keyword
https://read.qxmd.com/read/38507127/one-pot-synthesis-of-high-performance-green-emitting-carbon-dots-for-cd-2-sensing-and-anti-counterfeiting-applications
#21
JOURNAL ARTICLE
Shihua Liao, Jiamei Xiang, Shaogui Wu
This study presents a facile one-pot solvothermal synthesis of high-performance green fluorescent carbon dots (G-CDs) using o-phenylenediamine and ethylenediamine as precursors. The G-CDs show excellent optical, temporal, and chemical stability. Notably, they exhibit the highest quantum yield of 24.2% in ethanol and a strong green emission peaking at 546 nm under 440-490 nm excitation. In addition, G-CDs have outstanding salt resistance and multi-solvent compatibility. Due to its bright photoluminescence, G-CDs can be used as a secure ink for anti-counterfeiting...
March 20, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38506595/lithium-borohydride-nanorods-self-assembling-growth-and-remarkable-hydrogen-cycling-properties
#22
JOURNAL ARTICLE
Wenxuan Zhang, Linming Zhou, Xin Zhang, Zhenguo Huang, Fang Fang, Zijian Hong, Juan Li, Mingxia Gao, Wenping Sun, Hongge Pan, Yongfeng Liu
Nanostructured metal hydrides with unique morphology and improved hydrogen storage properties have attracted intense interests. However, the study of the growth process of highly active borohydrides remains challenging. Herein, for the first time the synthesis of LiBH4 nanorods through a hydrogen-assisted one-pot solvothermal reaction is reported. Reaction of n-butyl lithium with triethylamine borane in n-hexane under 50 bar of H2 at 40-100 °C gives rise to the formation of the [100]-oriented LiBH4 nanorods with 500-800 nm in diameter, whose growth is driven by orientated attachment and ligand adsorption...
March 20, 2024: Small
https://read.qxmd.com/read/38505382/a-green-bio-organic-catalyst-taurine-promoted-one-pot-synthesis-of-r-s-2-thioxo-3-4-dihydropyrimidine-tdhpm-5-carboxanilides-chiral-investigations-using-circular-dichroism-and-validation-by-computational-approaches
#23
JOURNAL ARTICLE
Mehul P Parmar, Disha P Vala, Savan S Bhalodiya, Dipti B Upadhyay, Chirag D Patel, Subham G Patel, Srinivasa R Gandholi, Althaf H Shaik, Amy Dunne Miller, Joaquina Nogales, Sourav Banerjee, José M Padrón, Nasser Amri, Nagesh Kumar Kandukuri, Hitendra M Patel
Owing to the massive importance of dihydropyrimidine (DHPMs) scaffolds in the pharmaceutical industry and other areas, we developed an effective and sustainable one-pot reaction protocol for the synthesis of ( R / S )-2-thioxo-DHPM-5-carboxanilides via the Biginelli-type cyclo-condensation reaction of aryl aldehydes, thiourea and various acetoacetanilide derivatives in ethanol at 100 °C. In this protocol, taurine was used as a green and reusable bio-organic catalyst. Twenty-three novel derivatives of ( R / S )-TDHPM-5-carboxanilides and their structures were confirmed by various spectroscopy techniques...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38504637/total-synthesis-of-pallamolides-a-e
#24
JOURNAL ARTICLE
Yu Zhang, Lijun Chen, Yanxing Jia
We have achieved the first total synthesis of pallamolides A-E, of which pallamolides B-E possess intriguing tetracyclic skeletons with novel intramolecular transesterifications. Key transformations include highly diastereoselective sequential Michael additions to construct the bicyclo[2.2.2]octane core with simultaneous generation of two quaternary carbon centers, a one-pot SmI2-mediated intramolecular ketyl-enoate cyclization/ketone reduction to generate the key oxabicyclo[3.3.1]nonane moiety, and an acid-mediated deprotection/oxa-Michael addition/β-hydroxy elimination cascade sequence to assemble pallamolides tetracyclic skeletons...
March 20, 2024: Angewandte Chemie
https://read.qxmd.com/read/38504560/%C3%AF-stacking-controlled-dearomatic-sulfur-shifted-ene-reaction-of-ketenes-and-polycyclic-arylthiiranes-access-to-areno-d-%C3%AE%C2%B5-thiolactones
#25
JOURNAL ARTICLE
Yinqiao Wang, Yixiang Chen, Jiaxi Xu
Electrophilic ring-expansion of polycyclic arylthiiranes and ketenes generated from alkoxy/aryloxyacetyl chlorides in the presence of triethylamine (TEA) is developed and provides a new strategy for the synthesis of areno[ d ]-ε-thiolactones, areno[ d ]thiepinones, directly without catalysts or additives. This strategy features atom- and step-economic one-pot characteristic via a tandem sequence of in situ ketene generation, π-stacking-controlled dearomatic sulfur-shifted ene, and aromatization...
March 19, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38502744/metal-free-nitrogen-doped-mesoporous-carbons-for-the-mild-and-selective-synthesis-of-pyrroles-from-nitroarenes-via-cascade-reaction
#26
JOURNAL ARTICLE
Xiangzhu Yu, Meng Miao, Shuxiao Huo, Xinyue Tang, Ling Ni, Shaowei Liu, Lianyue Wang
The cascade synthesis of pyrroles from nitroarenes is an attractive alternative strategy. However, metal catalysts and relatively high temperatures cover the existing reported catalytic systems for this strategy. The development of nonmetallic heterogeneous catalytic systems for the one-pot synthesis of pyrrole from nitroarenes under mild conditions is both worthwhile and challenging. Herein, we describe an exceptionally efficient method for the synthesis of N -substituted pyrroles by the reductive coupling of nitroarenes and diketones over heterogeneous metal-free catalysts under mild conditions...
March 19, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38501981/pd-ii-catalyzed-cascade-annulation-of-n-substituted-anilines-with-co-nh-4-oac-and-aldehydes-to-n-1-substituted-2-3-dihydroquinazolin-4-1-h-ones
#27
JOURNAL ARTICLE
Xiaopeng Zhang, Qiuyang Pang, Dan Liu, Zhenhua Guo, Guisheng Zhang
A facile and direct approach to N 1-substituted 2,3-dihydroquinazolin-4(1 H )-ones has been developed via Pd(II)-catalyzed one-pot cascade annulation of N -substituted anilines with CO, NH4 OAc and aldehydes, and it features an intrinsic directing strategy, cheap and easily obtainable raw materials, low cost, high step economy and efficiency, broad substrate scope and good product diversity. This protocol has been successfully applied to the synthesis of glycozolone A and gram-level experiments. Based on the control experiments and the literature, the reaction mechanism was proposed...
March 19, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38501865/iodosylbenzene-promoted-glycosylation-with-selenoglycosides-application-in-one-pot-glycosylation
#28
JOURNAL ARTICLE
Ao Sun, Ting Liu, Zipeng Li, Shuai Meng, Xiangbao Meng, Zhongtang Li, Zhongjun Li
A novel method for the glycosylation of selenoglycosides activated by iodosylbenzene was developed. The glycosylation reaction conditions were mild, fast, and efficient, with a high tolerance to diverse protecting groups and a wide substrate scope, which is advantageous for synthesizing complex glycosides. In addition, selenoglycosides were shown to be orthogonal to thioglycosides under the promotion of iodosylbenzene. Notably, a high yield of the poorly reactive glucuronidation reaction product was obtained by acetyl-protected selenoglycoside...
March 19, 2024: Organic Letters
https://read.qxmd.com/read/38501258/preparation-of-monolith-for-online-extraction-and-lc-ms-analysis-of-%C3%AE-estradiol-in-serum-via-a-simple-multicomponent-reaction
#29
JOURNAL ARTICLE
Andrea Cerrato, Sara Elsa Aita, Chiara Cavaliere, Aldo Laganà, Carmela Maria Montone, Susy Piovesana, Enrico Taglioni, Anna Laura Capriotti
Multicomponent reactions offer efficient and environmentally friendly strategies for preparing monoliths suitable for applications in analytical chemistry. In the described study, a multicomponent reaction was utilized for the one-pot miniaturized preparation of a poly(propargyl amine) polymer inside commercial silica-lined PEEK tubing. The reaction involved only small amounts of reagents and was characterized by atom economy. The resulting monolithic column was incorporated into an autosampler system for the online extraction and cleanup of β-estradiol from human serum...
March 19, 2024: Analytical Chemistry
https://read.qxmd.com/read/38497643/ionic-liquid-crystals-based-on-loop-shaped-copper-i-complexes
#30
JOURNAL ARTICLE
Nicolas Del Giudice, Guillaume Voegeli, Jean-Marc Strub, Benoît Heinrich, Laurent Douce
This paper describes the synthesis and characterization of liquid crystals based on loop-shaped cationic copper(I) complexes of a multidentate ligand. Their synthesis involves the one-pot reaction of an alkyloxy-decorated pyridine-aldehyde unit with a diamine (2,2'-(ethylenedioxy)bis(ethylamine)) spacer to form in situ a pyridine-imine quadridentate-N4 -donor ligand, L, which is able to chelate a copper(I) center associated with various noncoordinating anions. All of these compounds were characterized by NMR, IR, and electronic absorption spectroscopy, and more particularly by X-ray diffraction and mass spectroscopy, enabling unambiguous assignment of the [ML]+ mononuclear nature of the cationic components...
March 18, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38497561/microwave-assisted-one-pot-telescoped-synthesis-of-2-amino-1-3-thiazoles-selenazoles-imidazo-1-2-a-pyridines-and-other-heterocycles-from-alcohols
#31
JOURNAL ARTICLE
Pablo Macías-Benítez, Alfonso Sierra-Padilla, Francisco M Guerra, F Javier Moreno-Dorado
Primary and secondary alcohols have been converted into 2-amino-1,3-thiazoles under microwave irradiation, employing trichloroisocyanuric acid (TCCA) as a dual oxidant and chlorine source, TEMPO as a co-oxidant, and thiourea. Secondary alcohols underwent a single-stage, one-pot conversion process, while primary alcohols required a two-stage, one-pot procedure. Both transformations were completed within minutes (25-45 min). The versatility of this protocol extends to the synthesis of other heterocycles, including 1,3-selenazoles, 2-aminoimidazoles, imidazo[1,2- a ]pyridines, quinoxalines, and hydrazino thiazoles by replacing thiourea with the appropriate surrogates...
March 18, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38496929/sustainable-and-environmentally-friendly-approach-for-the-synthesis-of-azoxybenzenes-from-the-reductive-dimerization-of-nitrosobenzenes-and-the-oxidation-of-anilines
#32
JOURNAL ARTICLE
Idris Karakaya, Mehmet Mart, Ramazan Altundas
This study demonstrates a comparative synthesis of azoxybenzenes through the reductive dimerization of nitrosobenzenes and the oxidation of anilines. Utilizing the cost-effective DIPEA catalyst at room temperature with water as a green solvent, the one-pot procedure involves in situ generation of nitrosobenzene derivatives from anilines in the presence of oxone, followed by DIPEA addition. Both methods yield azoxybenzenes with high selectivity, showcasing the versatility of DIPEA in facilitating the synthesis of azoxybenzenes with various substituents in ortho, meta, and para positions, encompassing electron-donating and electron-withdrawing groups...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38494207/threading-the-needle-achieving-simplicity-and-performance-in-cellulose-alkanoate-%C3%AF-carboxyalkanoates-for-amorphous-solid-dispersion
#33
JOURNAL ARTICLE
Stella P Petrova, Mennatallah A Mohamed, Huiming Wu, Lynne S Taylor, Kevin J Edgar
Most active pharmaceutical ingredients (APIs) suffer from poor water solubility, often keeping them from reaching patients. To overcome the issues of poor drug solubility and subsequent low bioavailability, amorphous solid dispersions (ASDs) have garnered much attention. Cellulose ester derivatives are of interest for ASD applications as they are benign, sustainable-based, and successful in commercial drug delivery systems, e.g. in osmotic pump systems and as commercial ASD polymers. Synthesis of carboxy-pendant cellulose esters is a challenge, due in part to competing reactions between carboxyls and hydroxyls, forming ester crosslinks...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38494206/enhancing-char-formation-of-flame-retardant-epoxy-composites-onigiri-like-zif-67-modification-with-carboxymethyl-%C3%AE-cyclodextrin-crosslinking
#34
JOURNAL ARTICLE
Qianlong Li, Zhengde Han, Xiaoning Song, Ye-Tang Pan, Zhishuai Geng, Henri Vahabi, Vera Realinho, Rongjie Yang
To enhance char formation of flame retardant epoxy (EP) composites, carboxymethyl β-cyclodextrin (CM-β-CD) is employed as an etchant for or ZIF-67 derivatives. In the early stage, etching plays a dominant role. The mismatch in size between CM-β-CD opening and ZIF-67 pore leads to the stacking of carboxyl cobalt complexes on the shell. When the reaction time is prolonged, crosslinking occurs between carboxyl and hydroxyl groups. Crosslinked CM-β-CD weakens and eventually stops the etching process...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38494200/enzymatic-modular-synthesis-of-asymmetrically-branched-human-milk-oligosaccharides
#35
JOURNAL ARTICLE
Yinshuang Li, Yi Li, Yuxi Guo, Congcong Chen, Lin Yang, Qian Jiang, Peixue Ling, Shuaishuai Wang, Lei Li, Junqiang Fang
Human milk oligosaccharides (HMOs) are intricate glycans that promote healthy growth of infants and have been incorporated into infant formula as food additives. Despite their importance, the limited availability of asymmetrically branched HMOs hinders the exploration of their structure and function relationships. Herein, we report an enzymatic modular strategy for the efficient synthesis of these HMOs. The key branching enzyme for the assembly of branched HMOs, human β1,6-N-acetylglucosaminyltransferase 2 (GCNT2), was successfully expressed in Pichia pastoris for the first time...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493118/nanoscale-engineering-of-gold-nanostars-for-enhanced-photoacoustic-imaging
#36
JOURNAL ARTICLE
Rui Zhang, Sven Thoröe-Boveleth, Dmitry N Chigrin, Fabian Kiessling, Twan Lammers, Roger M Pallares
Photoacoustic (PA) imaging is a diagnostic modality that combines the high contrast resolution of optical imaging with the high tissue penetration of ultrasound. While certain endogenous chromophores can be visualized via PA imaging, many diagnostic assessments require the administration of external probes. Anisotropic gold nanoparticles are particularly valued as contrast agents, since they produce strong PA signals and do not photobleach. However, the synthesis of anisotropic nanoparticles typically requires cytotoxic reagents, which can hinder their biological application...
March 16, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38491788/nitrogen-bridged-symmetrical-homogeneous-and-heterogeneous-binuclear-dioxidomolybdenum-vi-complexes-and-their-catalytic-potential-for-efficient-synthesis-of-2-amino-3-cyano-4h-chromenes-pyrans
#37
JOURNAL ARTICLE
Mannar R Maurya, Monojit Nandi, Naveen Kumar, Fernando Avecilla
Reaction of 2-chloromethylbenzimidazole with known intermediates (i - iii), prepared from diaminoguanidine hydrochloride with salicylaldehyde, 5-bromo-salicylaldehyde or 3,5-di-tert-butylsalicylaldehyde, led to the formation of benzimidazole appended new ligands, H4L1-H4L3 (I-III). The homogeneous nitrogen-bridged symmetrical binuclear complexes, [(MoVIO2)2(L1)(H2O)2] (1), [(MoVIO2)2(L2)(H2O)2] (2) and [(MoVIO2)2(L3)(MeOH)2] (3) and mononuclear complexes, [MoVIO2(H2L1)(MeOH)] (4), [MoVIO2(H2L2)(H2O)] (5) and [MoVIO2(H2L3)(MeOH)] (6)...
March 15, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38490041/efficient-green-cr-vi-adsorbent-from-sorghum-waste-eco-designed-functionalized-mesoporous-silica-fdu-12
#38
JOURNAL ARTICLE
Saeed Shirazian, Thoa Huynh, Niloofar Pirestani, Roozbeh Soltani, Azam Marjani, Ahmad B Albadarin, Shaheen M Sarkar
This paper presents an eco-design approach to the synthesis of a highly efficient Cr(VI) adsorbent, utilizing a positively charged surface mesoporous FDU-12 material (designated as MI-Cl-FDU-12) for the first time. The MI-Cl-FDU-12 anion-exchange adsorbent was synthesized via a facile one-pot synthesis approach using sodium silicate extracted from sorghum waste as a green silica source, 1-methyl-3-(triethoxysilylpropyl) imidazolium chloride as a functionalization agent, triblock copolymer F127 as a templating or pore-directing agent, trimethyl benzene as a swelling agent, KCl as an additive, and water as a solvent...
March 7, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38487783/exploring-pyrrolidinyl-spirooxindole-natural-products-as-promising-platforms-for-the-synthesis-of-novel-spirooxindoles-as-egfr-cdk2-inhibitors-for-halting-breast-cancer-cells
#39
JOURNAL ARTICLE
Mohamed S Nafie, Abdullah Mohammed Al-Majid, M Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery. Drawing inspiration from pyrrolidinyl-spirooxindole natural products, a novel series of spirooxindoles has been synthesized through a one-pot three-component reaction, involving a [3 + 2] cycloaddition reaction. The cytotoxicity against breast cancer cells (MCF-7 and MDA-MB-231) and safety profile against WISH cells of the newly developed library were assessed using the MTT assay...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38485991/valence-isomer-selective-cycloaddition-reaction-of-cycloheptatrienes-norcaradienes
#40
JOURNAL ARTICLE
Shingo Harada, Hiroki Takenaka, Tsubasa Ito, Haruki Kanda, Tetsuhiro Nemoto
The rapid and precise creation of complex molecules while controlling multiple selectivities is the principal objective in synthetic chemistry. Combining data science and organic synthesis to achieve this goal is an emerging trend, but few examples of successful reaction designs are reported. We develop an artificial neural network regression model using bond orbital data to predict chemical reactivities. Actual experimental verification confirms cycloheptatriene-selective [6 + 2]-cycloaddition utilizing nitroso compounds and norcaradiene-selective [4 + 2]-cycloaddition reactions employing benzynes...
March 14, 2024: Nature Communications
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