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Nodular thyroid disease

Antonio Rabal Fueyo, Magdalena Vilanova Serra, Enrique Lerma Puertas, Enrique Montserrat Esplugas, José Ignacio Pérez García, Eugenia Mato Matute, Alberto De Leiva Hidalgo, Antonio Moral Duarte
Objective: Ultrasonography and cytology obtained by fine-needle aspiration are part of the basic study of the thyroid nodule. Although they are not diagnostic in every case, they are cost-effective methods that inform surgical treatment and its extent. The purpose of this study was to evaluate the accuracy of ultrasonography associated with fine-needle aspiration to predict malignancy in nodular thyroid pathology. Design and patients: We collected prospective data from patients undergoing thyroidectomy by single nodule or multinodular goitre between 2006 and 2016...
July 2018: Endocrinology, Diabetes & Metabolism
Débora Melo, Joana Marantes Pimenta, Valter Paixão, José Cortés, Emilia Duro, Fátima Caratão
Renal cell carcinoma (RCC) accounts for 2-3% of all malignant tumors in adults. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after several years, is common. Involvement of the parathyroid gland has only four reported cases in literature. A 62-year-old Caucasian man was referred to our department due to an enlarging cervical mass. The patient's relevant past medical history included a left nephrectomy for RCC 12 years ago. After right thyroid lobectomy and isthmectomy, histopathology revealed an intrathyroidal nodule corresponding to the parathyroid gland with metastatic RCC...
February 2019: Journal of Surgical Case Reports
José María Fernández-Santos, José Carmelo Utrilla, Victoria Vázquez-Román, José Luis Villar-Rodríguez, Lorenzo Gutiérrez-Avilés, Inés Martín-Lacave
BACKGROUND: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. We have recently described that, in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen. METHODS: To better understand the role developed by PC in thyroid hormonogenesis, we investigated their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease and nodular hyperplasia/nodular goiter), in comparison with normal thyroid tissue, using immunofluorescence, morphometry and electron microscopy analyses...
February 15, 2019: Thyroid: Official Journal of the American Thyroid Association
Seyfullah Kan, Muhammed Kizilgul, Bulent Celik, Selvihan Beysel, Mustafa Caliskan, Mahmut Apaydin, Bekir Ucan, Erman Cakal
Nodular thyroid disease is a very common disorder in patients with acromegaly. Insulin-like growth factor-1 (IGF-1) is a thyroid growth factor, and there is a correlation between IGF-1 levels and thyroid volume (TV) in patients with acromegaly. There is no study investigating the impact of somatostatin analog (SSA) treatment on thyroid nodule volume in patients with acromegaly. We aimed to assess thyroid nodule volume change with SSA treatment in patients with persistent acromegaly. We retrospectively analyzed data from 108 consecutive patients with acromegaly who were followed up by our clinic after undergoing surgery between 2002 and 2014...
February 9, 2019: Endocrine Journal
Eleni Triantafillou, Georgios Papadakis, Fotini Kanouta, Styliani Kalaitzidou, Aspasia Drosou, Angeliki Sapera, Dimitra Tampouratzi, Michalis Kotis, Taxiarchis Kyrimis, Anna Dracopoulou, Eirini Veniou, Chrysa Karavasili, Victoria Kaltzidou, Styliani Plyta, Athanasia Tertipi
PURPOSE: Thyroid nodular disease (TND) is a frequent clinical problem and the major concern is the probability of malignancy in a solitary nodule or in one or more nodules of a multinodular goiter. For this purpose, neck ultrasound and fine needle aspiration biopsy (FNAB) under ultrasound guidance have been established as the initial investigation of choice. METHODS: A total of 1113 patients (210 male/903 female) underwent FNABs for the same number of thyroid nodules...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Hailu Abera Mulatu
Background: Thyro-cardiac disease describes the existence of a combination of thyroid toxicity and significant heart disease in an individual patient. The frequent manifestations of thyro-cardiac disease are hypertension, atrial flutter or fibrillation, pulmonary hypertension and dilated cardiomyopathy. The aim of the study was to determine the pattern and presentation of cardiovascular diseases in patients with hyperthyroidism on follow-up at St. Paul's Hospital endocrine clinic. Methods: It was a hospital based cross sectional study that evaluated hyperthyroid patients' on follow-up at St...
January 2019: Ethiopian Journal of Health Sciences
Nur Hidayati Mohamad Pakarul Razy, Wan Faiziah Wan Abdul Rahman, Thin Thin Win
Introduction: Vascular endothelial growth factor (VEGF) is an angiogenic factor that plays an important role in thyroid cancer. VEGF is known to have high affinity to VEGF receptors such as VEGFR-1 (Flt-1) and VEGFR-2 (KDR). Papillary thyroid carcinoma (PTC) is the most common thyroid cancer and studies showed the increasing incidence of PTC arising in nodular hyperplasia. Targeted therapy on these growth factors and receptors are used in management of both differentiated and undifferentiated thyroid carcinoma...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Chihiro Sakaguchi, Kenji Ashida, Kenichi Kohashi, Kenji Ohe, Yoichi Fujii, Seiichi Yano, Yayoi Matsuda, Shohei Sakamoto, Ryuichi Sakamoto, Yoshinao Oda, Masatoshi Nomura, Yoshihiro Ogawa
BACKGROUND: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS). CASE PRESENTATION: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses...
January 22, 2019: BMC Endocrine Disorders
Lauren Johansen, Wolfram Haller, Manigandan Thyagarajan, Deirdre Kelly, Patrick McKiernan
McCune Albright Syndrome (MAS) results from a GNAS gene mutation. It is associated with café-au-lait macules, fibrous dysplasia, and several endocrinopathies to include gonadotropin-independent precocious puberty, growth hormone excess, Cushing syndrome, thyroid disease, and renal phosphate wasting. It is recognised to be a rare cause of neonatal cholestasis.We describe the hepatic outcome of three children with MAS referred to a single national liver unit. All presented with high gamma-glutamyl transpeptidase cholestasis and hepatitis...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
Domenico Albano, Rexhep Durmo, Francesco Bertagna, Raffaele Giubbini
PURPOSE: Thyroid incidental uptake is defined as a thyroid uptake incidentally detected by imaging examinations performed for non-thyroid disease. The aim of this study was to establish the prevalence and the pathological nature of focal thyroid incidental uptake (FTIU) among patients studied with 18F-choline-PET/CT. MATERIALS AND METHODS: We retrospectively evaluated 368 patients who performed 18F-choline-PET/CT between June 2016 and August 2018. The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax) and the mean SUV (SUVmean) of the thyroid gland and of the FTIU; every focal thyroid uptake deviating from physiological distribution and background was considered FTIU...
December 29, 2018: Endocrine
Claudia Cipri, Fabio Vescini, Francesca Torresan, Gianmaria Pennelli, Maria Rosa Pellizzo, Vincenzo Triggiani, Edoardo Guastamacchia, Franco Grimaldi
BACKGROUND: Medullary thyroid cancer (MTC) accounts for 5% of all thyroid cancers and occurs either sporadically or in a hereditary pattern. Routine calcitonin (CT) measurement is suggested for MTC screening in patients with nodular thyroid disease. Patient Findings A 45 years-old woman incidentally discovered, with neck ultrasound, the presence of thyroid micronodules. Fine-needle aspiration (FNA) on thyroid prevailing nodule did not demonstrate cellular atypia. During follow-up, FNA was repeated on the previously analyzed nodule suspicious for Hürthle cell nodule suspicious for follicular neoplasm and on another hypoechoic right nodule which showed cellular atypia...
December 20, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Kewei Wang, Fuqiang Liu, Chuanlong Wu, Yan Liu, Lin Qi, Xiaohan Yang, Huizhen Zheng, Aixia Ma, Jiahui Wu, Fei Yan, Xinguo Hou, Li Chen, Ming Dong, Weikai Hou
Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Endocrinological examinations indicated CCS with periodic and intermittent increases in cortisol. Enhanced computed tomography (CT) revealed space occupying lesions on the upper lobe of left lung, and biopsy eventually proved that these were pulmonary carcinoid tumors with ectopic ACTH secretion, which was subsequently manifested a Cushing's syndrome...
December 19, 2018: Endocrine Journal
Anna B Banizs, Jan F Silverman
OBJECTIVES: Real-world clinical results of (1) Bethesda categorization, (2) mutation analysis, and (3) a microRNA classifier were correlated to show the utility of molecular analysis in assessing malignancy risk of indeterminate thyroid nodules. METHODS: Cytology and molecular results of clinically tested thyroid nodules were compared. An additional microRNA threshold was determined based on nodules with known disease status, establishing a 3-tiered microRNA approach to clinical risk assessments...
November 22, 2018: Diagnostic Cytopathology
Virginia A LiVolsi, Zubair W Baloch
This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism...
2018: Frontiers in Endocrinology
Belinda Hii, Dominic Maher, Meei Yeung, Eldho Paul, Jonathan W Serpell, James C Lee
BACKGROUND: Since the mid-1800s, thyroidectomy has transformed from a procedure associated with high to near-zero mortality. Nonetheless, surgeons must continue to strive to improve patient care. Using historical records and contemporary data, this study compares the practice and outcomes of thyroid surgery at a tertiary institution during two periods, 50 years apart. METHODS: 'The Alfred Hospital Clinical Reports' recorded all cases of surgically managed thyroid disease from 1946 to 1959...
December 7, 2018: World Journal of Surgery
Nadia Sawicka-Gutaj, Paulina Ziółkowska, Jerzy Sowiński, Agata Czarnywojtek, Katarzyna Milczarczyk, Paweł Gut, Marek Ruchała
INTRODUCTION Goiter recurrence occurs in a substantial number of patients after thyroid resection. OBJECTIVES We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). PATIENTS AND METHODS This was a case-control study. All thyroidectomized patients admitted within the past year to the outpatient department were included in the study and their medical records were analyzed...
December 5, 2018: Polish Archives of Internal Medicine
Pawel Domoslawski, Bartosz Pula, Mateusz Olbromski, Beata Wojtczak, Tadeusz Lukienczuk, Marzenna Podhorska-Okolow, Piotr Dziegiel
BACKGROUND/AIM: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. RESULTS: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients...
December 2018: Anticancer Research
Mandeep Singla, Abhinav Gupta
No abstract text is available yet for this article.
November 14, 2018: American Journal of Medicine
Xiaoxu Zhang, Miao Guo, Jing Yang, Yuxiao Zheng, Yanjie Xiao, Wei Liu, Fu Ren
Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recently observed in only a few solid tumors including breast, colon, lung cancers, and melanoma. However, its function in cancers remains unknown. Here, we investigated the expression of GARP in human papillary thyroid carcinoma (PTC) and its prognostic significance...
November 16, 2018: Endocrine Pathology
Sema Ciftci Dogansen, Artur Salmaslioglu, Gulsah Yenidunya Yalin, Seher Tanrikulu, Sema Yarman
PURPOSE: To investigate the nodular thyroid disease (NTD) and the natural course of thyroid nodules in patients with acromegaly. METHODS: 138 patients with acromegaly (73 F/65 M), whose initial thyroid ultrasonography performed in our university hospital, were included in this study. The frequencies of NTD, papillary thyroid cancer (PTC) and associated factors on nodule formation were investigated at initial assessment. Patients who had NTD continued to follow-up (n = 56) were re-evaluated with a ultrasonography performed after a mean 7-years follow-up period...
February 2019: Pituitary
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