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https://read.qxmd.com/read/30774828/advancement-in-stem-cell-therapy-for-ischemic-myocardial-cell-a-systematic-review
#1
REVIEW
Syeda Beenish Bareeqa, Fazeela Bibi, Syed Ijlal Ahmed, Syeda Sana Samar
Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30659359/pericardial-fluid-an-underrated-molecular-library-of-heart-conditions-and-a-potential-vehicle-for-cardiac-therapy
#2
REVIEW
Fábio Trindade, Rui Vitorino, Adelino Leite-Moreira, Inês Falcão-Pires
The remote but heart-encircling location of pericardial fluid confers this biofluid unique properties. Once past the limitation of the invasive collection, for instance, on occasion of heart surgery or pericardiocentesis, the scrutiny of pericardial fluid content can be of great interest in cardiovascular research. This liquid concentrates many heart-derived factors, thus enclosing several surrogate markers for the diagnosis or prognosis of a large spectrum of diseases either pericardial (e.g. malignant or tuberculous pericarditis) or non-pericardial/heart diseases (e...
January 18, 2019: Basic Research in Cardiology
https://read.qxmd.com/read/30621958/cardiomyopathy-and-heart-failure-in-patients-with-hiv-infection
#3
REVIEW
Panagiotis Savvoulidis, Javed Butler, Andreas Kalogeropoulos
With the advent and widespread use of antiretroviral therapy (ART), the epidemiology of cardiomyopathy and heart failure (HF) associated with HIV infection is changing. Near-normal life expectancy in contemporary HIV-infected populations has been associated with prolonged exposure to increased cardiometabolic burden and chronic immune activation and systemic inflammation. Therefore, the pre-ART phenotype of HIV-associated cardiomyopathy with overt left ventricular systolic dysfunction and poor prognosis has been replaced over time by cardiomyopathy with a more insidious course, more frequent ischemic background, and highly prevalent left ventricular diastolic dysfunction...
October 19, 2018: Canadian Journal of Cardiology
https://read.qxmd.com/read/30618111/prognostic-significance-of-prior-ischemic-stroke-in-patients-with-coronary-artery-disease-undergoing-percutaneous-coronary-intervention
#4
Hao Wang, Xiaohui Ning, Chenggang Zhu, Dong Yin, Lei Feng, Bo Xu, Changdong Guan, Kefei Dou
OBJECTIVES: To investigate the long-term outcomes of percutaneous coronary intervention (PCI) in patients with previous ischemic stroke. BACKGROUND: Ischemic stroke and coronary artery disease (CAD) are leading causes of death that often coexist with each other. With the increased use of PCI in high-risk patients with CAD, the association between prior ischemic stroke and cardiovascular/cerebrovascular events in patients with CAD undergoing PCI has been a topic of interest...
January 7, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30599216/postmortem-ige-determination-in-coronary-artery-disease
#5
Karine Lambert, Rexson Tse, Camilla Tettamanti, Maria Pia Scarpelli, Guillaume Rousseau, Alessandro Bonsignore, Cristian Palmiere
Allergic, IgE-mediated inflammation is thought to play a role in atherogenesis and atherosclerotic disease progression. In this study, total IgE and mast cell tryptase were measured in a series of forensic autopsy cases including non-allergic cardiac deaths (14 cases with minimal or no coronary atherosclerosis, 14 cases with significant coronary artery atherosclerosis without acute coronary thrombosis, and 14 cases with significant coronary artery atherosclerosis and acute coronary thrombosis or myocardial infarction) and non-allergic non-cardiac deaths (21 cases with death due to hanging and 21 cases with death due to intracranial gunshot wounds), in order to correlate laboratory results with morphological findings and compare them to conclusions reported in the clinical setting...
December 24, 2018: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/30527593/meta-analysis-design-and-results-in-real-life-problem-solvers-or-detour-to-maze-a-critical-review-of-meta-analysis-of-dapt-randomized-controlled-trials
#6
REVIEW
Ivan J Núñez Gil, Ainhoa Elizondo, Simona Gradari, Pedro A Villablanca, Hector Bueno, Gisela Feltes, Alicia Quirós, Harish Ramakrishna, Louka Boshra, Antonio Fernandez-Ortiz
BACKGROUND: Therapeutic strategies - such as duration of dual antiplatelet therapy after coronary artery stenting - usually generate a large quantity of meta-analyses. The meta-analyses that include the same randomized clinical trials should produce similar results. Our aim in the study is to analyze the quality and to compare the results of meta-analyses focused on a controversial topic such as dual antiplatelet therapy after percutaneous coronary intervention. METHODS: We searched all published meta-analyses published up to November 2015 (near DAPT trial publication) selecting those that included the same randomized clinical trials comparing patterns of briefer versus longer-term double antiplatelet therapy...
October 27, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/30510637/coronary-spasm-it-s-common-but-it-s-still-unsolved
#7
EDITORIAL
Hiroki Teragawa, Chikage Oshita, Tomohiro Ueda
Coronary spasm is caused by a transient coronary narrowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. In addition, several new findings of the mechanism of coronary spasm have emerged recently...
November 26, 2018: World Journal of Cardiology
https://read.qxmd.com/read/30506432/mitral-valve-velocity-time-integral-and-passive-leg-raise-as-a-measure-of-volume-responsiveness
#8
Ralphe Bou Chebl, Gilbert Abou Dagher, Jeffrey Wuhantu, Rana Bachir, Jennifer Carnell
BACKGROUND: Fluid responsiveness is an important topic for clinicians. Aggressive hydration has been shown to lead to worse outcomes. The aim of this study was to investigate the sensitivity and specificity of mitral valve (MV) velocity time integral (VTI) as a non-invasive marker of volume responsiveness. METHODS: This was a prospective observational study conducted in a tertiary emergency department. End-stage renal disease patients presenting to the emergency department requiring emergent hemodialysis were enrolled...
December 2, 2018: Critical Ultrasound Journal
https://read.qxmd.com/read/30410795/radiation-induced-coronary-artery-disease-and-its-treatment-a-quick-review-of-current-evidence
#9
REVIEW
Christopher DeZorzi
As advances in medical technology arise and the availability of cancer treatment increases, an increased number of patients are receiving cancer treatment. Radiation therapy has evolved to become one of the cornerstones of treatment for various types of cancers. One of the long-term consequences of radiation therapy is radiation-induced coronary artery disease (RICAD). Although the pathophysiology of RICAD may be slightly different and more acute onset than the commonly seen "generic" coronary artery disease, it is common practice to treat RICAD in the same method as nonradiation-induced CAD...
2018: Cardiology Research and Practice
https://read.qxmd.com/read/30405035/electronic-cigarettes-and-smoking-cessation-in-the-perioperative-period-of-cardiothoracic-surgery-views-of-australian-clinicians
#10
Nia A Luxton, Patti Shih, Muhammad Aziz Rahman
For patients who smoke, electronic cigarettes may offer a pathway to achieve tobacco abstinence and reduce the risk of postoperative complications. Clinicians have a pivotal role in supporting smoking cessation by patients with lung cancer and coronary artery disease throughout the perioperative period of cardiothoracic surgery. However, the views of Australian cardiothoracic clinicians on electronic cigarettes and smoking cessation are unknown. Semi-structured interviews were conducted with 52 cardiothoracic surgeons, anaesthetists, nurses and physiotherapists in six hospitals in Sydney and thematically analysed...
November 7, 2018: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30370501/coronary-arterial-vasculature-in-the-pathophysiology-of-hypertrophic-cardiomyopathy
#11
REVIEW
Richard J Marszalek, R John Solaro, Beata M Wolska
Alterations in the coronary vascular system are likely associated with a mismatch between energy demand and energy supply and critical in triggering the cascade of events that leads to symptomatic hypertrophic cardiomyopathy. Targeting the early events, particularly vascular remodeling, may be a key approach to developing effective treatments. Improvement in our understanding of hypertrophic cardiomyopathy began with the results of early biophysical studies, proceeded to genetic analyses pinpointing the mutational origin, and now pertains to imaging of the metabolic and flow-related consequences of such mutations...
October 29, 2018: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/30345804/characterization-of-the-recommendations-in-the-choosing-wisely-initiative
#12
Kelsey Corrigan, Leonid Aksenov, Alexandra Paul, Banafsheh Sharif-Askary, Sarvesh Agarwal, Arif Kamal
Choosing Wisely is a comprehensive set of recommendations that guides clinicians and patients away from low-value services. The recommendations were reviewed to investigate their breadth and limitations. The authors performed an abstraction of all Choosing Wisely recommendations between March 1 and May 27, 2016. Descriptive statistics were used to characterize various topics found in the recommendations. Of the 461 Choosing Wisely recommendations, 48% targeted workup studies, 26% non-medication management, 20% medication management, and 6% disease prevention...
October 20, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://read.qxmd.com/read/30309628/acute-and-subacute-triggers-of-cardiovascular-events
#13
REVIEW
Bryan G Schwartz, Robert A Kloner, Morteza Naghavi
Inability to predict short-term cardiovascular (CV) events and take immediate preemptive actions has long been the Achilles heel of cardiology. However, certain triggers of these events have come to light. Although these triggers are nonspecific and are part of normal life, studying their temporal relationship with the onset of CV events provides an opportunity to alert high-risk atherosclerotic patients who may be most vulnerable to such triggers, the "vulnerable patient". Herein, we review the literature and shed light on the epidemiology and underlying pathophysiology of different triggers...
December 15, 2018: American Journal of Cardiology
https://read.qxmd.com/read/30279830/acute-compartment-syndrome-a-rare-but-important-complication-of-transradial-cardiac-catheterization
#14
Tom J O'Donohoe, Ryan G Schrale
The transradial approach has become the gold-standard for coronary angiography. It is better tolerated by patients, associated with less bleeding, earlier post-procedure mobilization, and reduced mortality in patients with myocardial infarction. Given the hand's dual arterial supply and extensive collateral circulation, the risk of serious functional injury after radial catheterization is essentially reduced to zero. However, even a small amount of bleeding in the volar compartment can lead to compartment syndrome (CS) and permanent neurovascular injury...
December 2017: Journal of Cardiology Cases
https://read.qxmd.com/read/30239376/the-roma-trial-why-it-is-needed
#15
Mario F L Gaudino, David P Taggart, Stephen E Fremes
PURPOSE OF REVIEW: We herein summarize the current evidence on the clinical outcome associated with the use of single and multiple arterial grafts for coronary bypass surgery and the role and importance of the Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts (ROMA) trial. RECENT FINDINGS: Observational evidence suggests that the use of multiple arterial grafts is associated with better clinical outcomes compared to the use of a single arterial graft...
November 2018: Current Opinion in Cardiology
https://read.qxmd.com/read/30213005/rationale-and-design-of-randomized-controlled-trial-protocol-of-cardiovascular-rehabilitation-based-on-the-use-of-telemedicine-technology-in-the-czech-republic-cr-gps
#16
RANDOMIZED CONTROLLED TRIAL
Ladislav Batalik, Filip Dosbaba, Martin Hartman, Katerina Batalikova, Jindrich Spinar
BACKGROUND: Cardiovascular diseases remain the most common causes of death in the world. Instructions for secondary prevention recommend multifaceted approach in cardiovascular diseases risk management. Center-based physical exercise training is considered as an important integral part of cardiac rehabilitation (CR). Despite all recognized benefits CR brings, active interest of patients remains low in many countries, including the Czech Republic. That is why there is a need to focus on more effective patients' participation in CR with respect to their preferences and needs...
September 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30145662/dental-management-of-patient-with-dual-antiplatelet-therapy-a-meta-analysis
#17
Lin Li, Wenyi Zhang, Yun Yang, Liyuan Zhao, Xinyao Zhou, Jian Zhang
BACKGROUND: It is more common to need dual antiplatelet therapy (DAPT) for patients who had recently inserted coronary artery stent. However, the postoperative bleeding risk of patients in DAPT could significantly increase. The dental management of patients with antithrombotic therapy has always been a controversial problem. Focusing on this issue, this review discussed the available evidence to provide optimal strategy for patients taking dual antiplatelet agents in the dental setting...
August 25, 2018: Clinical Oral Investigations
https://read.qxmd.com/read/30094215/coronary-artery-bypass-grafting-cabg-vs-percutaneous-coronary-intervention-pci-in-the-treatment-of-multivessel-coronary-disease-quo-vadis-a-review-of-the-evidences-on-coronary-artery-disease
#18
EDITORIAL
Cristiano Spadaccio, Umberto Benedetto
The optimal treatment of ischemic coronary artery disease (CAD) is still controversial. A number of randomized controlled trials (RCT) and several meta-analyses have been performed and are inspiring the current guidelines. However, a univocal consensus on the optimal therapeutic strategy for multivessel disease has still not been reached yet. We reviewed the current evidence on this topic, focusing on both RCT and meta-analyses. From both short and long-term studies, it emerges that in patients with multivessel disease, coronary artery bypass grafting (CABG) is associated with better survival, lower rates of major cardiovascular events (specifically myocardial infarction or stroke) and repeat revascularization as compared with percutaneous coronary intervention (PCI) with drug-eluting stents...
July 2018: Annals of Cardiothoracic Surgery
https://read.qxmd.com/read/30052998/does-the-use-of-an-in-situ-or-y-configuration-for-bilateral-internal-thoracic-arteries-influence-long-term-survival-patency-or-repeat-revascularization-in-coronary-bypass-surgery
#19
Rory Kelleher, Damian Gimpel, David J McCormack, Adam El-Gamel
A best evidence topic was constructed according to a structured protocol. The question addressed was whether the configuration of bilateral internal thoracic arteries (BITAs) influences survival, patency or repeat revascularization in patients undergoing coronary artery bypass grafting. Five hundred and seventy-one papers were found using the reported searches, of which 8 represented the best evidence to answer the clinical question. One systematic review, 4 randomized trials and 3 observational studies were selected...
July 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://read.qxmd.com/read/30041259/-policy-paper-nuclear-cardiology-update-2018-current-status-of-clinical-practice
#20
Oliver Lindner, Johann Bauersachs, Frank M Bengel, Wolfgang Burchert, Jürgen Vom Dahl, Rolf Dörr, Marcus Hacker, Malte Kelm, Tienush Rassaf, Christoph Rischpler, Wolfgang Schäfer, Michael A Schäfers, Sigmund Silber, Rainer Zimmermann
The joint position paper of the working community "Cardiovascular Nuclear Medicine" of the German Society of Nuclear Medicine (DGN) and the working group "Nuclear Cardiology Diagnostics" of the German Cardiac Society (DKG) updates the former 2009 paper. It is the purpose of this paper to provide an overview about the application fields, the state-of-the-art and the current value of nuclear cardiology imaging. The topics covered are chronic coronary artery disease, including viability imaging, furthermore cardiomyopathies, infective endocarditis, cardiac sarcoidosis and amyloidosis...
August 2018: Nuklearmedizin. Nuclear Medicine
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