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acute heart failure, mortality

Persio D Lopez, Pankaj Nepal, Adedoyin Akinlonu, Divya Nekkalapudi, Kwon Kim, Eder H Cativo, Ferdinand Visco, Savi Mushiyev, Gerald Pekler
BACKGROUND: Heart failure (HF) is a syndrome associated with exercise intolerance, and its symptoms are more common in patients with low skeletal muscle mass (SMM). Estimation of muscle mass can be cumbersome and unreliable, particularly in patients with varying body weight. The psoas muscle area (PMA) can be used as a surrogate of sarcopenia and has been associated with poor outcomes in other populations. OBJECTIVES: The aim of this study was to assess if sarcopenia is associated with the survival of patients with HF after an acute hospitalization...
March 20, 2019: Cardiology
Hung-Yu Chang, An-Ning Feng, Man-Cai Fong, Eric Chong, Wei-Hsian Yin
BACKGROUND: The prognostic significance and the optimal treatment strategy for patients with atrial fibrillation (AF) with heart failure (HF) remain controversial. METHODS: We extracted data from a large prospective national database involving Taiwanese patients with AF who were hospitalized for acute HF with reduced ejection fraction. Baseline characteristics, AF types, medications, and 1-year outcomes of the patients were analyzed. RESULTS: At baseline, 393 (26%) patients had AF, including 117 (29...
March 11, 2019: Journal of the Chinese Medical Association: JCMA
Ji Hyun Lee, Jin Joo Park, Youngjin Cho, Il Young Oh, Byung Su Yoo, Jae Joong Kim, Kye Hun Kim, Seok Min Kang, Sang Hong Baek, Eun Seok Jeon, Myeong Chan Cho, Shung Chull Chae, Byung Hee Oh, Dong Ju Choi
BACKGROUND AND OBJECTIVES: Conflicting data exist regarding the prognostic implication of ventricular conduction disturbance pattern in patients with heart failure (HF). This study investigated the prognostic impact of ventricular conduction pattern in hospitalized patients with acute HF. METHODS: Data from the Korean Acute Heart Failure registry were used. Patients were categorized into four groups: narrow QRS (<120 ms), right bundle branch block (RBBB), left bundle branch block (LBBB), and nonspecific intraventricular conduction delay (NICD)...
February 26, 2019: Korean Circulation Journal
Satoshi Shoji, Yasuyuki Shiraishi, Mitsuaki Sawano, Yoshinori Katsumata, Shinsuke Yuasa, Takashi Kohno, Keiichi Fukuda, John A Spertus, Shun Kohsaka
Patient-reported quality of life (PRQL) is a primary therapeutic target for patients with chronic heart failure (HF) and is associated with long-term prognosis. However, its utility in hospitalized HF (HHF) patients in the acute setting remains unclear. We aimed to assess the utility of PRQL (the Kansas City Cardiomyopathy Questionnaire [KCCQ]) in HHF patients and its association with long-term prognosis as well as with the clinical risk score (Get With The Guidelines-Heart Failure [GWTG-HF] risk score). PRQL was evaluated using the KCCQ in consecutive 114 HHF patients...
March 18, 2019: Heart and Vessels
Jens K Skov, Hans-Henrik Kimose, Jacob Greisen, Carl-Johan Jakobsen
OBJECTIVES: In this propensity-matched study we investigated the outcome after grafting with either a single vein or a sequential vein grafting strategy. Outcomes were primarily risk of reintervention and death in the short, intermediate and long term (10 years). MATERIALS: In the period from 2000 to 2016, data from 24 742 patients undergoing coronary artery bypass grafting were extracted from the Western Denmark Heart Registry, where data are registered perioperatively...
March 18, 2019: Interactive Cardiovascular and Thoracic Surgery
Tobias Täger, Hanna Fröhlich, Mirjam Seiz, Hugo A Katus, Lutz Frankenstein
The majority of patients with chronic heart failure (HF) receive long-term treatment with loop diuretics. The comparative effectiveness of different loop diuretics is unknown. We searched PubMed, , the Cochrane Central Register of Controlled Trials and the European Union Clinical Trials Register for randomised clinical trials exploring the efficacy of the loop diuretics azosemide, bumetanide, furosemide or torasemide in patients with HF. Comparators included placebo, standard medical care or any other active treatment...
March 14, 2019: Heart Failure Reviews
Peter Huckfeldt, José Escarce, Neeraj Sood, Zhiyou Yang, Ioana Popescu, Teryl Nuckols
Importance: The Medicare Hospital Readmissions Reduction Program (HRRP) has disproportionately penalized hospitals that treat many black patients, which could worsen health outcomes in this population. Objective: To determine whether short-term mortality rates increased among black and white adults 65 years and older after initiation of the HRRP and whether trends differed by race. Design, Setting, and Participants: In a cohort study using an interrupted time-series analysis conducted from March 15, 2018, to January 23, 2019, in 3263 eligible acute care hospitals nationally, risk-adjusted mortality rates observed after Medicare started to impose penalties (October 1, 2012, to November 30, 2014) were compared with projections based on pre-HRRP trends (January 1, 2007, to March 31, 2010) among adults 65 years and older with acute myocardial infarction (AMI), heart failure (HF), or pneumonia...
March 1, 2019: JAMA Network Open
Min-Yu Lai, Wei-Chih Kan, Ya-Ting Huang, John Chen, Chih-Chung Shiao
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is an excellent prognostic⁻predictive tool in heart failure (HF) patients, but its plasma level changes following therapy. The comparison of prognosis⁻predictivity of a single measurement of plasma NT-pro BNP in different follow-up periods in acute HF patients has been less studied. This study aimed to evaluate whether the association between initial plasma NT-proBNP levels and all-cause mortality would decrease along with an increased follow-up period in patients with acute HF...
March 13, 2019: Journal of Clinical Medicine
Alfonso Campanile, Claudia Castellani, Andrea Santucci, Roberto Annunziata, Cristina Tutarini, Matteo Rocco Reccia, Maurizio Del Pinto, Paolo Verdecchia, Claudio Cavallini
AIMS: Objective data on epidemiology, management and outcome of patients with acute cardiac illness are still scarce, and producing evidence-based guidelines remains an issue. In order to define the clinical characteristics and the potential predictors of in-hospital and long-term mortality, we performed a retrospective, observational study, in a tertiary cardiac centre in Italy. METHODS: One thousand one hundred and sixty-five consecutive patients, admitted to our intensive cardiac care unit (ICCU) during the year 2016, were included in the study...
March 8, 2019: Journal of Cardiovascular Medicine
Guillaume Besch, Sebastien Pili-Floury, Caroline Morel, Martine Gilard, Guillaume Flicoteaux, Lucie Salomon du Mont, Andrea Perrotti, Nicolas Meneveau, Sidney Chocron, Francois Schiele, Herve Le Breton, Emmanuel Samain, Romain Chopard
BACKGROUND: Glycemic variability is associated with worse outcomes after cardiac surgery, but the prognosis value of early glycemic variability after transcatheter aortic valve implantation is not known. This study was therefore designed to analyze the prognosis significance of post-procedural glycemic variability within 30 days after transcatheter aortic valve implantation. METHODS: A post hoc analysis of patients from our center included in the FRANCE and FRANCE-2 registries was conducted...
March 11, 2019: Cardiovascular Diabetology
Martina Kleber, Nikola Kozhuharov, Zaid Sabti, Bettina Glatz, Rahel Isenreich, Desiree Wussler, Albina Nowak, Raphael Twerenbold, Patrick Badertscher, Christian Puelacher, Jeanne du Fay de Lavallaz, Thomas Nestelberger, Jasper Boeddinghaus, Karin Wildi, Dayana Flores, Joan Walter, Katharina Rentsch, Arnold von Eckardstein, Assen Goudev, Tobias Breidthardt, Christian Mueller
BACKGROUND: Relative hypochromia of erythrocytes defined as a reduced mean corpuscular hemoglobin concentration (MCHC) is a surrogate of iron deficiency. We aimed to evaluate the prevalence and prognostic impact of relative hypochromia in acute heart failure (AHF). METHODS: We prospectively characterized 1574 patients presenting with an adjudicated diagnosis of AHF to the emergency department. Relative hypochromia was defined as a MCHC ≤330 g/l and determined at presentation...
February 27, 2019: International Journal of Cardiology
N G Vinogradova
Actuality. In the Russian Federation, there has been an increase in the number of patients with chronic heart failure (CHF) of the III-IV functional class, who are characterized by frequent development of acute decompensation of СHF and frequent repeated hospitalizations. This dictates the need to create a system of effective control over the conduct of drug therapy and physical rehabilitation after discharge from the hospital at the outpatient stage. OBJECTIVE: to identify the differences between the two strategies for monitoringatients with CHF after decompensation and to determine the effectiveness of treatment, rehabilitation measures and life prognosis depending on the observation in the system of the specialized City Center for Treatment of CHF (Heart failure clinic) and in real outpatient practice...
March 7, 2019: Kardiologiia
Eva M Hau, Julien N Caccia, Rahel Kasteler, Ben Spycher, Thomas Suter, Roland A Ammann, Nicolas X von der Weid, Claudia E Kuehni
BACKGROUND AND AIMS: Cardiovascular diseases (CVD) increase late morbidity and mortality in survivors of acute lymphoblastic leukaemia (ALL). We compared the risk of CVD in ALL survivors to siblings, examined time trends, quantified treatment-related risks, and investigated whether risk extends beyond patients treated with anthracyclines and chest radiotherapy. METHODS: The Swiss Childhood Cancer Survivor Study assessed CVD by patient questionnaire in 5-year ALL survivors diagnosed between 1976 and 2005 and their siblings...
February 25, 2019: Swiss Medical Weekly
Joseph Scarpa, Emilie Bruzelius, Patrick Doupe, Matthew Le, James Faghmous, Aaron Baum
Importance: The randomized Systolic Blood Pressure Intervention Trial (SPRINT) showed that lowering systolic blood pressure targets for adults with hypertension reduces cardiovascular morbidity and mortality in general. However, whether the overall benefit from intensive blood pressure control masks important heterogeneity in risk is unknown. Objective: To test the hypothesis that the overall benefit observed in SPRINT masked important heterogeneity in risk from intensive blood pressure control...
March 1, 2019: JAMA Network Open
Shunsuke Kubo, Kyohei Yamaji, Taku Inohara, Shun Kohsaka, Hiroyuki Tanaka, Hideki Ishii, Shiro Uemura, Tetsuya Amano, Masato Nakamura, Kazushige Kadota
In-hospital complications and their predictors in acute coronary syndrome (ACS) patients with cardiogenic shock (CS) have not been fully investigated, particularly in those who underwent invasive revascularization procedures. This study investigated the in-hospital outcomes, along with the volume-outcome relationship of ACS patients with CS, using a contemporary large-scale nationwide percutaneous coronary intervention (PCI) registry in Japan. We analyzed PCI procedural data on ACS patients treated between 2014 and 2016 in a nationwide Japanese PCI registry...
February 22, 2019: American Journal of Cardiology
Domingo A Pascual-Figal, Antoni Bayes-Genis, Maria C Asensio-Lopez, Alvaro Hernández-Vicente, Iris Garrido-Bravo, Francisco Pastor-Perez, Javier Díez, Borja Ibáñez, Antonio Lax
BACKGROUND: Soluble ST2 (sST2), which is the soluble form of interleukin (IL)-1 receptor-like 1, identifies risk in acutely decompensated heart failure (ADHF). IL-1β is an inflammatory cytokine that has deleterious effects in myocardial remodeling and function. IL-1β inhibition has beneficial effects after acute myocardial infarction. However, the role of IL-1β in ADHF and its relationship to ST2 remain unclear. OBJECTIVES: This study sought to investigate the relationship between IL-1β and sST2, and the prognostic impact of such a relationship in patients with ADHF...
March 12, 2019: Journal of the American College of Cardiology
Chan Soon Park, Jin Joo Park, Alexandre Mebazaa, Il-Young Oh, Hyun-Ah Park, Hyun-Jai Cho, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
Background Many patients with heart failure ( HF ) with reduced ejection fraction ( HF r EF ) experience improvement or recovery of left ventricular ejection fraction ( LVEF ). Data on clinical characteristics, outcomes, and medical therapy in patients with HF with improved ejection fraction (HFiEF) are scarce. Methods and Results Of 5625 consecutive patients hospitalized for acute HF in the KorAHF (Registry [Prospective Cohort] for Heart Failure in Korea) study, 5103 patients had baseline echocardiography and 2302 patients had follow-up echocardiography at 12 months...
March 19, 2019: Journal of the American Heart Association
Beatriz Rodríguez-Cubillo, Manuel Carnero-Alcázar, Javier Cobiella-Carnicer, Antolina Rodríguez-Moreno, Ali Alswies, Mercedes Velo-Plaza, Daniel Pérez-Camargo, Ana Sánchez Fructuoso, Luis Maroto-Castellanos
OBJECTIVES: We investigated the impact of acute kidney failure after a heart valve procedure among patients with or without chronic kidney disease (CKD). METHODS: All patients who had undergone a surgical valve procedure between 2005 and 2017 at our institution were divided into 2 groups depending on whether they had previous history of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) or not. Homogeneous groups were obtained by propensity score matching...
March 7, 2019: Interactive Cardiovascular and Thoracic Surgery
Ovidiu Chioncel, Sean P Collins, Andrew P Ambrosy, Peter S Pang, Razvan I Radu, Elena-Laura Antohi, Josep Masip, Javed Butler, Vlad Anton Iliescu
BACKGROUND: Cardiogenic shock (CS) is a life-threatening state of tissue hypoperfusion, associated with a very high risk of mortality, despite intensive monitoring and modern treatment modalities. The present review aimed at describing the therapeutic advances in the management of CS. AREAS OF UNCERTAINTY: Many uncertainties about CS management remain in clinical practice, and these relate to the intensity of invasive monitoring, the type and timing of vasoactive therapies, the risk-benefit ratio of mechanical circulatory support (MCS) therapy, and optimal ventilation mode...
March 2019: American Journal of Therapeutics
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