Angela D'Ascola, Michele Scuruchi, Rosaria Maddalena Ruggeri, Angela Avenoso, Giuseppe Mandraffino, Teresa Manuela Vicchio, Salvatore Campo, Giuseppe Maurizio M Campo
Autoimmune Thyroid diseases, such as Hashimoto's thyroiditis, is characterized by lymphocytic infiltration and altered function of the thyroid. During inflammation, it has been reported a decreased expression in Tg and NIS, accompanied by an increase in HA production that accumulates in the gland. HA fragments produced in different pathological states can modulate gene expression in a variety of cell types and may prime inflammatory response by interacting with the TLR-2, TLR-4 and CD44 that, in turn, induce NF-kB activation finally responsible of inflammatory mediator transcription, such as IL-1β, TNF-α and IL-6...
September 22, 2020: Archives of Biochemistry and Biophysics