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Michael scott

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https://read.qxmd.com/read/30786091/coordinating-tissue-regeneration-through-tgf-%C3%AE-activated-kinase-1-tak1-in-activation-and-re-activation
#1
Hsiao Hsin Sung Hsieh, Shailesh Agarwal, David J Cholok, Shawn J Loder, Kieko Kaneko, Amanda Huber, Michael T Chung, Kavitha Ranganathan, Joe Habbouche, John Li, Jonathan Butts, Jonathan Reimer, Arminder Kaura, James Drake, Christopher Breuler, Caitlin R Priest, Joe Nguyen, Cameron Brownley, Jonathan Peterson, Serra Ucer Ozgurel, Yashar S Niknafs, Shuli Li, Maiko Inagaki, Greg Scott, Paul Krebsbach, Michael T Longaker, Kenneth Westover, Nathanael Gray, Jun Ninomiya-Tsuji, Yuji Mishina, Benjamin Levi
Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of TGF-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by re-activation to elicit differentiation and extracellular matrix (ECM) production...
February 20, 2019: Stem Cells
https://read.qxmd.com/read/30785895/transverse-tendon-stiffness-is-reduced-in-people-with-achilles-tendinopathy-a-cross-sectional-study
#2
Evan Finnamore, Charlotte Waugh, Lyndal Solomons, Michael Ryan, Christopher West, Alexander Scott
OBJECTIVES: The objective of the current cross-sectional study was to examine Achilles tendon transverse stiffness in a group of recreational runners with Achilles tendinopathy, in comparison to an asymptomatic group of runners with similar training history. We also aimed to determine the between-week intra-individual reliability of this measurement technique. DESIGN: Cross-sectional cohort study. METHODS: A hand-held dynamometer was used to assess the transverse stiffness of the Achilles tendon (AT) in twenty-five recreational runners...
2019: PloS One
https://read.qxmd.com/read/30785788/the-biospecimen-preanalytical-variables-program-a-multiassay-comparison-of-effects-of-delay-to-fixation-and-fixation-duration-on-nucleic-acid-quality
#3
Latarsha J Carithers, Rachana Agarwal, Ping Guan, Hana Odeh, Michael C Sachs, Kelly B Engel, Sarah R Greytak, Mary Barcus, Conrado Soria, Chih-Jian Jason Lih, P Mickey Williams, Philip A Branton, Leslie Sobin, Benjamin Fombonne, Therese Bocklage, Chris Andry, Elizabeth R Duffy, Gabriel Sica, Rajiv Dhir, Scott Jewell, Nancy Roche, Helen M Moore
CONTEXT.—: Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing remain largely unknown. OBJECTIVE.—: To elucidate molecular effects associated with clinically relevant preanalytical variability, the National Cancer Institute initiated the Biospecimen Preanalytical Variables (BPV) program. DESIGN.—: The BPV program, a well-controlled series of systematic, blind and randomized studies, investigated whether a delay to fixation (DTF) or time in fixative (TIF) affects the quantity and quality of DNA and RNA isolated from FFPE colon, kidney, and ovarian tumors in comparison to case-matched snap-frozen controls...
February 20, 2019: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/30784979/subcellular-control-of-membrane-excitability-in-the-axon
#4
REVIEW
Scott A Alpizar, In Ha Cho, Michael B Hoppa
Ion channels are microscopic pore proteins in the membrane that open and close in response to chemical and electrical stimuli. This simple concept underlies rapid electrical signaling in the brain as well as several important aspects of neural plasticity. Although the soma accounts for less than 1% of many neurons by membrane area, it has been the major site of measuring ion channel function. However, the axon is one of the longest processes found in cellular biology and hosts a multitude of critical signaling functions in the brain...
February 19, 2019: Current Opinion in Neurobiology
https://read.qxmd.com/read/30784673/effects-of-sacubitril-valsartan-on-biomarkers-of-extracellular-matrix-regulation-in-patients-with-hfref
#5
Michael R Zile, Eileen O'Meara, Brian Claggett, Margaret F Prescott, Scott D Solomon, Karl Swedberg, Milton Packer, John J V McMurray, Victor Shi, Martin Lefkowitz, Jean Rouleau
BACKGROUND: Myocardial fibrosis is an important pathophysiological mechanism underlying the development of heart failure (HF). Given the biochemical targets of sacubitril/valsartan, we hypothesized that circulating biomarkers reflecting the mechanisms that determine extracellular matrix (ECM) homeostasis, including collagen synthesis, processing, and degradation, are altered by sacubitril/valsartan in comparison to enalapril. OBJECTIVES: The purpose of this study was to examine the effects of sacubitril/valsartan on biomarkers of ECM homeostasis and the association between the rate of primary composite outcome (cardiovascular death or HF hospitalization) and these biomarkers...
February 26, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30784634/effect-of-10-valent-pneumococcal-conjugate-vaccine-on-the-incidence-of-radiologically-confirmed-pneumonia-and-clinically-defined-pneumonia-in-kenyan-children-an-interrupted-time-series-analysis
#6
Micah Silaba, Michael Ooko, Christian Bottomley, Joyce Sande, Rachel Benamore, Kate Park, James Ignas, Kathryn Maitland, Neema Mturi, Anne Makumi, Mark Otiende, Stanley Kagwanja, Sylvester Safari, Victor Ochola, Tahreni Bwanaali, Evasius Bauni, Fergus Gleeson, Maria Deloria Knoll, Ifedayo Adetifa, Kevin Marsh, Thomas N Williams, Tatu Kamau, Shahnaaz Sharif, Orin S Levine, Laura L Hammitt, J Anthony G Scott
BACKGROUND: Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of pneumococcal disease in low-income and middle-income countries is dominated by pneumonia, most of which is non-bacteraemic. We examined the effect of 10-valent PCV on the incidence of pneumonia in Kenya. METHODS: We linked prospective hospital surveillance for clinically-defined WHO severe or very severe pneumonia at Kilifi County Hospital, Kenya, from 2002 to 2015, to population surveillance at Kilifi Health and Demographic Surveillance System, comprising 45 000 children younger than 5 years...
March 2019: Lancet Global Health
https://read.qxmd.com/read/30783629/emergent-magnetic-monopole-dynamics-in-macroscopically-degenerate-artificial-spin-ice
#7
Alan Farhan, Michael Saccone, Charlotte F Petersen, Scott Dhuey, Rajesh V Chopdekar, Yen-Lin Huang, Noah Kent, Zuhuang Chen, Mikko J Alava, Thomas Lippert, Andreas Scholl, Sebastiaan van Dijken
Magnetic monopoles, proposed as elementary particles that act as isolated magnetic south and north poles, have long attracted research interest as magnetic analogs to electric charge. In solid-state physics, a classical analog to these elusive particles has emerged as topological excitations within pyrochlore spin ice systems. We present the first real-time imaging of emergent magnetic monopole motion in a macroscopically degenerate artificial spin ice system consisting of thermally activated Ising-type nanomagnets lithographically arranged onto a pre-etched silicon substrate...
February 2019: Science Advances
https://read.qxmd.com/read/30781818/characterization-of-spatial-air-pollution-patterns-near-a-large-railyard-area-in-atlanta-georgia
#8
Halley L Brantley, Gayle S W Hagler, Scott C Herndon, Paola Massoli, Michael H Bergin, Armistead G Russell
Railyards are important transportation hubs, and they are often situated near populated areas with high co-located density of manufacturing, freight movement and commercial enterprises. Emissions occurring within railyards can affect nearby air quality. To better understand the air pollution levels in proximity to a major railyard, an intensive mobile air monitoring study was conducted in May 2012 around a major railyard area in Atlanta, GA, constituted of two separate facilities situated side-by-side. A total of 19 multi-hour mobile monitoring sessions took place over different times of day, days of the week, and under a variety of wind conditions...
February 13, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30781798/profiling-volatile-constituents-of-homemade-preserved-foods-prepared-in-early-1950s-south-dakota-usa-using-solid-phase-microextraction-spme-with-gas-chromatography%C3%A2-mass-spectrometry-gc-ms-determination
#9
Lucas J Leinen, Vaille A Swenson, Hope L Juntunen, Scott E McKay, Samantha M O'Hanlon, Patrick Videau, Michael O Gaylor
An essential dimension of food tasting (i.e., flavor) is olfactory stimulation by volatile organic compounds (VOCs) emitted therefrom. Here, we developed a novel analytical method based on solid-phase microextraction (SPME) sampling in argon-filled gas sampling bags with direct gas chromatography⁻mass spectrometry (GC-MS) determination to profile the volatile constituents of 31 homemade preserves prepared in South Dakota (USA) during the period 1950⁻1953. Volatile profiles varied considerably, but generally decreased in detected compounds, complexity, and intensity over three successive 2-h SPME sampling periods...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30779174/prophylactic-pulmonary-vein-isolation-during-cavotricuspid-isthmus-ablation-for-atrial-flutter-a-meta-analysis
#10
Scott M Koerber, Mohit K Turagam, Sandeep Gautam, Jeffrey Winterfield, J Marcus Wharton, Dhanunjaya Lakkireddy, Michael R Gold
BACKGROUND: Atrial arrhythmias (AA), including atrial fibrillation (AF), have been reported in patients after cavotricuspid isthmus ablation (CTI) for typical atrial flutter (AFL). Several studies have examined the effect of performing concomitant pulmonary vein isolation (PVI) with CTI on recurrent AA. These studies were analyzed to determine the overall effect of this approach on recurrent AA. METHODS: PubMed and Google Scholar was searched for randomized trials comparing the incidence of AA after CTI versus CTI + PVI until June 2018...
February 18, 2019: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/30778252/subsets-of-exhausted-cd8-t-cells-differentially-mediate-tumor-control-and-respond-to-checkpoint-blockade
#11
Brian C Miller, Debattama R Sen, Rose Al Abosy, Kevin Bi, Yamini V Virkud, Martin W LaFleur, Kathleen B Yates, Ana Lako, Kristen Felt, Girish S Naik, Michael Manos, Evisa Gjini, Juhi R Kuchroo, Jeffrey J Ishizuka, Jenna L Collier, Gabriel K Griffin, Seth Maleri, Dawn E Comstock, Sarah A Weiss, Flavian D Brown, Arpit Panda, Margaret D Zimmer, Robert T Manguso, F Stephen Hodi, Scott J Rodig, Arlene H Sharpe, W Nicholas Haining
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood. Here we show that such therapy acts on a specific subpopulation of exhausted CD8+ tumor-infiltrating lymphocytes (TILs). Dysfunctional CD8+ TILs possess canonical epigenetic and transcriptional features of exhaustion that mirror those seen in chronic viral infection. Exhausted CD8+ TILs include a subpopulation of 'progenitor exhausted' cells that retain polyfunctionality, persist long term and differentiate into 'terminally exhausted' TILs...
March 2019: Nature Immunology
https://read.qxmd.com/read/30778226/protein-coding-variants-implicate-novel-genes-related-to-lipid-homeostasis-contributing-to-body-fat-distribution
#12
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie C Y Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul I W de Bakker, Simon de Denus, Renée de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dörr, Fotios Drenos, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna M M Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon L R Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Krämer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian'an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas G D Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O'Connell, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John R B Perry, Tune H Pers, Ailith Ewing, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin M A Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, Fernando Rivadeneira, Ingrid B Borecki, J Andrew Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltán Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth J F Loos, Kari E North, Cecilia M Lindgren
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants...
February 18, 2019: Nature Genetics
https://read.qxmd.com/read/30777000/glucose-modifies-the-effect-of-endovascular-thrombectomy-in-patients-with-acute-stroke
#13
Ángel Chamorro, Scott Brown, Sergio Amaro, Michael D Hill, Keith W Muir, Diederik W J Dippel, Wim van Zwam, Ken Butcher, Gary A Ford, Heleen M den Hertog, Peter J Mitchell, Andrew M Demchuk, Charles B L M Majoie, Serge Bracard, Igor Sibon, Ashutosh P Jadhav, Blanca Lara-Rodriguez, Aad van der Lugt, Elizabeth Osei, Arturo Renú, Sébastien Richard, David Rodriguez-Luna, Geoffrey A Donnan, Anand Dixit, Mohammed Almekhlafi, Sandrine Deltour, Jonathan Epstein, Benoit Guillon, Serge Bakchine, Meritxell Gomis, Richard du Mesnil de Rochemont, Demetrius Lopes, Vivek Reddy, Gernot Rudel, Yvo B W E M Roos, Alain Bonafe, Hans-Christoph Diener, Olvert A Berkhemer, Geoffrey C Cloud, Stephen M Davis, Robert van Oostenbrugge, Francis Guillemin, Mayank Goyal, Bruce C V Campbell, Bijoy K Menon
Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices])...
February 19, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30776994/impact-of-balloon-guide-catheter-use-on-clinical-and-angiographic-outcomes-in-the-stratis-stroke-thrombectomy-registry
#14
Osama O Zaidat, Nils H Mueller-Kronast, Ameer E Hassan, Diogo C Haussen, Ashutosh P Jadhav, Michael T Froehler, Reza Jahan, Mohammad Ali Aziz-Sultan, Richard P Klucznik, Jeffrey L Saver, Frank R Hellinger, Dileep R Yavagal, Tom L Yao, Rishi Gupta, Coleman O Martin, Hormozd Bozorgchami, Ritesh Kaushal, Raul G Nogueira, Ravi H Gandhi, Eric C Peterson, Shervin Dashti, Curtis A Given, Brijesh P Mehta, Vivek Deshmukh, Sidney Starkman, Italo Linfante, Scott H McPherson, Peter Kvamme, Thomas J Grobelny, Muhammad Shazam Hussain, Ike Thacker, Nirav Vora, Peng Roc Chen, Stephen J Monteith, Robert D Ecker, Clemens M Schirmer, Eric Sauvageau, Alex Bou Chebl, Colin P Derdeyn, Lucian Maidan, Aamir Badruddin, Adnan H Siddiqui, Travis M Dumont, Abdulnasser Alhajeri, Muhammad A Taqi, Khaled Asi, Jeffrey Carpenter, Alan Boulos, Gaurav Jindal, Ajit S Puri, Rohan Chitale, Eric M Deshaies, David Robinson, David F Kallmes, Blaise W Baxter, Mouhammed Jumaa, Peter Sunenshine, Aniel Majjhoo, Joey D English, Shuichi Suzuki, Richard D Fessler, Josser Delgado-Almandoz, Jerry C Martin, David S Liebeskind
Background and Purpose- Mechanical thrombectomy has been shown to improve clinical outcomes in patients with acute ischemic stroke. However, the impact of balloon guide catheter (BGC) use is not well established. Methods- STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter study of patients with large vessel occlusion treated with the Solitaire stent retriever as first-line therapy. In this study, an independent core laboratory, blinded to the clinical outcomes, reviewed all procedures and angiographic data to classify procedural technique, target clot location, recanalization after each pass, and determine the number of stent retriever passes...
February 19, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30776519/intra-arterial-dantrolene-for-refractory-cerebral-vasospasm-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#15
Michael Ortiz, Muhammad Jahngir, Kathryn Qualls, N Scott Litofsky, Premkumar Nattanmai, Adnan I Qureshi
BACKGROUND: Dantrolene has a safe side-effect profile and a mechanism of action that makes it attractive as an option for treatment of cerebral vasospasm. The authors report two cases of refractory cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that were successfully treated with intra-arterial dantrolene. CASE DESCRIPTIONS: Two patients, a 63-year-old woman and 36-year-old woman, developed severe vasospasm refractory to intra-arterial vasodilators after rupture of anterior communicating artery aneurysms...
February 15, 2019: World Neurosurgery
https://read.qxmd.com/read/30776374/cardiac-specific-deletion-of-gcn5l1-restricts-recovery-from-ischemia-reperfusion-injury
#16
Janet R Manning, Dharendra Thapa, Manling Zhang, Michael W Stoner, Javier Traba, Charles F McTiernan, Catherine Corey, Sruti Shiva, Michael N Sack, Iain Scott
GCN5L1 regulates mitochondrial protein acetylation, cellular bioenergetics, reactive oxygen species (ROS) generation, and organelle positioning in a number of diverse cell types. However, the functional role of GCN5L1 in the heart is currently unknown. As many of the factors regulated by GCN5L1 play a major role in ischemia-reperfusion (I/R) injury, we sought to determine if GCN5L1 is an important nexus in the response to cardiac ischemic stress. Deletion of GCN5L1 in cardiomyocytes resulted in impaired myocardial post-ischemic function and increased infarct development in isolated work-performing hearts...
February 15, 2019: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30775624/early-mortality-among-peritoneal-dialysis-and-hemodialysis-patients-who-transitioned-with-an-optimal-outpatient-start
#17
Hui Zhou, John J Sim, Simran K Bhandari, Sally F Shaw, Jiaxiao Shi, Scott A Rasgon, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Michael H Kanter, Steven J Jacobsen
Introduction: Lower early mortality observed in peritoneal dialysis (PD) compared with hemodialysis (HD) may be due to differential pre-end-stage renal disease (ESRD) care and the stable setting of transition to dialysis where PD starts are more frequently outpatient rather than during an unscheduled hospitalization. To account for these circumstances, we compared early mortality among a matched cohort of PD and HD patients who had optimal and outpatient starts. Methods: Retrospective cohort study performed among patients with chronic kidney disease (CKD) who transitioned to ESRD from 1 January 2002 to 31 March 2015 with an optimal start in an outpatient setting...
February 2019: KI Reports
https://read.qxmd.com/read/30775204/the-importance-of-determining-trainee-perspectives-on-procedural-competencies-during-spine-surgery-clinical-fellowship
#18
Antony H Bateman, Jeremie Larouche, Christina L Goldstein, Daniel M Sciubba, Theodore J Choma, Brandon Lawrence, Joseph Cheng, Michael G Fehlings, Scott J Paquette, Albert J M Yee
Study Design: Longitudinal survey. Objective: It remains important to align competence-based objectives for training as deemed important by clinical fellows to those of their fellowship supervisors and program educators. The primary aim of this study was to determine trainee views on the relative importance of specific procedural training competencies. Secondarily, we aimed to evaluate self-perceived confidence in procedural performance at the commencement and completion of fellowship...
February 2019: Global Spine Journal
https://read.qxmd.com/read/30774981/a-phenome-wide-association-study-to-discover-pleiotropic-effects-of-pcsk9-apob-and-ldlr
#19
Maya S Safarova, Benjamin A Satterfield, Xiao Fan, Erin E Austin, Zhan Ye, Lisa Bastarache, Neil Zheng, Marylyn D Ritchie, Kenneth M Borthwick, Marc S Williams, Eric B Larson, Aaron Scrol, Gail P Jarvik, David R Crosslin, Kathleen Leppig, Laura J Rasmussen-Torvik, Sarah A Pendergrass, Amy C Sturm, Bahram Namjou, Amy Sanghavi Shah, Robert J Carroll, Wendy K Chung, Wei-Qi Wei, QiPing Feng, C Michael Stein, Dan M Roden, Teri A Manolio, Daniel J Schaid, Joshua C Denny, Scott J Hebbring, Mariza de Andrade, Iftikhar J Kullo
We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes PCSK9 , APOB , and LDLR . Using high-density genotype data, we tested the associations of variants in the three genes with 1232 EHR-derived binary phecodes in 51,700 European-ancestry (EA) individuals and 585 phecodes in 10,276 African-ancestry (AA) individuals; 457 PCSK9 , 730 APOB , and 720 LDLR variants were filtered by imputation quality ( r 2  > 0...
2019: NPJ Genomic Medicine
https://read.qxmd.com/read/30773988/diagnostic-algorithms-to-study-post-concussion-syndrome-using-electronic-health-records-validating-a-method-to-capture-an-important-patient-population
#20
Jessica Dennis, Aaron Michael Yengo-Kahn, Paul Kirby, Gary S Solomon, Nancy J Cox, Scott L Zuckerman
Post-concussion syndrome (PCS) is characterized by persistent cognitive, somatic, and emotional symptoms after a mild traumatic brain injury (mTBI). Genetic and other biological variables may contribute to PCS etiology, and the emergence of biobanks linked to electronic health records (EHR) offers new opportunities for research on PCS. We sought to validate the use of EHR data of PCS patients by comparing two diagnostic algorithms deployed in the Vanderbilt University Medical Center de-identified database of 2...
February 16, 2019: Journal of Neurotrauma
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