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Glycemic control for diabetes patient

Fatemeh Sadeghi, Saedeh Salehi, Ali Kohanmoo, Masoumeh Akhlaghi
Background: Due to high content of fructose, honey has been introduced as a suitable natural sweetener for patients with type 2 diabetes. We investigated the effect of honey consumption on glycemic control and anthropometric measures of patients with type 2 diabetes. Methods: This randomized controlled crossover clinical trial was conducted on 53 patients with type 2 diabetes. The participants were randomly divided into groups of control (weight maintenance diet) or treatment (weight maintenance diet +50 g/day honey) for 8 weeks...
2019: International Journal of Preventive Medicine
Eisei Hori, Chigusa Kikuchi, Kenro Imaeda, Naotsuka Okayama, Tadashi Suzuki, Tamihide Matsunaga
It is reported that statins have inconsistent effects on glycemic status and adiponectin concentrations in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the effect of statins on these variables in patients with T2DM and hypercholesterolemia. A control group comprising 24 patients with T2DM but without hypercholesterolemia was observed for more than 12 weeks, while 24 patients with T2DM and hypercholesterolemia were treated with statins for the same period (statin group). The percentage changes in the glycemic status (blood glucose and glycated hemoglobin [HbA1c]), and levels of plasma adiponectin (total and high molecular weight [HMW]) were compared between the two groups...
February 15, 2019: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Tetsuro Tsujimoto, Hiroshi Kajio
BACKGROUND: This study aimed to assess strategies of insulin-providing (IP) or insulin-sensitizing (IS) therapy for glycemic control in nonobese diabetic patients with coronary artery disease (CAD) with possibly higher cardiovascular risk and lower insulin secretion than obese diabetic patients with CAD. METHODS: We used data from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial to calculate hazard ratio (HR) with 95% confidence interval (95%CI) for outcome events in patients with type 2 diabetes and CAD using Cox proportional hazard models...
February 7, 2019: International Journal of Cardiology
Maria Pia Francescato, Miloš Ajčević, Agostino Accardo
Physical activity is a keystone of a healthy lifestyle as well as of management of patients with type 1 diabetes. The risk of exercise-induced hypoglycemia, however, is a great challenge for these patients. The glycemic response to exercise depends upon several factors concerning the patient him/herself (eg, therapy, glycemic control, training level) and the characteristics of the exercise performed. Only in-depth knowledge of these factors will allow to develop individualized strategies minimizing the risk of hypoglycemia...
February 15, 2019: Journal of Diabetes Science and Technology
Ichiro Nakamura, Hiroshi Maegawa, Kazuyuki Tobe, Satoshi Uno
INTRODUCTION: The present interim report of the STELLA-LONG TERM study aimed to examine the safety and effectiveness of ipragliflozin in real-word clinical practice in Japan using data up to 12 months. We also evaluated the effect of ipragliflozin on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with normal vs. abnormal liver function. METHODS: This is an ongoing 3-year post-marketing surveillance study. We analyzed data from Japanese type 2 diabetes mellitus (T2DM) patients who were first prescribed ipragliflozin between 17 July 2014 and 16 October 2015 at participating centers in Japan, and whose data were locked by 16 January 2018...
February 14, 2019: Advances in Therapy
Jasjeet S Wasir, Ambrish Mithal, Paras Agarwal, Apeksha Mittal
Aims: To evaluate the real-world efficacy, durability, and side-effect profile of once weekly GLP1RA: dulaglutide in Indian type 2 diabetes mellitus (T2DM) patients. Materials and Methods: A retrospective observational study. Data for efficacy (HbA1c and weight), adherence/discontinuation and patient reported side-effects, of 117 patients who were prescribed dulaglutide were analyzed. Results: Final analysis was done on complete data of 74 patients (6 months follow-up), this indicated that dulaglutide is effective (mean-reduction at 6 months of: HbA1c; 0...
November 2018: Indian Journal of Endocrinology and Metabolism
Erin S Morgan, Li-Jung Tai, Nguyen C Pham, Julia K Overman, Lynnetta M Watts, Anne Smith, Shiangtung W Jung, Martin Gajdošík, Martin Krššák, Michael Krebs, Richard S Geary, Brenda F Baker, Sanjay Bhanot
OBJECTIVE: To evaluate the safety and efficacy of IONIS-GCGRRx , a 2'- O -methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on stable metformin therapy. RESEARCH DESIGN AND METHODS: In three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGRRx (50-200 mg) or placebo for 13 or 26 weeks...
February 14, 2019: Diabetes Care
Maarten Coemans, Elisabet Van Loon, Evelyne Lerut, Pieter Gillard, Ben Sprangers, Aleksandar Senev, Marie-Paule Emonds, Jan Van Keer, Jasper Callemeyn, Liesbeth Daniëls, Jeroen Sichien, Geert Verbeke, Dirk Kuypers, Chantal Mathieu, Maarten Naesens
OBJECTIVE: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control. RESEARCH DESIGN AND METHODS: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. The effects of pretransplant diabetes and glycemic control (glycated hemoglobin levels) on the posttransplant histology were studied...
February 14, 2019: Diabetes Care
Charrise M Ramkissoon, Athur Bertachi, Aleix Beneyto, Jorge Bondia, Josep Vehi
The purpose of this study was to develop an algorithm that detects aerobic exercise and triggers disturbance rejection actions to prevent exercise-induced hypoglycemia. This approach can provide a solution to poor glycemic control during and after aerobic exercise, a major hindrance in the participation of exercise by patients with type 1 diabetes. This novel exercise-induced hypoglycemia reduction algorithm (EHRA) detects exercise using a threshold on a disturbance term, a parameter estimated from an augmented minimal model using an Unscented Kalman Filter...
February 11, 2019: IEEE Journal of Biomedical and Health Informatics
Joshua Steinberg, Lyndsay Carlson
A concise way to evaluate pharmacotherapy options for type 2 diabetes mellitus is to use the five patient-oriented STEPS criteria: safety, tolerability, efficacy, price, and simplicity. The first-line treatment option, metformin, is safe and fairly well-tolerated, has excellent long-term efficacy for patient-oriented outcomes, is moderately priced, and has a simple dosing regimen. However, most patients with type 2 diabetes require more than one medication. The STEPS approach can help choose subsequent medications if metformin does not provide adequate glycemic control...
February 15, 2019: American Family Physician
Alena Gerlinde Thiele, Maren Heckenmüller, Heike Bartelt, Sabine Klamt, Wieland Kiess, Thomas Michael Kapellen
OBJECTIVE: Continuous intravenous (IV) insulin infusion therapy minimizes blood glucose (BG) fluctuations and prevents metabolic deterioration in pediatric patients with type 1 diabetes (T1D) during intercurrent illness and surgery. However, data on the adequate fluid and insulin substitution in this situation is rare. We evaluated the effectiveness and safety of IV insulin therapy according to our local protocol. RESEARCH DESIGN AND METHODS: Retrospective study of 124 cases of hospitalization with IV insulin therapy due to intercurrent illness (n=78) or minor surgery (n=46) in 62 patients with T1D (mean age: 9...
February 13, 2019: Pediatric Diabetes
Remi Kodera, Yuko Chiba, Yoshiaki Tamura, Rieko Miyazawa, Ryoji Tanei, Seijiro Mori, Hideki Ito, Atsushi Araki
AIM: Bullous pemphigoid (BP) is an autoimmune skin disorder characterized by the production of autoantibodies. Several recent reports have described the occurrence of BP in diabetic patients treated with dipeptidyl peptidase-4 (DPP-4) inhibitors. However, the clinical features of BP in diabetic patients, particularly in those treated with DPP-4 inhibitors, have not yet been examined. The aim of this study was to clarify clinical characteristics of BP in elderly type 2 diabetic patients...
2019: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Xuemei Wang, Wei Shu, Jian Du, Maolin Du, Peiyu Wang, Mingming Xue, Huiqiu Zheng, Yufeng Jiang, Shaohua Yin, Danyan Liang, Ruiqi Wang, Lina Hou
BACKGROUND: As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective of this study was to carry out a systematic review and meta-analysis using the available literature reporting findings on mHealth interventions, which may improve the management of type 1 diabetes...
February 13, 2019: BMC Endocrine Disorders
Priscilla Hollander, Julie Hill, Jeremy Johnson, Zhi Wei Jiang, Gregory Golm, Susan Huyck, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring, Jie Liu
OBJECTIVE: To assess the safety and efficacy of ertugliflozin over 104 weeks in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin. METHODS: In this double-blind, multicenter, randomized, Phase III study (VERTIS SU; NCT01999218), adults with T2DM and glycated hemoglobin (HbA1c) 7.0-9.0% on metformin ≥1500 mg/day received ertugliflozin 5 mg, 15 mg, or glimepiride. The primary efficacy time point was Week 52; double-blinded treatment continued until Week 104...
February 14, 2019: Current Medical Research and Opinion
Asmaa M Zahran, Ismail L Mohamed, Osama M El Asheer, Deiaaeldin M Tamer, Mohamed G M Abo-ELela, Mona H Abdel-Rahim, Omnia H B El-Badawy, Khalid I Elsayh
BACKGROUND AND AIM: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile of circulating endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), endothelial and platelet derived micropaticles (EMPs, PMPs) and total microparticles (TMPs), in T1D children in relation to each other and to the metabolic disorders accompanying T1D...
January 2019: Clinical and Applied Thrombosis/hemostasis
Angelo Maria Patti, Dragana Nikolic, Antonio Magan-Fernandez, Rosaria Vincenza Giglio, Giuseppa Castellino, Roberta Chianetta, Roberto Citarrella, Egle Corrado, Francesca Provenzano, Vincenzo Provenzano, Giuseppe Montalto, Ali A Rizvi, Manfredi Rizzo
AIM: To evaluate the effect of exenatide long acting release (LAR) on carotid intima-media thickness (IMT) and endothelial function in patients with type 2 diabetes mellitus. METHODS: Sixty subjects with type 2 diabetes mellitus were treated with exenatide LAR as add-on to stable doses of metformin for 8 months in an open label study. Anthropometric variables, lipid profile and glycemic parameters were assessed by routine analysis. Carotid IMT by Doppler ultrasound and endothelial function by flow-mediated dilation of the brachial artery were also assessed...
February 10, 2019: Diabetes Research and Clinical Practice
Ewa Konduracka, Grażyna Cieślik, Maciej T Małecki, Grzegorz Gajos, Aleksander Siniarski, Krzysztof P Malinowski, Magdalena Kostkiewicz, Lucyna Mastalerz, Jadwiga Nessler, Wiesława Piwowarska
INTRODUCTION It is widely believed that patients with diabetes are at increased risk of severe and premature coronary artery disease (CAD) when compared to non-diabetic individuals. OBJECTIVES To evaluate the prevalence, 7-year incidence, predictors, and outcomes of obstructive and non-obstructive CAD in patients with long-lasting type 1 diabetes. PATIENTS AND METHODS We enrolled 2330 patients at a median age of 50 years with a median diabetes duration of 32 years. All study participants underwent diagnostic work-up for CAD with an exercise treadmill test (ETT) and/or single-photon emission computed tomography (SPECT)...
February 13, 2019: Polish Archives of Internal Medicine
Takumi Nishi, Akira Babazono, Toshiki Maeda
BACKGROUND: This study aimed to evaluate the effects of income levels on physician visit patterns and to quantify the consequent impact of irregular physician visits on glycemic control, among employees' health insurance beneficiaries in Japan. METHOD: We obtained specific health check-up data on untreated diabetes patients from the Fukuoka branch of the Japanese Health Insurance Association. We selected 2,981 insurance beneficiaries, and classified 650 and 2,331 patients into, respectively, the regular visit and irregular visit group...
February 13, 2019: Journal of Diabetes Investigation
Shaofang Lv, Shanlan Yu, Rongxiang Chi, Dongmei Wang
OBJECTIVES: To determine the effects of nutritional nursing intervention based on glycemic load (GL) for patients with gestational diabetes mellitus. MATERIAL AND METHODS: One hundred thirty-four patients diagnosed with gestational diabetes mellitus at our hospital were selected from March 2015 to March 2017 and randomly divided into the observation (n = 67) and control groups (n = 67). All of the patients in the observation and control groups received conventional nutritional nursing...
2019: Ginekologia Polska
Sérgio Azevedo, Joana Saraiva, Francisco Caramelo, Lúcia Fadiga, Luísa Barros, Carla Baptista, Miguel Melo, Leonor Gomes, Francisco Carrilho
INTRODUCTION: The use of continuous subcutaneous insulin infusion therapy in type 1 diabetes mellitus has increased due to its benefits on glycemic control and on the lifestyle flexibility. The aim of this study was to assess the impact of continuous subcutaneous insulin infusion therapy on glycemic control, body mass index, total daily dose of insulin and complications associated with this therapy, during 20 years of experience in Centro Hospitalar e Universitário de Coimbra. MATERIAL AND METHODS: This retrospective study included patients with type 1 diabetes mellitus who started continuous subcutaneous insulin infusion therapy up until 2005, followed at Centro Hospitalar e Universitário de Coimbra...
February 1, 2019: Acta Médica Portuguesa
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