Jiaying Li, Ping Yang, Linjie Hong, Wushuang Xiao, Luyu Zhang, Zhen Yu, Jieming Zhang, Miaomiao Pei, Ying Peng, Xiangyang Wei, Xiaosheng Wu, Weimei Tang, Yingying Zhao, Juanying Yang, Zhizhao Lin, Ping Jiang, Li Xiang, Hui Zhang, Jianjiao Lin, Jide Wang
Gastric cancer (GC) constitutes substantial cancer mortality worldwide. Several cancer types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9). BST2 was significantly upregulated in GC tissues and promoted epithelial-mesenchymal transition and metastasis of GC. BST2 knockdown reversed HOXD9's oncogenic effect on GC metastasis...
January 10, 2024: Molecular Carcinogenesis