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Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, W Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis N Shannon, Mandeep Tamber, John C Wellons, William E Whitehead, Nicole Mayer-Hamblett
OBJECTIVECSF shunt infection treatment requires both surgical and antibiotic decisions. Using the Hydrocephalus Clinical Research Network (HCRN) Registry and 2004 Infectious Diseases Society of America (IDSA) guidelines that were not proactively distributed to HCRN providers, the authors previously found high adherence to surgical recommendations but poor adherence to intravenous (IV) antibiotic duration recommendations. In general, IV antibiotic duration was longer than recommended. In March 2017, new IDSA guidelines expanded upon the 2004 guidelines by including recommendations for selection of specific antibiotics...
February 15, 2019: Journal of Neurosurgery. Pediatrics
Jiayi Huang, Rekha Chaudhary, Adam L Cohen, Karen Fink, Samuel Goldlust, John Boockvar, Prakash Chinnaiyan, Leping Wan, Stephen Marcus, Jian L Campian
PURPOSE: Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II study aimed to estimate the potential effectiveness of DSF/Cu to re-sensitize recurrent GBM to TMZ. METHODS: This open-label, single-arm phase II study treated recurrent TMZ-resistant GBM patients with standard monthly TMZ plus concurrent daily DSF 80 mg PO TID and Cu 1...
February 15, 2019: Journal of Neuro-oncology
Ramesh Yadav, Denise Taylor, Gordon Taylor, Jenny Scott
Background Opioid substitution therapy involves prescribing of medical substitutes like methadone and buprenorphine to patients who are addicted to opioids. The majority of opioid substitution therapy dispensing in the UK is done by community pharmacists and they often see the patients on daily basis. It is unknown to what extent community pharmacists implement the policy to prevent overdose in patients receiving such treatment. Objective To explore what UK community pharmacists think about their role in preventing opium substitution-related deaths, their understanding of the risks associated with this substitution therapy and their views on what else community pharmacists could do to reduce such deaths...
February 15, 2019: International Journal of Clinical Pharmacy
Jesper Grønlund Holm, Tove Agner, Maja-Lisa Clausen, Simon Francis Thomsen
We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age)...
February 15, 2019: Archives of Dermatological Research
Shinjini Bhatnagar, Partha P Majumder, Dinakar M Salunke
Globally, preterm birth is a major public health problem. In India, 3.6 million of the 27 million infants born annually are preterm. Risk stratification of women based on multidimensional risk factors assessed during pregnancy is critical for prevention of preterm birth. A cohort study of pregnant women was initiated in May 2015 at the civil hospital in Gurugram, Haryana, India. Women are enrolled within 20 weeks of gestation and are followed until delivery and once postpartum. The objectives are to identify clinical, epidemiologic, genomic, epigenomic, proteomic, and microbial correlates; discover molecular-risk markers by using an integrative -omics approach; and generate a risk-prediction algorithm for preterm birth...
February 16, 2019: American Journal of Epidemiology
Oyunchimeg Orsoo, Yu Mon Saw, Enkhbold Sereenen, Buyanjargal Yadamsuren, Ariunsanaa Byambaa, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima
BACKGROUND: Mongolia was one of the four countries that received a measles-elimination certificate from the World Health Organization Regional Office for the Western Pacific in 2014. Following the outbreaks in many countries including China, a large measles outbreak occurred in Mongolia in 2015. This study reports 2015-2016 measles outbreak incidence, mortality, and complications, according to time, geographical distribution, and host characteristics. METHODS: The epidemiological characteristics and trends of measles outbreak were analyzed using the Mongolian national surveillance data reported to the Center for Health Development, Ministry of Health, from January 2015 to December 2016...
February 15, 2019: BMC Public Health
Yamei Jiang, Turun Song, Jinpeng Liu, Zhiling Wang, Xianding Wang, Zhongli Huang, Yu Fan, Tao Lin
INTRODUCTION: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors. METHODS: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non-AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes...
February 15, 2019: Pediatric Transplantation
Kathleen M Andersen, Ayano Kelly, Anne Lyddiatt, Clifton O Bingham, Vivian P Bykerk, Adena Batterman, Joan Westreich, Michelle K Jones, Marita Cross, Peter Brooks, Lyn March, Beverley Shea, Peter Tugwell, Lee S Simon, Robin Christensen, Susan J Bartlett
OBJECTIVE: The OMERACT Safety Working Group is identifying core safety domains that matter most to rheumatic disease patients. METHODS: International focus groups were held with 39 inflammatory arthritis patients to identify DMARD experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees. RESULTS: Patients view DMARD side effects as a continuum and consider cumulative impact on day-to-day function...
February 15, 2019: Journal of Rheumatology
Maarten Boers, Dorcas E Beaton, Beverley J Shea, Lara J Maxwell, Susan J Bartlett, Clifton O Bingham, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten P de Wit, Laure Gossec, Lyn March, Lee S Simon, Jasvinder A Singh, Vibeke Strand, George A Wells, Peter Tugwell
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 framework was developed in 2014 to aid core outcome set development by describing the full universe of "measurable aspects of health conditions" from which core domains can be selected. This paper provides elaborations and updated concepts (OMERACT Filter 2.1). METHODS: At OMERACT 2018, we discussed challenges in the framework application caused by unclear or ambiguous wording and terms and incompletely developed concepts...
February 15, 2019: Journal of Rheumatology
Susan Humphrey-Murto, Richard Crew, Beverley Shea, Susan J Bartlett, Lyn March, Peter Tugwell, Lara J Maxwell, Dorcas Beaton, Shawna Grosskleg, Maarten de Wit
OBJECTIVE: Developing international consensus on outcome measures for clinical trials is challenging. The following paper will review consensus building in Outcome Measures in Rheumatology (OMERACT), with a focus on the Delphi. METHODS: Based on the literature and feedback from delegates at OMERACT 2018, a set of recommendations is provided in the form of the OMERACT Delphi Consensus Checklist. RESULTS: The OMERACT delegates generally supported the use of the checklist as a guide...
February 15, 2019: Journal of Rheumatology
Zhou Zhou, Yanni Fan, Wenxi Tang, Xinyue Liu, Darren Thomason, Zheng-Yi Zhou, Dendy Macaulay, Aryeh Fischer
OBJECTIVE: To quantify healthcare resource utilization (HRU), work loss, and annual direct and indirect healthcare costs among patients with systemic sclerosis (SSc) compared to matched controls in the United States. METHODS: Data were obtained from a large US commercial claims database. Patients were ≥ 18 years old at the index date (first SSc diagnosis) and had ≥ 1 SSc diagnosis in the inpatient (IP) or emergency room (ER) setting, or ≥ 2 SSc diagnoses on 2 different dates in the outpatient (OP) setting between January 1, 2005, and March 31, 2015; continuous enrollment was required during the followup period (12 months after the index date)...
February 15, 2019: Journal of Rheumatology
Lara J Maxwell, Dorcas E Beaton, Beverley J Shea, George A Wells, Maarten Boers, Shawna Grosskleg, Clifton O Bingham, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten P de Wit, Laure Gossec, Lyn March, Lee S Simon, Jasvinder A Singh, Vibeke Strand, Peter Tugwell
OBJECTIVE: To describe the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 methodology for core domain set selection. METHODS: The "OMERACT Way for Core Domain Set selection" framework consists of 3 stages: first, generating candidate domains through literature reviews and qualitative work, then a process of consensus to obtain agreement from those involved, and finally formal voting on the OMERACT Onion. The OMERACT Onion describes the placement of domains in layers/circles: mandatory in all trials/mandatory in specific circumstances (inner circle); important but optional (middle circle); or research agenda (outer circle)...
February 15, 2019: Journal of Rheumatology
Asokumar Buvanendran, Craig J Della Valle, Jeffrey S Kroin, Mahendra Shah, Mario Moric, Kenneth J Tuman, Robert J McCarthy
BACKGROUND: Approximately 15% of patients report persistent knee pain despite surgical success following total knee arthroplasty (TKA). The purpose of this study was to determine the association of acute-postsurgical pain (APSP) with chronic postsurgical pain (CPSP) 6 months after TKA controlling for patient, surgical and psychological confounding factors. METHODS: Adult patients with osteoarthritis undergoing primary elective tricompartmental TKA, with the operated knee the primary source of preoperative pain, were studied between March 2011 and February 2017...
February 15, 2019: Regional Anesthesia and Pain Medicine
Ulas Akgun, Umut Canbek, Cem Yalin Kilinc, Ahmet Emrah Acan, Nazim Karalezli, Nevres Hurriyet Aydogan
Distal tibia and fibula fractures are challenging injuries to treat as evidenced by the high rates of wound complications because of vulnerable soft tissue coverage. The aim of this study was to examine the effect on soft tissue complications of the pie-crusting technique when applied between 2 incisions in distal tibia and fibula fractures treated with open reduction and internal fixation. We reviewed 34 patients with distal tibia and fibula fractures treated between September 2014 and March 2017. The pie-crusting technique was performed during wound closure in 16 (47...
February 13, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Mirco Sgroi, Thomas Loitsch, Heiko Reichel, Thomas Kappe
PURPOSE: To analyze and compare the diagnostic value and interpretation of 6 established clinical tests for infraspinatus tendon tears; to assess their ability to distinguish between partial- and full-thickness tears of the infraspinatus tendon; and to investigate whether conducting multiple tests increases the precision of diagnosis. METHODS: A total of 91 patients scheduled for shoulder arthroscopy from March 2015 to April 2017 were included in the present study...
February 12, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Isabella Pacchiarotti, Jari Tiihonen, Georgios D Kotzalidis, Norma Verdolini, Andrea Murru, José Manuel Goikolea, Marc Valentí, Alberto Aedo, Eduard Vieta
Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression)...
February 12, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Won Chul Shin, Jae Hoon Jang, Jae Yoon Jeong, Kuen Tak Suh, Nam Hoon Moon
INTRODUCTION: Although various clinical applications of geneX® ds have been reported, no study has reported the clinical application of geneX® ds in osteoporotic hip fracture. The present study aimed to identify the clinical effect of the application of geneX® ds in elderly patients with intertrochanteric fracture treated using proximal femoral nail antirotation (PFNA). MATERIALS AND METHODS: From March 2014 to October 2017, 233 patients with intertrochanteric fracture (65 men and 168 women) were enrolled in this study...
February 12, 2019: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Robert Ritson, Dustin H Ranglack, Nate Bickford
A wide variety of environmental stimuli can influence the behavior of animals including temperature, weather, light, lunar and seasonal cycles, seismic activity, as well as other perturbations to their circadian rhythm. Solar eclipses offer a unique opportunity to evaluate the relative influence of unexpected darkness on behavior of animals due to their sudden interference with local light levels and meteorology. Though occasionally bizarre, modern studies have lent support to the idea that at least some individuals of certain species display altered behavior during these events...
February 14, 2019: Animals: An Open Access Journal From MDPI
Wanchana Singhan, Somratai Vadcharavivad, Nutthada Areepium, Supeecha Wittayalertpanya, Weerachai Chaijamorn, Nattachai Srisawat
PURPOSE: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH). MATERIAL AND METHODS: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy...
February 5, 2019: Journal of Critical Care
A M Alguacil-Ramos, A Portero-Alonso, E Pastor-Villalba, J Muelas-Tirado, J Díez-Domingo, A Sanchis-Ferrer, J A Lluch-Rodrigo
OBJECTIVES: The enhanced safety surveillance for seasonal influenza vaccines established by the European Medicines Agency is required each season. Therefore, a registry capable of rapidly detecting and evaluating potential new safety concerns is needed. The aim of the study is to demonstrate the effectiveness of the vaccine information system of the Valencia region to make a rapid assessment of the influenza vaccine safety and describe the safety of the two vaccine types used in the 2017/2018 season...
February 12, 2019: Public Health
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