Marco A Bottelier, Marieke L J Schouw, Anne Klomp, Hyke G H Tamminga, Anouk G M Schrantee, Cheima Bouziane, Michiel B de Ruiter, Frits Boer, Henricus G Ruhé, Damiaan Denys, Roselyne Rijsman, Ramon J L Lindauer, Hans B Reitsma, Hilde M Geurts, Liesbeth Reneman
BACKGROUND: Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans. METHODS/DESIGN: Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques...
February 19, 2014: BMC Psychiatry