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https://read.qxmd.com/read/30895888/microfilaria-not-always-associated-with-eosinophilia
#1
Neha Garg, Shilpi More, Monika Sharma, Mrinalini Kotru
Filariasis is a parasitic infection seen predominantly in tropical and subtropical countries including India. In clinically suspected cases, examining a thick wet mount smear or a buffy coat film is most informative. In unsuspected cases, however, eosinophilia in a peripheral blood smear (PBS) may be the sole indicator of parasitaemia. A few cases of tissue microfilaria with the absence of peripheral blood eosinophilia (PBE) have been reported. Here, we report two cases of microfilaria in PBS in the absence of PBE...
March 21, 2019: Tropical Doctor
https://read.qxmd.com/read/30889686/screen-printed-interdigitated-electrodes-modified-with-nanostructured-carbon-nano-onion-films-for-detecting-the-cancer-biomarker-ca19-9
#2
Gisela Ibáñez-Redín, Roberto H M Furuta, Deivy Wilson, Flavio M Shimizu, Elsa M Materon, Lidia Maria Rebolho Batista Arantes, Matias E Melendez, André L Carvalho, Rui Manuel Reis, Manuel N Chaur, Débora Gonçalves, Osvaldo N Oliveira
Nanostructured capacitive biosensors, combined with inexpensive fabrication technologies, may provide simple, sensitive devices for detecting clinically relevant cancer biomarkers. Herein, we report a novel platform for detecting the pancreatic cancer biomarker CA19-9 using low-cost screen-printed interdigitated electrodes (SPIDEs). The SPIDEs were modified by carbon nano-onions (CNOs) and graphene oxide (GO) films, on which a layer of anti-CA19-9 antibodies was immobilized. The modification with CNOs and GO significantly improved the analytical performance of the biosensor, which displayed superior results to those prepared only with GO...
June 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30889559/first-principles-dft-insights-into-the-structural-elastic-and-optoelectronic-properties-of-%C3%AE-and-%C3%AE-znp-sub-2-sub-implications-for-photovoltaic-applications
#3
Aleksandar Živković, Barbara Farkaš, Veikko Uahengo, Nora H de Leeuw, Nelson Yaw Dzade
Binary II-V semiconductors are highly optically active materials, possess high intrinsic mechanical and
 chemical durability, and have electronic properties ideal for optoelectronic applications. Among them,
 zinc diphosphide (ZnP2) is a promising earth-abundant absorber material for solar energy conversion.
 We have investigated the structural, mechanical, and optoelectronic properties of both the tetragonal
 (α) and monoclinic (β) phases of ZnP2 using standard, Hubbard-corrected and screened hybrid density
 functional theory (DFT) methods...
March 19, 2019: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://read.qxmd.com/read/30885615/oligodepsipeptide-nano-carriers-computational-design-and-analysis-of-enhanced-drug-loading
#4
Nadia Brunacci, Axel T Neffe, Christian Wischke, Toufik Naolou, Ulrich Nöchel, Andreas Lendlein
High drug loads of nanoparticles are essential to efficiently provide a desired dosage in the required timeframe, however, these conditions may not be reached with so far established degradable matrices. Our conceptual approach for increasing the drug load is based on strengthening the affinity between drug and matrix in combination with stabilizing drug-matrix-hybrids through strong intermolecular matrix interactions. Here, a method for designing such complex drug-matrix hybrids is introduced employing computational methods (molecular dynamics and docking) as well as experimental studies (affinity, drug loading and distribution, drug release from films and nanoparticles)...
March 15, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30874339/technical-approaches-to-select-high-performance-instant-skin-smoothing-formulations-correlation-of-in-vitro-and-in-vivo-assessment-methods
#5
Robert Maidhof, Elizabeth Knapp, Frank Liebel, Michael Fair, Emily H Rubinson
BACKGROUND: Contractile films that smooth the surface of skin upon drying are popular among consumers due to their "instant" effect and perceivable smoothing benefits. The objective of our study was to correlate an in vitro measurement of contractile force with in vivo smoothing performance, thereby enabling rapid screening of film-forming technologies for impactful cosmetic results. METHODS: We introduce and characterize an in vitro method to measure drying stress of film-containing formulations...
March 15, 2019: Skin Research and Technology
https://read.qxmd.com/read/30869658/fast-screening-of-illicit-drugs-in-beverages-and-biological-fluids-by-direct-coupling-of-thin-film-microextraction-to-dielectric-barrier-discharge-ionization-mass-spectrometry
#6
Mario F Mirabelli, Emanuela Gionfriddo, Janusz Pawliszyn, Renato Zenobi
A direct and fast method for screening and quantification of illicit drugs in beverages and biological fluids was developed by using dielectric barrier discharge (DBD) as ionization technique, in combination with high-resolution mass spectrometry. Extraction of the targeted analytes was carried out with thin film microextraction (TFME) using ultrasound as agitation method. The targeted analytes were then thermally desorbed and introduced into the source without the need for any cryofocusing apparatus. The performance of this new analytical set up were compared to conventional TFME-TDU-GC/MS, showing enhanced linear dynamic range and lower limits of quantitation (low pg ml-1) achievable at the same extraction conditions (5 min extraction time)...
March 14, 2019: Analyst
https://read.qxmd.com/read/30866947/a-comparison-of-thick-film-microscopy-rapid-diagnostic-test-and-polymerase-chain-reaction-for-accurate-diagnosis-of-plasmodium-falciparum-malaria
#7
Kenji O Mfuh, Olivia A Achonduh-Atijegbe, Obase N Bekindaka, Livo F Esemu, Calixt D Mbakop, Krupa Gandhi, Rose G F Leke, Diane W Taylor, Vivek R Nerurkar
BACKGROUND: Accurate diagnosis of malaria is important for effective disease management and control. In Cameroon, presumptive clinical diagnosis, thick-film microscopy (TFM), and rapid diagnostic tests (RDT) are commonly used to diagnose cases of Plasmodium falciparum malaria. However, these methods lack sensitivity to detect low parasitaemia. Polymerase chain reaction (PCR), on the other hand, enhances the detection of sub-microscopic parasitaemia making it a much-needed tool for epidemiological surveys, mass screening, and the assessment of interventions for malaria elimination...
March 12, 2019: Malaria Journal
https://read.qxmd.com/read/30865217/reproductive-factors-and-mammographic-density-associations-among-24-840-women-and-comparison-of-studies-using-digitized-film-screen-mammography-and-full-field-digital-mammography
#8
Stacey E Alexeeff, Nnaemeka U Odo, Russell McBride, Valerie McGuire, Ninah Achacoso, Joseph H Rothstein, Jafi A Lipson, Rhea Y Liang, Luana Acton, Martin J Yaffe, Alice S Whittemore, Daniel L Rubin, Weiva Sieh, Laurel A Habel
Breast density is a modifiable factor that is strongly associated with breast cancer risk. We sought to understand the influence of newer technologies of full-field digital mammography (FFDM) on breast density research and to determine whether results are comparable across studies using FFDM and previous studies using traditional film-screen mammography. We studied 24,840 screening-age (40-74 years) non-Hispanic white women who were participants in the Research Program on Genes, Environment and Health of Kaiser Permanente Northern California and underwent screening mammography with either Hologic (Hologic, Inc...
March 13, 2019: American Journal of Epidemiology
https://read.qxmd.com/read/30863900/photolithographic-fabrication-of-micro-apertures-in-dry-film-polymer-sheets-for-channel-recordings-in-planar-lipid-bilayers
#9
Mario El Khoury, Tobias Winterstein, Wadim Weber, Viktor Stein, Helmut F Schlaak, Gerhard Thiel
Planar lipid bilayers constitute a versatile method for measuring the activity of protein channels and pores on a single molecule level. Ongoing efforts attempt to tailor this method for detecting biomedically relevant target analytes or for high-throughput screening of drugs. To improve the mechanical stability of bilayer recordings, we use a thin-film epoxy resist ADEX as septum in free-standing vertical bilayers. Defined apertures with diameters between 30 µm and 100 µm were micro-fabricated by photolithography...
March 12, 2019: Journal of Membrane Biology
https://read.qxmd.com/read/30853307/screening-sensitivity-according-to-breast-cancer-location
#10
Isabelle Théberge, Marie-Hélène Guertin, Nathalie Vandal, Gary Côté, Michel-Pierre Dufresne, Éric Pelletier, Jacques Brisson
PURPOSE: To examine the relation between breast cancer location and screening mammogram sensitivity, and assess whether this association is modified by body mass index (BMI) or breast density. METHODS: This study is based on all interval cancers (n = 481) and a random sample of screen-detected cancers (n = 481) diagnosed in Quebec Breast Cancer Screening Program participants in 2007. Film-screening mammograms, diagnostic mammograms, and ultrasound reports (when available) were requested for these cases...
March 7, 2019: Canadian Association of Radiologists Journal
https://read.qxmd.com/read/30851845/direct-screening-of-food-packaging-materials-for-post-polymerization-residues-degradation-products-and-additives-by-liquid-extraction-surface-analysis-nanoelectrospray-mass-spectrometry-lesa-nesi-ms
#11
Ambre Issart, Simon Godin, Hugues Preud'homme, Katarzyna Bierla, Ahmed Allal, Joanna Szpunar
Materials in direct contact with food should be monitored for the presence of species able to migrate into food. A direct method based on liquid extraction surface analysis nanoelectrospray mass spectrometry (LESA-nanoESI-MS) was developed for the analysis of the migrating species from a polymer film. Different types of molecules: post-polymerization residues, degradation products (oligomers resulting from polymer recycling, products of polymer oxidative degradation) and anti-oxidant additives (vitamin E) were demonstrated to be detected and identified, and determined quantitatively if relevant calibration standards are available...
June 13, 2019: Analytica Chimica Acta
https://read.qxmd.com/read/30849130/is-there-a-fundamental-flaw-in-canada-s-post-arrival-immigrant-surveillance-system-for-tuberculosis
#12
Richard Long, Leyla Asadi, Courtney Heffernan, James Barrie, Christopher Winter, Mary Lou Egedahl, Catherine Paulsen, Brenden Kunimoto, Dick Menzies
BACKGROUND: New immigrants to Canada with a history of tuberculosis or evidence of old healed tuberculosis on chest radiograph are referred to public health authorities for medical surveillance. This ostensible public health protection measure identifies a subgroup of patients (referrals) who are at very low risk (compared to non-referrals) of transmission. METHODS: To assess whether earlier diagnosis or a different phenotypic expression of disease explains this difference, we systematically reconstructed the immigration and transmission histories from a well-defined cohort of recently-arrived referral and non-referral pulmonary tuberculosis cases in Canada...
2019: PloS One
https://read.qxmd.com/read/30847286/commercial-application-of-cellulose-nano-composites-a-review
#13
REVIEW
Amita Sharma, Manisha Thakur, Munna Bhattacharya, Tamal Mandal, Saswata Goswami
Cellulose is the biosynthetic product from plants, animals and bacteria. Cellulose is the most abundant polymer having long linear chain like structure composed of (1,4) linked β-D glucopyranosyl units assembled into hierarchical structures of microfibrils with excellent strength and stiffness. And 'nanocellulose' refers to the cellulosic materials with defined nano-scale structural dimensions. They may be cellulose nanocrystal (CNC or NCC), cellulose nanofibers (CNF) or bacterial nanocellulose. Nanocellulose is non-toxic, biodegradable and biocompatible with no adverse effects on health and environment...
March 2019: Biotechnology Reports
https://read.qxmd.com/read/30844232/development-of-a-high-throughput-screening-method-for-oxide-ion-conductors-and-its-application-to-bismuth-based-oxide-library-thin-films
#14
Masato Matsubara, Akitoshi Suzumura, Shin Tajima, Ryoji Asahi
To accelerate material discovery, we develop a screening method for oxide-ion conductors that comprises combinatorial synthesis using chemical-solution deposition, and high-throughput measurements using x-ray diffraction and conductivity. The present method allows us to form an arbitrary and uniform composition within an evaluation area at an arbitrary position in the library on a substrate. This screening method is applied to ABi2Zrx(Nb1-yTay)1-xO9 bismuth-layered compounds, which are known to have relatively high oxide-ion conductivities but are yet to be examined thoroughly...
March 7, 2019: ACS Combinatorial Science
https://read.qxmd.com/read/30842502/statistics-of-thermomagnetic-breakdown-in-nb-superconducting-films
#15
S Blanco Alvarez, J Brisbois, S Melinte, R B G Kramer, A V Silhanek
Superconductors are well known for their ability to screen out magnetic fields. In type-II superconductors, as the magnetic field pressure is progressively increased, magnetic flux accumulates at the periphery of the sample, very much like charges accumulate in a capacitor when voltage is increased. As for capacitors, exceeding certain threshold field causes the blocked magnetic flux to abruptly penetrate into the sample. This phenomenon, triggered by a thermomagnetic instability, is somewhat analogous to the dielectric breakdown of the capacitor and leaves behind a similar Lichtenberg imprinting...
March 6, 2019: Scientific Reports
https://read.qxmd.com/read/30838501/golden-ages-and-silver-screens-the-construction-of-the-physician-hero-in-1930-1940-american-cinema
#16
Christopher R Cashman
During the 1940s in America, as medicine became more research-focused, medical researcher heroes were described as devotedly pursuing miraculous medicine. At the same time, Hollywood thrived, and films were an effective means to help build the myth of the physician hero. Cinematic techniques, rather than only the narrative, of four films, Dr. Arrowsmith, The Story of Louis Pasteur, Dr. Ehrlich's Magic Bullet, and Dr. Jekyll and Mr. Hyde, are discussed to understand how they helped construct the image of the physician hero, both in terms of what they were and what they were not...
March 6, 2019: Journal of Medical Humanities
https://read.qxmd.com/read/30818262/sensitive-amperometric-biosensors-for-detection-of-glucose-and-cholesterol-using-a-platinum-reduced-graphene-oxide-poly-3-aminobenzoic-acid-film-modified-screen-printed-carbon-electrode
#17
Sopit Phetsang, Jaroon Jakmunee, Pitchaya Mungkornasawakul, Rawiwan Laocharoensuk, Kontad Ounnunkad
A facile one-step electrochemical synthesis of a platinum/reduced graphene oxide/poly(3-aminobenzoic acid) (Pt/rGO/P3ABA) nanocomposite film on a screen-printed carbon electrode (SPCE) and its application in the development of sensitive amperometric biosensors was successfully demonstrated herein. The electropolymerization of P3ABA together with co-electrodeposition of rGO and Pt was conducted by cyclic voltammetry, as was the GO reduction to rGO. A Pt/rGO/P3ABA-modified SPCE exhibited excellent electrocatalytic oxidation towards hydrogen peroxide (H2 O2 ) and can be employed as an electrochemical platform for the immobilization of glucose oxidase (GOx) and cholesterol oxidase (ChOx) to fabricate glucose and cholesterol biosensors, respectively...
February 13, 2019: Bioelectrochemistry
https://read.qxmd.com/read/30817751/the-separation-of-trypanosomes-from-blood-by-anion-exchange-chromatography-from-sheila-lanham-s-discovery-50-years-ago-to-a-gold-standard-for-sleeping-sickness-diagnosis
#18
Veerle Lejon, Philippe Büscher, Romaric Nzoumbou-Boko, Géraldine Bossard, Vincent Jamonneau, Bruno Bucheton, Philippe Truc, Jean-Loup Lemesre, Philippe Solano, Philippe Vincendeau
Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease that is fatal if untreated, caused by Trypanosoma brucei gambiense and T. brucei rhodesiense. In its 2012 roadmap, WHO targeted HAT for elimination as a public health problem in 2020 and for zero transmission in 2030. Diagnosis of HAT is a multistep procedure comprising of clinical suspicion, confirmation, and stage determination. Suspects are identified on clinical signs and/or on screening for specific antibodies. Parasitological confirmation of suspects remains mandatory to avoid unnecessary toxic drug administration...
February 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30811174/electrochemical-screening-of-tungsten-trioxide-nickel-oxide-thin-film-combinatorial-library-at-low-nickel-concentrations
#19
Jun-Seob Lee, Cezarina Cela Mardare, Andrei Ionut Mardare, Achim Walter Hassel
The electrochemical behavior of a tungsten trioxide-nickel oxide (WO3 -NiO) thin film library was investigated using scanning droplet cell microscopy (SDCM) in 0.1 mol dm-3 sodium perchlorate (NaClO4 ) solution. The WO3 -Ni film library was deposited by thermal co-evaporation on an indium tin oxide (ITO)-coated glass substrate in an atomic Ni concentration range from 2.8 to 15.6 at.%. After an oxidation/crystallization heat treatment, the Ni was oxidized and the crystal structure of WO3 -NiO was transformed from monoclinic WO3 (3...
February 27, 2019: ACS Combinatorial Science
https://read.qxmd.com/read/30793604/environmental-copper-sensor-based-on-polyethyleneimine-functionalized-nanoporous-anodic-alumina-interferometers
#20
Simarpreet Kaur, Cheryl Suwen Law, Nathan Hu Williamson, Ivan M Kempson, Amirali Popat, Tushar Kumeria, Abel Santos
Anthropogenic copper pollution of environmental waters from sources such as acid mine drainage, antifouling paints and industrial waste discharge is a major threat to our environment and human health. This study presents an optical sensing system that combines self-assembled glutaraldehyde-crosslinked double-layered polyethyleneimine (PEI-GA-PEI)-modified nanoporous anodic alumina (NAA) interferometers with reflectometric interference spectroscopy (RIfS) for label-free, selective monitoring of ionic copper in environmental waters...
February 22, 2019: Analytical Chemistry
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