Lingjuan Wang, Yang Liu, Yinhua Song, Qiaojuan Mei, Hongbei Mou, Jiachen Wu, Xinyu Tang, Jihui Ai, Kezhen Li, Houxiu Xiao, Xiaotao Han, Liqun Lv, Huaibiao Li, Ling Zhang, Wenpei Xiang
Ovarian aging reduced the quality of oocytes, resulting in age-related female infertility. It is reported that mesenchymal stem cells (MSCs) therapy can improve age-related ovarian function decline and the success rate of in vitro maturation (IVM) in assisted reproductive therapy. In order to investigate the effectiveness and mechanisms of MSCs to enhance oocyte quality of cumulus oocyte complexes (COCs) in advanced age, this study focus on the respective functional improvement of oocytes and granulosa cells (GCs) from aging mice and further to explore and verify the possible mechanisms...
March 26, 2024: Reproductive Sciences