Margherita Barbuti, Marco Maiello, Vincenza Spera, Alessandro Pallucchini, Giulio E Brancati, Angelo G I Maremmani, Giulio Perugi, Icro Maremmani
Adults with attention deficit/hyperactivity disorder (ADHD) often present psychiatric comorbidities and, in particular, substance use disorder (SUD). ADHD-SUD comorbidity is characterized by greater severity of both disorders, earlier age of onset, higher likelihood of polydrug-abuse and suicidal behaviors, more hospitalizations, and lower treatment adherence. At the present stage, research focused on the pharmacological management of ADHD with comorbid SUD in both adolescents and adults is still lacking. Furthermore, while the short-term effects of stimulants are well studied, less is known about the chronic effects of these drugs on dopamine signaling...
April 24, 2023: Journal of Clinical Medicine