keyword
https://read.qxmd.com/read/35863285/deep-anterior-lamellar-limbo-keratoplasty-for-bilateral-limbal-stem-cell-deficiency-with-corneal-scarring-in-chemical-injury-sequelae-two-case-reports
#21
JOURNAL ARTICLE
Neha Jain, Anahita Kate, Sayan Basu
INTRODUCTION AND IMPORTANCE: This report describes a new technique of deep anterior lamellar limbo-keratoplasty for the management of bilateral limbal stem cell deficiency (LSCD) with corneal scarring. PRESENTATION OF CASES: A 45-year-old male presented with chronic sequelae of ocular chemical injury and had bilateral total LSCD with corneal scarring. The visual acuity (VA) in the right eye was counting fingers. A large diameter deep anterior lamellar limbo-keratoplasty (DAL-LK) was carried out and the donor cornea and limbus were sourced from a single tissue...
July 14, 2022: International Journal of Surgery Case Reports
https://read.qxmd.com/read/35854963/reticular-epithelial-edema-after-penetrating-keratoplasty-in-a-patient-taking-netarsudil
#22
Lauren J Jeang, Ankit S Shah, Jon D Hammer, Sonal S Tuli
Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of netarsudil that has been described in patients with preexisting corneal edema. We report the case of a healthy 76-year-old woman who developed reticular epitheliopathy after full-thickness penetrating keratoplasty that completely resolved following discontinuation of the medication...
2022: Digital Journal of Ophthalmology: DJO
https://read.qxmd.com/read/35790322/scleral-contact-lenses-for-optimal-visual-recovery-in-a-case-of-severe-acid-burn-with-total-lagophthalmos
#23
JOURNAL ARTICLE
Simmy Chaudhary, Subhajit Chatterjee, Neha Jain, Sayan Basu
Chemical injuries can severely damage the ocular surface. We present the case of a man in his 40s with severe periocular chemical injury with total lid loss and severe exposure keratopathy. He sustained burns to 45% of his body surface area and needed tracheostomy and multiple full-thickness skin grafts. Both eyes required surgery, Boston type 1 keratoprosthesis and penetrating keratoplasty for the right and left eye, respectively. There was melting in the right eye and a persistent epithelial defect in the left eye...
July 5, 2022: BMJ Case Reports
https://read.qxmd.com/read/35467647/ex-vivo-and-in-vivo-animal-models-for-mechanical-and-chemical-injuries-of-corneal-epithelium
#24
JOURNAL ARTICLE
Kuo Hsuan Hung, Lung Kun Yeh
Corneal injury to the ocular surface, including chemical burn and trauma, may cause severe scarring, symblepharon, corneal limbal stem cells deficiency, and result in a large, persistent corneal epithelial defect. Epithelial defect with the following corneal opacity and peripheral neovascularization result in irreversible visual impairment and hinder future management, especially keratoplasty. Since the animal model can be used as an effective drug development platform, models of corneal injury to the mouse and alkali burn to rabbit corneal epithelium are developed here...
April 6, 2022: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/35384455/the-treatment-of-end-stage-corneal-disease-penetrating-keratoplasty-compared-with-boston-type-1-keratoprosthesis
#25
REVIEW
Steven Bonneau, C Maya Tong, Yelin Yang, Mona Harissi-Dagher
Penetrating keratoplasty (PKP) yields excellent results for restoring vision in end-stage corneal diseases. However, its success is limited to high-risk diseases such as aniridia, chemical burns, autoimmune corneal diseases, and herpetic eye disease. Boston type 1 keratoprosthesis (BKPro) offers another option to these patients. Since 1992, improvements in perioperative management and device construction have significantly increased the use of BKPro worldwide and challenged the therapeutic role of PKP in these patients...
September 2022: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/35062892/corneal-endothelial-regeneration-in-human-eyes-using-endothelium-free-grafts
#26
JOURNAL ARTICLE
Lu-Yi Ying, Wen-Ya Qiu, Bing-Hong Wang, Ping Zhou, Bei Zhang, Yu-Feng Yao
BACKGROUND: To report on corneal endothelial regeneration, graft clarity, and vision recovery when using endothelium-free grafts. METHODS: We evaluated the donor's cell viability using trypan blue staining and dual staining with calcein acetoxy methyl ester and ethidium homodimer-1. To preserve eyeball integrity, we performed therapeutic penetrating keratoplasty using cryopreserved donor tissue without endothelium on 195 consecutive patients who suffered from corneal perforation due to progressive primary corneal disease such as herpes simplex keratitis, fungal keratitis, ocular thermal burns, keratoconus, and phlyctenular keratoconjunctivitis...
January 21, 2022: BMC Ophthalmology
https://read.qxmd.com/read/34915928/pythium-insidiosum-keratitis-reported-in-china-raising-the-alertness-to-this-fungus-like-infection-a-case-series
#27
JOURNAL ARTICLE
Hongyan Hou, Yue Wang, Lei Tian, Feng Wang, Ziyong Sun, Zhongju Chen
BACKGROUND: The objective of this study is to report typical clinical and laboratory characteristics of three cases of keratitis caused by Pythium insidiosum in China. CASE PRESENTATION: Three Chinese patients of Han nationality diagnosed with Pythium keratitis from 2017 to 2019 were included. One 45-year-old female and one 55-year-old male were exposed to river water, and one 51-year-old female was burned by ash in the eyes. All of them are of Han ethnicity. Upon slit-lamp examination, subepithelial and superficial stromal opacities were observed in a reticular pattern...
December 17, 2021: Journal of Medical Case Reports
https://read.qxmd.com/read/34656930/mini-conjunctival-autograft-combined-with-deep-anterior-lamellar-keratoplasty-for-chronic-sequelae-of-severe-unilateral-chemical-burn-a-case-report
#28
JOURNAL ARTICLE
Anahita Kate, Sayan Basu
INTRODUCTION AND IMPORTANCE: This case describes a novel technique combining a mini-conjunctival limbal autograft (CLAU) with a deep anterior lamellar keratoplasty (DALK) in a case of chemical injury sequelae. CASE PRESENTATION: A 19-year-old female presented with total limbal stem cell deficiency (LSCD) and a vascularized corneal scar in the visual axis of the left eye, 4 years following a chemical injury. In order to treat the LSCD and simultaneously visually rehabilitate the patient, a mini-CLAU with DALK was carried out...
November 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/34581853/-partial-visual-rehabilitation-5-and-6-years-after-a-gundersen-total-conjunctival-flap-procedure
#29
REVIEW
Y Abu Dail, L Daas, F A Flockerzi, B Seitz
BACKGROUND: We present the results of penetrating keratoplasty (PKP) after previous treatment with a total conjunctival flap in two patients. CASE REPORTS: Patient 1, a 66-year-old with a history of bilateral cement chemical burn in 1986 and external right-sided limbokeratoplasty in 2008 was treated externally with a total conjunctival flap in the right eye in 2014 due to a persistent corneal ulcer with imminent perforation. Best-corrected visual acuity (BCVA) in the right eye was light sensation, intraocular pressure on palpation was within normal range...
February 2022: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://read.qxmd.com/read/34118425/long-term-outcomes-of-the-micof-keratoprosthesis-surgery
#30
JOURNAL ARTICLE
Liqiang Wang, Xiezhou He, Qun Wang, Tengyun Wu, Anqi Liu, Yifei Huang
PURPOSE: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat end-stage corneal blindness. DESIGN: Retrospective review of consecutive clinical case series. PARTICIPANTS: Between October 2000 and October 2015, at the Department of Ophthalmology of Chinese PLA General Hospital (PLAGH), a total of 132 eyes of 131 patients had undergone a MICOF keratoprosthesis implantation. Of those, 91 eyes of 90 patients were included in this study...
July 2021: Ocular Surface
https://read.qxmd.com/read/33892048/hyperosmolar-eye-drops-for-diurnal-corneal-edema-in-fuchs-endothelial-dystrophy-a-double-masked-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Daniel B Zander, Daniel Böhringer, Marianne Fritz, Viviane Grewing, Philip C Maier, Thabo Lapp, Thomas Reinhard, Katrin Wacker
PURPOSE: The Eye Drops for Early Morning-Associated Swelling (EDEMAS) trial assessed the efficacy of hyperosmolar eye drops on corneal edema resolution. DESIGN: Double-masked, randomized controlled trial of hyperosmolar eye drops. PARTICIPANTS: Participants with Fuchs' dystrophy scheduled for Descemet membrane endothelial keratoplasty. METHODS: One eye was randomized to hyperosmolar eye drops (treatment); the fellow eye was randomized to artificial tears (placebo)...
November 2021: Ophthalmology
https://read.qxmd.com/read/33674425/long-term-outcomes-of-boston-keratoprosthesis-type-i-the-chinese-people-s-liberation-army-general-hospital-experience
#32
JOURNAL ARTICLE
Li-Qiang Wang, Teng-Yun Wu, Xiao-Niao Chen, Ze-Quan Xu, Min Yang, Ran Xiang, Xiao Ma, Shan Zhang, Yi-Fei Huang
PURPOSE: To report the long-term outcomes of Boston keratoprosthesis type I (B-KPro type I) implantation in the management of severe ocular surface disorders. METHODS: Retrospective case series. Patients who underwent B-KPro type I implantation at the People's Liberation Army General Hospital were enrolled between March 2011 and September 2019. Data regarding visual acuity (VA), B-KPro type I retention and postoperative complications were recorded and analysed. RESULTS: A total of 103 eyes of 100 patients who underwent B-KPro type I implantation were included...
March 5, 2021: British Journal of Ophthalmology
https://read.qxmd.com/read/33399412/tnf-%C3%AE-inhibitors-for-the-management-of-intractable-corneal-melt-report-of-three-cases-and-review-of-the-literature
#33
REVIEW
Canan Asli Utine, Merih Birlik, Denizcan Özizmirliler, Ali Karakaş, Betül Akbulut, Ismet Durak
OBJECTIVE: To report three consecutive cases with noninfectious corneal melting, whose disease progression could only be halted with tumor necrosis-α (TNF-α) inhibitor infusion, with a review of the relevant literature. MATERIALS AND METHODS: Patients with toxic epidermal necrolysis, severe alkaline burn, and Sjögren syndrome had experienced severe corneal melting following penetrating keratoplasty, Boston type 1 keratoprosthesis implantation or spontaneously, respectively...
June 1, 2021: Eye & Contact Lens
https://read.qxmd.com/read/32693061/glaucoma-after-ocular-surgery-or-trauma-the-role-of-infiltrating-monocytes-and-their-response-to-cytokine-inhibitors
#34
JOURNAL ARTICLE
Xiaoniao Chen, Fengyang Lei, Chengxin Zhou, James Chodosh, Liqiang Wang, Yifei Huang, Claes H Dohlman, Eleftherios I Paschalis
Glaucoma is a frequent and devastating long-term complication following ocular trauma, including corneal surgery, open globe injury, chemical burn, and infection. Postevent inflammation and neuroglial remodeling play a key role in subsequent ganglion cell apoptosis and glaucoma. To this end, this study was designed to investigate the amplifying role of monocyte infiltration into the retina. By using three different ocular injury mouse models (corneal suture, penetrating keratoplasty, and globe injury) and monocyte fate mapping techniques, we show that ocular trauma or surgery can cause robust infiltration of bone marrow-derived monocytes into the retina and subsequent neuroinflammation by up-regulation of Tnf, Il1b, and Il6 mRNA within 24 hours...
October 2020: American Journal of Pathology
https://read.qxmd.com/read/32243421/topical-voriconazole-as-supplemental-treatment-for-acanthamoeba-keratitis
#35
JOURNAL ARTICLE
Aytan Musayeva, Jana C Riedl, Alexander K Schuster, Joanna Wasielica-Poslednik, Norbert Pfeiffer, Adrian Gericke
PURPOSE: Voriconazole was shown to inhibit ergosterol synthesis in various acanthamoeba species. The purpose of this study was to evaluate the clinical outcome of treatment with supplemental topical voriconazole in patients with acanthamoeba keratitis (AK). METHODS: All patients who had been treated for AK with voriconazole 1% drops in conjunction with topical first-line antiacanthamoeba therapy composed of polyhexamethylene biguanide (PHMB) 0.02% and propamidine isethionate 0...
March 24, 2020: Cornea
https://read.qxmd.com/read/32157841/-osteo-odonto-keratoprosthesis-a-tooth-to-regain-sight
#36
JOURNAL ARTICLE
P Grobet, B Duchesne, M Jaumotte, F Pepinster, Y Gilon
As the leading cause of blindness in the world, corneal diseases are second only to cataracts. However, the epidemiology of corneal disease is complex and includes a wide variety of infectious and inflammatory eye diseases (trachoma), immune sequelae (cicatricial pemphigoid on Lyell's disease) of after trauma (chemical burn). The general treatment for severe corneal disease is the corneal transplantation with penetrating keratoplasty. However, the failure of this treatment is virtually certain when the ocular surface is severely compromised...
March 2020: Revue Médicale de Liège
https://read.qxmd.com/read/32040009/early-application-of-bevacizumab-after-sclerocorneal-grafting-for-patients-with-severe-late-stage-ocular-chemical-burns
#37
JOURNAL ARTICLE
Shi-Tong Huang, Tao Zhou, Yuan-Xia Yang, Bin-Bing Zhou, Xiao-Fang Yin, Shi-You Zhou
PURPOSE: To investigate whether subconjunctival bevacizumab help prevent corneal graft neovascularization and prolong the graft survival of patients with chemical burns. METHODS: We performed a prospective nonrandomized comparative case series study. Twenty-six eyes received subconjunctival bevacizumab (10 mg/0.4 mL) once and topical immunosuppressive agents after sclerocorneal lamellar keratoplasty as the treatment, and 13 eyes received a topical immunosuppressant alone and served as the control group...
February 7, 2020: Cornea
https://read.qxmd.com/read/31923476/descemet-membrane-detachment
#38
REVIEW
Deepali Singhal, Pranita Sahay, Siddhi Goel, Mohamed Ibrahime Asif, Prafulla K Maharana, Namrata Sharma
Descemet membrane detachment (DMD) is a potential vision-threatening complication that occurs most commonly after cataract surgery. DMD has also been reported to occur in various other surgeries such as keratoplasty, iridectomy, vitrectomy, trabeculectomy, holmium laser sclerostomy, alkali burn, and viscocanalostomy. Major risk factors include advanced age, preexisting endothelial diseases like Fuchs dystrophy or abnormality in the Descemet membrane and stromal interface, hard cataract, prolonged surgical time, ragged clear corneal incisions, and inadvertent trauma with blunt instruments or phacoemulsification probe...
May 2020: Survey of Ophthalmology
https://read.qxmd.com/read/31724985/design-and-outcomes-of-a-novel-keratoprosthesis-addressing-unmet-needs-in-end-stage-cicatricial-corneal-blindness
#39
JOURNAL ARTICLE
Shaunak K Bakshi, John Graney, Eleftherios I Paschalis, Shweta Agarwal, Sayan Basu, Geetha Iyer, Christopher Liu, Bhaskar Srinivasan, James Chodosh
PURPOSE: The most commonly applied prosthetic devices for corneal blindness in the setting of severe cicatricial keratoconjunctivitis are the Boston keratoprosthesis type II and the modified osteo-odonto-keratoprosthesis, with these requiring either normal eyelid skin or a healthy cuspid tooth, respectively. For patients with neither attribute, we developed a new keratoprosthesis device combining positive aspects of both Boston keratoprosthesis type II and modified osteo-odonto-keratoprosthesis, which we have named the "Lux...
November 8, 2019: Cornea
https://read.qxmd.com/read/31469894/induction-of-fibroblast-senescence-during-mouse-corneal-wound-healing
#40
JOURNAL ARTICLE
Xiaolei Wang, Mingli Qu, Jing Li, Patrik Danielson, Lingling Yang, Qingjun Zhou
Purpose: To investigate the presence and role of fibroblast senescence in the dynamic process of corneal wound healing involving stromal cell apoptosis, proliferation, and differentiation. Methods: An in vivo corneal wound healing model was performed using epithelial debridement in C57BL/6 mice. The corneas were stained using TUNEL, Ki67, and α-smooth muscle actin (α-SMA) as markers of apoptosis, proliferation, and myofibroblastic differentiation, respectively...
August 1, 2019: Investigative Ophthalmology & Visual Science
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