells such as monocytes. PICD from cord blood monocytes (CBMOs) was shown to be reduced as compared with that of peripheral blood monocytes (PBMOs) from adult donors in vitro...

OBJECTIVE: To determine the prevalence of thoracic musculoskeletal alterations and associated factors in infants born prematurely. METHODS: This was a cross sectional study with infants in the first year of age, born prematurely with birth weight < 2,000 g, who were followed up at the Premature Clinic from February, 2007 to December, 2008. Exclusion criteria were: major congenital malformations as defined by the Centers for Disease Control and Prevention (CDC), grade III/IV intraventricular hemorrhage, or periventricular leucomalacia...

Uniplanar nystagmus has been described in relation to pathology of the brain stem, retina, optic nerve, sensory visual deprivation, periventricular leucomalacia, and drug toxicity. This paper describes a case of uniplanar nystagmus associated with features of higher visual dysfunction and a presumed focal insult to the occipital lobes following an episode of neonatal apnea.

BACKGROUND: Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity. OBJECTIVES: To assess the effects of immediate versus deferred delivery of preterm babies with suspected fetal compromise on neonatal, maternal and long-term outcomes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (27 February 2012)...

UNLABELLED: Asphyxia in neonates with inadequate blood-inner ear barrier function causes damage to the inner ear included the degeneration of outer hair cells of the organ of Corti and oedematous changes in stria vascularis. The major consequences in the central nervous system (CNS) are found to be hypoxic-ischemic encephalopathy (HIE) in term newborns, peri- (PVH) or intraventricular hemorrhages (IVH) and periventricular leucomalacia (PVL) in preterm neonates. THE AIM OF THE STUDY: was to carry out the objective assessment of the cochlea development using CEOAEs in infants with CNS impairment occurring as an effect of perinatal asphyxia, imaged during trans-fontanel ultrasonography...

UNLABELLED: Increased survival in infants weighing less than 1500g (VLBW) in recent decades is largely due to active perinatal management and intensive neonatal care. AIMS: To analyze the relationship between antenatal corticosteroid (ACS) administration, mode of delivery and the short term outcome in VLBW infants. METHODS: A total of 563 neonates weighing < 1500 g was studied between 01.01.2008 and 30.06.2010, distributed according the outcome into 3 groups: 330 healthy, 150 with chronic morbidities (bronchopulmonary dysplasia - supplemental O2 at 28 days, intraventricular hemorrhage gr...

AIM: Because New Caledonia is geographically isolated from the nearest cardiac surgical centre, surgical closure of ductus arteriosus is not performed in very low-birthweight (VLBW) infants who have a persistent patent ductus in spite of having undergone treatment with ibuprofen. This study aimed at investigating the possible effect of persistent patent ductus in VLBW infants. METHODS: The study included 177 VLBW infants born at 25-31 weeks of gestation from January 2006 to May 2011...

Transcranial ultrasonography is the most widely used neuroimaging technique in both premature and full term infants. The high susceptibility to hypoxia of the preterm brain explains the raised prevalence of intracranial haemorrhages at this group of patients. Ultrasound examination contributes to assessment of the neurologic status in children by diagnosing and staging of the intracranial bleeding, and brings informations about immediate and long term prognosis. The two major pictures of cerebral damage secondary to perinatal hypoxia are: peri and intraventricular haemorrhages and periventricular leucomalacia respectively...

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OBJECTIVE: To identify the disease processes underlying the increasing rate of gestational age-specific perinatal mortality observed under the fetuses-at-risk model. DESIGN: Retrospective cohort study. SETTING: USA and Nova Scotia, Canada. POPULATION: Births in the USA (1995 and 2005) and Nova Scotia, Canada (1988-2007). METHODS: Incidence rates of perinatal death and serious neonatal morbidity were calculated using the fetuses-at-risk approach (e...

OBJECTIVE: The aim of the study was to identify whether tumor necrosis factor-α (TNF-α) (-308) and interleukin (IL)-10 (-1082; -819) genotypes were associated with preterm delivery and cystic periventricular leucomalacia (PVL). STUDY DESIGN: Venous blood, buccal swabs or cord blood were collected from mother/child pairs with infants born at term (200) or preterm (106) in the presence and absence of neonatal PVL and of premature infants with PVL (7). Extracted genomic DNA served as template for determination of IL-10 (-1082), IL-10 (-819) and TNF-α (-308) genotypes by allele-specific PCR...