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Chronical pancreatitis

Yixuan Liang, Xiaoke Wang, Dongmei He, Qi You, Tingting Zhang, Wanfa Dong, Jingjin Fei, Yun Xing, Jie Wu
AIMS: Recent studies have revealed that neutrophil extracellular traps (NETs) provide negative feedback in the progression to chronic inflammation and contribute to the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). In addition, accumulating evidences suggest that gut immunity play a key role in T1D pathogenesis. Our study aimed to evaluate whether staphylococcal nuclease (SNase) targeting intestinal NETs can ameliorate the intestinal inflammatory environment and protect against T1D development in non-obese diabetic(NOD) mice...
February 15, 2019: Life Sciences
Ashok Saluja, Vikas Dudeja, Rajinder Dawra, Raghuwansh P Sah
Premature activation of digestive enzymes in the pancreas has been linked to development of pancreatitis for more than a century. Recent development of novel models to study the role of pathologic enzyme activation has led to advances in our understanding of the mechanisms of pancreatic injury. Co-localization of zymogen and lysosomal fraction occurs early after pancreatitis causing stimulus. Cathepsin B activates trypsinogen in these co-localized organelles. Active trypsin increases permeability of these organelles resulting in leakage of cathepsin B into the cytosol leading to acinar cell death...
February 15, 2019: Gastroenterology
Toshimitsu Iwasaki, Nobuyoshi Hiraoka, Yoshinori Ino, Kosei Nakajima, Yoji Kishi, Satoshi Nara, Minoru Esaki, Kazuaki Shimada, Hitoshi Katai
Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. We retrospectively analyzed 256 patients with PDAC who underwent macroscopic curative surgery...
February 18, 2019: Cancer Science
Miroslav Vujasinovic, Aleksandra Hedström, Patrick Maisonneuve, Roberto Valente, Henrik von Horn, J-Matthias Löhr, Stephan L Haas
BACKGROUND: Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. AIM: To investigate serum zinc levels in patients with CP of various etiologies...
February 7, 2019: World Journal of Gastroenterology: WJG
G Y Yu, X Hong, W Li, Y Y Zhang, Y Gao, Y Chen, Z Y Zhang, X Y Xie, Z G Li, Y Y Liu, J Z Su, W X Zhu, Z P Sun
Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. The comorbid diseases of head and neck region including rhinosinusitis, allergic rhinitis, and lymphadenopathy were commonly seen, which could occur more early than enlargement of major salivary glands...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Namita Gupta, Shailender Singh, Luciano Vargas, Timothy E Moore, Valerie K Shostrom, Brian P Boerner
OBJECTIVES: Patients with chronic pancreatitis (CP) are at increased risk of low bone mineral density (BMD), although the prevalence of low BMD in patients with CP in the United States is lacking. We aimed to determine the prevalence of low BMD and identify potential risk factors, including hypogonadism and use of opioid medications, in subjects with CP in the United States. METHODS: This was a prospective, observational study. Subjects with CP underwent dual-energy x-ray absorptiometry scan...
February 14, 2019: Pancreas
Ding Long, Yujun Wang, Hui Wang, Xiaoling Wu, Li Yu
OBJECTIVES: The aim of the study was to investigate the correlation of serum and ascitic fluid soluble form urokinase plasminogen activator receptor (suPAR) levels with patients' complications, disease severity, inflammatory markers, and prognosis in patients with severe acute pancreatitis (SAP). METHODS: Fifty patients with SAP, 47 patients with mild acute pancreatitis, and 50 healthy controls were enrolled. Serum samples were obtained from all participants after enrollment; meanwhile, ascitic fluid samples were collected from 20 patients with SAP who developed ascites...
February 14, 2019: Pancreas
Xibei Liu, Jay J Shen, Pearl Kim, Sun Jung Kim, Johnson Ukken, Younseon Choi, In Choel Hwang, Jae-Hoon Lee, Sung-Youn Chun, Jinwook Hwang, Haneul Choi, Hyeyoung Yeom, Yong-Jae Lee, Ji Won Yoo
AIM: Pancreas cancer continues to carry a poor prognosis. Hospitalized patients with advanced chronic pancreatic illnesses increasingly receive palliative care due to its perceived clinical benefits. Meanwhile, a growing proportion of elderly patients are reportedly receiving life-sustaining procedures. Temporal trends in the utilization of life-sustaining procedures and palliative care consultation among dying patients with advanced chronic pancreatic illnesses in US hospitals were examined...
February 15, 2019: Journal of Palliative Care
M Shayne Gallaway, Bin Huang, Quan Chen, Thomas C Tucker, Jaclyn K McDowell, Eric Durbin, Sherri L Stewart, Eric Tai
PURPOSE: To examine smoking and use of smoking cessation aids among tobacco-associated cancer (TAC) or non-tobacco-associated cancer (nTAC) survivors. Understanding when and if specific types of cessation resources are used can help with planning interventions to more effectively decrease smoking among all cancer survivors, but there is a lack of research on smoking cessation modalities used among cancer survivors. METHODS: Kentucky Cancer Registry data on incident lung, colorectal, pancreatic, breast, ovarian, and prostate cancer cases diagnosed 2007-2011, were linked with health administrative claims data (Medicaid, Medicare, private insurers) to examine the prevalence of smoking and use of smoking cessation aids 1 year prior and 1 year following the cancer diagnosis...
February 14, 2019: Journal of Community Health
Patrick Manafa, Chide Okocha, Benedict Nwogho, John Aneke, Paul Smith Davis Okpara, Nancy Lbeh, George Chukwuma, Vera Manafa, Ejike Nwane
Background: Sickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. CA 19-9 levels have not been evaluated in SCD patients in our environment. Objectives: The study aimed to compare the levels of CA 19-9 in homozygous sickle cell disease subjects in steady state with those of (Hb AS) and normal healthy subjects (Hb AA)...
December 2018: African Health Sciences
Xiang-Peng Zeng, Ting-Ting Liu, Lu Hao, Lei Xin, Teng Wang, Lin He, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Hong-Lei Guo, Hui Chen, Wen-Bin Zou, Bai-Rong Li, Zhi-Jie Cong, Li-Sheng Wang, Zheng-Lei Xu, Ting Xie, Ming-Hao Liu, An-Mei Deng, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown. METHODS: Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Autoantibodies with frequency > 0.5% were enrolled to calculate the frequency in historial healthy controls through literature search in PubMed...
February 14, 2019: BMC Gastroenterology
Atsushi Kanno, Atsushi Masamune, Keiji Hanada, Masataka Kikuyama, Masayuki Kitano
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. PDAC is the fourth leading cause of death in the United States and Japan based on epidemiological data. Early detection of PDAC is very important to improve the prognosis of PDAC. Early detection of pancreatic ductal adenocarcinoma (PDAC) requires further examination after selecting cases with risk factors for the condition, such as family history, hereditary pancreatic carcinoma syndrome, intraductal papillary mucinous neoplasms, or chronic pancreatitis...
February 5, 2019: Diagnostics
Andrea Padoan, Mario Plebani, Daniela Basso
Systemic and local chronic inflammation might enhance the risk of pancreatic ductal adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor microenvironment concurs in enhancing tumor growth and metastasis. Inflammation is closely correlated with immunity, the same immune cell populations contributing to both inflammation and immune response. In the PDAC microenvironment, the inflammatory cell infiltrate is unbalanced towards an immunosuppressive phenotype, with a prevalence of myeloid derived suppressor cells (MDSC), M2 polarized macrophages, and Treg , over M1 macrophages, dendritic cells, and effector CD4⁺ and CD8⁺ T lymphocytes...
February 5, 2019: International Journal of Molecular Sciences
Thierry Brun, Clarissa Bartley, Pierre Maechler
While the use of fructose as a sweetener and its consumption are associated with increased fat storage prompted by the action of insulin, fructose alone does not acutely stimulate insulin exocytosis from the pancreatic beta-cell, as opposed to the chief secretagogue glucose. We investigated the effects of chronic exposure to fructose on beta-cell function. Our results reveal that chronic fructose induces extracellular ATP signaling in the beta-cell, resulting in the potentiation of glucose-stimulated insulin secretion...
February 13, 2019: Revue Médicale Suisse
Yiteng Meng, Shuo Sha, Jing Yang, Hongbo Ren
BACKGROUND: The Tec kinase family is involved in acute and chronic inflammatory diseases, but its relationship with severe acute pancreatitis (SAP) remains unclear. AIMS: To investigate whether Tec tyrosine kinase can be used as a target for severe acute pancreatitis-associated acute lung injury (PALI). METHODS: A total of 90 mice were randomly assigned into four groups: SAP (n = 15), control (n = 15), SAP + α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13) (pretreated with Tec kinase inhibitor LFM-A13, n = 15), and SAP + Tec siRNA (pretreated with PBS/negative control siRNA/Tec siRNA, n = 45)...
February 14, 2019: Digestive Diseases and Sciences
Mario Peláez-Luna, Claudia Medina-Campos, Luis Uscanga-Domínuez, Jorge Hernandez-Calleros, Carlos Chan-Nuñez, Eduardo Negrete, Arturo Angeles
BACKGROUND: Chronic pancreatitis (CP), pancreatic cancer (PCa), and autoimmune pancreatitis (AIP) often present as a pancreatic mass. Accurate diagnosis is not always possible; up to 8% of surgical procedures are performed in benign pancreatic masses presumed to be malignant. OBJECTIVES: We aimed to compare clinical and imaging characteristics of resected focal type 2 AIP, CP, and PCa and identify factors that could improve preoperative differential diagnosis. METHODS: Charts from patients that underwent pancreatic resection under suspicion of PCa between 2000 and 2014 were reviewed...
February 13, 2019: Digestion
O Strobel, M W Büchler
No abstract text is available yet for this article.
February 13, 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Xin-Ying Tang, Jin-Huan Lin, Wen-Bin Zou, Emmanuelle Masson, Arnaud Boulling, Shun-Jiang Deng, David N Cooper, Zhuan Liao, Claude Férec, Zhao-Shen Li, Jian-Min Chen
BACKGROUND: The clinical significance of SPINK1 intronic variants in chronic pancreatitis has been previously assessed by various approaches including a cell culture-based full-length gene assay. A close correlation between the results of this assay and in silico splicing prediction was apparent. However, until now, a clinical diagnostic pipeline specifically designed to classify SPINK1 intronic variants accurately and efficiently has been lacking. Herein, we present just such a pipeline and explore its efficacy and potential utility in potentiating the classification of newly described SPINK1 intronic variants...
February 12, 2019: Human Genomics
Temel Tirkes, Christie Y Jeon, Liang Li, Aron Y Joon, Ted A Seltman, Meghana Sankar, Scott A Persohn, Paul R Territo
OBJECTIVE: The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus. METHODS: Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging...
February 8, 2019: Pancreas
Srikanth Puttaiah Kadyada, Babu Ram Thapa, Narendra Dhaka, Anmol Bhatia, Jagadeesh Menon
OBJECTIVES: Endoscopic ultrasound (EUS) is a minimally invasive pancreatic imaging modality. We evaluated children with idiopathic acute pancreatitis (IAP) and acute recurrent pancreatitis (ARP) for changes of chronicity (Rosemont criteria) and biliary risk factors. Diagnostic yield of simultaneously performed transabdominal ultrasonography (TUS) was compared with EUS. METHODS: This was a prospective observational study. Patients underwent EUS and TUS after 2 months of pancreatitis attack...
February 8, 2019: Pancreas
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