Jonathan Ramírez-Prada, Juan S Rocha-Ortiz, Marta I Orozco, Pedro Moreno, Miguel Guevara, Mauricio Barreto, Maria E Burbano, Sara Robledo, Maria Del Pilar Crespo-Ortiz, Jairo Quiroga, Rodrigo Abonia, Viviana Cuartas, Braulio Insuasty
New pyridine-based chalcones 4a-h and pyrazolines 5a-h (N-acetyl), 6a-h (N-phenyl), and 7a-h (N-4-chlorophenyl) were synthesized and evaluated by the National Cancer Institute (NCI) against 60 different human cancer cell lines. Pyrazolines 6a, 6c-h, and 7a-h satisfied the pre-determined threshold inhibition criteria, obtaining that compounds 6c and 6f exhibited high antiproliferative activity, reaching submicromolar GI50 values from 0.38 to 0.45 μM, respectively. Moreover, compound 7g (4-CH3 ) exhibited the highest cytostatic activity of these series against different cancer cell lines from leukemia, nonsmall cell lung, colon, ovarian, renal, and prostate cancer, with LC50 values ranging from 5...
March 28, 2024: Archiv der Pharmazie