keyword
https://read.qxmd.com/read/36765890/niclosamide-revitalizes-sorafenib-through-insulin-like-growth-factor-1-receptor-igf-1r-stemness-and-metabolic-changes-in-hepatocellular-carcinoma
#21
JOURNAL ARTICLE
Syue-Wei Peng, Mai-Huong T Ngo, Yung-Che Kuo, Ming-Hao Teng, Chin-Lin Guo, Hung-Cheng Lai, Te-Sheng Chang, Yen-Hua Huang
Sorafenib is the first approved systemic targeting agent for advanced HCC; however, when used alone, drug resistance can result in considerably reduced efficacy. Here, we demonstrate that niclosamide, an antihelminthic agent approved by the US Food and Drug Administration, can be repurposed to increase sorafenib sensitivity in sorafenib-resistant HCC cells. We generated sorafenib-resistant HCC cell lines (HepG2215_R and Hep3B_R) with elevated IGF-1R levels and strong properties in terms of stemness and epithelial-mesenchymal transition...
February 1, 2023: Cancers
https://read.qxmd.com/read/36727994/similar-responses-in-the-akt-protein-kinase-b-signaling-pathway-following-different-lower-body-exercise-volumes-in-recreationally-active-men
#22
JOURNAL ARTICLE
Jeremy R Pearson, Nicole Moodie, Kevan W Stout, William C Hawkins, Mallory Matuszek, Zachary A Graham, Jacob A Siedlik, John P Vardiman, Philip M Gallagher
Pearson, JR, Moodie, N, Stout, KW, Hawkins, WC, Matuszek, M, Graham, ZA, Siedlik, JA, Vardiman, JP, and Gallagher, PM. Similar responses in the Akt/protein kinase B (PKB) signaling pathway after different lower-body exercise volumes in recreationally active men. J Strength Cond Res XX(X): 000-000, 2022-This project examined the differences between a single set (SS) compared to multiple sets (MS) of resistance exercise on the Akt/protein kinase B (PKB) signaling pathway, the expression of insulin-like growth factor-1 (IGF-1), and the receptor for IGF-1 (IGF-1R) to better understand the types of resistance training protocols that are most beneficial in stimulating the muscle hypertrophic response...
January 18, 2023: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/36696581/redundant-signaling-as-the-predominant-mechanism-for-resistance-to-antibodies-targeting-igf-1r-in-cells-derived-from-childhood-sarcoma
#23
JOURNAL ARTICLE
Terry J Shackleford, Seethalakshmi Hariharan, Angelina V Vaseva, Karina Alagoa, Maricruz Espinoza, Hemant K Bid, Fuyang Li, Haihong Zhong, Doris A Phelps, Ryan D Roberts, Hakan Cam, Cheryl A London, Denis C Guttridge, Yidong Chen, Manjeet Rao, Yuzuru Shiio, Peter J Houghton
Antibodies targeting IGF-1R induce objective responses in only 5-15% of children with sarcoma. Understanding mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R-targeted antibodies. Sensitivity to the IGF1R-targeting antibody TZ-1 was determined in rhabdomyosarcoma (RMS) and Ewing sarcoma (EWS) cell lines. Acquired resistance to TZ-1 was developed and characterized in sensitive Rh41 cells. BRD4 inhibitor, JQ1 was evaluated as an agent to prevent acquired TZ-1 resistance in Rh41 cells...
January 24, 2023: Molecular Cancer Therapeutics
https://read.qxmd.com/read/36499281/n-linked-glycosylation-in-chinese-hamster-ovary-cells-is-critical-for-insulin-like-growth-factor-1-signaling
#24
JOURNAL ARTICLE
Rupashree Salvi, Chandan Kumar, Krupanshi Brahmbhatt, Rambhadur Subedi, Susan Idicula-Thomas, Taruna Madan, Barnali Biswas
Cell surface proteins carrying N-glycans play important roles in inter- and intracellular processes including cell adhesion, development, and cellular recognition. Dysregulation of the glycosylation machinery has been implicated in various diseases, and investigation of global differential cell surface proteome effects due to the loss of N-glycosylation will provide comprehensive insights into their pathogenesis. Cell surface proteins isolated from Parent Pro-5 CHO cells (W5 cells), two CHO mutants with loss of N-glycosylation function derived from Pro-5 CHO (Lec1 and Lec4 cells), were subjected to proteome analysis via high-resolution LCMS...
November 29, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36496177/porcine-igf-1r-synonymous-mutations-in-the-extracellular-domain-affect-proliferation-and-differentiation-of-skeletal-muscle-cells
#25
JOURNAL ARTICLE
Zhaoguo Wang, Chunli Wang, Ying Zhang, Songcai Liu, Yunyun Cheng, Siyao Wang, Peijun Xia, Linlin Hao
OBJECTIVE: Miniature pigs are considered ideal organ donors for xenotransplantation in humans, but the mechanism underlying their dwarfism remains to be elucidated. IGF-1R is a crucial factor in body size formation in mammals, including skeletal muscle formation and development. The extracellular domain (ECD) binds to the ligand, a phenomenon that results in the activation of downstream pathways. METHODS: In this study, the coding sequences of two IGF-1R ECD haplotypes of the large Landrace (LP) pig and the small Bama Xiang (BM) pig were cloned into pcDNA3...
December 7, 2022: Gene
https://read.qxmd.com/read/36459361/advances-in-understanding-the-mitogenic-metabolic-and-cell-death-signaling-in-teleost-development-the-case-of-greater-amberjack-seriola-dumerili-risso-1810
#26
JOURNAL ARTICLE
Nikolas Panteli, Maria Demertzioglou, Konstantinos Feidantsis, Stelios Karapanagiotis, Nikoletta Tsele, Kalliopi Tsakoniti, Konstantinos Gkagkavouzis, Constantinos C Mylonas, Konstantinos Ar Kormas, Eleni Mente, Efthimia Antonopoulou
Cell growth and differentiation signals of insulin-like growth factor-1 (IGF-1), a key regulator in embryonic and postnatal development, are mediated through the IGF-1 receptor (IGF-1R), which activates several downstream pathways. The present study aims to address crucial organogenesis and development pathways including Akt, MAPKs, heat shock response, apoptotic and autophagic machinery, and energy metabolism in relation to IGF-1R activation during five developmental stages of reared Seriola dumerili: 1 day prior to hatching fertilized eggs (D-1), hatching day (D0), 3 days post-hatching larvae (D3), 33 (D33) and 46 (D46) days post-hatching juveniles...
December 2, 2022: Fish Physiology and Biochemistry
https://read.qxmd.com/read/36359767/empagliflozin-induced-ketosis-upregulated-igf-1-insulin-receptors-and-the-canonical-insulin-signaling-pathway-in-neurons-and-decreased-the-excitatory-neurotransmitter-glutamate-in-the-brain-of-non-diabetics
#27
JOURNAL ARTICLE
Konstantinos I Avgerinos, Roger J Mullins, Michael Vreones, Maja Mustapic, Qinghua Chen, Denise Melvin, Dimitrios Kapogiannis, Josephine M Egan
Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as empagliflozin, lower blood glucose in type 2 diabetes mellitus and improve cardiorenal outcomes regardless of diabetes presence. Whether SGLT2is exert any effects on the brain's metabolism has not been studied. We conducted a single-arm clinical trial to investigate the effects of once daily administration of oral empagliflozin (25 mg) for 14 days on systemic and brain metabolism in 21 non-diabetics aged 55 years old or older. Empagliflozin lowered circulating insulin and elevated β-hydroxybutyrate over 34-h periods, both following its first administration and after 14 days of daily administration, with minor alterations in glucose homeostasis...
October 25, 2022: Cells
https://read.qxmd.com/read/36325267/upregulation-of-klotho-aggravates-insulin-resistance-in-gestational-diabetes-mellitus-trophoblast-cells
#28
JOURNAL ARTICLE
Li Lin, Xinyu Wang, Weihua Zhao, Yaxuan Chen
Objective: Insulin resistance (IR) plays a key role in gestational diabetes mellitus (GDM) pathogenesis. The antiaging protein klotho has been proven to be closely related to IR. The purpose of this study was to investigate the effect of klotho on IR in GDM trophoblast cells. Methods: The GDM cell model of HTR-8/SVneo cells was induced by high glucose (HG). Plasmid transfection was used to mediate the overexpression or silencing of klotho. The effects of klotho on cell viability, IR, and the IGF-1/PI3K pathways were observed by RT-qPCR, western blot, Cell Counting Kit-8 detection, glucose uptake assay, and immunofluorescence detection...
2022: Genetics Research
https://read.qxmd.com/read/36240982/insulin-like-growth-factor-1-serum-levels-in-different-stages-of-gastric-cancer-and-their-association-with-helicobacter-pylori-status
#29
JOURNAL ARTICLE
Fatemeh Ghafari, Ali Mohammad Alizadeh, Shahram Agah, Shiva Irani, Marjan Mokhtare
High serum insulin-like growth factor 1 (IGF-1) and positive Helicobacter pylori (H. pylori) may increase the risk of gastric cancer (GC). We aimed to investigate IGF-1 serum levels in different stages of GC patients and their association with H. pylori status. A total of 90 participants, including 60 GC patients and 30 noncancerous (NC) individuals, were included in the present study. IGF-1 serum levels and candidate proteins were assessed using enzyme-linked immunosorbent and immunohistochemistry techniques...
October 12, 2022: Peptides
https://read.qxmd.com/read/36235757/the-promotion-of-migration-and-myogenic-differentiation-in-skeletal-muscle-cells-by-quercetin-and-underlying-mechanisms
#30
JOURNAL ARTICLE
Tzyh-Chyuan Hour, Thi Cam Tien Vo, Chih-Pin Chuu, Hsi-Wen Chang, Ying-Fang Su, Chung-Hwan Chen, Yu-Kuei Chen
Aging and muscle disorders frequently cause a decrease in myoblast migration and differentiation, leading to losses in skeletal muscle function and regeneration. Several studies have reported that natural flavonoids can stimulate muscle development. Quercetin, one such flavonoid found in many vegetables and fruits, has been used to promote muscle development. In this study, we investigated the effect of quercetin on migration and differentiation, two processes critical to muscle regeneration. We found that quercetin induced the migration and differentiation of mouse C2C12 cells...
October 2, 2022: Nutrients
https://read.qxmd.com/read/36096767/an-igf-1r-mtorc1-srpk2-signaling-axis-contributes-to-fasn-regulation-in-breast-cancer
#31
JOURNAL ARTICLE
Bryan McClellan, Paul Gries, Brittany Harlow, Stefano Tiziani, Christopher Jolly, Linda deGraffenried
BACKGROUND: Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcriptional regulation of lipogenic transcripts have been demonstrated as being mediated downstream of serine-arginine rich protein kinase 2 (SRPK2), which acts to phosphorylate serine-arginine rich splicing factors (SRSFs), resulting in RNA binding and various RNA regulatory processes...
September 12, 2022: BMC Cancer
https://read.qxmd.com/read/36036015/exercise-induced-signaling-pathways-to-counteracting-cardiac-apoptotic-processes
#32
REVIEW
Hamed Alizadeh Pahlavani
Cardiovascular diseases are the most common cause of death in the world. One of the major causes of cardiac death is excessive apoptosis. However, multiple pathways through moderate exercise can reduce myocardial apoptosis. After moderate exercise, the expression of anti-apoptotic proteins such as IGF-1, IGF-1R, p-PI3K, p-Akt, ERK-1/2, SIRT3, PGC-1α, and Bcl-2 increases in the heart. While apoptotic proteins such as PTEN, PHLPP-1, GSK-3, JNK, P38MAPK, and FOXO are reduced in the heart. Exercise-induced mechanical stress activates the β and α5 integrins and subsequently, focal adhesion kinase phosphorylation activates the Akt/mTORC1 and ERK-1/2 pathways, leading to an anti-apoptotic response...
2022: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/36009569/the-igf-1r-inhibitor-nvp-aew541-causes-insulin-independent-and-reversible-cardiac-contractile-dysfunction
#33
JOURNAL ARTICLE
Christina Schenkl, Andrea Schrepper, Estelle Heyne, Torsten Doenst, Michael Schwarzer
The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541's effects on cardiac function and insulin response in vivo and in isolated working hearts. We performed a dose-response analysis of NVP-AEW541 in male, 3-week-old rats and assessed the chronic effects of the clinically relevant dose in adult rats. We performed glucose tolerance tests and echocardiography; assessed the expression and phosphorylation of InsR/IGF-1R and Akt in vivo; and measured substrate oxidation, contractile function, and insulin response in the isolated working hearts...
August 19, 2022: Biomedicines
https://read.qxmd.com/read/35903524/genistein-promotes-m1-macrophage-apoptosis-and-reduces-inflammatory-response-by-disrupting-mir-21-tipe2-pathway
#34
JOURNAL ARTICLE
Li Cong, Xiaolin Xie, Sujuan Liu, Liping Xiang, Xiaohua Fu
Cardiovascular diseases are a major cause of mortality, and vascular injury, a common pathological basis of cardiovascular disease, is deeply correlated with macrophage apoptosis and inflammatory response. Genistein, a type of phytoestrogen, exerts cardiovascular protective activities, but the underlying mechanism has not been fully elucidated. In this study, RAW264.7 cells were treated with genistein, lipopolysaccharide (LPS), nuclear factor-kappa B (NF-κB) inhibitor, and/or protein kinase B (AKT) agonist to determine the role of genistein in apoptosis and inflammation in LPS-stimulated cells...
July 2022: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/35582669/cognitive-disorder-and-dementia-in-type-2-diabetes-mellitus
#35
REVIEW
Genaro G Ortiz, Miguel Huerta, Héctor A González-Usigli, Erandis D Torres-Sánchez, Daniela Lc Delgado-Lara, Fermín P Pacheco-Moisés, Mario A Mireles-Ramírez, Blanca Mg Torres-Mendoza, Roxana I Moreno-Cih, Irma E Velázquez-Brizuela
Insulin, a key pleiotropic hormone, regulates metabolism through several signaling pathways in target tissues including skeletal muscle, liver, and brain. In the brain, insulin modulates learning and memory, and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases. At the receptor level, in aging and Alzheimer's disease (AD) models, the amount of insulin receptors and their functions are decreased. Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels...
April 15, 2022: World Journal of Diabetes
https://read.qxmd.com/read/35529797/picropodophyllin-inhibits-the-growth-of-pemetrexed-resistant-malignant-pleural-mesothelioma-via-microtubule-inhibition-and-igf-1r-caspase-independent-pathways
#36
JOURNAL ARTICLE
Rong Sun, Ryosuke Tanino, Xuexia Tong, Eshat Fahmida Haque, Yoshihiro Amano, Takeshi Isobe, Yukari Tsubata
Background: Acquired pemetrexed resistance leads to treatment interruption in patients with malignant pleural mesothelioma (MPM). Insulin-like growth factor-I receptor (IGF-1R) inhibitor is a candidate for treating pemetrexed-naïve MPM. However, the efficacy of cytotoxic and targeted drugs in acquired-pemetrexed resistant MPM is unclear. We explored anticancer drugs, including the IGF-1R inhibitor picropodophyllin, against acquired pemetrexed-resistant MPMs. Methods: Acquired pemetrexed-resistant human MPM cell lines, named as H2452/PEM and 211H/PEM after their parental lines H2452 and 211H, respectively, were established by exposure to pemetrexed in vitro ...
April 2022: Translational Lung Cancer Research
https://read.qxmd.com/read/35409425/igfbp-3-regulates-mitochondrial-hyperfusion-and-metabolic-activity-in-ocular-surface-epithelia-during-hyperosmolar-stress
#37
JOURNAL ARTICLE
Whitney L Stuard, Melis K Guner, Danielle M Robertson
In the eye, hyperosmolarity of the precorneal tear film triggers inflammation and the development of dry eye disease (DED), a highly prevalent condition that causes depression and disability in severe forms. A member of the insulin-like growth factor (IGF) family, the IGF binding protein-3 (IGFBP-3), is a pleiotropic protein with known roles in growth downregulation and survival. IGFBP-3 exerts these effects by blocking IGF-1 activation of the type 1 IGF-receptor (IGF-1R). Here, we examined a new IGF-independent role for IGFBP-3 in the regulation of mitochondrial and metabolic activity in ocular surface epithelial cells subject to hyperosmolar stress and in a mouse model of DED...
April 6, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35399718/an-insulin-growth-factor-i-ii-neutralizing-monoclonal-antibody-in-combination-with-epidermal-growth-factor-receptor-inhibitors-potently-inhibits-tumor-cell-growth
#38
JOURNAL ARTICLE
Guofang Ma, Chengyue Tan, Yaming Shan, Ningyi Shao, Feng Wang, Dimiter S Dimitrov, Liping Wang, Qi Zhao
The insulin-like growth factors (IGFs), IGF-1 and IGF-II, which bind to the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), have been implicated in the growth, survival, and metastasis of tumor cells. We have previously identified a novel human monoclonal antibody (mAb), m708.5, which neutralizes both human IGF-I and IGF-II, and potently inhibits phosphorylation of the IGF-1R and the IR in breast cancer cells. In this study, m708.5 exhibited very strong synergy with the epidermal growth factor receptor (EGFR) inhibitor gefitinib, and synergy with chemotherapeutic agents in vitro against either neuroblastoma or breast cancer cells...
2022: Journal of Cancer
https://read.qxmd.com/read/35129018/igf-1r-yap-signaling-pathway-is-involved-in-collagen-v-induced-insulin-biosynthesis-and-secretion-in-rat-islet-ins-1-cells
#39
JOURNAL ARTICLE
Yingying Zhu, Shuaigao Chen, Weiwei Liu, Fanxing Xu, Jingyu Lu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
PURPOSE: Type V collagen (collagen V) is one of the important components of extracellular matrix (ECM) in pancreas. We previously reported that pre-coating collagen V on the culture dishes enhanced insulin production in INS-1 rat pancreatic β cells. In this study, we investigate the underlying mechanism. RESULTS: Insulin biosynthesis and secretion are both increased in INS-1 cells cultured on collagen V-coated dishes, accompanied by the reduced nuclear translocation of Yes-associated protein (YAP), a transcriptional co-activator...
February 7, 2022: Connective Tissue Research
https://read.qxmd.com/read/35125086/nimbolide-a-neem-limonoid-inhibits-angiogenesis-in-breast-cancer-by-abrogating-aldose-reductase-mediated-igf-1-pi3k-akt-signalling
#40
JOURNAL ARTICLE
Ramesh Nivetha, Soundararajan Arvindh, Abdul Basit Baba, Deepak Reddy Gade, Gopisetty Gopal, Chitrathara K, Kallamadi Prathap Reddy, G Bhanuprakash Reddy, Siddavaram Nagini
BACKGROUND & OBJECTIVE: The insulin/IGF-1R/PI3K/Akt signalling cascade is increasingly being linked to breast cancer development, with aldose reductase (AR) playing a key role in mediating the crosstalk between this pathway and angiogenesis. The current study was designed to investigate whether nimbolide, a neem limonoid, targets the oncogenic signaling network to prevent angiogenesis in breast cancer. METHODS: Breast cancer cells (MCF-7, MDA-MB-231), EAhy926 endothelial cells, MDA-MB-231 xenografted nude mice, and tumour tissues from breast cancer patients were used for the study...
2022: Anti-cancer Agents in Medicinal Chemistry
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