keyword
https://read.qxmd.com/read/38509341/effectiveness-and-safety-of-empagliflozin-final-results-from-the-emprise-study
#21
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
AIMS/HYPOTHESIS: Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering medications in individuals with type 2 diabetes with the broad spectrum of cardiovascular risk. The EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) cohort study was designed to monitor the safety and effectiveness of empagliflozin periodically for a period of 5 years with data collection from electronic healthcare databases. METHODS: We identified individuals ≥18 years old with type 2 diabetes who initiated empagliflozin or dipeptidyl peptidase-4 inhibitors (DPP-4i) from 2014 to 2019 using US Medicare and commercial claims databases...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38507056/short-and-long-term-outcomes-of-patients-with-active-cancer-presenting-with-an-acute-coronary-syndrome
#22
JOURNAL ARTICLE
Inbar Nardi Agmon, Ori Rahat, Roy Beigel, Tal Ovdat, Manhal Habib, Oran Tzuman, Limor Ilan Bushari, Ran Kornowski, Katia Orvin
BACKGROUND: Management of cancer patients presenting with an acute coronary syndrome (ACS) may be challenging. In this study, we sought to examine whether and how a concomitant diagnosis of active cancer affects patients' management and outcomes following an event of ACS. METHODS: We used a retrospective cohort data analysis of patients from the Acute Coronary Syndrome Israeli Survey (ACSIS) carried out between the years 2016-2021 to compare patients with and without a concomitant diagnosis of active cancer...
March 20, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38506045/virus-induced-acute-respiratory-distress-syndrome-causes-cardiomyopathy-through-eliciting-inflammatory-responses-in-the-heart
#23
JOURNAL ARTICLE
Jana Grune, Geetika Bajpai, Pervin Tülin Ocak, Eva Kaufmann, Kyle Mentkowksi, Steffen Pabel, Nina Kumowski, Fadi E Pulous, Kim A Tran, David Rohde, Shuang Zhang, Yoshiko Iwamoto, Gregory R Wojtkiewicz, Claudio Vinegoni, Ursula Green, Filip K Swirski, James R Stone, Jochen K Lennerz, Maziar Divangahi, Maarten Hulsmans, Matthias Nahrendorf
BACKGROUND: Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury during viral ARDS remains unknown. Here we investigate how immune signals typical for viral ARDS affect cardiac macrophage subsets, cardiovascular health, and systemic inflammation. METHODS: We assessed cardiac macrophage subsets using immunofluorescence histology of autopsy specimens from 21 patients with COVID-19 with SARS-CoV-2-associated ARDS and 33 patients who died from other causes...
March 20, 2024: Circulation
https://read.qxmd.com/read/38505303/the-intersection-of-atrial-fibrillation-and-coronary-artery-disease-in-middle-eastern-patients-analysis-from-the-jordan-atrial-fibrillation-study
#24
JOURNAL ARTICLE
Ayman Hammoudeh, Yahya Badaineh, Ramzi Tabbalat, Anas Ahmad, Mohammad Bahhour, Darya Ja'ara, Joud Shehadeh, Mohammad A Jum'ah, Afnan Migdad, Mohammad Hani, Imad A Alhaddad
BACKGROUND: There is a scarcity of clinical studies which evaluate the association of atrial fibrillation (AF) and coronary artery disease (CAD) in the Middle East. The aim of this study was to evaluate the impact of CAD on baseline clinical profiles and one-year outcomes in a Middle Eastern cohort with AF. METHODS: Consecutive AF patients evaluated in 29 hospitals and cardiology clinics were enrolled in the Jordan AF Study (May 2019-December 2020). Clinical and echocardiographic features, use of medications and one-year outcomes in patients with AF/CAD were compared to AF/no CAD patients...
2024: Global Heart
https://read.qxmd.com/read/38505065/prognostic-implication-of-vasoactive-inotropic-score-in-adult-patients-with-cardiogenic-shock-on-veno-arterial-extracorporeal-membrane-oxygenation
#25
JOURNAL ARTICLE
Yao Hu, Liangshan Wang, Feng Yang, Xiaomeng Wang, Shuai Zhang, Xing Hao, Hong Wang, Xiaotong Hou
BACKGROUND: Vasopressors and inotropes are crucial in managing cardiogenic shock (CS) as they enhance microcirculation in patients. Numerous studies have demonstrated the adverse outcomes associated with excessive use of vasoactive drugs and the vasoactive drug scoring system has emerged as a valuable prognostic tool, particularly in pediatric patients. This study aimed to examine the prognostic significance of the Vasoactive Inotropic Score (VIS) in adult patients with CS receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504228/ischemic-heart-disease-related-mortality-in-brazil-2006-to-2020-a-study-of-multiple-causes-of-death
#26
JOURNAL ARTICLE
Luiz A V M Bastos, Paolo B Villela, Jose L P Bichara, Emilia M do Nascimento, Eduardo L V M Bastos, Basilio de B Pereira, Glaucia M M Oliveira
CONTEXT: Both the aging of the population and the increase in noncommunicable diseases may influence the progression and outcomes culminating in death, changing the evolution of ischemic heart diseases (IHDs) and their associated causes. Using the multiple causes of death method could help understand the magnitude of these relationships and enable better targeting of investments in health. OBJECTIVES: To evaluate the mortality from IHD in Brazil between 2006 and 2020 using the method of multiple causes and identify differences in the distribution pattern of IHD mortality by sex and geographic region...
March 19, 2024: BMC Public Health
https://read.qxmd.com/read/38503643/utility-of-coronary-revascularization-in-patients-with-ischemic-left-ventricular-dysfunction
#27
REVIEW
Mohammed Al-Sadawi, Michael Tao, Simrat Dhaliwal, Archanna Radakrishnan, Yang Liu, Chad Gier, Ravi Masson, Tahmid Rahman, Edlira Tam, Noelle Mann
BACKGROUND: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of revascularization using percutaneous coronary intervention (PCI) versus coronary-artery bypass grafting (CABG). OBJECTIVES: The purpose of this meta-analysis is to evaluate the association of coronary revascularization with outcomes in patients with ischemic LV dysfunction...
March 5, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38502317/predictive-value-of-the-prognostic-nutritional-index-combined-with-serum-chloride-levels-for-the-prognosis-of-patients-with-acute-decompensated-heart-failure
#28
JOURNAL ARTICLE
Wenyi Gu, Yanji Zhou, Baotong Hua, Wenfang Ma, Ling Dong, Tao Shi, Jie Zou, Na Zhu, Lixing Chen
BACKGROUND: The prognostic nutritional index (PNI) and serum chloride level are related to adverse outcomes in patients with heart failure. However, little is known about the relationship between the PNI and serum chloride level in predicting the poor prognosis of patients with acute decompensated heart failure (ADHF). METHODS AND RESULTS: We reviewed 1221 consecutive patients with ADHF admitted to the First Affiliated Hospital of Kunming Medical University from January 2017 to October 2021...
March 19, 2024: Heart and Vessels
https://read.qxmd.com/read/38499082/sex-differences-in-heart-transplantation-analysis-of-the-national-inpatient-sample-2012-2019
#29
REVIEW
Nakeya Dewaswala, Huzefa Bhopalwala, Abdul Mannan Khan Minhas, Khadija Amanullah, Dmitry Abramov, Samiullah Arshad, Sourbha Dani, Gaurang Vaidya, Dipanjan Banerjee, Emma Birks, Erin Michos
INTRODUCTION: Advanced heart failure therapies and heart transplantation (HT) have been underutilized in women. Therefore, we aimed to explore the clinical characteristics and outcomes of HT by sex. METHODS: We conducted a retrospective analysis of adult discharges from the National Inpatient Sample (NIS) between 2012 and 2019. International Classification of Disease (ICD) procedure codes were used to identify those who underwent HT. RESULTS: A total of 20,180 HT hospitalizations were identified from 2012-2019...
March 16, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38494834/pupil-reflex-as-a-marker-of-activity-and-prognosis-in-heart-failure-a-longitudinal-and-prospective-study
#30
JOURNAL ARTICLE
Margarita Zamorano, Juan Manuel Monteagudo, Eduardo González, Isabel Rayo, Sara Fernández, Miguel Castillo, Qiheng Zhou, Pedro de la Villa, Jose Luis Zamorano
AIMS: Compensatory mechanisms in heart failure (HF) are triggered to maintain adequate cardiac output. Among them, hyperactivation of the sympathetic nervous system (SNS) is one of the main ones and carries a worse prognosis. The pupillary reflex depends on the SNS, and we can evaluate it through pupillometry. The aim of the study was to compare the differences in pupillary reflex between patients with acute HF and controls and to analyse whether these differences in pupillary reflex may offer a new and easy prognostic factor in such patients...
March 17, 2024: ESC Heart Failure
https://read.qxmd.com/read/38494197/machine-learning-model-and-nomogram-to-predict-the-risk-of-heart-failure-hospitalization-in-peritoneal-dialysis-patients
#31
JOURNAL ARTICLE
Liping Xu, Fang Cao, Lian Wang, Weihua Liu, Meizhu Gao, Li Zhang, Fuyuan Hong, Miao Lin
INTRODUCTION: The study presented here aimed to establish a predictive model for heart failure (HF) and all-cause mortality in peritoneal dialysis (PD) patients with machine learning (ML) algorithm. METHODS: We retrospectively included 1006 patients who initiated PD from 2010 to 2016. XGBoost, random forest (RF), and AdaBoost were used to train models for assessing risk for 1-year and 5-year HF hospitalization and mortality. The performance was validated using fivefold cross-validation...
December 2024: Renal Failure
https://read.qxmd.com/read/38493531/sex-disparities-in-cardiogenic-shock-insights-from-the-frenshock-registry
#32
JOURNAL ARTICLE
Stéphane Manzo-Silberman, Anne-Céline Martin, Florence Boissier, Caroline Hauw-Berlemont, Nadia Aissaoui, Nicolas Lamblin, François Roubille, Eric Bonnefoy, Laurent Bonello, Meyer Elbaz, Guillaume Schurtz, Olivier Morel, Guillaume Leurent, Bruno Levy, Bernard Jouve, Brahim Harbaoui, Gérald Vanzetto, Nicolas Combaret, Benoit Lattucca, Sébastien Champion, Pascal Lim, Cédric Bruel, Francis Schneider, Marie-France Seronde, Vincent Bataille, Edouard Gerbaud, Etienne Puymirat, Clément Delmas
BACKGROUND: Cardiogenic shock (CS) is the most severe form of acute heart failure. Discrepancies have been reported between sexes regarding delays, pathways and invasive strategies in CS complicating acute myocardial infarction. However, effect of sex on the prognosis of unselected CS remains controversial. OBJECTIVES: The aim was to analyze the impact of sex on aetiology, management and prognosis of CS. METHODS: The FRENSHOCK registry included all CS admitted in 49 French Intensive Care Units (ICU) and Intensive Cardiac Care Units (ICCU) between April and October 2016...
March 16, 2024: Journal of Critical Care
https://read.qxmd.com/read/38492617/a-multidisciplinary-approach-of-a-patient-with-pheochromocytoma-presenting-as-recurrent-acute-fulminant-myocarditis-a-rare-case-report-and-comprehensive-review-of-literature
#33
REVIEW
Januar Wibawa Martha, Hawani Sasmaya Prameswari, Fatihatul Firdaus Munita, Nuraini Yasmin Kusumawardhani, Melawati Hasan, Astri Astuti, Nanny Natalia Mulyani, Hasrayati Agustina, Minsy Titi Sari
Fulminant myocarditis (FM) is a rare illness characterized by abrupt and severe widespread cardiac inflammation, which frequently results in mortality due to cardiogenic shock, ventricular arrhythmias, or multiorgan system failure. Pheochromocytoma is an uncommon and difficult-to-diagnose cause of FM, and it is associated with a significant risk of recurrent acute myocarditis. There is, however, little information on reoccurring acute FM. Herein, we report a rare case of recurrent acute FM due to pheochromocytoma...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38490563/predicting-the-risk-of-1-year-mortality-among-patients-hospitalized-for-acute-heart-failure-in-china
#34
JOURNAL ARTICLE
Lihua Zhang, Wei Wang, Xiqian Huo, Guangda He, Yanchen Liu, Yan Li, Lubi Lei, Jingkuo Li, Boxuan Pu, Yue Peng, Jing Li
OBJECTIVES: We aimed to develop and validate a model to predict 1-year mortality risk among patients hospitalized for acute heart failure (AHF), build a risk score and interpret its application in clinical decision making. METHODS: By using data from China Patient-Centred Evaluative Assessment of Cardiac Events Prospective Heart Failure Study, which prospectively enrolled patients hospitalized for AHF in 52 hospitals across 20 provinces, we used multivariate Cox proportional hazard model to develop and validate a model to predict 1-year mortality...
March 13, 2024: American Heart Journal
https://read.qxmd.com/read/38488426/cardiovascular-safety-of-febuxostat-versus-allopurinol-among-the-asian-patients-with-or-without-gout-a%C3%A2-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Jian-Hao Deng, Peng-Hui Lai, Li-Shan Xie, Shu-Sheng Qiu, De-Sheng Qiu, Jia-Xing Zhang
The cardiovascular (CV) safety of febuxostat compared to allopurinol for the treatment of hyperuricemia among Asian patients is uncertain. In this study, we conducted a systematic review and meta-analysis to compare the CV safety profiles of febuxostat with allopurinol in Asian patients with hyperuricemia. A total of 13 studies were included. On the basis of the pooled results of cohort studies, febuxostat users were at a significantly higher risk for acute coronary syndrome (ACS; hazard ratio [HR]: 1.06, 95% confidence interval [CI]: 1...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38487715/optimal-p2y-12-inhibitor-durations-in-older-men-and-older-women-following-an-acute-myocardial-infarction-a-nationwide-cohort-study-using-medicare-data
#36
JOURNAL ARTICLE
Ryan P Hickson, Anna M Kucharska-Newton, Jo E Rodgers, Betsy L Sleath, Gang Fang
STUDY OBJECTIVE: Identify optimal P2Y12 inhibitor durations balancing ischemic-benefit and bleeding-risk outcomes after acute myocardial infarction (AMI) in older men and women. DESIGN: Observational retrospective cohort with 2 years of follow-up, using clone-censor-weight marginal structural models to emulate randomization. SETTING: 20 % sample of US Medicare administrative claims data. PARTICIPANTS: P2Y12 inhibitor new users ≥66 years old following 2008-2013 AMI hospitalization...
December 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38483761/atrial-fibrillation-complicating-acute-myocardial-infarction-prevalence-impact-and-management-considerations
#37
REVIEW
Besher Sadat, Haider Al Taii, Muhie Sabayon, Chockalingam A Narayanan
PURPOSE OF REVIEW: Atrial fibrillation (AF) and myocardial infarction (MI) often coexist, and this overlapping nature leads to heightened morbidity and increases the need for comprehensive risk management strategies. The precise trajectory and implications of atrial fibrillation complicating myocardial infarction remain subjects of debate, with divergent reports presenting varying accounts. This review seeks to provide an in-depth exploration of the existing literature to cover the predictors, implication, and available management of new onset atrial fibrillation (NOAF) complicating acute myocardial infarction (AMI)...
March 14, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38480608/outcome-and-risk-of-poststroke-pneumonia-in-patients-with-acute-ischemic-stroke-after-endovascular-thrombectomy-a-post-hoc-analysis-of-the-direct-mt-trial
#38
JOURNAL ARTICLE
Ping Zhang, Lei Chen, Xiao-Fei Ye, Tao Wu, Ben-Qiang Deng, Peng-Fei Yang, Yi Han, Yong-Wei Zhang, Jian-Min Liu
BACKGROUND: In this study, we aimed to investigate the risk factors and impact of poststroke pneumonia (PSP) on mortality and functional outcome in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). METHODS: This was a post hoc analysis of a prospective randomized trial (Direct intraarterial thrombectomy in order to revascularize AIS patients with large-vessel occlusion efficiently in Chinese tertiary hospitals: a multicenter randomized clinical trial)...
March 13, 2024: Neurocritical Care
https://read.qxmd.com/read/38478596/poor-in-hospital-congestion-improvement-in-acute-heart-failure-patients-classified-according-to-lvef-prognostic-implications
#39
JOURNAL ARTICLE
Gaetano Ruocco, Nicolas Girerd, Tripti Rastogi, Zohra Lamiral, Alberto Palazzuoli
BACKGROUND: Residual congestion in acute heart failure (AHF) is associated with poor prognosis. However, there is a lack of data on the prognostic value of changes in a combined assessment of in-hospital congestion. The present study sought to assess the association between in-hospital congestion changes and subsequent prognosis according to left ventricular ejection fraction (LVEF) classification. METHODS: Patients (N=244, 80.3±7.6 years, 50.8% male) admitted for acute HF in two European tertiary care centers underwent clinical assessment (congestion score included dyspnea at rest, rales, third heart sound, jugular venous distention, peripheral edema and hepatomegaly; simplified congestion score included rales and peripheral edema), echocardiography, lung ultrasound (LUS) and natriuretic peptides (NP) measurement at admission and discharge...
March 13, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38477207/pharmacological-considerations-during-percutaneous-treatment-of-heart-failure
#40
JOURNAL ARTICLE
Jose Antonio Sorolla-Romero, Javier Navarrete-Navarro, Julia Martinez-Sole, Hector M Garcia Garcia, Jose Luis Diez-Gil, Luis Martinez-Dolz, Jorge Sanz-Sanchez
Heart Failure (HF) remains a global health challenge, marked by its widespread prevalence and substantial resource utilization. Although the prognosis has improved in recent decades due to the treatments implemented, it continues to generate high morbidity and mortality in the medium to long term. Interventional cardiology has emerged as a crucial player in HF management, offering a diverse array of percutaneous treatments for both acute and chronic HF. This article aimed to provide a comprehensive review of the role of percutaneous interventions in HF patients, with a primary focus on key features, clinical effectiveness, and safety outcomes...
February 20, 2024: Current Pharmaceutical Design
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