keyword
https://read.qxmd.com/read/34438406/efficacy-and-safety-of-liquid-nitrogen-cryotherapy-for-lichen-simplex-chronicus-a-meta-analysis
#21
Lingyuan Zhong, Qiuyue Wang, Mao Li, Pingsheng Hao
BACKGROUND: Lichen simplex chronicus (LSC) is characterized by localized lichenification and intense itching. It has been reported that the added use of liquid nitrogen cryotherapy (LNC) for LSC has significant efficacy and notable safety. Therefore, we conducted a meta-analysis based on existing randomized controlled trials (RCTs). METHOD: We searched RCTs on LNC for LSC published up to August 2020 using various databases, including PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, China Network Knowledge Infrastructure (CNKI), Chinese Biomedicine (CBM), Chinese Scientific Journals Database (VIP), and WanFang Database...
2022: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/34321929/prevalence-and-medications-of-atopic-dermatitis-in-germany-claims-data-analysis
#22
JOURNAL ARTICLE
Kristina Hagenström, Kristin Sauer, Nicole Mohr, Marleen Dettmann, Gerd Glaeske, Jana Petersen, Claudia Garbe, Tim Steimle, Matthias Augustin
BACKGROUND: Information on the prevalence of atopic dermatitis (AD) varies greatly, and so far, only a few studies describe the healthcare of patients with AD in Germany. OBJECTIVE: The aim of the study is to describe the prevalence and medications of people with AD in Germany. METHODS: Health insurance data for the year 2019 were examined. Prevalence rates, the severity of disease, comorbidities and pharmaceutical supply were analyzed. Insured persons with AD were identified with at least one outpatient or inpatient International Classification Code of Diseases (L20)...
2021: Clinical Epidemiology
https://read.qxmd.com/read/34261335/prominent-role-of-type-2-immunity-in-skin-diseases-beyond-atopic-dermatitis
#23
JOURNAL ARTICLE
Lina Belmesk, Anastasiya Muntyanu, Emmanuelle Cantin, Zeinah AlHalees, Carolyn S Jack, Michelle Le, Denis Sasseville, Lisa Iannattone, Moshe Ben-Shoshan, Ivan Litvinov, Elena Netchiporouk
Type 2 immunity, illustrated by T helper 2 lymphocytes (Th2) and downstream cytokines (IL-4, IL-13, IL-31) as well as group 2 innate lymphoid cells (ILC2), is important in host defense and wound healing.1 The hallmark of type 2 inflammation is eosinophilia and/or high IgE counts and is best recognized in atopic diathesis. Persistent eosinophilia, such as seen in hypereosinophilic syndromes, leads to fibrosis and hence therapeutic Type 2 inhibition in fibrotic diseases is of high interest. Furthermore, as demonstrated in cutaneous T cell lymphoma, advanced disease is characterized by Th1 to Th2 switch allowing cancer progression and immunosuppression...
July 14, 2021: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/34224772/evidence-of-n-acetylcysteine-efficacy-for-skin-picking-disorder-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Angelina S Hwang, Elliott H Campbell, Julio C Sartori-Valinotti
No abstract text is available yet for this article.
July 2022: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/34115159/-the-skin-microbiome-useful-for-diagnosis-and-therapy
#25
REVIEW
Claudia Hülpüsch, Matthias Reiger
BACKGROUND: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors. AIM: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. MATERIALS AND METHODS: A literature search was performed...
June 11, 2021: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://read.qxmd.com/read/33593424/scabies-induced-lichen-simplex-chronicus-misdiagnosed-as-psychogenic-pruritus-a-case-report
#26
JOURNAL ARTICLE
Ozzy M Emmanuel, Ana V Karovska, Okey Ikedilo
INTRODUCTION: Lichen simplex chronicus has been defined as a localized skin condition characterized by thickening, hyperpigmentation and accentuated skin markings from chronic itching and from repeated scratching. The affected skin area is usually described as demarcated, and often circumscribed. It has even been defined as a "psychogenic pruritic disorder". The idea of a neurological component has also been suggested, hence the term 'neurodermatitis circumscripta'. However, the pathophysiology of this condition remains unclear...
February 17, 2021: Journal of Medical Case Reports
https://read.qxmd.com/read/33559259/prurigo-nodularis-comparative-treatment-outcome-in-patients-attending-a-tertiary-hospital-in-northern-tanzania
#27
JOURNAL ARTICLE
Elias V Mayala, Daudi R Mavura, Masanja Robert, Elisante J Masenga
BACKGROUND: Prurigo nodularis (PN) is a chronic, benign neurodermatitis of unclear etiology characterized by excoriated, intensely pruritic nodules secondary to an intense itch-scratch cycle. PN treatment is still a challenge, and it is frustrating for both dermatologists and patients. The evidence for the effectiveness of a readily available treatment like cryotherapy is limited. OBJECTIVE: To compare the efficacy of cryotherapy versus 0.05% clobetasol propionate in PN patients attending the RDTC, Northern Tanzania, from October 2018 to July 2019...
February 8, 2021: Dermatologic Therapy
https://read.qxmd.com/read/33426426/biologics-for-atopic-diseases-indication-side-effect-management-and-new-developments
#28
REVIEW
Uta Jappe, Hendrik Beckert, Karl-Christian Bergmann, Askin Gülsen, Ludger Klimek, Sandra Philipp, Julia Pickert, Michèle M Rauber-Ellinghaus, Harald Renz, Christian Taube, Regina Treudler, Martin Wagenmann, Thomas Werfel, Margita Worm, Torsten Zuberbier
With the advent of biologicals, more and more therapeutics are available that specifically address specific switch points in the pathomechanism of immunologically dominated diseases. Thus, the focus of diagnostics and therapy (precision medicine) is more on the individual disease characteristics of the individual patient. Regarding the different phenotypes of atopic diseases, severe asthma was the first entity for which biologicals were approved, followed by urticaria, and finally atopic dermatitis and chronic rhinosinusitis with nasal polyps...
2021: Allergologie Select
https://read.qxmd.com/read/33368555/mouse-models-of-atopic-dermatitis-a-critical-reappraisal
#29
JOURNAL ARTICLE
Amos Gilhar, Kristian Reich, Aviad Keren, Kenji Kabashima, Martin Steinhoff, Ralf Paus
Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this Viewpoint, we delineate why, unfortunately, none of the currently available so-called "AD" mouse models satisfactorily reflect the clinical complexity of human AD, but imitate more 'allergic' or 'irriant' contact dermatitis conditions. This evaluation limits the predictive value of AD models for clinical outcomes of new tested candidate AD therapeutics and the instructiveness of mouse models for human AD pathophysiology research...
December 23, 2020: Experimental Dermatology
https://read.qxmd.com/read/33221950/what-are-the-highest-yielding-search-strategy-terms-for-systematic-reviews-in-atopic-dermatitis-a-systematic-review
#30
JOURNAL ARTICLE
Marissa T Ayasse, Adnan Ahmed, Maria L Espinosa, Christina J Walker, Muhammad Yousaf, Jacob P Thyssen, Jonathan I Silverberg
The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed by running combinations of search terms in MEDLINE and EMBASE. Overall, 250 SR met inclusion criteria, of which 225 specified search strategies. SR using 5-6 terms (20.0% to 12.1%) or ≥ 7 (40...
November 2021: Archives of Dermatological Research
https://read.qxmd.com/read/33019475/cupping-for-neurodermatitis-a-protocol-of-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Li Peng, Qianying Yu, Jie Zhang, Xiongfei Mi, Wenxia Lin, Yuesi Qin, Ying He, Jing Guo, Min Xiao, Mingling Chen
BACKGROUND: Neurodermatitis is a common inflammatory and allergic disease, characterized by itching and lichenification plaque. Some studies have reported cupping therapy (CT) for the treatment of neurodermatitis. However, the effectiveness and safety are still uncertain. This study aims to evaluate the efficacy and safety of CT for the treatment of patients with neurodermatitis. METHODS: We will retrieve the following electronic databases systematically: Pubmed, Web of Science, Embase, the Cochrane Library, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, and Wanfang database from their inception to December 2020...
October 2, 2020: Medicine (Baltimore)
https://read.qxmd.com/read/32695687/impact-of-covid-19-pandemic-on-dermatologists-and-dermatology-practice
#32
EDITORIAL
Yasmeen Jabeen Bhat, Aaqib Aslam, Iffat Hassan, Sunil Dogra
The COVID-19 pandemic has directly or indirectly affected every human being on this planet. It's impact on the healthcare system has been devastating. The medical fraternity across the world, including India, is facing unprecedented challenges in striving to cope up with this catastrophic outbreak. Like all other specialties, dermatology practice has been profoundly affected by this pandemic. Measures have been taken by dermatologists to control the transmission of the virus, whereas providing health care to patients in the constrained environment...
May 2020: Indian Dermatology Online Journal
https://read.qxmd.com/read/32677246/awareness-of-psychodermatology-in-indian-dermatologists-a-south-indian-perspective
#33
JOURNAL ARTICLE
Bishurul Hafi, Ettappurath N Abdul Latheef, N A Uvais, Mohammad Jafferany, Muhammed Razmi T, Afra Tp, Silah Aysha Ks
This study was aimed to survey the awareness, knowledge, practicing patterns, and attitudes of dermatologists toward psychocutaneous disorders in a South Indian State. The questionnaire-based study was performed from August 1 to October 31, 2019. Study participants included 123 dermatologists. The questionnaire consisted of nine multiple-choice questions and two open-ended questions regarding knowledge, practicing patterns, and attitude to psychodermatology. Forty five (36.6%) dermatologists completed this online survey...
November 2020: Dermatologic Therapy
https://read.qxmd.com/read/32588415/a-systematic-analysis-of-evaluation-methods-for-inpatient-children-and-adolescents-rehabilitation-programs
#34
JOURNAL ARTICLE
Sarah Wolf, Roman Winkler
Increasing chronic diseases in children and adolescents such as obesity, asthma bronchiale, or mental disorders, result in a growing importance of rehabilitation programs and subsequent program evaluations. We conducted a systematic literature search in 5 databases and provided an overview of methods for evaluating inpatient child and adolescent rehabilitation programs. This included an identification of generic and indication-specific outcomes and standardized measuring instruments. Eighteen studies covering 8 indication groups were considered for the qualitative analysis according to the pre-defined inclusion and exclusion criteria...
June 25, 2020: Klinische Pädiatrie
https://read.qxmd.com/read/31529190/-the-health-status-of-children-and-adolescents-with-migration-background-in-germany-results-from-kiggs-wave-2
#35
REVIEW
Claudia Santos-Hövener, Benjamin Kuntz, Laura Frank, Carmen Koschollek, Ute Ellert, Heike Hölling, Roma Thamm, Anja Schienkiewitz, Thomas Lampert
BACKGROUND: Even though 36.5% of children and adolescents living in Germany have a migration background (MB), data on the health of this population is scarce. With population-based data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017), reliable statements can be given. METHODS: Data from KiGGS Wave 2 is used in order to report on general health status, mental health, and the distribution of allergic diseases among children and adolescents aged 3-17 years (n = 13,568)...
October 2019: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://read.qxmd.com/read/31443157/derailed-ceramide-metabolism-in-atopic-dermatitis-ad-a-causal-starting-point-for-a-personalized-basic-therapy
#36
REVIEW
Markus Blaess, Hans-Peter Deigner
Active rebuilding, stabilizing, and maintaining the lipid barrier of the skin is an encouraging disease management and care concept for dry skin, atopic dermatitis (eczema, neurodermatitis), and psoriasis. For decades, corticosteroids have been the mainstay of topical therapy for atopic dermatitis; however, innovations within the scope of basic therapy are rare. In (extremely) dry, irritated, or inflammatory skin, as well as in lesions, an altered (sphingo)lipid profile is present. Recovery of a balanced (sphingo)lipid profile is a promising target for topical and personalized treatment and prophylaxis...
August 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/29771216/mindfulness-based-cognitive-hypnotherapy-and-skin-disorders
#37
REVIEW
Philip D Shenefelt
Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo...
July 2018: American Journal of Clinical Hypnosis
https://read.qxmd.com/read/28447153/-neurodermatitis-atopy-of-the-skin
#38
REVIEW
R Fölster-Holst
Atopic dermatitis is one of the most common skin diseases and is associated with an impaired quality of life due to tormenting itching and stigmatization. The disease almost always manifests in early childhood and exhibits specific features in this phase, with involvement of the extensor sides of the extremities. During the further course of disease, the typical flexor involvement becomes quite clear and a considerable proportion of patients develop the associated atopic respiratory diseases. Therapeutic and prophylactic measures focus on the prevention of trigger factors, basic skin care, and application of lipid-replenishing creams, as well as patient and parent education...
June 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://read.qxmd.com/read/28338543/perianal-dermatitis
#39
JOURNAL ARTICLE
Alfredo-Daniel Agulló-Pérez, Marcos Hervella-Garcés, Saioa Oscoz-Jaime, Maialen Azcona-Rodríguez, Mónica Larrea-García, Juan-Ignacio Yanguas-Bayona
BACKGROUND: Perianal complaints are often consulted in dermatology clinics, and in many cases, a conclusive diagnosis is not easily made. OBJECTIVE: The aim of this study was to study and identify the epidemiological, clinical, and contact allergy features of patients with perianal dermatitis who attended at a contact dermatitis unit in a tertiary hospital in Spain. METHODS: Adult patients with long-lasting (>4 weeks) perianal dermatitis were recruited during the past 10 years for investigation and follow-up...
July 2017: Dermatitis
https://read.qxmd.com/read/28259230/vulvovaginal-issues-in-mature-women
#40
REVIEW
Mary L Marnach, Rochelle R Torgerson
Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. A vulvar biopsy is easy to perform and generally well tolerated when indicated for the diagnosis of lichen simplex chronicus, lichen sclerosus, and lichen planus...
March 2017: Mayo Clinic Proceedings
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