Tommaso Schirinzi, Giulia Di Lazzaro, Giulia Maria Sancesario, Susanna Summa, Simona Petrucci, Vito Luigi Colona, Sergio Bernardini, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Antonio Pisani
Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors...
June 2020: Neurobiology of Aging