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Damon Pabst, Richard K Ogden
No abstract text is available yet for this article.
March 19, 2019: American Journal of Health-system Pharmacy: AJHP
Westyn Branch-Elliman, Steven D Pizer, Elise A Dasinger, Howard S Gold, Hassen Abdulkerim, Amy K Rosen, Martin P Charns, Mary T Hawn, Kamal M F Itani, Hillary J Mull
Background: Guidelines recommend discontinuation of antimicrobial prophylaxis within 24 h after incision closure in uninfected patients. However, how facility and surgical specialty factors affect the implementation of these evidence-based surgical prophylaxis guidelines in outpatient surgery is unknown. Thus, we sought to measure how facility complexity, including ambulatory surgical center (ASC) status and availability of ancillary services, impact adherence to guidelines for timely discontinuation of antimicrobial prophylaxis after outpatient surgery...
2019: Antimicrobial Resistance and Infection Control
Stephanie L Lim, Laura J Havrilesky, Robert P Heine, Sarah Dotters-Katz
BACKGROUND: Chorioamnionitis affects 1-4% of pregnancies, and patients who undergo cesarean delivery in the setting of chorioamnionitis have an increased risk of endometritis and surgical site infection. The standard treatment for chorioamnionitis after cesarean delivery is a combination regimen of intravenous ampicillin, gentamicin, and clindamycin with variable duration (single dose to 24 hours). However, newer evidence suggests that ertapenem may decrease the risk of postoperative infectious morbidity with the added benefit of a single postpartum dose, compared to between 3-10 doses of AGC...
March 18, 2019: Journal of Maternal-fetal & Neonatal Medicine
D Greenwood, M P Tully, S Martin, D Steinke
Background Due to a shortage of emergency department doctors and nurses, hospitals have started to employ pharmacists who have additional clinical skills, known as Emergency Department Pharmacist Practitioners, to help deliver services. Objective To describe, compare and define the Emergency Department Pharmacist Practitioner role. Setting UK emergency departments. Method Using a purpose developed questionnaire hosted on a tablet computer, Emergency Department Pharmacist Practitioners were asked to report their contribution to patient care and the wider emergency department over 10 work days...
March 16, 2019: International Journal of Clinical Pharmacy
Sara E Heins, Katherine P Frey, G Caleb Alexander, Renan C Castillo
OBJECTIVE: To describe current state-level policies in the United States, January 1, 2007-June 1, 2017, limiting high morphine equivalent daily dose (MEDD) prescribing. METHODS: State-level MEDD threshold policies were reviewed using LexisNexis and Westlaw Next for legislative acts and using Google for nonlegislative state-level policies. The websites of each state's Medicaid agency, health department, prescription drug monitoring program, workers' compensation board, medical board, and pharmacy board were reviewed to identify additional policies...
March 13, 2019: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Maria Belén Marzal-Alfaro, Vicente Escudero-Vilaplana, Carmen Guadalupe Rodríguez-González, Eva González-Haba, Aitana Calvo, Santiago Osorio, Irene Iglesias-Peinado, Ana Herranz, María Sanjurjo
OBJECTIVE: The aim of the study was to analyze both the prevalence of errors with the implementation of an image-based workflow management system during the antineoplastic compounding process, and the estimated costs associated with the negative clinical outcome if the errors had not been intercepted. METHODS: Three months after the implementation of Phocus Rx system at a hospital pharmacy department, the identification, classification (type, preparation stage, and cause), and potential severity degree (from negligible to catastrophic) of the errors intercepted were determined...
March 6, 2019: Journal of Patient Safety
Kyung Suk Choi, Eunsook Lee, Sandy Jeong Rhie
Background Early interventions with clinical decision support system (CDSS) guidance have ensured appropriate drug dosing for patients with renal impairment. However, the low rates of physician compliance with CDSS alerts have been reported. Objective We investigated whether designated pharmacist interventions were associated with physician' acceptance of the knowledge-based renal dosage adjustment system (K-RDS) for patients with reduced renal function. Setting A retrospective, single-center study was conducted using a healthcare information system at a tertiary teaching hospital...
March 12, 2019: International Journal of Clinical Pharmacy
Laura A Hart, Zachary A Marcum, Shelly L Gray, Rod L Walker, Paul K Crane, Eric B Larson
OBJECTIVES: To examine the association between central nervous system (CNS)-active medication use and risk of fall-related injury in community-dwelling older adults following dementia onset. Further, to evaluate increased risk at higher doses or with greater number of CNS-active medications classes. METHODS: Participants included community-dwelling older adults aged ≥65 years with a dementia diagnosis participating in the Adult Changes in Thought Study. From automated pharmacy data, a time-varying composite measure of CNS-active medication use was created...
March 12, 2019: Pharmacotherapy
Sara Daliri, Jacqueline G Hugtenburg, Gerben Ter Riet, Bart J F van den Bemt, Bianca M Buurman, Wilma J M Scholte Op Reimer, Marie-Christine van Buul-Gast, Fatma Karapinar-Çarkit
BACKGROUND: Medication-related problems are common after hospitalization, for example when changes in patients' medication regimens are accompanied by insufficient patient education, poor information transfer between healthcare providers, and inadequate follow-up post-discharge. We investigated the effect of a pharmacy-led transitional care program on the occurrence of medication-related problems four weeks post-discharge. METHODS: A prospective multi-center before-after study was conducted in six departments in total of two hospitals and 50 community pharmacies in the Netherlands...
2019: PloS One
Brandy McGinnis, Eimeira Padilla, Pat Garret, Shewan Aziz
OBJECTIVES: To determine if telepharmacy can be used to collect medication histories on patients admitted in the emergency department (ED) in a large health system. PRACTICE DESCRIPTION: As part of an effort to address safety concerns, resource limitations, and a decline in medication history completions, a program was developed to use telepharmacy to conduct medication histories on patients admitted in the ED. SETTING: The medication history program covers 5 large facilities...
March 7, 2019: Journal of the American Pharmacists Association: JAPhA
Heather L Ourth, Julie A Groppi, Anthony P Morreale, Terri Jorgenson, Andrew S Himsel, David A Jacob
OBJECTIVES: To increase access to hepatitis C virus (HCV) care and cure by deploying clinical pharmacy specialist (CPS) providers across the largest integrated health care system in the United States. SETTING: National integrated health care system. PRACTICE DESCRIPTION: In late 2016, the Department of Veterans Affairs (VA) Pharmacy Benefits Management Clinical Pharmacy Practice Office (CPPO) partnered with the VA HIV, Hepatitis, and Related Conditions Program with the central priority of expanding veteran access to novel HCV treatments and timely cure to ultimately prevent morbidity and mortality associated with HCV disease progression...
March 7, 2019: Journal of the American Pharmacists Association: JAPhA
Tessa J Hastings, Lindsey A Hohmann, Jan Neal, Salisa C Westrick
OBJECTIVES: The Certified Aging Resource Educated Specialist (C.A.R.E.S.) Program was developed to increase pharmacist awareness of available programs for Medicare patients with limited income and to integrate an efficient referral process into the pharmacy workflow. The objective is to describe the program in terms of pharmacy personnel satisfaction, pharmacy personnel knowledge, and network outcomes including enrollment and referrals. SETTING: Alabama community pharmacies...
February 27, 2019: Journal of the American Pharmacists Association: JAPhA
T Joseph Mattingly, Neha S Pandit, Eberechukwu Onukwugha
INTRODUCTION: In patients with hepatitis C virus (HCV), human immunodeficiency virus (HIV) represents a major cause of morbidity and economic burden. Economic evaluations in HIV-HCV typically focus on government-sponsored insurance plans rather than a commercially insured cohort. This study evaluated the clinical and economic burden of HIV-HCV co-infection compared with HCV alone in commercially insured patients throughout the United States. METHODS: Commercial medical and pharmacy claims from 2007 to 2015 from a 10% random sample of enrollees within the IQVIA PharMetrics Plus™ administrative claims database were analyzed...
March 2, 2019: Infectious Diseases and Therapy
Xiaoxue Chen, Qinli Ma, John Barron, Andrea DeVries, Jennifer Horn, Abiy Agiro
BACKGROUND: The misuse of prescription drugs is a serious public health problem. Although controlled substance (CS) prescribing, in particular, opioid analgesics, has recently declined, the volume of prescriptions in 2015 was still 3 times higher than in 1999. To curb the high volume of CS prescribing, a national health plan has implemented a controlled substance utilization management (CSUM) program, a prescriber-focused educational intervention regarding patients at risk for CS misuse...
March 2019: Journal of Managed Care & Specialty Pharmacy
Anna Hung, C Daniel Mullins, Julia F Slejko, Stuart T Haines, Fadia Shaya, Amy Lugo
BACKGROUND: Traditional budget impact models predict the financial consequences of a new drug entering the market. This study provides an example of applying the budget impact framework to a new research question of interest to managed care organizations-what is the budget impact of our formulary and utilization management (UM) policy changes? OBJECTIVE: To predict the 3-year annual budgetary impact of TRICARE's antidiabetic formulary and UM policy changes using TRICARE claims data...
March 2019: Journal of Managed Care & Specialty Pharmacy
Phil Schwab, Patrick Racsa, Karen Rascati, Marc Mourer, Yunus Meah, Karen Worley
BACKGROUND: Adherence to oral antihyperglycemic agents (AHAs) is important for managing blood glucose levels and avoiding hospitalizations or diabetes complications. Previous studies have found that use of mail-order pharmacy dispensing channels results in greater adherence than use of community pharmacies, but the link between use of mail-order pharmacies and improved clinical outcomes has not been established. OBJECTIVE: To compare the effect of mail-order and community pharmacy use on adherence to oral AHAs, hemoglobin A1c (A1c) level, and glycemic control, as well as emergency department (ED) and inpatient hospital use...
March 2019: Journal of Managed Care & Specialty Pharmacy
Kibum Kim, Sudhir Unni, Carrie McAdam-Marx, Sheila M Thomas, Kimberly L Sterling, Cody J Olsen, Bryan Johnstone, Matt Mitchell, Diana Brixner
BACKGROUND: In the United States, more than 50% of patients with type 2 diabetes mellitus (T2DM) have hemoglobin A1c (A1c) levels that fail to achieve the recommended target of < 7.0%. Of these, 30%-45% have an A1c > 9.0%, the threshold for poorly controlled T2DM per National Committee for Quality Assurance (NCQA) measures. Treatment inertia is a known challenge. However, recent treatment intensification patterns and outcomes after treatment fails 2 classes of oral antidiabetic agents (OADs) are not well understood...
March 2019: Journal of Managed Care & Specialty Pharmacy
Casey Dempsey, Erik Skoglund, Kenneth L Muldrew, Kevin W Garey
BACKGROUND: Blood culture contamination with gram-positive organisms is a common occurrence in patients suspected of bloodstream infections, especially in emergency departments. Although numerous research studies have investigated the cost implications of blood culture contamination, a contemporary systematic review of the literature has not been performed. The aim of this project was to perform a systematic review of the published literature on the economic costs of blood culture contamination...
February 19, 2019: American Journal of Infection Control
Theodore J Cicero, Mario Mendoza, Michael Cattaneo, Richard C Dart, Jack Mardekian, Michael Polson, Carl L Roland, Sidney H Schnoll, Lynn R Webster, Peter W Park
OBJECTIVE: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients. METHODS: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from 1 January 2015, to 30 June 2016...
February 22, 2019: Postgraduate Medicine
Ana de Lorenzo-Pinto, Cristina Ortega-Navarro, Almudena Ribed, Álvaro Giménez-Manzorro, Sara Ibáñez-García, Ángeles de Miguel-Guijarro, María Dolores Ginel-Feito, Ana Herranz, María Sanjurjo-Sáez
WHAT IS KNOWN AND OBJECTIVES: Inadequate management of chronic medication puts patients at risk and causes unnecessary suspension of surgical procedures. The objective of the study was to calculate the rate of cancellation of elective surgical procedures due to inadequate management of chronic medications and to analyse the underlying causes of cancellation. METHODS: We designed an analytic, observational, retrospective study of all elective surgical procedures performed from July to October 2017 in a tertiary hospital...
February 21, 2019: Journal of Clinical Pharmacy and Therapeutics
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