keyword
https://read.qxmd.com/read/38542686/association-between-serum-phytosterols-and-lipid-levels-in-a-population-based-study
#1
JOURNAL ARTICLE
Laura Stanasila, Dieter Lütjohann, Julius Popp, Pedro Marques-Vidal
The association between phytosterols and lipid levels remains poorly assessed at a population level. We assessed the associations between serum levels of six phytosterols (campesterol, campestanol, stigmasterol, sitosterol, sitostanol and brassicasterol) and of lipids [total, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipopoprotein A-IV and lipoprotein Lp(a)] in two cross-sectional surveys of a population-based, prospective study. Data from 910 participants (59...
March 8, 2024: Nutrients
https://read.qxmd.com/read/38540758/bioactive-compounds-from-pigmented-corn-zea-mays-l-and-their-effect-on-health
#2
REVIEW
Yaír Adonaí Sánchez-Nuño, Martín Zermeño-Ruiz, Olga Deli Vázquez-Paulino, Karla Nuño, Angélica Villarruel-López
Pigmented corn is a gramineae food of great biological, cultural and nutritional importance for many Latin American countries, with more than 250 breeds on the American continent. It confers a large number of health benefits due to its diverse and abundant bioactive compounds. In this narrative review we decided to organize the information on the nutrients, bioactive compounds and phytochemicals present in pigmented corn, as well as their effects on human health. Phenolic compounds and anthocyanins are some of the most studied and representative compounds in these grasses, with a wide range of health properties, mainly the reduction of pro-oxidant molecules...
March 12, 2024: Biomolecules
https://read.qxmd.com/read/38540690/sterol-migration-during-rotational-frying-of-food-products-in-modified-rapeseed-and-soybean-oils
#3
JOURNAL ARTICLE
Magdalena Rudzińska, Anna Gramza-Michałowska, Monika Radzimirska-Graczyk, Eliza Gruczyńska-Sękowska
This study explores the impact of rotational frying of three different food products on degradation of sterols, as well as their migration between frying oils and food. The research addresses a gap in the existing literature, which primarily focuses on changes in fat during the frying of single food items, providing limited information on the interaction of sterols from the frying medium with those from the food product. The frying was conducted at 185 ± 5 °C for up to 10 days where French fries, battered chicken, and fish sticks were fried in succession...
February 23, 2024: Biomolecules
https://read.qxmd.com/read/38539914/dietary-antioxidants-may-support-cosmetic-treatment-in-patients-with-rosacea
#4
JOURNAL ARTICLE
Kinga Zujko-Kowalska, Joanna Masłowska, Małgorzata Knaś-Dawidziuk, Jadwiga Hamulka, Małgorzata Elżbieta Zujko
Rosacea is a chronic skin disease that significantly reduces the quality of life (QoL) of patients. The aim of this study was to assess whether dietary antioxidants can support the effect of cosmetic treatment in improving the QoL of patients with rosacea. Basic data about participants (N = 160) were collected using a self-reported survey. QoL was assessed using the standardized Dermatology Life Quality Index (DLQI) questionnaire. An interventional cosmetic treatment was performed using cavitation peeling and sonophoresis with a commercial capillary repair serum...
March 21, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539913/stigmasterol-exerts-an-anti-melanoma-property-through-down-regulation-of-reactive-oxygen-species-and-programmed-cell-death-ligand-1-in-melanoma-cells
#5
JOURNAL ARTICLE
Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon
Cancer immunotherapy as a promising anti-cancer strategy has been widely studied in recent years. Stigmasterol (STIG), a phytosterol, is known to have various pharmacological effects, including anti-inflammatory effects. However, the pharmacological role of STIG on melanoma immunotherapy has not been investigated. The present study demonstrates the anti-melanoma potency of STIG through the regulation of PD-L1 levels. The results reveal that STIG reduces reactive oxygen species (ROS) levels induced by hydrogen peroxide and increases glutathione levels decreased by α-MSH in B16F10 cells...
March 21, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38525815/resolving-phytosterols-in-microalgae-using-offline-two-dimensional-reversed-phase-liquid-chromatography-supercritical-fluid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#6
JOURNAL ARTICLE
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Sterols are unsaponifiable lipids resulting from plant metabolism that exhibit interesting bioactive properties. Microalgae are a major source of specific phytosterols, most of which are still not fully characterized. The similarity in sterol structures and the existence of positional isomers make the separation of phytosterols challenging. A method was developed based on an offline two-dimensional (2D) system, reversed-phase liquid chromatography (RPLC)-supercritical fluid chromatography (SFC)/quadrupole time-of-flight (Q-ToF) mass spectrometry, for the identification of sterols in microalgae...
March 25, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38518620/the-effect-of-extraction-methods-on-the-components-and-quality-of-camellia-oleifera-oil-focusing-on-the-flavor-and-lipidomics
#7
JOURNAL ARTICLE
Wenquan Zeng, Xudong Liu, Yan Chao, Yiying Wu, Shukun Qiu, Baining Lin, Rukuan Liu, Ruichang Tang, Suxi Wu, Zhihong Xiao, Changzhu Li
The objective of this study was to systematically elucidate the effects of conventional (Cold Pressing, CP; Hot Pressing, HP; Soxhlet Extraction; SE) and novel methods (Microwave-Assisted Extraction, MAE) on the physicochemical properties, bio-active substances, flavor and lipidomics of Camellia oleifera oil (COO). The cold-pressed COO contained the highest contents of squalene (176.38 mg/kg), α-tocopherol (330.52 mg/kg), polyphenols (68.33 mg/kg) and phytosterols (2782.55 mg/kg). Oleic acid was observed as the predominant fatty acid with the content of approximately 80%...
March 18, 2024: Food Chemistry
https://read.qxmd.com/read/38518371/development-of-phytosterol-loaded-silver-nanoparticles-for-ameliorating-hemorrhoidal-complications-via-ampk-pathway-a-mechanistic-approach
#8
JOURNAL ARTICLE
Tarkeshwar Dubey, Bhanukiran Kancharla, Hemalatha Siva
The current study was aimed to synthesize silver nanoparticles (PLSNPs) using green technology by means of phytosterol enriched fractions (EAF) from Blumea lacera extracts and evaluate its toxicological and anti-hemorrhoidal potential. The peak at 410 nm wavelength in the UV-Visible spectrophotometer verified the fabrication of PLSNPs because of surface plasmon resonance. Average size of synthesized particle was found to be 85.64 nm supported by SEM and TEM. EDS analysis showed the elemental composition of synthesized PLSNPs having carbon (C) 12...
March 22, 2024: Biomedical Materials
https://read.qxmd.com/read/38511776/phytochemical-analysis-toxicity-and-evaluation-of-antioxidant-and-antimicrobial-activities-of-leaves-of-dipteryx-alata-vogel
#9
JOURNAL ARTICLE
E Scapin, D R A Sarri, M A C Augusco, M A M Rodrigues, R M N Fernandes, J F M Silva, C A L Cardoso, M K D Rambo
In this study, our objective was to conduct a comprehensive phytochemical analysis, determine toxicity levels, and assess the antioxidant and antimicrobial properties of extracts derived from the leaves of Dipteryx alata Vogel, a native species of the Brazilian cerrado flora. Three distinct extracts were prepared utilizing assisted ultrasound and the Soxhlet apparatus, namely, Ultrasound Crude Extract (UCE), Soxhlet Crude Extract (SCE), and the Soxhlet Ethanol Extract (SEE). The phytochemical analysis revealed the presence of flavonoids, tannins, phytosterols, and saponins in all extracts...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38509904/phytochemical-analysis-gc-ms-characterization-and-antioxidant-activity-of-hordeum-vulgare-seed-extracts
#10
JOURNAL ARTICLE
Saman Shahab Farooqi, Safila Naveed, Fatima Qamar, Aisha Sana, Shahab H Farooqi, Neelam Sabir, Asra Mansoor, Halima Sadia
Barley scientifically known as Hordeum vulgare (HV) is a major grain crop. Over the course of time, great interest has been developed in the usage of barley, because of its various pharmacological activities. Current study is designed to determine the chemical constituents of Hordeum vulgare (HV) seed extract by GC-MS technique, and Invitro antioxidant assays i.e. 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) and 2-azino-bis(3-ethyl benzthiazoline-6-sulfonic acid) (ABTS) methods. GC-MS identified 16 non-polar compounds in the hexane extract of HV plant, which includes carboxylic acid (6...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509578/gene-variants-and-clinical-characteristics-of-children-with-sitosterolemia
#11
JOURNAL ARTICLE
Rui Gu, Hui Wang, Chun-Lin Wang, Mei Lu, Miao Miao, Meng-Na Huang, Yi Chen, Yang-Li Dai, Ming-Qiang Zhu, Qiong Zhou, Chao-Chun Zou
OBJECTIVE: To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients. METHODS: In this group, 26 children were diagnosed with sitosterolemia, 24 of whom underwent genetic analysis. Patient family medical history, physical symptoms, tests for liver function, lipid levels, standard blood tests, phytosterol levels, cardiac/carotid artery ultrasounds, fundus examinations, and treatment were collected...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38487178/phytosterol-organic-acid-esters-characterization-anti-inflammatory-properties-and-a-delivery-strategy-to-improve-mitochondrial-function
#12
JOURNAL ARTICLE
Xinyue Zou, Ting Xu, Tian Zhao, Jing Xia, Feifan Zhu, Yu Hou, Baiyi Lu, Yunfei Zhang, Xuan Yang
Phytosterol organic acid esters are important food resources and the components of biomembrane structure. Due to the lack of extraction and synthesis techniques, more research has been focused on phytosterols, and the research on phytosterol acid esters have encountered a bottleneck, but phytosterol acid esters confer substantial benefits to human health. In this study, stigmasteryl vanillate (VAN), stigmasteryl protocatechuate (PRO) and stigmasteryl sinapate (SIN) were prepared through the Steglich reaction...
2024: Current research in food science
https://read.qxmd.com/read/38481025/brazil-nut-bertholletia-excelsa-h-b-k-and-brazil-nut-oil-effects-on-oxidative-stress-and-potential-therapeutic-health-benefits-from-human-animal-and-cell-culture-models
#13
JOURNAL ARTICLE
Beatriz Alem Nascimento de Araújo, Luisa Maria Tavares da Silva de Campos, Gleiciane Teixeira Souza, Giovanna de Menezes Abreu, Carolina de Oliveira Ramos Petra de Almeida, Mariana Sarto Figueiredo
Brazil nut (Bertholletia excelsa H.B.K.) is characterized by its high nutritional and energetic value. It contains high levels of l-arginine, antioxidant vitamins, phenolic compounds, and phytosterols. In addition to their biological functions, bioactive compounds and essential fatty acids present therapeutic effects on chronic disease prevention through their antioxidant effects. Thus, this review aims to present the most recent scientific evidence on the effect of Brazil nut on human health. A search for scientific articles was carried out through the MEDLINE/PubMed, Science Direct, and LILACS databases, considering articles published between the years 2010 and 2023...
March 13, 2024: Nutrition Reviews
https://read.qxmd.com/read/38474591/a-new-glucosyl-flavone-with-inhibitory-activity-of-cancer-cell-viability-and-other-bioactive-constituents-from-the-traditional-kurdish-plant-plantago-loeflingii-l
#14
JOURNAL ARTICLE
Hawraz Ibrahim M Amin, Kamaran Younis M Amin, Chabaco Armijos, Faiq H S Hussain, Zanko Hassan Jawhar, Diego Caprioglio, Mariella Mella, Giovanni Vidari
A new glucosyl flavone, 5,7,2',5'-tetrahydroxyflavone 7- O -β-d-glucopyranoside, named loeflingiin, together with apigenin 6- C -glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild Plantago loeflingii L. ( Plantaginaceae ) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472086/octadecyl-and-sulfonyl-modification-of-diatomite-synergistically-improved-the-immobilization-efficiency-of-lipase-and-its-application-in-the-synthesis-of-pine-sterol-esters
#15
JOURNAL ARTICLE
Yifei Zhang, Wei Zhang, Guangzheng Ma, Binbin Nian, Yi Hu
Phytosterols usually have to be esterified to various phytosterol esters to avoid their disadvantages of unsatisfactory solubility and low bioavailability. The enzymatic synthesis of phytosterol esters in a solvent-free system has advantages in terms of environmental friendliness, sustainability, and selectivity. However, the limitation of the low stability and recyclability of the lipase in the solvent-free system, which often requires a relatively high temperature to induce the viscosity, also increased the industrial production cost...
March 2024: Biotechnology Journal
https://read.qxmd.com/read/38461862/a-scyl2-gene-from-oryza-sativa-is-involved-in-phytosterol-accumulation-and-regulates-plant-growth-and-salt-stress
#16
REVIEW
Minyan Xu, Ying Ni, Yaling Tu, Yanping Wang, Zhi Zhang, Yuhuan Jiao, Xin Zhang
Rice is a crucial food for humans due to its high nutritional value. Phytosterols, essential components of the plant membrane lipid bilayer, play a vital role in plant growth and contribute significantly to lipid-lowering, antitumor, and immunomodulation processes. In this study, SCY1-like protein kinases 2 (SCYL2) was found to be closely related to the accumulation of phytosterols. The levels of campesterol, stigmasterol, and β-sitosterol significantly increased in transgenic rice seeds, husks, and leaves, whereas there was a considerable reduction in scyl2 plants...
March 8, 2024: Plant Science: An International Journal of Experimental Plant Biology
https://read.qxmd.com/read/38461353/deciphering-the-effect-of-phytosterols-on-alzheimer-s-disease-and-parkinson-s-disease-the-mediating-role-of-lipid-profiles
#17
JOURNAL ARTICLE
Xingzhi Guo, Jing Yu, Rui Wang, Ning Peng, Rui Li
BACKGROUND: Studies have suggested that blood circulating phytosterols, plant-derived sterols analogous to cholesterol, were associated with blood lipid levels and the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). This Mendelian randomization (MR) study is performed to determine the causal effect of circulating phytosterols on AD and PD and evaluate the mediation effect of blood lipids. METHODS: Leveraging genome-wide association studies summary-level data for phytosterols, blood lipids, AD, and PD, univariable and multivariable MR (MVMR) analyses were conducted...
March 9, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38447903/solving-the-jigsaw-puzzle-of-phytosterol-diversity-by-a-novel-sterol-methyltransferase-from-zea-mays
#18
JOURNAL ARTICLE
Qinhua Gan, Haifeng Zheng, Xinyu Li, Jing Li, Jingxue Ma, Yuji Zhang, Jiakun Han, Lin Zhang, Wenxu Zhou, Yandu Lu
Phytosterols are vital structural and regulatory components in plants. Zea mays produces a series of phytosterols that are specific to corn. However, the underline biosynthetic mechanism remains elusive. In this study, we identified a novel sterol methyltransferase from Z. mays (ZmSMT1-2) which showed a unique feature compared with documented plant SMTs. ZmSMT1-2 showed a substrate preference for cycloartenol. Using S-adenosyl-L-methionine (AdoMet) as a donor, ZmSMT1-2 converted cycloartenol into alkylated sterols with unique side-chain architectures, including Δ25(27) (i...
March 4, 2024: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/38444505/-ephedra-alte-extracts-gc-ms-profiles-and-antimicrobial-activity-against-multidrug-resistant-pathogens-mrsa
#19
JOURNAL ARTICLE
Haya Ayyal Salman, Amira Suriaty Yaakop, Fuad Al-Rimawi, Ana Masara Ahmad Makhtar, Muath Mousa, Mohammad H Semreen, Naiyf S Alharbi
The extracts of E. alte offer promising potential as renewable resources for various chemical derivative products aimed at addressing antibiotic resistance. These extracts exhibited significant activity against methicillin-resistant Staphylococcus aureus (MRSA), a strain known for its resistance to multiple antibiotics. The extracts were found to be effective against several common antibiotics, including Imipenem, Ampicillin, Penicillin G, Oxacillin, and Amoxicillin-clavulanate. GC-MS analysis revealed that the phytoconstituents of E...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38444496/combination-of-fingerprint-and-chemometric-analytical-approaches-to-identify-the-geographical-origin-of-qinghai-tibet-plateau-rapeseed-oil
#20
JOURNAL ARTICLE
Ziqin Ye, Jinying Wang, Shengrui Gan, Guoxin Dong, Furong Yang
Verification of the geographical origin of rapeseed oil is essential to protect consumers from fraudulent products. A prospective study was conducted on 45 samples from three rapeseed oil-producing areas in Qinghai Province, which were analyzed by GC-FID and GC-MS. To assess the accuracy of the prediction of origin, classification models were developed using PCA, OPLS-DA, and LDA. It was found that multivariate analysis combined with PCA separate 96% of the samples, and the correct sample discrimination rate based on the OPLS-DA model was over 98%...
March 15, 2024: Heliyon
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