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Hirokazu Sasaki, Sachiko Mitani, Shigeru Kusumoto, Yoshiaki Marumo, Arisa Asano, Takashi Yoshida, Tomoko Narita, Asahi Ito, Hiroki Yano, Masaki Ri, Takashi Ishida, Hirokazu Komatsu, Shinsuke Iida
A 42-year-old female complaining of fever and night sweats was diagnosed with acute megakaryoblastic blast phase chronic myeloid leukemia (CML-BP). She had massive splenomegaly, left pleural effusion with leukemia infiltration, and moderate myelofibrosis. She received dasatinib monotherapy (140 mg/day) as for induction, after which her pleural effusion rapidly resolved and hematological remission was achieved. However, CML relapsed 4 months after starting dasatinib due to increased BCR-ABL fusion signals in the peripheral blood...
March 16, 2019: International Journal of Hematology
Johannes Kerschbaumer, Daniel Pinggera, Ruth Steiger, Andreas Rietzler, Adelheid Wöhrer, Marina Riedmann, Astrid Ellen Grams, Claudius Thomé, Christian Franz Freyschlag
BACKGROUND: Brain metastases (BM) are classically well-circumscribed lesions. Still, the amount of edema in these neoplasms suggested either mechanisms of infiltration or defense. A better understanding of the mechanisms within the edema of BM seems reasonable, to preoperatively identify areas of potential infiltration and resect them. AIM: BM represent tumors with high energy-demand and cell-turnover, therefore they qualify for preoperative investigation with 31-Phosphorus-MR-Spectroscopy (31PMRS), revealing information about those characteristics...
March 13, 2019: World Neurosurgery
Jesús Vaquero, Mercedes Zurita, Jorge Mucientes, Maria L Pascual, Cecilia Fernández-Mateos, Estefania Garcia, Sara Fernández-Guinea
BACKGROUND AIMS: After recent observations that intrathecal administration of autologous bone marrow mesenchymal stromal cells (MSCs) increases cerebral metabolism in patients with severe traumatic brain injury (TBI), we examined this type of cell therapy in Alzheimer's type dementia. METHODS: Three patients with clinical diagnosis of Alzheimer's disease received every 3 months 100 million autologous MSCs by intrathecal route, until a total dose of 300 million. RESULTS: During cell therapy the patients showed arrest in neurological deterioration and two of them manifested clear improvement of previous symptoms...
March 14, 2019: Cytotherapy
Javier Bolaños-Meade, Kenneth R Cooke, Christopher J Gamper, Syed Abbas Ali, Richard F Ambinder, Ivan M Borrello, Ephraim J Fuchs, Douglas E Gladstone, Christian B Gocke, Carol Ann Huff, Leo Luznik, Lode J Swinnen, Heather J Symons, Stephanie A Terezakis, Nina Wagner-Johnston, Richard J Jones, Robert A Brodsky
BACKGROUND: Although severe haemoglobinopathies can be cured with allogeneic blood or bone marrow transplantation, availability of matched donors and toxic effects can be problematic. We previously found that non-myeloablative haploidentical related bone marrow transplantation with post-transplantation cyclophosphamide expanded the donor pool while limiting graft-versus-host disease (GVHD). However, graft failure-albeit with full host haemopoietic recovery-occurred in 50% of patients...
March 13, 2019: Lancet Haematology
Rebecca Ye, Sirisha Kundrapu, Stanton L Gerson, James J Driscoll, Rose Beck, Naveed Ali, Ola Landgren, Willem VanHeeckeren, George Luo, Nicolaus Kroger, Paolo Caimi, Marcos De Lima, Ehsan Malek
BACKGROUND: High-dose chemotherapy and autologous stem cell transplantation (ASCT) are integral components of the overall treatment for patients with multiple myeloma (MM) aged ≤ 65 years. The emergence of oligoclonal immunoglobulin bands (ie, immunoglobulins differing from those originally identified at diagnosis [termed clonal isotype switch (CIS)]) has been reported in patients with MM after high-dose chemotherapy followed by autologous stem cell transplantation. However, the clinical relevance and the correlation with immune reconstitution remains unclear...
January 3, 2019: Clinical Lymphoma, Myeloma & Leukemia
Juan M Díaz-Tocados, María E Rodríguez-Ortiz, Yolanda Almadén, Carmen Pineda, Julio M Martínez-Moreno, Carmen Herencia, Noemi Vergara, M Victoria Pendón-Ruiz de Mier, Rafael Santamaría, Cristian Rodelo-Haad, Antonio Casado-Díaz, Víctor Lorenzo, Catarina Carvalho, João M Frazão, Arnold J Felsenfeld, William G Richards, Escolástico Aguilera-Tejero, Mariano Rodríguez, Ignacio López, Juan R Muñoz-Castañeda
Calcimimetics decrease parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism. The decrease in PTH should cause a reduction in bone turnover; however, the direct effect of calcimimetics on bone cells, which express the calcium-sensing receptor (CaSR), has not been defined. In this study, we evaluated the direct bone effects of CaSR activation by a calcimimetic (AMG 641) in vitro and in vivo. To create a PTH "clamp," total parathyroidectomy was performed in rats with and without uremia induced by 5/6 nephrectomy, followed by a continuous subcutaneous infusion of PTH...
March 12, 2019: Kidney International
Shigeo Fuji, Koichi Miyamura, Yoshinobu Kanda, Takahiro Fukuda, Takeshi Kobayashi, Yukiyasu Ozawa, Koji Iwato, Naoyuki Uchida, Tetsuya Eto, Takashi Ashida, Takehiko Mori, Masashi Sawa, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda
In Japan, use of unrelated peripheral blood stem cell transplantation (uPBSCT) from HLA-mismatched unrelated donors has recently been approved. We compared outcomes between HLA-matched and 1-locus mismatched uPBSCT, as well as the impact of HLA disparity in uPBSCT and in unrelated bone marrow transplantation (uBMT). In total, 5862 uBMT recipients and 234 uPBSCT recipients were included. In terms of HLA allele disparity, 185 uPBSCT patients (79.1%) had no HLA mismatch, and 49 (20.9%) had 1-locus mismatch; in comparison, 3585 uBMT patients (61...
March 15, 2019: International Journal of Hematology
Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh
OBJECTIVE: Pre-clinical studies with gallium-68 zoledronate ([68 Ga]Ga-DOTAZOL ) have proposed it to be a potent bisphosphonate for PET/CT diagnosis of bone diseases and diagnostic counterpart to [177 Lu]Lu-DOTAZOL and [225 Ac]Ac-DOTAZOL . This study aims to be the first human biodistribution and dosimetric analysis of [68 Ga]Ga-DOTAZOL . METHODS: Five metastatic skeletal disease patients (mean age: 72 years, M: F; 4:1) were injected with 150-190 MBq (4.05-5.14 mCi) of [68 Ga]Ga-DOTAZOL i...
March 15, 2019: Annals of Nuclear Medicine
Ingo Fiss, Abdelhalim Hussein, Alonso Barrantes-Freer, Swetlana Sperling, Silvia Hernandez-Duran, Christina Wolfert, Tobias Pukrop, Milena Ninkovic, Annalen Bleckmann, Veit Rohde, Dorothee Mielke, Bawarjan Schatlo
BACKGROUND: Brain metastases (BMs) are the most frequent malignancy of the central nervous system. Previous research suggested that some metastases show infiltrative behavior rather than sharp demarcation. We hypothesized that three magnetic resonance (MR) imaging parameters-(a) tumor size, (b) extent of peritumoral edema, and (c) presence of multiple BMs-are predictors of cellular invasion beyond the surgically identifiable tumor margins. METHODS: We performed a post hoc analysis on prospectively collected data of patients with BMs...
March 15, 2019: Acta Neurochirurgica
Toshio Kaneda, Yuki Nakajima, Sae Koshikawa, Alfarius Eko Nugroho, Hiroshi Morita
Previously, we reported that cyclolinopeptides (CLs) extracted from flaxseed inhibited receptor activator of nuclear factor κ-B ligand (RANKL)-induced osteoclastogenesis from mouse bone marrow cells in vitro. However, mode of action involved in CLs-inhibited osteoclastogenesis has been yet unknown. Therefore, in this study, we investigated the details of inhibitory activity of cyclolinopeptide-F (CL-F) in osteoclastogenesis, as a representative of CLs. CL-F dose-dependently inhibited RANKL-induced osteoclastogenesis (IC50 0...
March 15, 2019: Journal of Natural Medicines
Philipp Egenolf, Ibrahim Duran, Christina Stark, Kyriakos Martakis, Stefanie Hamacher, Eckhard Schoenau, Oliver Semler
The purpose of this study was to create growth-percentiles for Caucasian children with cerebral palsy (CP). The studied parameters were height and age. In a retrospective analysis, we converted measurements collected in our center to create disorder-specific percentiles of normative data. Patients were stratified due to sex (male and female) and to mobility levels using the gross motor function classification system (GMFCS) (A = walking; GMFCS I-III, B = non walking; GMFCS IV-V) into four groups. In total, 2363 measurements in patients 0-18 years were collected...
March 14, 2019: European Journal of Pediatrics
Panagiotis T Diamantopoulos, Christina-Nefeli Kontandreopoulou, Argiris Symeonidis, Ioannis Kotsianidis, Vassiliki Pappa, Athanasios Galanopoulos, Theodoros Vassilakopoulos, Maria Dimou, Eleni Solomou, Marie-Christine Kyrtsonis, Marina Siakantaris, Maria Angelopoulou, Alexandra Kourakli, Sotirios Papageorgiou, Georgia Christopoulou, Maria Roumelioti, Panayiotis Panayiotidis, Nora-Athina Viniou
Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that participates in the DNA repair of malignant cells, with various consequences on their survival. We have recently shown that PARP1 mRNA levels in the bone marrow of patients with myelodysplastic syndrome (MDS) are correlated to prognosis. To evaluate PARP1 as a biomarker of response to 5-azacytidine in patients with MDS, we measured PARP1 mRNA levels by a quantitative real-time PCR in diagnostic bone marrow samples of 77 patients with MDS treated with 5-azacytidine...
March 15, 2019: Annals of Hematology
Ramin Radpour, Carsten Riether, Cedric Simillion, Sabine Höpner, Rémy Bruggmann, Adrian F Ochsenbein
CD8+ T cell immunosurveillance is crucial in solid tumors and T cell dysfunction leads to tumor progression. In contrast, the role of CD8+ T cells in the control of leukemia is less clear. We characterized the molecular signature of leukemia stem/progenitor cells (LSPCs) and paired CD8+ T cells in patients with acute myeloid leukemia (AML). Epigenetic alterations via histone deacetylation reduced the expression of immune-related genes in bone marrow (BM)-infiltrating CD8+ T cells. Surprisingly, a silenced gene expression pattern in CD8+ T cells significantly correlated with an improved prognosis...
March 15, 2019: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Somayeh Niknazar, Hojjat-Allah Abbaszadeh, Hassan Peyvandi, Omidvar Rezaei, Hosna Forooghirad, Shahrokh Khoshsirat, Ali Asghar Peyvandi
Oxidative stress plays an important role in auditory dysfunction. Exogenous cell therapy has brought new hopes for repairing mammalian inner ear hair cells. However, poor cell viability of transplanted cells under oxidative stress conditions has limited their therapeutic potential. The adipocytokine apelin-13 was isolated from a bovine stomach. Apelin-13 might protect oxidative stress-induced hair cell damage was raised considering other oxidative stress-induced injury, including brain ischemia-induced cell death...
March 12, 2019: European Journal of Pharmacology
Fang Liu, Zhuanzi Wang, Wenjian Li, Libin Zhou, Yang Du, Miaomiao Zhang, Yanting Wei
S. cerevisiae-derived-beta-d-glucan (S. cerevisiae-BG) is a natural polysaccharide with various biological effects. The present study was to investigate the protective effect of S. cerevisiae-BG on the injury induced by high linear-energy-transfer (LET) carbon ion irradiation and to reveal the protective mechanisms. Female mice were orally administrated with S. cerevisiae-BG before irradiation. 30-day survival of 6 Gy irradiated-mice was monitored. The damage and recovery of hematopoietic system were evaluated after 2 Gy irradiation, cytokines in plasma were detected, transcriptomics of bone marrow mononuclear cells (BMMNCs) were detected and analyzed...
March 12, 2019: International Journal of Biological Macromolecules
Kyouhei Akisato, Reisuke Nishihara, Hajime Okazaki, Takanori Masuda, Ayako Hironobe, Hiromi Ishizaki, Kondo Shota, Hiroshi Yamaguchi, Yoshinori Funama
RATIONALE AND OBJECTIVES: This study investigated detecting bone marrow edema (BME) in patients with vertebral compression fractures. We compared dual-energy material density analysis images to magnetic resonance imaging (MRI), which is considered the gold standard. MATERIALS AND METHODS: In this retrospective study, 260 vertebral bodies from 30 patients (11 males, 19 females, mean age of 81) were assessed by MRI and dual-energy material density analysis. Diagnostic accuracy was assessed using the receiver operating characteristic (ROC) curve...
March 12, 2019: Academic Radiology
Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P Baklaushev, Xin Wang, Guowen Wang
BACKGROUND: The purpose of the present study was to characterize the prevalence, associated factors, and to construct a nomogram for predicting bone metastasis (BM) with different histological types of lung cancer. PATIENTS AND METHODS: This study was a descriptive study that basing on the invasive lung cancer patients diagnosed between 2010 and 2014 in Surveillance, Epidemiology, and End Results program. A total of 125,652 adult patients were retrieved. Logistic regression analysis was conducted to investigate homogeneous and heterogeneous factors for BM occurrence...
March 15, 2019: BMC Cancer
Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe, Jianjing Yang
BACKGROUND: Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injured brain. It is well known that calpain activation plays a critical role in traumatic brain injury (TBI)-mediated inflammation and cell death; previous studies showed that inhibiting calpain activation is neuroprotective after TBI...
March 15, 2019: Stem Cell Research & Therapy
Yifan Dong, Hyojung Cha, Jiangbin Zhang, Ernest Pastor, Pabitra Shakya Tuladhar, Iain McCulloch, James R Durrant, Artem A Bakulin
Recent progress in organic photovoltaics (OPVs) has been enabled by optimization of the energetic driving force for charge separation, and thus maximization of open-circuit voltage, using non-fullerene acceptor (NFA) materials. In spite of this, the carrier dynamics and relative energies of the key states controlling the photophysics of these systems are still under debate. Herein, we report an in-depth ultrafast spectroscopic study of a representative OPV system based on a polymer donor PffBT4T-2OD and a small-molecule NFA EH-IDTBR...
March 14, 2019: Journal of Chemical Physics
Shanshan Chen, Minchun Yi, Guozhong Zhou, Yuechang Pu, Yi Hu, Mihua Han, Hua Jin
BACKGROUND This study aimed to investigate the effects of abdominal aortic transplantation of bone marrow mesenchymal stem cells (BMMSCs) on the expression of inflammatory cytokines in a rat model of spinal cord ischemia-reperfusion injury. MATERIAL AND METHODS Adult female Sprague-Dawley rats (N=160) were divided into five groups: the sham operation group (N-32); the control group (N=32); the BMMSC transplanted group (N=32); the anti-ciliary neurotrophic factor (CNTF)-treated BMMSC transplanted group (N=32); and the CNTF small interfering RNA (siRNA)-treated BMMSC transplanted group (N=32)...
March 15, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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