Yee Hui Yeo, Hsiu J Ho, Hwai-I Yang, Tai-Chung Tseng, Tetsuya Hosaka, Huy N Trinh, Min-Sun Kwak, Young Min Park, James Yan Yue Fung, Maria Buti, Manuel Rodríguez, Sombat Treeprasertsuk, Carmen Monica Preda, Teerapat Ungtrakul, Phunchai Charatcharoenwitthaya, Xiangyong Li, Jiayi Li, Jian Zhang, Michael Huan Le, Bin Wei, Biyao Zou, An Le, Donghak Jeong, Nicholas Chien, Leslie Kam, Chiao-Chin Lee, Mar Riveiro-Barciela, Doina Istratescu, Tassanee Sriprayoon, Yutian Chong, Tawesak Tanwandee, Mariko Kobayashi, Fumitaka Suzuki, Man-Fung Yuen, Hyo-Suk Lee, Jia-Horng Kao, Anna S Lok, Chun-Ying Wu, Mindie H Nguyen
BACKGROUND & AIMS: Seroclearance of hepatitis B surface antigen (HBsAg) is a marker for clearance of chronic hepatitis B virus (HBV) infection, but reported annual incidence rates of HBsAg seroclearance vary. We performed a systematic review and meta-analysis to provide more precise estimates of HBsAg seroclearance rates among subgroups and populations. METHODS: We searched PubMed, Embase, and the Cochrane library for cohort studies that reported HBsAg seroclearance in adults with chronic HBV infection with more than 1 year of follow-up and at least 1 repeat test for HBsAg...
February 2019: Gastroenterology