Yuqi Shi, Lin Wang, Yubing Hu, Yihan Zhang, Wenhao Le, Guohui Liu, Michael Tomaschek, Nan Jiang, Ali K Yetisen
Contact lens sensors have been emerging as point-of-care devices in recent healthcare developments for ocular physiological condition monitoring and diagnosis. Fluorescence sensing technologies have been widely applied in contact lens sensors due to their accuracy, high sensitivity, and specificity. As ascorbic acid (AA) level in tears is closely related to ocular inflammation, a fluorescent contact lens sensor incorporating a BSA-Au nanocluster (NC) probe is developed for in situ tear AA detection. The NCs are firstly synthesized to obtain a fluorescent probe, which exhibits high reusability through the quench/recover (KMnO4 /AA) process...
January 6, 2024: Biosensors & Bioelectronics