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Emiri Miura, Naho Tsuchiya, Yu Igarashi, Ritsuko Arakawa, Etsuhiro Nikkuni, Tokiwa Tamai, Masao Tabata, Shinya Ohkouchi, Toshiya Irokawa, Hiromasa Ogawa, Takako Takai-Igarashi, Yoichi Suzuki, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto, Hajime Kurosawa
BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data...
February 12, 2019: Respiratory Investigation
Marcia Soares, Matthew Richardson, James Thorpe, John Owers-Bradley, Salman Siddiqui
The use of commercialised forced oscillation (FOT) devices to assess impedance in obstructive diseases such as asthma has gained popularity. However, it has yet to be fully established whether resistance and reactance measurements are comparable across different FOT devices, particularly in disease. We compared two commercially available FOT devices: Impulse Oscillometry (IOS) and TremoFlo FOT (Thorasys) in a) clinical adult population of healthy controls (n = 14), asymptomatic smokers (n = 17) and individuals with asthma (n = 73) and b) a 3D printed CT-derived airway tree model resistance, as well as a 3 L standardised volume reactance...
February 14, 2019: Scientific Reports
Stephen Milne, Kanika Jetmalani, David G Chapman, Joseph M Duncan, Claude S Farah, Cindy Thamrin, Gregory G King
Respiratory system reactance (Xrs) measured by the forced oscillation technique (FOT) is theoretically and experimentally related to lung volume. In chronic obstructive pulmonary disease (COPD), the absolute volume measured by body plethysmography includes a proportion which is inaccessible to pressure oscillations applied via the mouth - that is, a 'non-communicating' lung volume. We hypothesized that, in COPD, the presence of non-communicating lung would disrupt the expected Xrs-volume relationship when compared to plethysmographic functional residual capacity (FRCpleth )...
February 14, 2019: Journal of Applied Physiology
Kanokporn Udomittipong, Jurairut Triwatanawong, Akarin Nimmannit, Chulaluk Komoltri
BACKGROUND: Forced oscillation technique (FOT) requires minimal patient cooperation and is particularly useful in young children. Bronchodilator test is a valuable tool for wheezy and asthmatic patients. The cut-off value for bronchodilator response by FOT in healthy Thai children has not been reported. OBJECTIVE: To determine the cut-off values for positive bronchodilator response in healthy Thai preschool children using pseudorandom FOT. METHODS: FOT was used to measure respiratory function at baseline and after 400 mcg MDI salbutamol in healthy Thai children aged 3-6 years...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Andrew J Krum, Richard J Hanowski, Andrew Miller, Andy Schaudt, Susan Soccolich
One focus of the U.S. Federal Motor Carrier Safety Administration (FMCSA) is to provide leadership in the testing and evaluation of promising safety technologies developed for use in commercial motor vehicles (CMVs). To this end, a program was developed by FMCSA to conduct independent, short-turnaround evaluations of promising safety technologies. Vendors who had promising safety technologies, focused in the commercial vehicle domain, were solicited to participate and submit an application. One technology was selected by FMCSA for each evaluation cycle (lasting approximately 18 months)...
January 9, 2019: Accident; Analysis and Prevention
J L Wu, J X Hou
No matter what kind of therapies you choose, clear aligner treatment (CAT) or fixed orthodontic treatment (FOT), the therapy must be performed on the basis of periodontal health and follow the rule that the treatment cannot be harmful to the periodontal tissues. Doctors and patients prefer the clear aligner treatment because of its features, such as aesthetic, removable and comfortable. There are many studies which consider the influences of CAT on the periodontal health, and the conclusions are relatively consistent...
January 9, 2019: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Yoshitaka Isobe, Satoru Ito, Toshiaki Matsuda, Shingo Iwano, Akemi Uchida, Nobunori Takahashi, Toshihisa Kojima, Keiko Wakahara, Etsuro Yamaguchi, Yoshinori Hasegawa
The aim of this study was to examine long-term changes in pulmonary function and respiratory impedance (Zrs) as assessed by forced oscillation technique (FOT) of rheumatoid arthritis (RA)-related pulmonary disorders. Data of 42 RA patients who underwent pulmonary function tests and Zrs measurements at least twice at a >900-day interval were retrospectively reviewed. Zrs, respiratory resistance (Rrs) and reactance (Xrs), were measured as a function of oscillatory frequency from 4 to 36 Hz. The Rrs and difference between inspiratory and expiratory phases of Xrs were significantly decreased...
December 21, 2018: Respiratory Physiology & Neurobiology
Pinyapa Mukdjindapa, Wiparat Manuyakorn, Potjanee Kiewngam, Cherapat Sasisakulporn, Pisut Pongchaikul, Wasu Kamchaisatian, Suwat Benjaponpitak
BACKGROUND: The reference values of Forced Oscillation Technique (FOT) parameters of the inspiratory and expiratory phase for preschool children have not yet been established. OBJECTIVE: To evaluate FOT measures in Thai healthy preschool children. METHODS: Preschool children, aged 3-6 years, were screened. Children who were positive for the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for asthma, positive family history of allergic diseases, recent lower respiratory tract infections, and environmental tobacco smoke were excluded...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Yu-Chuan Wang, Bo Huang, Kang Li, Peng-Kang He, Er-Dong Chen, Yu-Long Xia, Jie Jiang, Qin-Hui Sheng, Jing Zhou, Yan-Sheng Ding
Objectives: To identify optimal predefined criteria (OPC) for filters of the VisiTag™ module in the CARTO 3 system during pulmonary vein isolation (PVI). Methods: Thirty patients with atrial fibrillation (AF) who experienced PVI first were enrolled. PVI was accomplished by using a Thermocool SmartTouch catheter. Ablation lesions were tagged automatically as soon as predefined criteria of the VisiTag™ module were met. OPC should be that ablation with the setting resulting in the conduction gap (CG) as few as possible, while contiguous encircling ablation line (CEAL) without the tag gap (TG) on the 3D anatomic model as much as possible...
2018: Cardiology Research and Practice
Behrouz Mostafavi, Sandra Diaz, Eeva Piitulainen, Berend C Stoel, Per Wollmer, Hanan A Tanash
Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to emphysema. A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was identified by the Swedish national neonatal AAT screening program in 1972-1974 and has been followed-up since birth. Our aim was to study whether the cohort has signs of emphysema in pulmonary function tests (PFTs) and computed tomography (CT) densitometry at 38 years of age in comparison with an age-matched control group, randomly selected from the population registry...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Ryan P Butzko, Anays M Sotolongo, Drew A Helmer, Jacquelyn C Klein-Adams, Omowunmi Y Osinubi, Andrew R Berman, Ronaldo Ortiz-Pacheco, Michael J Falvo
PURPOSE: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. METHODS: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV1 /FVC, FEV1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal...
November 30, 2018: Respiratory Physiology & Neurobiology
Diane M Gray, Dorottya Czovek, Lauren McMillan, Lidija Turkovic, Jacob A M Stadler, Anessa Vanker, Bence L Radics, Zoltan Gingl, Graham L Hall, Peter D Sly, Heather J Zar, Zoltán Hantos
RATIONALE: Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and non-invasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. OBJECTIVE: To investigate whether lung function derived from the intra-breath forced oscillation technique (FOT), was able to identify healthy infants at risk of LRTI in the first year. METHODS AND MEASUREMENTS: Lung function was measured with the novel intra-breath FOT, in six-week infants in a South African birth cohort (Drakenstein Child Health Study)...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Genny Raffaeli, Chiara Veneroni, Stefano Ghirardello, Anna Lavizzari, Sofia Passera, Fabio Mosca, Giacomo Cavallaro, Raffaele L Dellacà
Respiratory management during extracorporeal membrane oxygenation (ECMO) is complex. Assessment of lung mechanics might support a patient-tailored ventilatory strategy. We report, for the first time, the use of the forced oscillation technique (FOT) to evaluate lung function during neonatal ECMO to improve the individualization of respiratory support. The patient was a formerly preterm infant at a corrected age of 40 weeks (gestational age 32 weeks) undergoing veno-arterial ECMO for refractory respiratory failure secondary to influenza A (H1N1) pneumonia...
2018: Frontiers in Pediatrics
Ning Yang, Zhenming Ling, Liang Peng, Yanlai Liu, Pu Liu, Kai Zhang, Aman, Juanjuan Shi, Xiangkai Li
Fusarium oxysporum trypsin (FOT) is a fungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichiapastoris by engineering the natural propeptide APQEIPN. In this study, we constructed two recombinant enzymes with engineered amino acid sequences added to the N-terminus of FOT and expressed in P. pastoris . The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, and the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature (40°C) and pH (8...
September 28, 2018: Journal of Microbiology and Biotechnology
Caroline Oliveira Ribeiro, Alvaro Camilo Dias Faria, Agnaldo José Lopes, Pedro Lopes de Melo
Purpose: The aim of the present study was to evaluate the performance of the forced oscillation technique (FOT) for the early diagnosis of the effects of smoking and COPD. The contributions of the integer-order (InOr) and fractional-order (FrOr) models were also evaluated. Patients and methods: In total, 120 subjects were analyzed: 40 controls, 40 smokers (20.3±9.3 pack-years) and 40 patients with mild COPD. Results: Initially, it was observed that traditional FOT parameters and the InOr and FrOr models provided a consistent description of the COPD pathophysiology...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Enrico Lombardi, Valentina Fainardi, Claudia Calogero, Monia Puglia, Fabio Voller, Marina Cuttini, Franca Rusconi
OBJECTIVE: We assessed lung function and respiratory health in an area-based prospective cohort of preschool children born very preterm. DESIGN: Lung function was measured by interrupter respiratory resistance (Rint) and forced oscillation technique (FOT) (respiratory resistance (Rrs8), reactance (Xrs8), and area under the reactance curve (AX)) at a median age of 5.2 years in a cohort of 194 children born at 22-31 weeks of gestational age (GA) in Tuscany, Italy...
December 2018: Pediatric Pulmonology
Nengchao Lyu, Yue Cao, Chaozhong Wu, Jin Xu, Lian Xie
Deceleration lanes improve traffic flow by reducing interference, increasing capacity and enhancing safety. However, accident rates are higher on these interchange segments than on other freeway segments. It is important to attempt to reduce traffic accidents on these interchange segments by further exploring the behavior of different types of drivers on a highway deceleration lane. In this study, with field operational test (FOT) data from 89 driving instances (derived from 46 participants driving the test road twice) on a typical freeway deceleration lane, section speed profiles, vehicle trajectories, lane position and other key parameters were obtained...
September 17, 2018: Accident; Analysis and Prevention
L Starczewska-Dymek, A Bozek, M Jakalski
The forced oscillation technique (FOT) requires minimal patient cooperation and is useful for children. However, comprehensive values of respiratory impedance at baseline and after the reversibility test have not been definitively confirmed. The aim of this study was to evaluate the basic parameters of FOT reactance (Xrs) and resistance (Rrs) in groups of healthy children and children with controlled and uncontrolled asthma. The second aim was the assessment of the reversibility bronchial test using the forced oscillation method in children with bronchial asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
L S Jiang, B He
No abstract text is available yet for this article.
August 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Chiara Veneroni, Linda Wallström, Richard Sindelar, Raffaele L Dellacaʼ
BACKGROUND: We aimed to evaluate if lung mechanics measured by forced oscillatory technique (FOT) during the first day of life help identify extremely low gestational age newborns (ELGANs) at risk of prolonged mechanical ventilation (MV) and oxygen dependency. METHODS: Positive end-expiratory pressure (PEEP) was increased 2 cmH2 O above the clinically set PEEP, then decreased by four 5-min steps of 1 cmH2 O, and restored at the clinical value. At each PEEP, FOT measurements were performed bedside during MV...
February 2019: Pediatric Research
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