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Thomas W McDade, Calen P Ryan, Meaghan J Jones, Morgan K Hoke, Judith Borja, Gregory E Miller, Christopher W Kuzawa, Michael S Kobor
OBJECTIVES: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines. METHODS: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20...
February 16, 2019: American Journal of Physical Anthropology
Jonathan D Miller, Adam J Sterczala, Michael A Trevino, Mandy E Wray, Hannah L Dimmick, Trent J Herda
PURPOSE: Previous research has indicated greater muscle activation is needed for children (CH) to match relative intensity submaximal contractions in comparison with adults (AD). However, no study has compared motor unit (MU) firing and recruitment patterns between children and adults. Therefore, MU action potential amplitudes (MUAPAMP ) and firing rates were examined during two repetitive submaximal contractions of the first dorsal interosseous in children and adults. METHODS: Twenty-two children (age 9...
February 15, 2019: European Journal of Applied Physiology
Sherene Loi, Sathana Dushyanthen, Paul A Beavis, Roberto Salgado, Carsten Denkert, Peter Savas, Susan Combs, David L Rimm, Jennifer M Giltnane, Monica V Estrada, Violeta Sánchez, Melinda E Sanders, Rebecca S Cook, Mark A Pilkinton, Simon A Mallal, Kai Wang, Vincent A Miller, Phil J Stephens, Roman Yelensky, Franco D Doimi, Henry Gómez, Sergey V Ryzhov, Phillip K Darcy, Carlos L Arteaga, Justin M Balko
No abstract text is available yet for this article.
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Alice C O'Farrell, Ian S Miller, Rhys Evans, Marina Alamanou, Maurice Cary, Girish Mallya Udupi, Adam Lafferty, Naser Monsefi, Mattia Cermona, Jochen Hm Prehn, Henk M Verheul, William M Gallagher, Mathias Gehrmann, Annette T Byrne
The tyrosine kinase inhibitor (TKI) sunitinib is a multi-targeted agent approved across multiple cancer indications. Nevertheless, since approval, data has emerged to describe a worrisome side effect profile including hypertension, hand-foot syndrome, fatigue, diarrhoea, mucositis, proteinuria and (rarely) congestive heart failure. It has been hypothesised that the observed multi-parameter toxicity profile is related to 'on-target' kinase inhibition in 'off-target' tissues. Herein, to interrogate off-target effects in pre-clinical studies, a reverse phase protein array (RPPA) approach was employed...
February 15, 2019: Proteomics. Clinical Applications
Kengo Hanaya, Jun Ohata, Mary K Miller, Alicia E Mangubat-Medina, Michael J Swierczynski, David C Yang, Reece M Rosenthal, Brian V Popp, Zachary T Ball
S-Arylation of cysteine residues is an increasingly powerful tool for site-specific modification of proteins, providing novel structure and electronic perturbation. The present work demonstrates an operationally-simple cysteine arylation reaction 2-nitro-substituted arylboronic acids, promoted by a simple nickel(ii) salt. The process exhibits strikingly fast reaction rates under physiological conditions in purely aqueous media with excellent selectivity toward cysteine residues. Cysteine arylation of natural proteins and peptides allows attachment of useful reactive handles for stapling, imaging, or further conjugation...
February 15, 2019: Chemical Communications: Chem Comm
Robert Ws Coulter, Jordan M Sang, William Louth-Marquez, Emmett R Henderson, Dorothy Espelage, Simon C Hunter, Matthew DeLucas, Kaleab Z Abebe, Elizabeth Miller, Brooke A Morrill, Kimberly Hieftje, Mark S Friedman, James E Egan
BACKGROUND: Sexual and gender minority youth (SGMY; eg, lesbian, gay, bisexual, and transgender youth) experience myriad substance use and mental health disparities compared with their cisgender (nontransgender) heterosexual peers. Despite much research showing these disparities are driven by experiences of bullying and cyberbullying victimization, few interventions have aimed to improve the health of bullied SGMY. One possible way to improve the health of bullied SGMY is via a Web-accessible game intervention...
February 15, 2019: JMIR Research Protocols
Zoe A Miller, Ayush Amin, Joanthan Tu, Ana Echenique, Ronald S Winokur
The current model for medical education is based on the Master-Apprentice model which was adopted into practice over a century ago. Since then, there have been many changes in healthcare and the environment in which trainees learn, practice and become proficient in procedural and critical thinking skills. The current model for medical education has however, not changed considerably in this time frame, resulting in significant limitations to trainee education. Simulator-based training is a technique which can minimize the limitations of the apprenticeship model by mitigating the effect of time constraints, increased emphasis on patient safety and satisfaction and nonstandardization of Interventional Radiology (IR) curricula...
March 2019: Techniques in Vascular and Interventional Radiology
J L Klotz, J L Britt, M F Miller, M A Snider, G E Aiken, N M Long, S L Pratt, J G Andrae, S K Duckett
Previous research has shown that livestock exposed to ergot alkaloids results in decreased vasoactivity of gastrointestinal and peripheral vasculature. Little is known regarding the effect ergot alkaloid exposure during gestation may have on vasculature supporting the fetus. The objective of this study was to evaluate contractile responses of uterine and umbilical arteries collected from ewes consuming ergot alkaloids during gestation. On d 35 of gestation, 36 Suffolk ewes (78.24 ±9.5 kg) were assigned to endophyte-infected (E+) or endophyte-free (E-) tall fescue seed treatments that were fed either throughout or switched on d 86 of gestation, creating four seed treatments E+E+, E+E-, E-E+, E-E-...
February 14, 2019: Journal of Animal Science
Susan S Huang, Raveena Singh, James A McKinnell, Steven Park, Adrijana Gombosev, Samantha J Eells, Daniel L Gillen, Diane Kim, Syma Rashid, Raul Macias-Gil, Michael A Bolaris, Thomas Tjoa, Chenghua Cao, Suzie S Hong, Jennifer Lequieu, Eric Cui, Justin Chang, Jiayi He, Kaye Evans, Ellena Peterson, Gail Simpson, Philip Robinson, Chester Choi, Charles C Bailey, James D Leo, Alpesh Amin, Donald Goldmann, John A Jernigan, Richard Platt, Edward Septimus, Robert A Weinstein, Mary K Hayden, Loren G Miller
BACKGROUND: Hospitalized patients who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) are at high risk for infection after discharge. METHODS: We conducted a multicenter, randomized, controlled trial of postdischarge hygiene education, as compared with education plus decolonization, in patients colonized with MRSA (carriers). Decolonization involved chlorhexidine mouthwash, baths or showers with chlorhexidine, and nasal mupirocin for 5 days twice per month for 6 months...
February 14, 2019: New England Journal of Medicine
Robbie P Miller, Marie E Berlouis, Alan G Hall, A Hamish R W Simpson, Innes D M Smith, Andrew C Hall
OBJECTIVE: Septic arthritis results from joint infection by Staphylococcus aureus, which produces potent α-toxin causing cell death, potentially leading to permanent cartilage damage. Treatment is by joint irrigation and antibiotics, although it is unclear if, following treatment with antibiotics which cause bacterial lysis, there is release of additional stored α-toxin. DESIGN: A rabbit erythrocyte hemolysis assay was optimised to assess biologically-active α-toxin from cultured S...
February 14, 2019: Cartilage
Boris A Noskov, Kirill Timoshen, Alexander V Akentiev, Nikolay S Chirkov, Ignat Dubovsky, Vasili Lebedev, Shi-Yow Lin, Giuseppe Loglio, Reinhard Miller, Victor Sedov, Alina Borisenkova
Application of the dilational surface rheology, surface tensiometry, ellipsometry, Brewster angle, transmission electron and atomic force microscopies allowed estimation of the structure of the adsorption layer of a fullerenol with a large number of hydroxyl groups, C60(OH)X (X = 30 ±2). The surface properties of fullerenol solutions proved to be similar to the properties of dispersions of solid nanoparticles and differ from those of the solutions of conventional surfactants and amphiphilic macromolecules...
February 14, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Monica Margoni, Maria Petracca, Simona Schiavi, Michelle Fabian, Aaron Miller, Fred D Lublin, Matilde Inglese
BACKGROUND: Diffuse white matter (WM) injury is prominent in primary progressive multiple sclerosis (PP-MS) pathology and is a potential biomarker of disease progression. Diffusion Kurtosis Imaging (DKI) allows the quantification of non-Gaussian water diffusion, providing metrics with high WM pathological specificity. OBJECTIVE: To characterize the pathological changes occurring in the normal appearing white matter (NAWM) of patients with PP-MS at baseline and at 1-year follow-up and to assess their impact on disability and short-term disease progression...
February 13, 2019: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Peter S Pressman, Kelly Gola, Suzanne M Shdo, Bruce L Miller, Carolyn Fredericks, Clinton Mielke, Victoria Pelak, Katherine P Rankin
OBJECTIVE: To compare recognition of facial expression (FE) vs recognition of facial identity (FI) in posterior cortical atrophy (PCA), with the hypothesis that FE recognition would be relatively preserved in PCA. METHODS: In this observational study, FI and expression recognition tasks were performed by 194 participants in 4 groups, including 39 with Alzheimer disease (AD) (non-PCA), 49 with behavioral variant frontotemporal dementia (bvFTD), 15 with PCA, and 91 healthy controls...
February 13, 2019: Neurology
Joseph M Jacob, Elizabeth K Ferry, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, Shakti Ramkissoon, Eric Severson, Andrea Necchi, J Keith Killian, Siraj M Ali, Alexa B Schrock, Nick W Liu, J Chung, V A Miller, P J Stephens, A Welsh, Robert J Corona, Jeffrey S Ross, Gennady Bratslavsky
PURPOSE: Metastatic penile squamous cell carcinoma is an aggressive malignancy with limited treatment options. We compared the potential therapy impacting genomic alterations between metastatic penile squamous cell carcinoma and nonpenile metastatic cutaneous squamous cell carcinoma. MATERIALS AND METHODS: DNA was extracted from 40 μ of formalin fixed, paraffin embedded samples from 78 cases of metastatic penile squamous cell carcinoma and 338 of metastatic cutaneous squamous cell carcinoma...
March 2019: Journal of Urology
Michael O Rivett, Laura Budimir, Nicholas Mannix, Alexandra V M Miller, Marc J Addison, Phideria Moyo, Gift J Wanangwa, Owen L Phiri, Chrispine E Songola, Muthi Nhlema, Mavuto A S Thomas, Reid T Polmanteer, Amando Borge, Robert M Kalin
Effective response to groundwater salinity in the developing world may critically safeguard drinking-water supplies. Groundwater resources throughout rural Africa are exploited by a vast and increasing number of hand-pumped boreholes for community supply. Our research in TA Ngabu (Shire Valley), Southern Malawi aims to: define groundwater-salinity problem occurrence within the semi-arid alluvial-valley aquifer, rural developing-world setting; critique current capacity to respond; and, to discuss future response options - in particular considering the need to explore alternative options that boldly go beyond the world of hand-pumped groundwater supply...
February 25, 2019: Science of the Total Environment
Jenessa S Price, Sadie E Larsen, Lawrence A Miller, Heather M Smith, Jennifer A Apps, Jo M Weis
Nutrition deficits are common in patients with chronic illnesses reliant upon nutrition support and can contribute to an increase in cognitive deficits that impact treatment adherence and challenge patients' abilities to cope and successfully implement appropriate psychological and psychosocial interventions. Adopting a multidisciplinary approach addresses biological, psychological, and social barriers that help patients, families, and caregivers develop and maintain proper nutrition behaviors that can enhance patients' quality of life and reduce frustration and misunderstandings with medical providers...
February 12, 2019: Nutrition in Clinical Practice
James A McKinnell, Raveena D Singh, Loren G Miller, Ken Kleinman, Gabrielle Gussin, Jiayi He, Raheeb Saavedra, Tabitha D Dutciuc, Marlene Estevez, Justin Chang, Lauren Heim, Stacey Yamaguchi, Harold Custodio, Shruti K Gohil, Steven Park, Steven Tam, Philip A Robinson, Thomas Tjoa, Jenny Nguyen, Kaye D Evans, Cassiana E Bittencourt, Bruce Y Lee, Leslie E Mueller, Sarah M Bartsch, John A Jernigan, Rachel B Slayton, Nimalie D Stone, Matthew Zahn, Vincent Mor, Kevin McConeghy, Rosa R Baier, Lynn Janssen, Kathleen O'Donnell, Robert A Weinstein, Mary K Hayden, Micaela H Coady, Megha Bhattarai, Ellena M Peterson, Susan S Huang
Background: Multidrug-resistant organisms (MDROs) spread between hospitals, nursing homes (NH), and long-term acute care facilities (LTACs) via patient transfers. SHIELD OC is a regional public health collaborative involving decolonization at 38 healthcare facilities selected based upon their high degree of patient sharing. We report baseline MDRO prevalence in 21 NH/LTACs. Methods: A random sample of 50 adults for 21 NH/LTACs (18 NHs, 3 LTACs) were screened for methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus spp...
February 11, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Katherine L Wisner, Emily S Miller, Darius Tandon
No abstract text is available yet for this article.
February 12, 2019: JAMA Psychiatry
Tyler M Bauer, Myles S Dworkin, Stanton B Miller, Charles J Yeo, Scott W Cowan
No abstract text is available yet for this article.
November 1, 2018: American Surgeon
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