Leydi M Moreno, Jairo Quiroga, Rodrigo Abonia, María Del P Crespo, Carlos Aranaga, Luis Martínez-Martínez, Maximiliano Sortino, Mauricio Barreto, María E Burbano, Braulio Insuasty
This study presents the synthesis of four series of novel hybrid chalcones ( 20,21 ) a - g and ( 23,24 ) a - g and six series of 1,3,5-triazine-based pyrimido[4,5- b ][1,4]diazepines ( 28 - 33 ) a - g and the evaluation of their anticancer, antibacterial, antifungal, and cytotoxic properties. Chalcones 20b , d , 21a,b , d , 23a , d - g , 24a - g and the pyrimido[4,5- b ][1,4]diazepines 29e , g , 30g , 31a , b , e - g , 33a , b , e - g exhibited outstanding anticancer activity against a panel of 60 cancer cell lines with GI50 values between 0...
March 23, 2024: International Journal of Molecular Sciences